Keywords: میکروسوم کبد انسان; Vildagliptin; Drug-induced liver injury; Hypersensitivity; Covalent binding; Nucleophilic trapping agents; ALG; alogliptin; ANG; anagliptin; CRP; C-reactive protein; CYP; cytochrome P450; DILI; drug-induced liver injury; DLST; drug-induced lymphocyte stim
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Keywords: میکروسوم کبد انسان; ADAM; advanced dissolution, absorption, and metabolism; AED; antiepileptic drug; AUC; area-under-the-curve; B/P; blood to plasma ratio; BID; twice daily; BMI; body mass index; CBZ; carbamazepine; CLint; intrinsic clearance; CLR; renal clearance; CL; clear
Hepatic and renal metabolism of genistein: An individual-based model to predict glucuronidation behavior of genistein in different organs
Keywords: میکروسوم کبد انسان; CYP; cytochrome P-450; HKM; human kidney microsomes; HLM; human liver microsome; HNF4α; Hepatocyte nuclear factor 4α; HPLC-ESI-Q-TOF-MS; High-performance liquid chromatography coupled with electrospray ionization/quadrupole-time-of-flight mass spectrome
Keywords: میکروسوم کبد انسان; GSH; glutathione; LC/MS; liquid chromatography/mass spectrometry; MRM; multiple reaction monitoring; HRMS; high resolution mass spectrometry; Qtrap; triple quadrupole linear ion trap; EMS; enhanced MS; NL; neutral loss scan; PI; precursor ion scan; MIM; m
Keywords: میکروسوم کبد انسان; AUC; area under the plasma concentration curve; Cmax; maximal plasma concentration; CMPF; 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid; CRF; chronic renal failure; CYP; cytochrome P450; ESRD; end-stage renal disease; HLM; human liver microsome; IC50;
Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of Glibenclamide in rat: An herb-drug interaction study
Keywords: میکروسوم کبد انسان; TC; Tinospora cordifolia; TCE; Tinospora cordifolia extract; CYP; Cytochrome P450; CAM; complementary and alternative medicine; IS; internal standard; LLOQ-QC; quality control sample at lowest limit of quantification level; LQC; low quality control sample
An appraisal on synthetic and pharmaceutical perspectives of pyrazolo[4,3-d]pyrimidine scaffold
Keywords: میکروسوم کبد انسان; A. flavus; Aspergillus flavus; C. albicans; Candida albicans; cAMP; cyclic adenosine monophosphate; CDK; cyclin-dependent kinase; CNS; central nervous system; COX; cyclooxygenase; CRF; corticotropin-releasing hormone; CRK; cdc2-related kinase; CYC6; cycli
In vitro metabolism of 4, 5-dimethoxycanthin-6-one by human liver microsomes and its inhibition on human CYP1A2
Keywords: میکروسوم کبد انسان; 4,5-dimethoxycanthin-6-one; Cytochrome P450; Human liver microsome; Metabolic interaction;
Identification of cytochrome P450 isoforms involved in the metabolism of Syl930, a selective S1PR1 agonist acting as a potential therapeutic agent for autoimmune encephalitis
Keywords: میکروسوم کبد انسان; Syl930; Hydroxylated metabolites; CYP450 isoforms; Metabolism; LC-MS/MS; CYPs; cytochrome P450 isoforms; LM; liver microsome; HLM; human liver microsome; RLM; rat liver microsome; MS; multiple sclerosis; S1PRs; sphingosine-1-phosphate receptors; S1PR1; sp
The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement
Keywords: میکروسوم کبد انسان; NaV1.7; voltage gated sodium channel 1.7; SCN9A; sodium voltage-gated channel alpha subunit 9; TM; transmembrane; VSD; voltage sensing domain; CLu; unbound clearance; HLM; human liver microsome; RLM; rat liver microsome; PX; patch express; LLE; ligand lip
Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus
Keywords: میکروسوم کبد انسان; SSTR5; somatostatin receptor subtype 5; OGTT; oral glucose tolerance test; hERG; human ether-a-go-go related gene; DM; diabetes mellitus; HFD; high-fat diet; NCS; N-chlorosuccinimide; WSC; 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride; HOB
Systematic comparison of the mono-, dimethyl- and trimethyl 3-hydroxy-4(1H)-pyridones - Attempted optimization of the orally active iron chelator, deferiprone
Keywords: میکروسوم کبد انسان; HPO; Iron(III)chelator; Orally active; density functional theory; DFT; mass spectroscopy; MS; dimethyl sulfoxide; DMSO; electrospray ionization; ESI; 3-morpholinopropanesulfonic acid; MOPS; human liver microsome; HLM; solid phase extraction; SPE; acetonit
Human arylacetamide deacetylase hydrolyzes ketoconazole to trigger hepatocellular toxicity
Keywords: میکروسوم کبد انسان; AADAC; arylacetamide deacetylase; BNPP; bis-(p-nitrophenyl) phosphate; CES; carboxylesterase; DFP; diisopropyl fluorophosphate; DMSO; dimethyl sulfoxide; G6P; glucose 6-phosphate; G6PDH; glucose 6-phosphate dehydrogenase; HLM; human liver microsome; HPLC;
Optimization of a novel series of N-phenylindoline-5-sulfonamide-based acyl CoA:monoacylglycerol acyltransferase-2 inhibitors: Mitigation of CYP3A4 time-dependent inhibition and phototoxic liabilities
Keywords: میکروسوم کبد انسان; ACAT; acyl CoA:cholesterol acyltransferase; ADME; absorption, distribution, metabolism and excretion; APCI; atomospheric pressure chemical ionization; CM; chylomicron; dba; dibenzylideneacetone; CYP; cytochrome P450; DDI; drug-drug interaction; DGAT; ac
Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold
Keywords: میکروسوم کبد انسان; AD; Alzheimer's disease; ANK; ankyrin repeat domain; ARM; armadillo repeat domain; AUC; area under the curve; BA; brain availability; BBB; blood brain barrier; BCRP; breast cancer related protein; BI; brain impairment; CSD; Cambridge Structural Database
Absolute quantification of UGT1A1 in various tissues and cell lines using isotope label-free UPLC-MS/MS method determines its turnover number and correlates with its glucuronidation activities
Keywords: میکروسوم کبد انسان; UGT; uridine 5â²-diphospho-glucuronosyltransferase (UDP-glucuronosyltransferase); CYP; cytochrome P450; UPLC; ultra performance liquid chromatography; MRM; multiple reaction monitoring; DP; declustering potential; CE; collision energy; CXP; collision cel
In vitro metabolism of brucine by human liver microsomes and its interactions with CYP substrates
Keywords: میکروسوم کبد انسان; Brucine; Human liver microsome; CYP3A4; Metabolism; Interaction
Effect of endogenous steroid hormones on 17-alpha-hydroxyprogesterone caproate metabolism
Keywords: میکروسوم کبد انسان; 17-alpha-hydroxyprogesterone caproate; drug-drug interaction; human liver microsome; metabolism; steroid hormone;
Capture hydrolysis signals in the microsomal stability assay: Molecular mechanisms of the alkyl ester drug and prodrug metabolism
Keywords: میکروسوم کبد انسان; Hydrolysis; Carboxylesterase; Carboxylic acid ester; Human liver microsome; Drug metabolism;
Induction of cytochrome P450 3A by Shexiang Baoxin Pill and its main components
Keywords: میکروسوم کبد انسان; P450; cytochrome P450; CYP3A; cytochrome P450 3A; DDI; drug-drug interaction; TCM; traditional Chinese medicine; SBP; Shexiang Baoxin Pill; MDZ; midazolam; CHD; coronary heart diseases; MUS; muscone; TES; testosterone; GRf; ginsenoside Rf; GRg1; ginseno
Human metabolites of brevetoxin PbTx-2: Identification and confirmation of structure
Keywords: میکروسوم کبد انسان; Brevetoxins; PbTx-2; Metabolism; Cytochrome P450; Human liver microsome
The algal hepatoxoxin okadaic acid is a substrate for human cytochromes CYP3A4 and CYP3A5
Keywords: میکروسوم کبد انسان; Okadaic acid; Diarrheic shellfish poisoning (DSP); Cytochrome P450; Metabolism; Human liver microsome; Protein phosphatase inhibitors
Determination of 13-O-demethyl tacrolimus in human liver microsomal incubates using liquid chromatography-mass spectrometric assay (LC-MS)
Keywords: میکروسوم کبد انسان; Tacrolimus; 13-O-demethyl tacrolimus; LC/ESI/MS; Human liver microsome; Protease inhibitors;
Role of Human Liver Cytochrome P450 2C9 in the Metabolism of a Novel α4β1/α4β7 Dual Antagonist, TR-14035
Keywords: میکروسوم کبد انسان; α4β1/α4β7 antagonist; CYP2C9; genetic polymorphism; metabolism; human liver microsome;
Nitrogen-substitution effects on the mutagenicity and cytochrome P450 isoform-selectivity of chrysene analogs
Keywords: میکروسوم کبد انسان; Aza-substitution; Human liver microsome; Ames test;