Keywords: Abl2; Arg kinase; Ifenprodil; Incubation; OFC; Orbital; Response-outcome;
مقالات ISI (ترجمه نشده)
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Keywords: Ifenprodil; Bupivacaine; Motor function; Nociception; Spinal block
First report of a putative involvement of the NMDA pathway in Pacific oyster (Crassostrea gigas) development: Effect of NMDA receptor ligands on oyster metamorphosis with implications for bivalve hatchery management
Keywords: NMDA receptor; Pacific oyster; Metamorphosis; Neuroendocrine pathways; Ifenprodil; MK-801;
The GluN1/GluN2B NMDA receptor and metabotropic glutamate receptor 1 negative allosteric modulator has enhanced neuroprotection in a rat subarachnoid hemorrhage model
Keywords: Subarachnoid hemorrhage; Glutamate excitotoxicity; Ifenprodil; JNJ16259685; Ca2Â + overloading;
Does status epilepticus modify the effect of ifenprodil on cortical epileptic afterdischarges in immature rats?
Keywords: Status epilepticus; Immature rats; Ifenprodil; Cortical stimulation; Epileptic afterdischarges;
CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility
Keywords: CDKL5; Developmental disorders; Epilepsy; Hippocampus; Excitatory synapses; NMDA receptors; GluN2B; SAP102; Ifenprodil;
Blocking GluN2B subunits reverses the enhanced seizure susceptibility after prolonged febrile seizures with a wide therapeutic time-window
Keywords: FSs; febrile seizures; IL-1β; interleukin-1β; IL-1Ra; interleukin-1 receptor antagonist; TLE; temporal lobe epilepsy; MES; maximal electrical shock; KA; kainic acid; CB1R; cannabinoid type 1 receptor; Febrile seizures; GluN2B; IL-1β; Seizure susceptibi
Interleukin-6 reduces NMDAR-mediated cytosolic Ca2+ overload and neuronal death via JAK/CaN signaling
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BDNF; brain-derived neurotrophic factor; bFGF; basic fibroblast growth factor; CaN; calcineurin; CGNs; cerebellar granule neurons; CNS; central nervous system; Ifen; ifenprodil; IL-6; interleuki
Pentamidine analogs as inhibitors of [3H]MK-801 and [3H]ifenprodil binding to rat brain NMDA receptors
Keywords: Pentamidine; NMDA receptor; Ifenprodil; Polyamine; Bisbenzamidine; Alkylation; Coupling; Radioligand binding; Rat brain; Molecular docking;
From NMDA receptor antagonists to discovery of selective Ï2 receptor ligands
Keywords: Glutamate; GluN2B/NMDA; Sigma receptor; Indoles; Ifenprodil;
The effects of ifenprodil on the activity of antidepressant drugs in the forced swim test in mice
Keywords: Ifenprodil; Antidepressant-like activity; Forced swim test; Mice
Synthesis, modelling and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-d-aspartate receptors
Keywords: Glutamate; GluN2B; Indoles; Ifenprodil; Molecular docking;
Metabolism studies of ifenprodil, a potent GluN2B receptor antagonist
Keywords: BSA; bovine serum albumin; CNS; central nervous system; COMT; catechol-O-methyl transferase; EIC; extracted ion current; NADPH; nicotinamide adenine dinucleotide phosphate; NMDA; N-methyl-d-aspartate; PAPS; adenosine-3â²-phosphate-5â²-phosphosulfate lit
Short communicationLow doses of the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, induces social facilitation in adolescent male rats
Keywords: Adolescence; Social interactions; Rat; MK-801; PEAQX; Ifenprodil;
Effects of ifenprodil on the antidepressant-like activity of NMDA ligands in the forced swim test in mice
Keywords: CGP 37849; dl-/E/-amino-4-methyl-5-phosphono-3-pentenoic acid; DCS; d-cycloserine (d-4-amino-3-isoxazolidone); DS; d-serine; FST; forced swim test; i.c.v; intracerebroventricularly; i.p; intraperitoneally; L-701,324; 7-chloro-4-hydroxy-3-(3-phenoxy)phenyl
Determination of ifenprodil by LC–MS/MS and its application to a pharmacokinetic study in healthy Chinese volunteers
Keywords: Ifenprodil; Liquid/liquid extraction; LC–MS/MS; Pharmacokinetics; Intravenous infusion; Human; Plasma
On mechanism of allosteric modulation of NMDA receptor via amino-terminal domains
Keywords: NMDA, N-methyl-d-aspartate; AMPA, amino-3-hydroxy-5-methyl-4-isoxazolepropionate; ATD, amino-terminal domainIonotropic glutamate receptor; N-methyl-d-aspartate receptor; NMDA receptor; Allosteric modulation; Ifenprodil; Molecular dynamics
Ex vivo depotentiation of conditioning-induced potentiation at thalamic input synapses onto the lateral amygdala requires GluN2B-containing NMDA receptors
Keywords: Fear extinction; Lateral amygdala; GluN2B-containing NMDA receptor; Ifenprodil; Ro25-6981
Synthesis of a series of γ-amino alcohols comprising an N-methyl isoindoline moiety and their evaluation as NMDA receptor antagonists
Keywords: NMDA; Ifenprodil; Isoindoline; Amino alcohol; Biological activity
Interneurons in the basolateral amygdala
Keywords: Learning and memory; Anxiety; GABA receptors; NR2B subunits; Ifenprodil; LTP
Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors
Keywords: Amyloid β; Synapses; Long-term potentiation; Ifenprodil; Ro 25–6981; NR2B-containing NMDA receptor; Jacob
Nickel modulates the electrical activity of cultured cortical neurons through a specific effect on N-methyl-d-aspartate receptor channels
Keywords: rat brain embryonic cultures; NR2 subunits; NR2B antagonists; heavy metal; in vitro development; neurotoxicity; AMPA; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate; APV; d(â)-2-amino-5-phosphonopentanoic acid; DIV; days in vitro; HEPES; 4-(2-hyd
NMDA NR2B subtype-selective receptor antagonists fail to antagonize electrically-precipitated seizures and elicit popping in mice
Keywords: NMDA receptor; MK-801; NR2B; Ifenprodil; Ro 25-6981; Ro 8-4304; Medication; Seizures
Development of a selective competitive receptor binding assay for the determination of the affinity to NR2B containing NMDA receptors
Keywords: NMDA receptor; NR2B; Ifenprodil; Recombinant receptor; Binding assay
The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil
Keywords: Analgesia; Inflammatory pain; Ketamine; Ifenprodil; (Rat)
Polyaminergic agents modulate contextual fear extinction in rats
Keywords: Fear extinction; Polyamine; Memory; Spermidine; Ifenprodil; Traxoprodil; Arcaine
The role of N-methyl-d-aspartate receptor subunit NR2B in spinal cord in cancer pain
Keywords: NR2B; Cancer pain; Ifenprodil; Mouse model; NMDA receptor;
Differential NR2B subunit expression at dorsal root and ventrolateral funiculus synapses on lumbar motoneurons of neonatal rat
Keywords: MK-801; EPSP; NMDA receptor; ifenprodil; NR2B; ACSF; artificial cerebrospinal fluid; CGP 46381; Ciba Geigy Product 46381; CNQX; 6-cyano-7-nitroquinoxaline-2,3-dione; DR; dorsal root; EPSP; excitatory postsynaptic potential; MK-801; (5R,10S)-(+)-5-methyl-1
NR2A/B-containing NMDA receptors mediate cocaine-induced synaptic plasticity in the VTA and cocaine psychomotor sensitization
Keywords: Cocaine; NMDA receptor; NVP-AAM077; Sensitization; VTA; Synaptic plasticity; Ifenprodil;
Different effects of two N-methyl-d-aspartate receptor antagonists on seizures, spontaneous behavior, and motor performance in immature rats
Keywords: Memantine; Ifenprodil; Pentylenetetrazol; Convulsions; Behavior; Ontogeny; Rat
Neurosteroids allosterically modulate the ion pore of the NMDA receptor consisting of NR1/NR2B but not NR1/NR2A
Keywords: Neurosteroid; NMDA receptor; NR2B subunit; Pregnenolone; Pregnanolone; Ifenprodil; Allosteric modulation; MK-801; Hippocampus; Receptor binding; Kinetics; Ion channel; CHO; Nanomolar; Pregnenolone sulphate; Pregnanolone sulphate
Reactive derivatives for affinity labeling in the ifenprodil site of NMDA receptors
Keywords: Ifenprodil; NR2B; NMDA
Neurosteroids alter glutamate-induced changes in neurite morphology of NG108-15 cells
Keywords: NMDA receptor; NR2B subunit; Neurosteroids; Ifenprodil; Pregnenolone sulphate (PS); Pregnanolone sulphate (3α5βS); NG108-15; Neurite outgrowth; Cell adhesion
Excitotoxicity in vitro by NR2A- and NR2B-containing NMDA receptors
Keywords: NR2A subtype; NR2B subtype; Ifenprodil; CP-101,606; NVP-AAM077; Gene-targeted mice
Increased vulnerability of hippocampal neurons with age in culture: Temporal association with increases in NMDA receptor current, NR2A subunit expression and recruitment of L-type calcium channels
Keywords: NMDA receptor; Age in culture; Concentration-response; Patch clamp; Excitotoxicity; Ifenprodil;
The effect of dehydroepiandrosterone sulfate and allopregnanolone sulfate on the binding of [3H]ifenprodil to the N-methyl-d-aspartate receptor in rat frontal cortex membrane
Keywords: NMDA receptor; NR2B subunit; Neurosteroid; Ifenprodil; Receptor binding; Allosteric modulation; DHEAS; ALLOPREGS;
Production of NGF, BDNF and GDNF in mouse astrocyte cultures is strongly enhanced by a cerebral vasodilator, ifenprodil
Keywords: Astrocyte; Ifenprodil; Neurotrophic factor; Nerve growth factor (NGF); Brain-derived neurotrophic factor (BDNF); Glial cell line-derived neurotrophic factor (GDNF);
AMPA and NMDA receptor-mediated currents in developing dentate gyrus granule cells
Keywords: Neurotransmitters, modulators, transporters, and receptors; Excitatory amino acid receptors: physiology, pharmacology, and modulation; Hippocampal slices; Glutamatergic neurotransmission; Ifenprodil;
Allosteric modulation of 5-HT3 serotonin receptors
Keywords: 5-HT3 serotonin receptor binding; NG 108-15 cell; Allosteric modulation; Slope of displacement; Verapamil; Ifenprodil;
The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect
Keywords: NMDA; CGP37849; Neramexane; L-701.324; Ifenprodil; Alcohol deprivation effect (ADE); Relapse; NMDA; N-methyl-d-aspartate; ADE; alcohol deprivation effect;
Acute effects of ethanol on hippocampal long-term potentiation and long-term depression are mediated by different mechanisms
Keywords: ethanol; synaptic plasticity; hippocampus; ifenprodil; blackouts; ACSF; artificial cerebrospinal fluid; APV; d,l-2-amino-5-phosphonovalerate; EPSPs; excitatory postsynaptic potentials; LTD; long-term depression; LTP; long-term potentiation; NMDARs; N-meth
The lateral amygdala processes the value of conditioned and unconditioned aversive stimuli
Keywords: fear conditioning; freezing; ifenprodil; muscimol; shock; CeA; central nucleus; CS; conditioned stimulus; CX; context; HAB; habituation; LA; lateral nucleus; LED; light-emitting diode; MUS-HI; high dose of muscimol; MUS-LO; low dose of muscimol; RETEST; r
A single day of ethanol exposure during development has persistent effects on bi-directional plasticity, N-methyl-d-aspartate receptor function and ethanol sensitivity
Keywords: ethanol; ifenprodil; synapses; memory; plasticity; neurodevelopment; ACSF; artificial cerebrospinal fluid; ANOVA; analysis of variance; APV; 2-amino-5-phosphonovalerate; CNQX; 6-cyano-7-nitroquinoxaline-2,3-dione; EPSPs; excitatory postsynaptic potentials
Are unconventional NMDA receptors involved in slowly adapting type I mechanoreceptor responses?
Keywords: Merkel cell; glutamate; NR1; NR2A/B; ifenprodil; mechanogated channels; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; CK 20; cytokeratin 20; CNQX; 6-Cyano-7-nitroquinoxaline-2,3-dione; COV; coefficient of variation; d-AP5; d-(-)-2-amino-5-phosp
In vitro characterization of novel NR2B selective NMDA receptor antagonists
Keywords: N-Methyl-d-aspartate (NMDA); NMDA receptors; Ifenprodil; MERCK 1; MERCK 2; MERCK 3; Subtype-selectivity; Kinetics; Maximal inhibition;
Greater contribution of N-methyl-d-aspartic acid receptors in ventral compared to dorsal hippocampal slices in the expression and long-term maintenance of epileptiform activity
Keywords: septotemporal; electrophysiology; magnesium; plasticity; seizure; sharp waves; ACSF; artificial cerebrospinal fluid; CNQX; 6-cyano-7-nitroquinoxaline-2,3-dione disodium; d-AP5; d-(â)-2-amino-5-phosphonopentanoic acid; DH; dorsal hippocampus; EA; epilept