کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9426234 | 1295913 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A single day of ethanol exposure during development has persistent effects on bi-directional plasticity, N-methyl-d-aspartate receptor function and ethanol sensitivity
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کلمات کلیدی
FAEFASIfenprodilEPSPsNMDARaCSFAPV2-amino-5-phosphonovalerate - 2-آمینو-5-فسفونوالرات6-Cyano-7-nitroquinoxaline-2,3-dione - 6-Cyano-7-nitroquinoxaline-2،3-dioneEthanol - اتانولFetal alcohol effects - اثرات الکل جنینlong-term depression - افسردگی طولانی مدتanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancelong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP neurodevelopment - توسعه عصبیMemory - حافظهpostnatal day - روز پس از زایمانFetal alcohol syndrome - سندرم جنینی الکلCNQX - سیانکیوایکسSynapses - سیناپس هاartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیLTD - محدودexcitatory postsynaptic potentials - پتانسیل های پست پراکنده تحریک پذیرPlasticity - پلاستیکN-methyl-d-aspartate receptor - گیرنده N-methyl-d-aspartate
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
To determine factors that contribute to the learning deficits observed in individuals with fetal alcohol syndrome, we examined the effects of early postnatal ethanol exposure on forms of synaptic plasticity thought to underlie memory. Treatment of rat pups with ethanol on postnatal day 7 impaired the induction of N-methyl-d-aspartate receptor-dependent long-term potentiation and abolished homosynaptic long-term depression in the CA1 region of hippocampal slices prepared at postnatal day 30. An N-methyl-d-aspartate receptor-independent form of long-term potentiation induced by very high frequency stimulation could be induced in slices from ethanol-treated rats. Defects in long-term depression correlated with a diminished contribution of ifenprodil-sensitive N-methyl-d-aspartate receptors to synaptic transmission and defects in a spontaneous alternation behavioral task. Rats exposed to ethanol on postnatal day 7 also exhibited diminished sensitivity of synaptic N-methyl-d-aspartate receptors to block by ethanol at postnatal day 30 and decreased behavioral sedation to systemic ethanol injections. These results indicate that changes in synaptic plasticity and N-methyl-d-aspartate receptor function are likely to provide a neural substrate for the cognitive and behavioral changes that follow developmental ethanol exposure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 136, Issue 1, 2005, Pages 269-279
Journal: Neuroscience - Volume 136, Issue 1, 2005, Pages 269-279
نویسندگان
Y. Izumi, R. Kitabayashi, M. Funatsu, M. Izumi, C. Yuede, R.E. Hartman, D.F. Wozniak, C.F. Zorumski,