ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions. A method to directly monitor the active conformation of LRRK2?
Keywords: IP; immunoprecipitates; LRRK2; leucine-rich repeat kinase 2; PD; Parkinson's disease; Roc; Ras of complex protein; SILAC; stable isotope labeling of amino acids in culture; LRRK2; Kinase domain; Activation segment; Conformation; Antibody; Immunoprecipitat