Keywords: برازنده; Kinesin; Molten globule; Conformational selection; Induced fit; Osmolyte effect;
مقالات ISI برازنده (ترجمه نشده)
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Keywords: برازنده; Fluctuation ratchet; Self-assembly; Substrate selection; Binding specificity; Induced fit
Keywords: برازنده; Conformational selection; Induced fit; Net flux; Kinetic cooperativity; Glucokinase; Steady state;
Keywords: برازنده; AAT; alpha-1 antitrypsin (alpha-1 proteinase inhibitor, α-1 PI); AATD; alpha-1 antitrypsin deficiency; ALI; acute lung injury; ARDS; acute respiratory distress syndrome; BE; bronchiectasis; CF; cystic fibrosis; COPD; chronic obstructive pulmonary disease
Keywords: برازنده; Porphyrins; Chiral recognition; Amine recognition; Anion recognition; Induced fit;
Keywords: برازنده; Induced fit; Conformational selection; Kinetics; Protein-protein interactions;
Keywords: برازنده; Binding polynomial; Allostery; Induced fit; Adair–Klotz model; Binding model; Enzymology; Calmodulin
Keywords: برازنده; Relaxation kinetics; Ligand binding; Trypsin-like protease; Induced fit; Conformational selection; Thrombin;
Keywords: برازنده; Conformational selection; Induced fit; Allostery; Allosteric; Binding; Molecular recognition;
Keywords: برازنده; Conformational selection; Induced fit; Single enzyme; Allosteric regulation; In silico drug design; De novo protein synthesis;
Design, synthesis and biological evaluation of novel indole-benzimidazole hybrids targeting estrogen receptor alpha (ER-α)
Keywords: برازنده; Breast cancer; Estrogen receptor alpha; Induced fit; Indole-benzimidazole hybrids; RT-PCR; Western blotting;
Molecular dynamics and ligand docking of a hinge region variant of South African HIV-1 subtype C protease
Keywords: برازنده; HIV-1; Subtype C; Protease; Flap dynamics; Hinge region; Ligand docking; Molecular dynamics; Induced fit;
Discovery of new MurA inhibitors using induced-fit simulation and docking
Keywords: برازنده; MurA inhibitors; ProBiS-CHARMMing web server; Induced fit; Small-molecule inhibitors; Antibacterial agents;
The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with the small G-protein Ral identifies conformational intermediates of the exchange reaction and the basis for the selectivity
Keywords: برازنده; Ras-family of G-proteins; Induced fit; CDC25-homology domain; Guanine nucleotide exchange reaction;
Electrostatic free energies in translational GTPases: Classic allostery and the rest
Keywords: برازنده; ATP/GTP; adenosine/guanosine triphospate; aIF2/aIF5B; archaeal Initiation Factor 2/5B; IS/OS; Inner/Outer Sphere; MD; molecular dynamics; MDFE; molecular dynamics free energy; PBFE; Poisson-Boltzmann free energy; Molecular recognition; induced fit; mole
Interplay between conformational selection and induced fit in multidomain protein-ligand binding probed by paramagnetic relaxation enhancement
Keywords: برازنده; Paramagnetic relaxation enhancement; Sparsely-populated transient state; Conformational selection; Induced fit; Maltose binding protein; Calmodulin;
Global analysis of riboswitches by small-angle X-ray scattering and calorimetry
Keywords: برازنده; Small-angle X-ray scattering; Isothermal titration calorimetry; Enthalpy-entropy compensation; Conformational selection; Induced fit;
Promiscuous and specific recognition among ephrins and Eph receptors
Keywords: برازنده; Eph receptor tyrosine kinase; Conformational selection; Induced fit; Protein–protein interaction; Energy landscape; Conformational dynamics
How conformational changes can affect catalysis, inhibition and drug resistance of enzymes with induced-fit binding mechanism such as the HIV-1 protease
Keywords: برازنده; Enzyme dynamics; Induced fit; Conformational selection; HIV-1 protease; Non-active-site mutation; Multi-drug resistance;
Exploring the binding of peptidic West Nile virus NS2B-NS3 protease inhibitors by NMR
Keywords: برازنده; WNV protease; Peptide inhibitors; NMR study; Induced fit;
Stereochemical features of the envelope protein Domain III of dengue virus reveals putative antigenic site in the five-fold symmetry axis
Keywords: برازنده; Dengue virus; Domain III; Molecular dynamics; Putative epitope; Surface pore; Induced fit;
Geometric, electronic and NMR properties of hemicucurbit[n]urils and their anionic complexes
Keywords: برازنده; Hemicucurbit[n]uril; DFT; NMR; Anionic complex; Host-guest complex; Induced fit;
The unusual mechanism of inhibition of the p90 ribosomal S6 kinase (RSK) by flavonol rhamnosides
Keywords: برازنده; RSK, ribosomal S6 kinase; NTKD, N-terminal kinase domain; CTKD, C-terminal kinase domain; PKA, protein kinase A; AMPPNP, 5′-adenylyl-imidodiphosphateRSK kinase; SL0101; Quercitrin; Flavonol; Induced fit; Conformational selection
Allosteric post-translational modification codes
Keywords: برازنده; allostery; propagation; signaling proteins; conformational ensembles; signaling pathways; protein structure; population shift; conformational selection; induced fit
Structural basis of coagulation factor V recognition for cleavage by RVV-V
Keywords: برازنده; Blood coagulation; Snake venom; Serine proteinase; Substrate recognition; Induced fit
Allostery in the lac operon: Population selection or induced dissociation?
Keywords: برازنده; Allostery; Lac repressor; Induced fit; Population selection; Kinetics of allostery; Tertiary capture;
Enhanced resolution of molecular recognition to distinguish structurally similar molecules by different conformational responses of a protein upon ligand binding
Keywords: برازنده; Induced fit; Molecular dynamics simulation; Conformational substates
In silico analysis of the binding of agonists and blockers to the β2-adrenergic receptor
Keywords: برازنده; G protein-coupled receptor; Agonists; Blockers; Induced Fit; Docking; Linear discriminant analysis; Molecular dynamics
Basic statistical recipes for the emergence of biochemical discernment
Keywords: برازنده; Entropy; Cooperativity; Induced fit; Information; Life; Brillouin
Experimental and computational determination of tRNA dynamics
Keywords: برازنده; EF-Tu, elongation factor Tu; aaRS, aminoacyl-tRNA synthetase; FRET, fluorescence resonance energy transfer; MD, molecular dynamics; RMSF (RMSD), root mean squared fluctuations (deviations)tRNA; Flexibility; Conformational change; Induced fit; Molecular dy
Homology-Modelling Protein–Ligand Interactions: Allowing for Ligand-Induced Conformational Change
Keywords: برازنده; ACE, angiotensin-converting enzyme; PI, Poisson Index; HMG, 3-hydroxy-3-methyl-glutaric acid; PDB, Protein Data Bankhomology modelling; induced fit; protein–ligand; structural alignment; conformational change
Structure based virtual screening of GSK-3β: Importance of protein flexibility and induced fit
Keywords: برازنده; GSK-3β; Virtual screening; Docking; Induced fit;
Identification of PDE4B Over 4D subtype-selective inhibitors revealing an unprecedented binding mode
Keywords: برازنده; Lead optimisation; Ligand docking; Induced fit; SAR
Concerted bifunctionality of the dCTP deaminase-dUTPase from Methanocaldococcus jannaschii: A structural and pre-steady state kinetic analysis
Keywords: برازنده; Bifunctional; dUTPase; dCTP deaminase; Induced fit; Deoxy-ribonucleotide metabolism; Deamination
Site-specific labeling of T7 DNA polymerase with a conformationally sensitive fluorophore and its use in detecting single-nucleotide polymorphisms
Keywords: برازنده; DNA polymerase; Fluorescence labeling; Fidelity; Conformational changes; Induced fit; Single-nucleotide polymorphisms
Inside the Hsp90 inhibitors binding mode through induced fit docking
Keywords: برازنده; Heat shock protein; Geldanamicyn; Radicicol; Induced fit; Molecular docking
Characterization of the papillomavirus α1E2 peptide unfolded to folded transition upon DNA binding
Keywords: برازنده; Molecular dynamics; Papillomavirus; E2 protein; DNA structure; Induced fit
Structural and functional diversity of ferredoxin-NADP+ reductases
Keywords: برازنده; Flavoprotein; FAD; NADP; Photosynthesis; Induced fit; Electron transfer; Apicomplexa; Plasmodium falciparum; Malaria;
Reversible covalent inhibition of a phenol sulfotransferase by coenzyme A
Keywords: برازنده; Sulfotransferase; SULT1A1; Inhibition; Inactivation; Kinetics; CoA; Regulation; Model; Induced fit
Substrate Modulation of Enzyme Activity in the Herpesvirus Protease Family
Keywords: برازنده; KSHV, Kaposi's sarcoma herpesvirus; HCMV, human cytomegalovirus; EBV, Epstein-Barr virus; DFP, diisopropyl fluorophosphonate; R, release; M, maturationallostery; induced fit; viral protease; protein-protein interactions; X-ray structure
Energetic basis of molecular recognition in a DNA aptamer
Keywords: برازنده; DNA; Aptamer; Thermodynamics; Entropy; Enthalpy; Calorimetry; Circular dichroism; Molecular recognition; Induced fit;
Enzyme conformational dynamics during catalysis and in the ‘resting state’ monitored by hydrogen/deuterium exchange mass spectrometry
Keywords: برازنده; Steady-state; Carboxypeptidase B; Lysozyme; Conformational change; Induced fit
Transport catalysis
Keywords: برازنده; Transport; Catalytic energy; Induced fit; Active transport; Electrochemical gradient
Structure and Reaction Mechanism of l-Rhamnulose Kinase from Escherichia coli
Keywords: برازنده; hexokinase-hsp70-actin superfamily; induced fit; in-line phosphoryl transfer; rhamnose degradation; X-ray diffractionapo RhuK, enzyme without a bound ligand; holo RhuK, enzyme with bound ADP and β-l-fructose; RhuK, l-rhamnulose 1-kinase: here the enzyme f
Structures of Human N-Acetylglucosamine Kinase in Two Complexes with N-Acetylglucosamine and with ADP/Glucose: Insights into Substrate Specificity and Regulation
Keywords: برازنده; GlcNAc, N-acetylglucosamine; SeMet, selenomethionine; GST, glutathione-S-transferase; PEG, polyethylene glycolN-acetylglucosamine kinase; crystal structure; domain rotation; induced fit; sugar kinase
Structural Basis for Molecular Recognition in an Affibody:Affibody Complex
Keywords: برازنده; NOE, nuclear Overhauser effect; NOESY, NOE spectroscopyprotein–protein interactions; protein engineering; molecular recognition; NMR spectroscopy; induced fit
Structural and Kinetic Analysis of Caspase-3 Reveals Role for S5 Binding Site in Substrate Recognition
Keywords: برازنده; Cho, aldehyde; pNA, p-nitroanilideenzyme catalysis; cysteine protease; apoptosis; induced fit
New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies
Keywords: برازنده; HERG potassium channel; HERG blockers; Homology modeling; Induced fit; Terfenadine; MK-499; Cisapride; Sertindole; Clofilium; Ibutilide
Target flexibility in molecular recognition
Keywords: برازنده; Structure-based drug discovery; Computer-aided drug design; Induced fit; Molecular dynamics; Computer simulation; Free energy;
Insights into the induced fit mechanism in antithrombin-heparin interaction using molecular dynamics simulations
Keywords: برازنده; Carbohydrate; Molecular dynamics; Serpin; Antithrombin; Synthetic pentasaccharide; Heparin; Induced fit;