Stereochemical features of the envelope protein Domain III of dengue virus reveals putative antigenic site in the five-fold symmetry axis

► We deal with dengue mechanisms of infection through molecular dynamics. ► Specific regions of the Domain III are very flexible, with fingerprint-like features. ► These loops compose envelope pores, are coordinated and suggest induced fit behavior. ► This point towards sites of relevance in the immunogenicity of dengue. ► Successful molecular design to this sites could probably halt infection stages.