Keywords: آنزیم تحقیر کننده انسولین; Insulin degrading enzyme; IDE; Diabetes mellitus; Alzheimer's disease; Insulin;
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Keywords: آنزیم تحقیر کننده انسولین; Stress; Amyloid; Norepinephrine; Dopamine-β-hydroxylase; Depression; Adrenergic receptors; AD; Alzheimer's disease; HPA; hypothalamo-pituitary adrenal; PFC; prefrontal cortex; DMN; default mode network; SP; senile plaque; NFT; neurofibrillary tangle; MMS
Keywords: آنزیم تحقیر کننده انسولین; ABAD; Aβ binding alcohol dehydrogenase; AD; Alzheimer's disease; ADAM; A Disintegrin and metalloproteinase; AICD; APP intracellular domain; APH1; anterior pharynx-defective 1; APP; amyloid precursor protein; ATP; adenosine triphosphate; Aβ; amyloid be
Keywords: آنزیم تحقیر کننده انسولین; AD; Alzheimer's disease; BBB; blood brain barrier; RAGE; Receptor for Advanced Glycation End products; AGE; advanced glycation end products; IL1β; interleukin 1 beta; Aβ; amyloid beta; TNF â;  tumor necrosis factor alpha; TGFβ; transforming growth
Keywords: آنزیم تحقیر کننده انسولین; AD; Alzheimer's disease; Aβ; amyloid-β; APP; amyloid-β precursor protein; ApoE-ε4; apolipoprotein E-ε4; BBB; blood-brain barrier; CTF; C-terminal fragment; DMN; default mode network; ER; endoplasmic reticulum; GLP-1; glucagon-like peptide-1; GLP-
Keywords: آنزیم تحقیر کننده انسولین; Aβ; beta-amyloid peptide; AAV; adeno-associated virus; ABAD; amyloid-beta-binding alcohol dehydrogenase; AD; Alzheimer's disease; ALP; autophagy-lysosome pathways; Apaf-1; apoptic protease-activating factor 1; APP; amyloid precursor protein; AICD; APP in
Keywords: آنزیم تحقیر کننده انسولین; AD; Alzheimer disease; APP; amyloid precursor protein; CREB; CAMP-response element binding; GFAP; Glial Fibrillary Acidic Protein; GTT; glucose tolerance test; HFD; high fat diet; HFS; high fat diet with sugar; HOMA; homeostatic model assessment; IDE; ins
Keywords: آنزیم تحقیر کننده انسولین; Insulin resistance; Alzheimer disease; Diabetes mellitus; Insulin degrading enzyme; Aβ; Oxidative stress;
Keywords: آنزیم تحقیر کننده انسولین; insulin degrading enzyme; type 2 diabetes mellitus; Alzheimer's disease; small molecule inhibitors
Keywords: آنزیم تحقیر کننده انسولین; AD; Alzheimer's disease; T2DM; type II diabetes mellitus; Aβ; amyloid beta; NFT; neurofibrillary tangles; IR; insulin resistance; InsR; insulin receptors; IRS; InsR substrate; IGF; insulin growth factor; ICV; intracerebroventricular; STZ; streptozotocin;
Keywords: آنزیم تحقیر کننده انسولین; Streptozotocin; Alzheimer's disease; M30 compound; HLA20 compound; Memory; Tau protein; Insulin degrading enzyme
Keywords: آنزیم تحقیر کننده انسولین; AFP; alpha fetoprotein; BBB; blood brain barrier; BMT; bone marrow transplant; CNS; central nervous system; EAE; experimental autoimmune encephalomyelitis; EGF; epidermal growth factor; ET; embryo transfer; EVT; extravillous trophoblasts; FDA; Food and Dr
Microglia-derived extracellular vesicles in Alzheimer's Disease: A double-edged sword
Keywords: آنزیم تحقیر کننده انسولین; AD; Alzheimer's Diseases; APP; Amyloid Precursor Protein; Aβ; amyloid; Bcl-2; B-cell lymphoma 2; BBB; blood brain barrier; BMECs; brain microvascular endothelial cells; CNS; central nervous system; CSF; cerebrospinal fluid; EVs; extracellular vesicles;
Oleocanthal-rich extra-virgin olive oil enhances donepezil effect by reducing amyloid-β load and related toxicity in a mouse model of Alzheimer's disease
Keywords: آنزیم تحقیر کننده انسولین; AD; Alzheimer's disease; Aβ; amyloid-β; APP; amyloid precursor protein; ApoE; apo-lipoprotein E; ABCA1; ATP-binding cassette transporter A1; BBB; blood-brain barrier; EVOO; extra-virgin olive oil; GFAP; glial fibrillary acidic protein; IL-1β; inter
Vitamin D3 intake as regulator of insulin degrading enzyme and insulin receptor phosphorylation in diabetic rats
Keywords: آنزیم تحقیر کننده انسولین; Insulin degrading enzyme; Insulin receptors phosphorylation; Insulin resistance; Glucagon; Hyperlipidemia;
Worsening of memory deficit induced by energy-dense diet in a rat model of early-Alzheimer's disease is associated to neurotoxic Aβ species and independent of neuroinflammation
Keywords: آنزیم تحقیر کننده انسولین; 3-TyrNO2; 3-nitrotyrosine; AβN3(pE); pyroglutamate-Aβ; iAβ; intraneuronal Aβ; BBB; blood-brain barrier; BHI; Bioenergetic Health Index; CRTC; CREB-regulated transcription coactivator; IDE; insulin degrading enzyme; IR; insulin resistance; MetS; metabo
Metabolic relationship between diabetes and Alzheimer's Disease affected by Cyclo(His-Pro) plus zinc treatment
Keywords: آنزیم تحقیر کننده انسولین; Diabetes; Alzheimer's Disease; Metabolic disease; Cyclo(His-Pro); Zinc; Insulin degrading enzyme;
Palmitate-induced Endoplasmic Reticulum stress and subsequent C/EBPα Homologous Protein activation attenuates leptin and Insulin-like growth factor 1 expression in the brain
Keywords: آنزیم تحقیر کننده انسولین; 4-PBA; 4-phenyl butyric acid; 6-OHDA; 6-hydroxydopamine; Aβ; amyloid beta; AD; Alzheimer's disease; ATF3; activating transcription factor 3; ATF4; activating transcription factor 4; ATF6; activating transcription factor 6; BACE1; β-site APP cleaving enz
Identification and functional characterization of a putative IDE, C28F5.4 (ceIDE-1), in Caenorhabditis elegans: Implications for Alzheimer's disease
Keywords: آنزیم تحقیر کننده انسولین; Alzheimer disease; Insulin degrading enzyme; C28F5.4, ceIDE-1; Caenorhabditis elegans (C. elegans); Functional genomics; Amyloid beta;
Insulin-degrading enzyme is activated by the C-terminus of α-synuclein
Keywords: آنزیم تحقیر کننده انسولین; Insulin degrading enzyme; Parkinson's disease; α-Synuclein; Amyloid; Proteolysis
C allele of the rs2209972 single nucleotide polymorphism of the insulin degrading enzyme gene and Alzheimer's disease in type 2 diabetes, a case control study
Keywords: آنزیم تحقیر کننده انسولین; Alzheimer’ disease; Dementia; Elderly; Insulin degrading enzyme; Type 2 diabetes mellitusEnfermedad de Alzheimer; Demencia; Ancianos; Enzima degradadora de insulina; Diabetes mellitus tipo 2
C allele of the rs2209972 single nucleotide polymorphism of the insulin degrading enzyme gene and Alzheimer's disease in type 2 diabetes, a case control study
Keywords: آنزیم تحقیر کننده انسولین; Alzheimer' disease; Dementia; Elderly; Insulin degrading enzyme; Type 2 diabetes mellitus; Enfermedad de Alzheimer; Demencia; Ancianos; Enzima degradadora de insulina; Diabetes mellitus tipo 2;
An Aβ42 uptake and degradation via Rg3 requires an activation of caveolin, clathrin and Aβ-degrading enzymes in microglia
Keywords: آنزیم تحقیر کننده انسولین; Rg3; Aβ42; Macrophage scavenger receptor class A; Endocytosis; Neprilysin; Insulin degrading enzyme;
Hypercholesterolemia and neurodegeneration. Comparison of hippocampal phenotypes in LDLr knockout and APPswe/PS1dE9 mice
Keywords: آنزیم تحقیر کننده انسولین; FAD; familial Alzheimer's disease; LDLr; low-density lipoprotein receptor; ApoE; Apolipoprotein E; APP; amyloid precursor protein; ROS; reactive oxygen species; OXPHOS; oxidative phosphorylation; NRF; nuclear respiratory factors; PGC-1α; peroxisome proli
B-type Natriuretic Peptide circulating forms: Analytical and bioactivity issues
Keywords: آنزیم تحقیر کننده انسولین; ANP; A-type Natriuretic Peptide (atrial natriuretic peptide); BNP; B-type Natriuretic Peptide (brain natriuretic peptide); CNP; C-type Natriuretic Peptide; proBNP; pro B-type Natriuretic Peptide; NT-proBNP; amino-terminal proBNP; IDE; Insulin Degrading En
Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice
Keywords: آنزیم تحقیر کننده انسولین; AD; Alzheimer's disease; Aβ; amyloid-β; APP; amyloid-β precursor protein; BBB; blood-brain barrier; BCI; brain clearance index; CAA; cerebral amyloid angiopathy; DEA; diethylamine; EVOO; extra-virgin olive oil; FA; formic acid; IDE; insulin degradi
Prediabetes-induced vascular alterations exacerbate central pathology in APPswe/PS1dE9 mice
Keywords: آنزیم تحقیر کننده انسولین; Alzheimer's disease; Prediabetes; Hyperinsulinemia; Amyloid-β; Tau; Microglia; Insulin degrading enzyme; Neprilysin; Haemorrhage
Featured ArticleThe influence of insulin infusion on the metabolism of amyloid β peptides in plasma
Keywords: آنزیم تحقیر کننده انسولین; Alzheimer's disease; Diabetes mellitus; Insulin; Amyloid β; Insulin degrading enzyme;
IDE (rs6583817) polymorphism and type 2 diabetes differentially modify executive function in older adults
Keywords: آنزیم تحقیر کننده انسولین; Aging; Executive functions; Insulin degrading enzyme; Type 2 diabetes; Victoria Longitudinal Study;
Research reportCognitive decline in STZ-3V rats is largely due to dysfunctional insulin signalling through the dentate gyrus
Keywords: آنزیم تحقیر کننده انسولین; 3V; dorsal third ventricle; Ab; amyloid beta; AD; Alzheimer's disease; CA; cornu ammonis; DG; dentate gyrus; IDE; insulin degrading enzyme; IR; insulin receptor; LTP; long-term potentiation; MAPK; mitogen-activated protein kinase; MWM; Morris water maze;
JD-30, an active fraction extracted from Danggui-Shaoyao-San, decreases β-amyloid content and deposition, improves LTP reduction and prevents spatial cognition impairment in SAMP8 mice
Keywords: آنزیم تحقیر کننده انسولین; Aβ; β-amyloid; AD; Alzheimer's disease; APP; amyloid protein precursor; BACE1; beta-site amyloid cleave enzyme-1; CatB; cathepsin B; DG; dentate gyrus; DSS; Danggui-Shaoyao-San; GAPDH; glyceraldehyde phosphate dehydrogenase; HFS; high frequency stim
Exploration of 16 candidate genes identifies the association of IDE with Alzheimer's disease in Han Chinese
Keywords: آنزیم تحقیر کننده انسولین; Insulin degrading enzyme; Alzheimer's disease; Genetics; Single nucleotide polymorphism; Association;
Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines
Keywords: آنزیم تحقیر کننده انسولین; Abeta star 56 kDa; ADAM10; APP; Beta amyloid; Canine; Cingulate; C-terminal fragments of APP; Dog; Insulin degrading enzyme; Neprilysin; Oligomer; Secretase; Temporal;
Isoform-specific proteolysis of apolipoprotein-E in the brain
Keywords: آنزیم تحقیر کننده انسولین; Aβ; amyloid-β; Ab; antibody; AD; Alzheimer's disease; apoE; apolipoprotein-E; CatD; cathepsin-D; CNS; central nervous system; CSF; cerebrospinal fluid; CON; control; FC; frontal cortex; gHCl; guanidine hydrochloride; HI-Thr; heat-inactivated thrombin; H
β-Amyloid precursor protein and tau protein levels are differently regulated in human cerebellum compared to brain regions vulnerable to Alzheimer's type neurodegeneration
Keywords: آنزیم تحقیر کننده انسولین; Alzheimer's disease; Amyloid precursor protein; APP; Tau; GSK3; Insulin degrading enzyme
Oligomerization and insulin interactions of proinsulin C-peptide: Threefold relationships to properties of insulin
Keywords: آنزیم تحقیر کننده انسولین; Proinsulin C-peptide; Insulin degrading enzyme; Oligomerization; Mass spectrometry; Diabetes types 1 and 2; Peptide deposits
β-Amyloid precursor protein metabolism: focus on the functions and degradation of its intracellular domain
Keywords: آنزیم تحقیر کننده انسولین; APP; AICD; Fe65; Proteasome; Insulin degrading enzyme
Differential cerebral deposition of IDE and NEP in sporadic and familial Alzheimer's disease
Keywords: آنزیم تحقیر کننده انسولین; Alzheimer's disease; Amyloid β; Insulin degrading enzyme; Neprilysin; Human brain; Presenilin; Astrocytes
The insulin degrading enzyme binding domain of varicella-zoster virus (VZV) glycoprotein E is important for cell-to-cell spread and VZV infectivity, while a glycoprotein I binding domain is essential for infection
Keywords: آنزیم تحقیر کننده انسولین; Glycoprotein E; Varicella-zoster virus; Herpes simplex virus; Glycoprotein I; Insulin degrading enzyme
Focal cerebral ischemia in rats alters APP processing and expression of Aβ peptide degrading enzymes in the thalamus
Keywords: آنزیم تحقیر کننده انسولین; Aβ-peptide; Alzheimer's disease; β-secretase; Calcium; Golgi-localized γ-ear-containing ARF binding protein; Insulin degrading enzyme; Ischemia; Neprilysin; Thalamus
Inflammation in Alzheimer's disease: Amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors
Keywords: آنزیم تحقیر کننده انسولین; AD; Alzheimer 's disease; ADDL; amyloid-β derived diffusible ligand; APP; amyloid-β precursor protein; BBB; blood-brain barrier; CNS; central nervous system; CSF; cerebrospinal fluid; DAMP; danger-associated molecular pattern; FPR; N-formyl peptide re
Endophenotypes in normal brain morphology and Alzheimer's disease: a review
Keywords: آنزیم تحقیر کننده انسولین; endophenotypes; brain morphology; Alzheimer's disease; cognitive impairment; ADAS-Cog; Alzheimer Disease Assessment Scale-Cognitive subscale; APOE; apolipoprotein E; CCMS; Cache County Study of Memory in Aging; CIND; cognitive impairment no dementia; CR;
How the binding and degrading capabilities of insulin degrading enzyme are affected by ubiquitin
Keywords: آنزیم تحقیر کننده انسولین; Surface plasmon resonance; Mass spectrometry; Noncovalent interaction; Ubiquitin; Insulin degrading enzyme
Hypercholesterolemia-induced Aβ accumulation in rabbit brain is associated with alteration in IGF-1 signaling
Keywords: آنزیم تحقیر کننده انسولین; Akt; Alzheimer's disease; β-amyloid; Cholesterol; CREB; GSK-3α; Hippocampus; Insulin degrading enzyme; 27-hydroxycholesterol
Aggregation and catabolism of disease-associated intra-Aβ mutations: reduced proteolysis of AβA21G by neprilysin
Keywords: آنزیم تحقیر کننده انسولین; Alzheimer's disease; Amyloid beta-protein; Aggregation; Degradation; Insulin degrading enzyme; Plasmin
Intranasal delivery of insulin and a nitric oxide synthase inhibitor in an experimental model of amyotrophic lateral sclerosis
Keywords: آنزیم تحقیر کننده انسولین; amyotrophic lateral sclerosis; insulin; free oxygen radicals; endplate innervation; behavior testing; electrophysiology; ALS; amyotrophic lateral sclerosis; ChAT; choline acetyltransferase; CMAP; compound motor action potential; CREB; cAMP response elemen
Neurosecretases provide strategies to treat sporadic and familial Alzheimer disorders
Keywords: آنزیم تحقیر کننده انسولین; ADAM; a disintegrin and metalloprotease; ACDL; acidic dileucine; ADDL; amyloid-β derived diffusible ligands; APP; amyloid precursor protein; Aph; anterior pharynx defective phenotype; APLP; APP-like protein; AICD; APP intracellular domain; AD; Alzheimer'
The pharmacokinetics of pulmonary insulin in the in vitro isolated perfused rat lung: Implications of metabolism and regional deposition
Keywords: آنزیم تحقیر کننده انسولین; APN; aminopeptidase N; ANP; atrial natriuretic peptide; BAC; bacitracin; BSA; bovine serum albumin; Cmax; the maximum serum/plasma concentration; COD; coefficient of determination; EIA; enzyme immunoassay; ELISA; enzyme-linked immunosorbent assay; FD-4; f