کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8336758 | 1540642 | 2015 | 46 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
liver-X receptorLRP1LXRBCIRXRretinoid-X receptorAPPPPARγEVOOP-gpAβCAADEASDSP-glycoprotein - P-گلیکوپروتئینTHs - THSamyloid-β - آمیلوئید βinsulin degrading enzyme - آنزیم تحقیر کننده انسولینcerebral amyloid angiopathy - آنژیوپاتی آمیلوئید مغزیFormic acid - اسید فرمیکIDE - اینجاAlzheimer’s disease - بیماری آلزایمرclearance - ترخیص کالا از گمرکThioflavin S - تیوفلاوین STau - خود راdiethylamine - دیاتیلامینExtra-virgin olive oil - روغن زیتون اضافیBlood–brain barrier - سد خونی مغزیBBB - سد خونی مغزیNEP - نپNeprilysin - نپریلینlow-density lipoprotein receptor-related protein 1 - پروتئین مرتبط با گیرنده لیپوپروتئین با چگالی کم 1amyloid-β precursor protein - پروتئین پیش ماده آمیلئید β
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Extra-virgin olive oil (EVOO) is one of the main elements of Mediterranean diet. Several studies have suggested that EVOO has several health promoting effects that could protect from and decrease the risk of Alzheimer's disease (AD). In this study, we investigated the effect of consumption of EVOO-enriched diet on amyloid- and tau-related pathological alterations that are associated with the progression of AD and cerebral amyloid angiopathy (CAA) in TgSwDI mice. Feeding mice with EVOO-enriched diet for 6 months, beginning at an age before amyloid-β (Aβ) accumulation starts, has significantly reduced total Aβ and tau brain levels with a significant improvement in mouse cognitive behavior. This reduction in brain Aβ was explained by the enhanced Aβ clearance pathways and reduced brain production of Aβ via modulation of amyloid-β precursor protein processing. On the other hand, although feeding mice with EVOO-enriched diet for 3 months, beginning at an age after Aβ accumulation starts, showed improved clearance across the blood-brain barrier and significant reduction in Aβ levels, it did not affect tau levels or improve cognitive functions of TgSwDI mouse. Collectively, results of this study suggest that the long-term consumption of EVOO-containing diet starting at early age provides a protective effect against AD and its related disorder CAA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 26, Issue 12, December 2015, Pages 1479-1490
Journal: The Journal of Nutritional Biochemistry - Volume 26, Issue 12, December 2015, Pages 1479-1490
نویسندگان
Hisham Qosa, Loqman A. Mohamed, Yazan S. Batarseh, Saeed Alqahtani, Baher Ibrahim, Harry III, Jeffrey N. Keller, Amal Kaddoumi,