Keywords: ADAM; a disintegrin and metalloproteinase; COMP; cartilage oligomeric matrix protein; CTGF/CCN2; connective tissue growth factor; DMD; Duchenne Muscular Dystrophy; ECM; extracellular matrix; ER; endoplasmic reticulum; IPF; idiopathic pulmonary fibrosis; L
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Keywords: Aβ; amyloid-β-peptide; ACh; acetylcholine; Apo; apolipoprotein; APP; amyloid precursor protein; CYP; cytochrome P-450; DYRK1; dual specificity tyrosine-phosphorylation-regulated kinase 1A; GABA; γ-aminobutyric acid; GSK; glycogen synthase- kinase; HSV-
Keywords: CAD; coronary artery disease; CD40L; CD40 ligand; CRP; C-reactive protein; EAT; epicardial adipose tissue; FFA; free fatty acids; GLP-1; glucagon-like peptide-1; HbA1c; hemoglobin A1c; HMG-CoA; 3-hydroxy-3-methyl-glutaryl-CoA; LDL; low density lipoprotein
Keywords: 4-HNE; 4-HydroxyNonenal; AD; Alzheimer's Disease; AICD; Amino-terminal APP Intra Cellular Domain; ApoE; Apolipoprotein E; APP; Amyloid Precursor Protein; ATP; Adenosine TriPhosphate; Aβ; Amyloid beta peptide; AβDP; Aβ-Degrading Proteases; CNS; Centra
Keywords: APC; antigen-presenting cell; ATG; autophagy-related gene; ATP; adenosine triphosphate; ANXA1; annexin A1; BECN1; beclin-1; CD; cluster of differentiation; CRT; calreticulin; CTL; cytotoxic T lymphocyte; (CTLA)-4; CTL associated protein-4; DAMP; danger-as
Keywords: Polymeric nanomedicines; Peptide; Cancer therapy; Therapeutic delivery; AF; aminoflavone; ANG; angiopep-2; BBB; blood brain barrier; BCECs; brain capillary endothelial cells; BP; bortezomib-pinanediol; bPEISS; bioreducible branched polyethylenimine; BPLP;
Keywords: Atherosclerosis; Cardiovascular diseases; Cell cycle; Proliferation; Pulmonary hypertension; Restenosis; Signaling pathway; Vascular smooth muscle cells; ACE; angiotensin converting enzyme; aFGF; acidic FGF; Ang II; angiotensin II; AP-1; activating protei
Keywords: Lactoferrin; Autophagy; LC3; LRP1; AMPK signaling;
Keywords: 7AAD; 7-aminoactinomycin D; αSMA; alpha smooth muscle actin; AKT; protein kinase B; ALK; activin receptor-like kinase; Ang; angiopoietin; Ang II; angiotensin II; BCRP1; breakpoint cluster region pseudogene; bFGF; basic fibroblast growth factor; C1P; cera
Keywords: BBB; bloodâbrain barrier; Col-IV; collagen IV; DHA; docosahexaenoic acid; EPA; eicosapentaenoic acid; EB; evans blue; FcRn; neonatal Fc receptor; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; H/I; hypoxic/ischemic; LRP1; low-density lipoprotein recep
Keywords: Insulin, metabolic syndrome; Insulin resistance; LRP1; Chylomicron remnant; Diabetes; Lipoprotein; PDGF
Keywords: Alzheimer's disease; Aβ; Cholesterol; apoE; PCSK9; LRP1;
Keywords: Aβ; β-Amyloid peptide; Aβ40; 40-amino acid isoform of β-Amyloid peptide; Aβ42; 42-amino acid isoform of β-Amyloid peptide; Aβ42/Aβ40; ratio of measured steady-state levels of Aβ42 and Aβ40; AD; Alzheimer's Disease; AICD; APP intracellular domain
Keywords: ALP; alkaline phosphatase; apoE; apolipoprotein E; BAT; brown adipose tissue; BMD; bone mineral density; CVD; cardiovascular disease; DIO; diet-induced obesity; EpiWAT; epididymal white adipose tissue; FPLC; fast performance liquid chromatography; HDL; hi
Keywords: 5-ALA; 5-amino-levulinic acid; RGD; arginine-glycine-aspartic acid; BBB; blood-brain barrier; BCNU; carmustine; CASANT; carmustine sustained-release implant; CNS; central nervous system; CED; convection-enhanced delivery; c(RGDyK); cyclic arginineâ
A Genome-Wide Association Study Finds Genetic Associations with Broadly-Defined Headache in UK Biobank (NÂ =Â 223,773)
Keywords: Headache; Genome-wide association study; LRP1; UK biobank; Tissue expression;
Overexpression of low density lipoprotein receptor-related protein 1 (LRP1) is associated with worsened prognosis and decreased cancer immunity in clear-cell renal cell carcinoma
Keywords: Clear-cell renal cell carcinoma; LRP1; Cancer immunity; Prognosis;
PID1 in adipocytes modulates whole-body glucose homeostasis
Keywords: PID1; Insulin resistance; LRP1; GLUT4;
Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-β pathology in amyloid model mice
Keywords: Amyloid-β; Alzheimer's disease; C3H/10T1/2; LRP1; Pericytes; Stem cell therapy;
Site-specific effects of apolipoprotein E expression on diet-induced obesity and white adipose tissue metabolic activation
Keywords: ALT; Alanine transaminase; Apoa1; Mouse apolipoprotein A-I; Apoa2; Mouse apolipoprotein A-II; Apoc1; Mouse apolipoprotein C-I; Apoc3; Mouse apolipoprotein C-III; Apoe; Mouse apolipoprotein E; APOE2; Human apolipoprotein E2; APOE3; Human apolipoprotein E3;
Part B: Morphometric and transcriptomic responses to sub-chronic exposure to the polycyclic aromatic hydrocarbon phenanthrene in the fathead minnow (Pimephales promelas)
Keywords: PNPLA2; patatin-like phospholipase domain containing 2; APOE; apolipoprotein E; NPC1; Niemann-Pick disease, type C1; LCAT; lecithin-cholesterol acyltransferase; DGAT1; diacylglycerol O-acyltransferase 1; LRP1; low density lipoprotein-related protein 1 (al
Part A: Temporal and dose-dependent transcriptional responses in the liver of fathead minnows following short term exposure to the polycyclic aromatic hydrocarbon phenanthrene
Keywords: SREBF1; sterol regulatory element binding transcription factor 1; FASN; fatty acid synthase; HSD17B12; hydroxysteroid (17-beta) dehydrogenase 12; ACACA; acetyl-CoA carboxylase alpha; CYB5A; cytochrome b5 type A (microsomal); SLC27A4; solute carrier family
LRP1: A chameleon receptor of lung inflammation and repair
Keywords: LRP1; Lung; Inflammation; Repair; Fibrosis;
A novel peptide ligand RAP12 of LRP1 for glioma targeted drug delivery
Keywords: RAP; Miniaturization; LRP1; Glioma; Blood-brain barrier; Blood-brain tumor barrier; Drug targeting delivery;
Efferocytosis in atherosclerotic lesions: Malfunctioning regulatory pathways and control mechanisms
Keywords: ABC; ATP-binding cassette; ABCA1; ATP-binding membrane cassette transporter A1; ABCG1; ATP binding cassette transporter G1; ABCA7; ATP-binding cassette transporters A7; Abs; Antibodies; ACs; Apoptotic cells; AICAR; 5-aminoimidazole-4-carboxamide-1-β-d-ri
Oleocanthal-rich extra-virgin olive oil enhances donepezil effect by reducing amyloid-β load and related toxicity in a mouse model of Alzheimer's disease
Keywords: AD; Alzheimer's disease; Aβ; amyloid-β; APP; amyloid precursor protein; ApoE; apo-lipoprotein E; ABCA1; ATP-binding cassette transporter A1; BBB; blood-brain barrier; EVOO; extra-virgin olive oil; GFAP; glial fibrillary acidic protein; IL-1β; inter
The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis
Keywords: ACAT; Acyl-CoA:cholesterol acyltransferase; ADAM17; a disintegrin and metalloproteinase 17; APO; apolipoprotein; COL18; collagen XVIII; CS/DS; chondroitin sulfate/dermatan sulfate; FLOT1; flotilin-1; GLCE; C5 epimerase; GPIHBP1; glycosylphosphatidylinosit
APP, APLP2 and LRP1 interact with PCSK9 but are not required for PCSK9-mediated degradation of the LDLR in vivo
Keywords: PCSK9; proprotein convertase subtilisin/kexin type 9; LDLR; low-density lipoprotein receptor; APP; amyloid precursor protein; APLP2; amyloid precursor-like protein 2; LRP1; LDL receptor-related protein 1; DSP; dithiobis[succinimidylpropionate]; SDA; (succ
ReviewAmylin and its G-protein-coupled receptor: A probable pathological process and drug target for Alzheimer's disease
Keywords: AD; Alzheimer's disease; AmR; amylin receptor; Aβ; amyloid-β peptide; BBB; blood-brain barrier; CGRP; calcitonin gene-related peptide; CTR; calcitonin receptor; GPCR; G-protein-coupled receptor; IDE; insulin-degrading enzyme; LRP1; lipoprotein recep
Lactoferrin-induced growth factors and cytokines expression profile in pre-osteoblast MC3T3-E1 cell and LRP1 stable knockdown MC3T3-E1 cell
Keywords: Lactoferrin; Osteoblast; Differentiation; LRP1; Growth factors; Cytokines; NOV/CCN3/IGFBP-9; CCN family member 3/Insulin-like growth factor binding protein 9; Osteopontin; Osteopontin; SDF-1/CXCL12; Chemokine (C-X-C motif) ligand 12/stromal cell-derived f
Polyamine- and NADPH-dependent generation of ROS during Helicobacter pylori infection: A blessing in disguise
Keywords: 8-OHdG; 8-hydroxy-2-deoxyguanosine; ABL1; ABL proto-oncogene 1; AhpC; alkyl hydroperoxide reductase; AKT1; V-Akt murine thymoma viral oncogene homolog 1; APEX1; endonuclease apurinic/apyrimidinic endodeoxyribonuclease 1; ARG1; arginase 1; ARG2; arginase 2
Low-Density Lipoprotein Receptor-Related Protein-1 Is a Therapeutic Target in Acute Myocardial Infarction
Keywords: ischemia reperfusion; low-density lipoprotein receptor-related protein-1; serine protease inhibitor; SERPINs; A2MG; alpha-2 macroglobulin; AAT; alpha-1 antitrypsin; AMI; acute myocardial infarction; ATIII; antithrombin III; HRP; horseradish peroxidase; IL
HIV and its relationship to insulin resistance and lipid abnormalities
Keywords: ABCA1; adenosine-triphosphate-binding cassette transporter A1; AIDS; acquired immunodeficiency syndrome; AMI; acute myocardial infarction; Apo-B; apolipoprotein B; cART; combined antiretroviral therapy; CRP; c-reactive protein; DM; diabetes mellitus; HDL-
Deletion of liver-specific STAT5 gene alters the expression of bile acid metabolism genes and reduces liver damage in lithogenic diet-fed mice
Keywords: STAT5; signal transducer and activator of transcription 5; GH; growth hormone; IGF-1; insulin-like growth factor-1; LDLR; low-density lipoprotein receptor; STAT5 LKO; liver-specific STAT5 knock-out; STAT5 fl/fl; STAT5 flox/flox; TG; triacylglycerol; ChMCs
Andrographolide-loaded nanoparticles for brain delivery: Formulation, characterisation and in vitro permeability using hCMEC/D3 cell line
Keywords: AG; andrographolide; ATM; adsorptive-mediated transcytosis; BBB; blood-brain barrier; BSA; bovine serum albumin; CNS; central nervous system; DLS; Dynamic Light Scattering; DMSO; dimethyl sulfoxide; ECA; ethylcyanoacrylate; EE; encapsulation efficiency; E
A telomerase-derived peptide regulates reactive oxygen species and hepatitis C virus RNA replication in HCV-infected cells via heat shock protein 90
Keywords: Antioxidant; GV1001; Heat shock protein 90; Hepatitis C virus; Low-density lipoprotein receptor-related protein 1; eHSP90; extracellular heat-shock protein 90; NOX; NADPH oxidase; LRP1; low-density lipoprotein receptor-related protein 1; NS5A; hepatitis C
LXR activation protects hippocampal microvasculature in very old triple transgenic mouse model of Alzheimer's disease
Keywords: AD; Alzheimer's disease; BBB; blood brain barrier; Aβ; Amyloid beta; LRP1; low-density lipoprotein related protein 1; LXR; liver X receptor; GFAP; glial fibrillary acidic protein; Iba1; ionized calcium-binding adapter molecule 1; GW3965; Alzheimer's
The P2Y2 receptor mediates uptake of matrix-retained and aggregated low density lipoprotein in primary vascular smooth muscle cells
Keywords: LRP1; P2Y2R; LRP1; low-density lipoprotein receptor related protein; agLDL; aggregated low-density lipoproteins; P2Y2R; P2Y2 receptor;
Research reportNeuronal low-density lipoprotein receptor-related protein 1 (LRP1) enhances the anti-apoptotic effect of intravenous immunoglobulin (IVIg) in ischemic stroke
Keywords: APP; amyloid precursor protein; BBB; blood brain barrier; IFN-γ; interferon-gamma; IVIg; Intravenous immunoglobulin; I/R; ischemia and reperfusion; LDL; low-density lipoprotein; LRP1; low-density lipoprotein receptor-related protein 1; LPS; lipopolysacch
TGF-β1-induced PAI-1 contributes to a profibrotic network in patients with eosinophilic esophagitis
Keywords: Eosinophil; esophagitis; SerpinE1; remodeling; fibrosis; TGF-β1; BZH; Basal zone hyperplasia; EoE; Eosinophilic esophagitis; LP; Lamina propria; LRP1; Lipoprotein receptor-related protein 1; MMP; Matrix metalloproteinases; PAI-1; Plasminogen activator
Brain cortical cholesterol metabolism is highly affected by human APP overexpression in mice
Keywords: Alzheimer's disease; Aβ; Cholesterol; Amyloid precursor protein overexpression; Mouse model; APPSL; AD; Alzheimer's disease; Aβ; amyloid beta; ACAT; Acetyl-CoA acetyltransferases; APP; amyloid precursor protein; ApoB-100; apolipoprotein B-100; ApoE; apo
Low density lipoprotein receptor-related protein 1 mediated endocytosis of β1-integrin influences cell adhesion and cell migration
Keywords: LRP1; low density lipoprotein receptor related-protein 1; Snx17; Sorting nexin 17; PSD95; postsynaptic density protein 95; Dab-2; disabled homolog 2; ECM; extracellular matrix; RMS; rostral migratory stream; BrdU; 5-bromo-2-deoxyuridine; CPZ; chlorpromazi
Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics
Keywords: AC; adenylyl cyclase; AI; anemia of inflammation; cdks; cyclin-dependent kinases; bFGF; basic fibroblast growth factor; BpT; 2-benzoylpyridine thiosemicarbazone; Bp4eT; 2-benzoylpyridine 4-ethyl-3-thiosemicarbazone; Bp44mT; 2-benzoylpyridine 4,4-dimethyl-
Map kinase and PKC signaling pathways modulate NGF-mediated apoE transcription
Keywords: ANOVA; analysis of variance; AD; Alzheimer's disease; AP-1; activator protein 1; APP; amyloid precursor protein; apoE; apolipoprotein E; BIS-1; bisindolylmaleimide 1; ChaT; choline acetyltransferase; L-NAME; NÏ-nitro-L-arginine methylester; LRP1; low d
Triterpenoid-enriched extract of Ilex kudingcha inhibits aggregated LDL-induced lipid deposition in macrophages by downregulating low density lipoprotein receptor-related protein 1 (LRP1)
Keywords: Ilex kudingcha; Triterpenoid-enriched extract; Foam cell; Low density lipoprotein receptor-related protein 1; Latifoloside G (PubChem CID: 44566333); Latifoloside H (PubChem CID: 44566328); ABCA1; ATP-binding cassette subfamily A member-1; AgLDL; aggregat
A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavage
Keywords: CL-PAI-1; cleaved PAI-1; FL-PAI-1; full-length PAI-1; HNE; human neutrophil elastase; HuCASMCs; human carotid artery smooth muscle cells; LRP1; low density lipoprotein receptor-related protein 1; pAkt; phospho-Akt; PAI-1; plasminogen activator inhibitor-1
Hypoxia-driven sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) downregulation depends on low-density lipoprotein receptor-related protein 1 (LRP1)-signalling in cardiomyocytes
Keywords: LRP1; Pyk2; SERCA2; Hypoxia; Cardiomyocytes;
Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice
Keywords: AD; Alzheimer's disease; Aβ; amyloid-β; APP; amyloid-β precursor protein; BBB; blood-brain barrier; BCI; brain clearance index; CAA; cerebral amyloid angiopathy; DEA; diethylamine; EVOO; extra-virgin olive oil; FA; formic acid; IDE; insulin degradi
Deletion of ADAMTS5 does not affect aggrecan or versican degradation but promotes glucose uptake and proteoglycan synthesis in murine adipose derived stromal cells
Keywords: A2M; alpha-2-macroglobulin; ADSC; adipose derived stromal cell; Acan; aggrecan; Vcan; versican; CS/DS; chondroitin/dermatan sulfate; DE52; diethyl-amino-ethyl cellulose; ECM; extracellular matrix; HA; hyaluronan; IHC; immunohistochemistry; KO; knockout; L
An apolipoprotein E modified liposomal nanoparticle: Ligand dependent efficiency as a siRNA delivery carrier for mouse-derived brain endothelial cells
Keywords: siRNA; short interference RNA; ApoE; apolipoprotein E; NVU; neurovascular unit; BBB; blood brain barrier; pDNA; plasmid DNA; MEND; multi-functional envelop-type nano device; LDLR; low-density lipoprotein receptor; LRP1; LDLR-related protein 1; VLDLR; very