Effects of testosterone and metformin on glucose metabolism in endometrium
Keywords: PCOS; metformin; endometrium; IRS-1; GLUT-4
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High-frequency electrically stimulated skeletal muscle contractions increase p70s6k phosphorylation independent of known IGF-I sensitive signaling pathways
Keywords: Akt; phosphatidylinosoltol regulated protein kinase; IGF-I; insulin-like growth factor-I; IOD; integrated optical densities; IRS-1; insulin related substrate-1; MKR; IGF-I receptor mutant mouse; mTOR; mammalian target of rapamycin; PI3K; phosphatidylinoso
GSK-3β and control of glucose metabolism and insulin action in human skeletal muscle
Keywords: Glycogen synthase kinase 3; Insulin action; Muscle (human skeletal); Glucose uptake; IRS-1
Transcription factor AP-2β: A negative regulator of IRS-1 gene expression
Keywords: AP-2β; IRS-1; Insulin resistance; 3T3-L1 adipocytes; Type 2 diabetesAP-2, activating enhancer-binding protein 2; DMEM, Dulbecco’s modified Eagle’s medium; EMSA, Electrophoretic mobility shift assay; luc, luciferase; MOI, multiplicity of infection; MT, mut
Prolonged tyrosine kinase activation of insulin receptor by pY27-caveolin-2
Keywords: pY27-caveolin-2; Insulin receptor; PTPs; SOCS-3; IRS-1; Rapamycin; pS727-STAT3;
IGF-I stimulates reactive oxygen species (ROS) production and inhibits insulin-dependent glucose uptake via ROS in 3T3-L1 adipocytes
Keywords: IGF-I; Adipocytes; 3T3-L1 adipocyte; ROS; Insulin resistance; IRS-1
Polymorphisms of the insulin receptor and the insulin receptor substrates genes in polycystic ovary syndrome: A Mendelian randomization meta-analysis
Keywords: Polycystic ovary syndrome; ΙNSR; IRS-1; Meta-analysis; Random-effects; Mendelian randomization; Genetic epidemiology
The ginsenoside Rg3 has a stimulatory effect on insulin signaling in L6 myotubes
Keywords: Rg3; Ginsenoside; Insulin signaling; IRS-1;
Sensitivity of breast cancer cell lines to the novel insulin-like growth factor-1 receptor (IGF-1R) inhibitor NVP-AEW541 is dependent on the level of IRS-1 expression
Keywords: Breast cancer; IGF-1R; IRS-1; Tyrosine kinase inhibitor
17β-Estradiol treatment is unable to reproduce p85α redistribution associated with gestational insulin resistance in rats
Keywords: Insulin resistance; 17β-Estradiol; Glut4; p85α; IRS-1; Pregnancy
The cell growth suppressor, mir-126, targets IRS-1
Keywords: microRNA; mir-126; Cell growth; Target genes; IRS-1; PolyA RT PCR
SH3 domain of the phosphatidylinositol 3-kinase regulatory subunit is responsible for the formation of a sequestration complex with insulin receptor substrate-1
Keywords: PI-3kinase; CHO-IR cells; IRS-1; Insulin; Akt;
Differential subcellular localization of insulin receptor substrates depends on C-terminal regions and importin β
Keywords: Insulin receptor substrate (IRS)-3; IRS-1; IRS-2; Importin β; Nuclear transport; Pleckstrin homology (PH) domain; Phosphotyrosine binding (PTB) domain
ATM protein kinase mediates full activation of Akt and regulates glucose transporter 4 translocation by insulin in muscle cells
Keywords: A-T; Ataxia-telangiectasia; IR; Insulin receptor; IRS-1; Insulin receptor substrate 1; ATM; A-T mutated; PI 3-kinase; Phosphotidylinositol 3-kinase; GLUT4; Glucose transporter 4; QUICKI; Quantitative Insulin Sensitivity Check Index; GFP; Green fluorescenc
Long-term effects of rapamycin treatment on insulin mediated phosphorylation of Akt/PKB and glycogen synthase activity
Keywords: Rapamycin; Insulin; Akt/PKB phosphorylation; IRS-1; Glycogen synthase; Protein phosphatase-1; HepG2 cells
Role of resistin in cardiac contractility and hypertrophy
Keywords: Resistin; Cardiac hypertrophy; Insulin resistance; Diabetes; MAP kinases; IRS-1; Contractility; Ca2+ transients
Virus-induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C
Keywords: AMPK; adenosine monophosphate-activated protein kinase; CHC; chronic hepatitis C; GSK-3β; glycogen synthase kinase-3 beta; IRS-1; insulin-receptor substrate 1; mTOR; mammalian target of rapamycin; PDK1; phosphoinositide-dependent kinase 1; PP2A; protein
Effects of triglyceride on ER stress and insulin resistance
Keywords: ER stress; Triglyceride; Insuline resistance; IRS-1; JNK
The depletion of cellular mitochondrial DNA causes insulin resistance through the alteration of insulin receptor substrate-1 in rat myocytes
Keywords: IRS, insulin receptor substrate; GLUT4, facilitative glucose transporter isoform 4; PI3K, phosphatidylinositol 3-kinase; PDK-1, 3-phosphoinositide-dependent protein kinase-1; Akt2/PKB, protein kinase BmtDNA; GLUT4; Insulin resistance; IRS-1; Akt2/PKB
IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance
Keywords: IRS-1; Insulin resistance; TNF-α
Akyrin repeat and SOCS box containing protein 4 (Asb-4) interacts with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activity
Keywords: Asb-4; ankyrin repeat and SOCS box-containing protein 4; Asb-4/Îsb; Asb-4 minus its SOCS box; GPS1; G-protein pathway suppressor 1; CSN1; COP9 signalosome, subunit 1; ARC; arcuate nucleus; POMC; pro-opiomelanocortin; NPY; neuropeptide Y; QDO; quadruple d
WISP3 suppresses insulin-like growth factor signaling in human chondrocytes
Keywords: CCN6; Chondrocytes; Collagen II; ERK; IGF-IR; IRS-1; SEDT-PA; WISP3
Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development
Keywords: p190-B; ARHGAP5; IGF-1R; IRS-1; IRS-2; Mammary bud; Epithelial–mesenchymal
Induction of SOCS-3 is insufficient to confer IRS-1 protein degradation in 3T3-L1 adipocytes
Keywords: Adipocyte; IRS-1; SOCS-3; STAT3; Degradation
Vitamin E protects the insulin sensitivity and redox balance in rat L6 muscle cells exposed to oxidative stress
Keywords: Insulin resistance; Oxidative stress; IRS-1; GLUT-4; Glucose uptake
PKCθ is a key player in the development of insulin resistance
Keywords: PKCθ; Insulin resistance; Hepatocytes; IRS-1; akt/PKB
Protein kinase Cα regulates insulin receptor signaling in skeletal muscle
Keywords: PKCα; IRS-1; PKB; Threonine phosphorylation; Serine phosphorylation; Insulin signaling; Blood glucose
Insulin receptor tyrosine kinase activity and substrate 1 (IRS-1) expression in human myometrium and leiomyoma
Keywords: Leiomyoma; Myometrium; Insulin receptor; Tyrosine kinase; IRS-1;
Common polymorphisms in the PPARγ2 and IRS-1 genes and their interaction influence serum adiponectin concentration in young Finnish men
Keywords: PPARγ2; IRS-1; Adiponectin; Insulin resistance; Insulin; Gene;
Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action
Keywords: GIP; IRS-1; PPARα; Energy expenditure;
Low adipocyte IRS-1 protein expression is associated with an increased arterial stiffness in non-diabetic males
Keywords: Arterial stiffness; Endothelium; Insulin resistance; IRS-1; Adipose tissue;
Insulin-induced stimulation of JNK and the PI 3-kinase/mTOR pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubes
Keywords: JNK; PI 3-kinase; mTOR; IRS-1; Serine 318; C2C12 myotubes; Insulin resistance;
Effect of food restriction on the insulin signalling pathway in rat skeletal muscle and adipose tissue
Keywords: Food restriction; Insulin; Insulin receptor; IRS-1; Glut4;
ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages
Keywords: EN; ETV6-NTRK3; ETV6; ETS variant gene 6; NTRK3; neurotrophic tyrosine kinase, receptor, type 3; PTK; protein tyrosine kinase; ERK; extracellular signal-regulated kinase; IGFIR; insulin-like growth factor-I receptor; IRS-1; insulin receptor substrate-1;
ERK1/2 activation by angiotensin II inhibits insulin-induced glucose uptake in vascular smooth muscle cells
Keywords: Insulin resistance; Angiotensin II; Vascular smooth muscle cell; Glucose uptake; MAP kinase; IRS-1;
Tumor necrosis factor (TNF) interferes with insulin signaling through the p55 TNF receptor death domain
Keywords: Tumor necrosis factor; Sphingomyelinase; Ceramide; Insulin; Diabetes; A-SMase; N-SMase; IRS-1;
Effects of long-term caloric restriction on glucose homeostasis and on the first steps of the insulin signaling system in skeletal muscle of normal and Ames dwarf (Prop1df/Prop1df) mice
Keywords: Ames dwarf mice; Aging; Caloric restriction; Insulin sensitivity; Insulin receptor; IRS-1; PI 3-kinase;
Diet high in lipid hydroperoxide by vitamin E deficiency induces insulin resistance and impaired insulin secretion in normal rats
Keywords: FFA; free fatty acids; IRI; immunoreactive insulin; IRS; insulin receptor substrate; LPO; lipid hydroperoxide; OGTT; oral glucose tolerance test; SSBG; steady-state blood glucose; SSPI; steady-state plasma insulin; TBARS; thiobarbituric acid reactive subs
Early signaling interactions between the insulin and leptin pathways in bovine myogenic cells
Keywords: IR; insulin receptor kinase; IRS-1; insulin receptor substrate-1; PI; phosphatidylinositol; GLUT4; glucose transporter 4; ObR; leptin receptor; JAK-2; Janus kinase-2; BMC; bovine myogenic cells; Insulin resistance; Signal transduction; Insulin receptor; I
Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic β-cell dysfunction and insulin resistance
Keywords: Ad; adenovirus; Bip; immunoglobulin binding protein; DN; dominant-negative; eIF2α; α subunit of translation initiation factor 2; ER; endoplasmic reticulum; IRS-1; insulin receptor substrate 1; IP-1; JNK-interacting protein-1; JNK; c-Jun N-terminal kinas