کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9112394 | 1155749 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Diet high in lipid hydroperoxide by vitamin E deficiency induces insulin resistance and impaired insulin secretion in normal rats
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کلمات کلیدی
NF-κBFFALPOTBARSSSPIIRSPI3-kinaseIRS-1OGTTIRI - IROral glucose tolerance test - آزمون تحمل گلوکز خوراکیFree fatty acids - اسیدهای چرب آِزادimmunoreactive insulin - انسولین ایمنی فعالinsulin receptor substrate - انسولین بستر گیرندهInsulin secretion - ترشح انسولینPhosphatidylinositol 3-kinase - فسفاتیدیلینواستیل 3-کینازInsulin resistance - مقاومت به انسولینthiobarbituric acid reactive substances - مواد واکنش پذیر اسید تیوباربیتوریکLipid hydroperoxide - هیدروپراکسید لیپیدLipid peroxide - پراکسید لیپید
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
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چکیده انگلیسی
To clarify the effect of dietary lipid hydroperoxide (LPO) on development of glucose intolerance, we fed Sprague-Dawley rats on a diet containing elevated LPO level for 10 weeks and measured both insulin sensitivity and insulin secretion. The contents of LPO in both plasma and skeletal muscle in the LPO-fed rats were significantly higher than those in the controls. Both insulin resistance evaluated by steady-state blood glucose (SSBG) methods and impaired insulin secretion evaluated by oral glucose tolerance test (OGTT) were found in the LPO-fed rats as compared with control rats. Furthermore, the levels of insulin receptor substrate (IRS)-1 protein in the skeletal muscle were significantly lower in the LPO-fed rats. Those impairments were not reversed in LPO-fed rats with supernormal levels of plasma vitamin E following vitamin E supplementation for 5 weeks. Moreover, the immunohistochemical study revealed that NF-κB-p50 protein was found in the nucleus of pancreatic β-cells of the LPO-fed rats, whereas it was not observed in the nucleus of the islets in the control rats. These findings indicate that NF-κB is activated in response to oxidative stress in pancreatic islet cells in LPO-fed rats. In conclusion, our studies reveal that diet high in LPO by vitamin E deficiency accelerates glucose intolerance through impairments of both sensitivity and secretion of insulin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 67, Issue 2, February 2005, Pages 99-109
Journal: Diabetes Research and Clinical Practice - Volume 67, Issue 2, February 2005, Pages 99-109
نویسندگان
Katsumasa Tsujinaka, Takaaki Nakamura, Hiroshi Maegawa, Mineko Fujimiya, Yoshihiko Nishio, Motoi Kudo, Atsunori Kashiwagi,