دانلود مقالات ISI درباره Pi3-Kinase + ترجمه فارسی

اثرات و مکانیزم های پزشکی ترکیبی چینی و مواد تشکیل دهنده اصلی بر اختلال عملکرد میکرو سیکلوکتون و آسیب اندام ناشی از ایسکمی / رپرفیوژن

Effects and mechanisms of compound Chinese medicine and major ingredients on microcirculatory dysfunction and organ injury induced by ischemia/reperfusion

Keywords: AA; Angelica Archangelica; AGNHW; AnGongNiuHuang Wan; AM; Astragalus membranaceus; AMP; adenosine monophosphate; AMPK; adenosine 5′-monophosphate activated protein kinase; Ang II; angiotensin II; AP; Astragalus polysaccharide; ASIV; astragaloside IV; AS

دانلود رایگان متن کامل مقاله ISI 106 صفحه سال انتشار : 2017 سفارش ترجمه

مهار کننده های پروتئین کیناز وابسته به سیکلین از جمله پالوبسیکلیب به عنوان داروهای ضد سرطان

Cyclin-dependent protein kinase inhibitors including palbociclib as anticancer drugs

Keywords: 7-Hydroxystaurosporine (PubMed CID: 72271); Abemaciclib (PubMed CID: 46220502); Alvocidib (PubMed CID: 5287969); AT7519 (PubMed CID: 11338033); BMS-387032 (PubMed CID: 3025986); Dinaciclib (PubMed CID: 46926350); Palbociclib (PubMed CID: 5330286); Ribocic

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2016 سفارش ترجمه

فارماکولوژی گیرنده اسیدی صفراوی: تکامل اسیدهای صفراوی از مواد شوینده ساده تا مولکول های سیگنال پیچیده

Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules

Keywords: ABCB; ATP-binding cassette sub-family B; Apo; apolipoprotein; ASBT; apical sodium dependent bile acid transporter; BDL; bile duct ligation; BSEP; bile salt export pump; CA; cholic acid; CDCA; chenodeoxycholic acid; C/EBP; CCAAT-enhancer-binding protein; C

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2016 سفارش ترجمه

هدف قرار دادن پاسخ شوک گرما در ترکیب با پرتودرمانی: حساسیت سلول های سرطانی به مرگ سلولی ناشی از اشعه و افزایش ایمنی بدن آنها

Targeting the heat shock response in combination with radiotherapy: Sensitizing cancer cells to irradiation-induced cell death and heating up their immunogenicity

Keywords: 17-AAG; 17-(Allylamino)-17-demethoxygeldanamycin; 17-DMAG; 17-Dimethylaminoethylamino-17-demethoxygeldanamycin; AKT; v-akt murine thymoma viral oncogene homolog; APC; antigen presenting cell; ATM; Ataxia telangiectasia mutated; ATR; Ataxia telangiectasia

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2015 سفارش ترجمه

درمان های غیر دارویی برای سکته مغزی: مکانیسم ها و پیامدهای بالینی

Non-pharmaceutical therapies for stroke: Mechanisms and clinical implications

Keywords: ACP; antegrade cerebral perfusion; AMES; assisted movement with enhanced sensation; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid; BAIPC; bilateral arm ischemic preconditioning; BBB; blood-brain barrier; BCI; Brain-Computer Interface; B

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2014 سفارش ترجمه

اثرات پیشگیرانه استئوکالسین غیر قلبی بی کربن بر آپوپتوز اندوتلیال ناشی از اسید چرب آزاد از طریق فعال سازی مسیر سیگنالینگ فسفاتیدیلینواستیل 3-کیناز / آکت

The preventive effect of uncarboxylated osteocalcin against free fatty acid-induced endothelial apoptosis through the activation of phosphatidylinositol 3-kinase/Akt signaling pathway

Keywords: OC; osteocalcin; cOC; carboxylated osteocalcin; ucOC; uncarboxylated osteocalcin; PI3-kinase; phosphatidylinositol 3-kinase; FFA; free fatty acid; HAEC; human aortic endothelial cell; LA; linoleic aicd; PARP; poly (ADP-ribose) polymerase; eNOS; endothelia

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Deciphering the pathways that protect from IL-13-mediated potentiation of oxidative stress-induced dopaminergic nerve cell death

Keywords: Parkinson's disease; mTOR; Jak; Akt; 4E-BP1; Oxidative stress; BSA; bovine serum albumin; CM-H2DCFDA; 5-(and-6)-chloromethyl-2′,7′-dichlorofluorescein diacetate; mTOR; mammalian target of rapamycin; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetr

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

ERK-TSC2 signalling in constitutively-active HRAS mutant HNSCC cells promotes resistance to PI3K inhibition

Keywords: Head and neck cancer; PI3-kinase; Precision medicine; Extracellular signal-regulated MAP kinases; HRAS protein; Hotspot mutation; Genes; RAS; NVP-BYL719;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Dual loss of p110δ PI3-kinase and SKAP (KNSTRN) expression leads to combined immunodeficiency and multisystem syndromic features

Keywords: PIK3CD; PI3-kinase; SKAP; KNSTRN; syndromic; immunodeficiency; lymphocyte; MAP4; microtubule; CID; Combined immunodeficiency; KO; Knockout; MAP4; Microtubule-associated protein 4; MTOC; Microtubule organizing center; NK; Natural killer; RCS; Roifman-Chita

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Caffeic acid phenethyl ester rescued streptozotocin-induced memory loss through PI3-kinase dependent pathway

Keywords: Caffeic acid phenethyl ester; PI3-kinase; Memory; Wortmannin; Endothelial NOS; NFκB;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Fasudil hydrochloride ameliorates memory deficits in rat model of streptozotocin-induced Alzheimer's disease: Involvement of PI3-kinase, eNOS and NFκB

Keywords: Fasudil; PI3-kinase; Wortmannin; Endothelial NOS; NFκB; Memory; Acetylcholinesterase;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

Neonatal Fc receptor FcRn is involved in intracellular transport of the Fc fusion protein aflibercept and its transition through retinal endothelial cells

Keywords: Retinal endothelial cells; Aflibercept; Fc fusion protein; IgG; Neonatal Fc receptor; Internalization; Transport; Transcytosis; DMSO; dimethyl sulfoxide; EEA1; early endosome antigen 1; Fc; fragment crystalisable; FcRn; neonatal Fc receptor; FBS; fetal bo

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Fluid shear stress applied by orbital shaking induces MG-63 osteosarcoma cells to activate ERK in two phases through distinct signaling pathways

Keywords: FSS; fluid shear stress; PI3-kinase; phosphoinositide-3-kinase; Rho kinase; Rho-associated kinase; Mechanoresponse; Fluid flow; Shear stress; Osteoblast; Orbital shaking;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Cytokine IL-10, activators of PI3-kinase, agonists of α-2 adrenoreceptor and antioxidants prevent ischemia-induced cell death in rat hippocampal cultures

Keywords: Ischemia; OGD; Interleukin-10; PI3-Kinase; Alpha-2 adrenoreceptor; Antioxidant enzyme; Neuroprotective agents; Hippocampal cell culture; Global [Ca2+]i increase; Fura-2; Ca2+ imaging; Cell survival;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

The role of phosphatidylinositol-3-OH-kinase (PI3-kinase) and respiratory burst enzymes in the [omim][BF4]-mediated toxic mode of action in mussel hemocytes

Keywords: Hemocytes; DNA damage; Lipid peroxidation; NADPH oxidase; NO synthase; [omim][BF4]; PI3-Kinase;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Insulin-like growth factor 1 specifically up-regulates expression of modifier subunit of glutamate-cysteine ligase and enhances glutathione synthesis in SH-SY5Y cells

Keywords: Neurotrophic factor; Oxidative stress; Neuroprotection; PI3-kinase; Extracellular signal-regulated kinase

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Cell confluence induces switching from proliferation to migratory signaling by site-selective phosphorylation of PDGF receptors on lipid raft platforms

Keywords: DAG; diacylglycerol; GM1; monosialotetrahexosylganglioside; GRB2; growth factor receptor binding protein-2; IP3; inositol 1,4,5-trisphosphate; PDGF; platelet-derived growth factor; PDGF-BB; homodimer of the B isoform of platelet derived growth factor); PD

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Rat aorta as a pharmacological tool for in vitro and in vivo studies

Keywords: BH4; tetrahydrobiopterin; cGMP; cyclic guanine monophosphate; COX; cyclooxygenase; cNOS; constitutive NOS; DAG; diacylglycerol; DMEM; Dulbecco's modified eagle's medium; eNOS; endothelial NOS; EDHF; endothelium dependent hyperpolarization factor; EGTA; et

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation

Keywords: mTOR; mammalian target of rapamycin; UVB; ultraviolet-B; NMSC; non-melanoma skin cancer; mTORC1; mTOR complex 1; mTOC2; mTOR complex 2; AKT/PKB; protein kinase B; SCC; squamous cell carcinoma; ERK; extracellular-signal-regulated kinases; MEK; mitogen-acti

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2016 سفارش ترجمه

Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction

Keywords: AMPK; AMP-activated protein kinase; ATM; adipose tissue macrophages; CCL; chemokine (C-C motif) ligand; CCR2; chemokine (C-C motif) receptor 2; CX3CL1; chemokine (C-X3-C motif) ligand 1; CX3CR1; chemokine (C-X3-C motif) receptor; CXCL; CXC chemokine ligan

دانلود رایگان متن کامل مقاله ISI 69 صفحه سال انتشار : 2016 سفارش ترجمه

A review on the possible molecular mechanism of action of N-acetylcysteine against insulin resistance and type-2 diabetes development

Keywords: N-acetyl-l-cysteine (NAC) (PubChem CID: 12035); AKT; protein kinase B; AP-1; activator protein 1; CCL2; chemokine (C-C motif) ligand 2; eNOS; endothelial nitric oxide synthase; ERK; extracellular signal-regulated kinase; FFA; free fatty acid; GLUT; gluc

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Harpagoside ameliorates the amyloid-β-induced cognitive impairment in rats via up-regulating BDNF expression and MAPK/PI3K pathways

Keywords: AChE; acetylcholinesterase; AD; Alzheimer's disease; Aβ; β-amyloid; BCA; bicinchoninic acid; BDNF; brain-derived neurotrophic factor; ChAT; choline acetyltransferase; DAB; 3,3′-diaminobenzidine; DMEM; Dulbecco's Modified Eagle Medium; ELISA; enzym

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Serotonin induces depolarization in lateral amygdala neurons by activation of TRPC-like current and inhibition of GIRK current depending on 5-HT2C receptor

Keywords: Lateral amygdala; Serotonin; TRPC; GIRK; PIP2; PI3-kinase;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Vasopressin activates Akt/mTOR pathway in smooth muscle cells cultured in high glucose concentration

Keywords: AVP; arginine vasopressin; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; PI3K; phosphatidyl inositol-3 kinase; AMPK; AMP-activated protein kinase; PKC; protein kinase C, Akt or protein kinase B; TSC1/TSC2; tubero sclerosis protein 1 and 2;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase β isoform

Keywords: PI3-kinase; Isoform selectivity; Structure-based ligand design;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

An Infernal Trio: The chemokine CXCL12 and its receptors CXCR4 and CXCR7 in tumor biology

Keywords: AP-1; activator protein 1; cAMP; cyclic adenosine monophosphate; CNS; central nervous system; CREB; cAMP response element-binding; DPP; dipeptidyl peptidase; ECM; extracellular matrix; ELK-1; ETS-like transcription factor 1; ERK; extracellular-signal rela

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Cis-Amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase

Keywords: PI3-kinase; Isostere; Structure-based design; Property-guided design

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Induction of steroid sulfatase expression in PC-3 human prostate cancer cells by insulin-like growth factor II

Keywords: Steroid sulfatase; Insulin-like growth factor-II; PI3-kinase; Akt; NF-κBEST, estrone sulfotransferase; HSD, 17β-hydroxysteroid dehydrogenase; IGF, insulin-like growth factor; IL-6, interleukin 6; NBD, nemo binding domain; STS, steroid sulfatase; TNF, tumo

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Evidence for phosphatidylinositol-3-OH-kinase (PI3-kinase) involvement in Cd-mediated oxidative effects on hemocytes of mussels

Keywords: Cadmium; Hemocytes; Lipid peroxidation; Nitric oxide; PI3-kinase; PKC; Superoxide; Wortmannin;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Co-regulation of survival of motor neuron and Bcl-xL expression: Implications for neuroprotection in spinal muscular atrophy

Keywords: DMEM; Dulbecco's modified eagle medium; GFP; green fluorescent protein; PBS; Phosphate buffered saline; PCR; Polymerase chain reaction; PI3-kinase; phosphatidylinositol-3 kinase; PrP-SMN; transgenic mouse over-expressing SMN via the prion promoter; SMA;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Arabidopsis AtVPS15 Plays Essential Roles in Pollen Germination Possibly by Interacting with AtVPS34

Keywords: Arabidopsis; AtVPS15; Pollen germination; PI3-kinase

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Structure-based design of thienobenzoxepin inhibitors of PI3-kinase

Keywords: Structure-based design; PI3-kinase

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Genipin up-regulates heme oxygenase-1 via PI3-kinase-JNK1/2-Nrf2 signaling pathway to enhance the anti-inflammatory capacity in RAW264.7 macrophages

Keywords: Genipin; HO-1; Nrf2; PI3-kinase; JNK1/2; Anti-inflammatory;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Regulation of ROCKII membrane localization through its C-terminus

Keywords: ROCK; Rho; PI3-kinase; Membrane targeting; Coincidence detector

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Occult hepatitis C virus elicits mitochondrial oxidative stress in lymphocytes and triggers PI3-kinase-mediated DNA damage response

Keywords: 8-oxo-dG; 8-oxo-2′-deoxyguanosine; ALT; alanine transferase; ARP; aldehyde-reactive probe; CM-H2DCFDA; 5-(and-6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate acetyl ester; DCF; 2′,7′-dichlorofluorescin; DSB; double-strand break; EDTA;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells

Keywords: Prolactin signaling; ERK activation; PI3-kinase; Rac/PAK; Cross-talk; Breast cancer

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Ephexin4 and EphA2 mediate resistance to anoikis through RhoG and phosphatidylinositol 3-kinase

Keywords: Ephexin4; RhoG; Anoikis; PI3-kinase; Akt; EphA2

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase

Keywords: PI3-kinase; Oncology; Structure-based drug design

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors

Keywords: PI3-Kinase

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Effects of PI3K inhibition and low docosahexaenoic acid on cognition and behavior

Keywords: PI3-kinase; Wortmannin; Docosahexaenoic acid; Alzheimer's disease; Diabetes

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Regulation of membrane biogenesis in autophagy via PI3P dynamics

Keywords: Autophagy; PI3-kinase; PI3-phosphatase; PI3P; Autophagosome;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

BRAF as therapeutic target in melanoma

Keywords: Melanoma; BRAF; MAP kinase; Sorafenib; PI3-kinase; MITF

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

The C-terminal flanking peptide (CTFP) of progastrin inhibits apoptosis via a PI3-kinase-dependent pathway

Keywords: CTFP; C-terminal flanking peptide; PI3-kinase; phosphatidylinositol-3-kinase; MAP kinase; mitogen activated protein kinase; Ggly; glycine-extended gastrin; Gamide; amidated gastrin; PI; propidium iodide; CRC; colorectal carcinoma; C-terminal flanking pept

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Vascular insulin resistance in prehypertensive rats: Role of PI3-kinase/Akt/eNOS signaling

Keywords: Insulin resistance; Hypertension; Vasorelaxation; PI3-kinase; Akt

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Physiological role of autophagy as an intracellular recycling system: With an emphasis on nutrient metabolism

Keywords: AMP; adenosine monophosphate; AMPK; AMP-activated protein kinase; Atg; autophagy-related; ATP; adenosine triphosphate; Bak; Bcl-2 homologous antagonist/killer; Bax; Bcl-2 associated X protein; Bcl-2; B-cell leukemia/lymphoma 2; Cvt; cytoplasm-to-vacuole t

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Tetramethylpyrazine inhibits production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through blockade of MAPK and PI3K/Akt signaling pathways, and suppression of intracellular reactive oxygen specie

Keywords: Tetramethylpyrazine; Inflammation; Inducible nitric oxide synthase; Microglial cell; Mitogen-activated protein kinase; PI3-kinase

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Initiation of neuronal differentiation requires PI3-kinase/TOR signalling in the vertebrate neural tube

Keywords: Vertebrate neurogenesis; Chick; Mouse; PI3-kinase; TOR; Rapamycin; Neuronal differentiation; Cell cycle; Tuberous sclerosis

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Altered Macrophage Function Contributes to Colitis in Mice Defective in the Phosphoinositide-3 Kinase Subunit p110δ

Keywords: Inflammatory Bowel Diseases; Innate Immunity; PI3-Kinase; Enteric Microbiota; BMM; bone marrow-derived macrophage; ELISA; enzyme-linked immunosorbent assay; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GF; germ-free; hpf; high-power field; IFN; inte

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2010 سفارش ترجمه

Evidence that low-dose, long-term genistein treatment inhibits oestradiol-stimulated growth in MCF-7 cells by down-regulation of the PI3-kinase/Akt signalling pathway

Keywords: Genistein; PI3-kinase; Akt; MCF-7

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

ARF6, PI3-kinase and host cell actin cytoskeleton in Toxoplasma gondii cell invasion

Keywords: Toxoplasma gondii; Host cell invasion; Parasitophorous vacuole; ARF6; PI3-kinase; Actin cytoskeleton

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه