کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1375372 981937 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors
چکیده انگلیسی

This article describes the syntheses and SAR of a series of imidazolopyrimidine derivatives, which are evaluated as inhibitors of PI3-Kinase (PI3 K) and mTOR. These compounds were found to be ATP competitive with good tumor cell growth inhibition, and suppression of pathway specific biomakers such as phosphorylation of Akt at T308.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 2, 15 January 2010, Pages 653–656
نویسندگان
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