Regulation of extracellular signal-regulated kinase phosphorylation in cultured rat striatal neurons
Keywords: Glutamate; CaMK; PI3-kinase; PKA; PKC; Tyrosine kinase; Striatum
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Regulation of GAP-43 at serine 41 acts as a switch to modulate both intrinsic and extrinsic behaviors of growing neurons, via altered membrane distribution
Keywords: Filopodia formation; Cell-cell adhesion; Nuerite outgrowth; PKC; GAP-43; SY5Y neuroblastoma; Transfection; cDNA; PI3-kinase; Neurotubulin
Oscillatory control of insulin secretion
Keywords: Insulin secretion; Oscillations; Metabolism; Ca2+; cAMP; Phospholipase C; PIP2; PI3-kinase; PIP3
Role of AMP-activated protein kinase in autophagy and proteasome function
Keywords: AICAR; AMPK; Proteasome; PI3-kinase; Protein degradation; Autophagy
PI3-K- and PKC-dependent up-regulation of APP processing enzymes by retinoic acid
Keywords: ADAM10; APP; BACE1; BDNF; PI3-kinase; Protein kinase C; Retinoic acid; TACE
Upregulation of heme oxygenase-1 by brazilin via the phosphatidylinositol 3-kinase/Akt and ERK pathways and its protective effect against oxidative injury
Keywords: Brazilin; Heme oxygenase-1; Oxidative stress; Auditory cells; PI3-kinase
Caveolin-1 increases basal and TGF-β1-induced expression of type I procollagen through PI-3 kinase/Akt/mTOR pathway in human dermal fibroblasts
Keywords: Caveolin-1; Type I procollagen; TGF-beta1; PI3-kinase; Akt; mTOR
Increased Rac activity is required for the progression of T-lymphomas induced by Pten-deficiency
Keywords: PTEN; PI3-kinase; Rac; Tiam1; T-lymphoma; Tumor progression
A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes 1
Keywords: Adipokines; Adiponectin; Nitric oxide synthase; PI3-Kinase; Chondrocytes
Dual regulation of glucocorticoid-induced leucine zipper (GILZ) by the glucocorticoid receptor and the PI3-kinase/AKT pathways in multiple myeloma
Keywords: Multiple myeloma; Glucocorticoid; Glucocorticoid receptor; GILZ; PI3-kinase; AKT; Signal transduction
Deletion of exon 8 increases cisplatin-induced E-cadherin cleavage
Keywords: AEC; anti-E-cadherin antibody; Akt/PKB; Akt/protein kinase B; cl; cleaved; CTL; control; DAPI; 4,6-diamidino-2-phenylindole; DMSO; dimethyl sulfoxide; del 8 E-cadherin, d8; E-cadherin with deletion of exon 8; fl; full length; MDA; untransfected, parental
PI3-kinase and mitogen-activated protein kinase in cumulus cells mediate EGF-induced meiotic resumption of porcine oocyte
Keywords: Meiotic resumption; EGF/EGFR; MAPK; PI3-kinase; Cumulus cells;
Differential subcellular membrane recruitment of Src may specify its downstream signalling
Keywords: Src; Rafts; Endosomes; Plasma membrane; PI3-kinase; MAP-kinase
Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity
Keywords: Ser/Thr kinases; PDK1; Akt; PI3-kinase; Cancer
Different signaling pathways utilized by insulin to regulate the expression of ENT2, CNT1, CNT2 nucleoside transporters in rat cardiac fibroblasts
Keywords: Cardiac fibroblast; Insulin; ENT2; CNT1; CNT2; MAP kinases; PI3-kinase; mTOR;
Activated macrophages in HIV encephalitis and a macaque model show increased [3H](R)-PK11195 binding in a PI3-kinase-dependent manner
Keywords: Peripheral benzodiazepine receptor; Macrophages; PK11195; PI3-kinase; HIV encephalitis; SIV encephalitis
Apoptosis and inactivation of the PI3-kinase pathway by tetrocarcin A in breast cancers
Keywords: Tetrocarcin A; PTEN; PI3-kinase; PDK1; Akt; Breast cancer; Apoptosis; Phosphorylation; Dephosphorylation; Survival factor; Bcl-2; Bcl-XL; Caspase
Requirement for Akt-mediated survival in cell transformation by the dbl oncogene
Keywords: Akt; Apoptosis; Dbl; PI3-kinase; Rho GTPase; Survival; Transformation;
SHP-2 and PI3-kinase genes PTPN11 and PIK3R1 may influence serum apoB and LDL cholesterol levels in normal women
Keywords: SHP-2; PI3-kinase; apoB; LDL-cholesterol; Metabolic syndrome; Genetic susceptibility
EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by α2A-adrenoreceptor in intestinal epithelial cells: A role in wound healing
Keywords: α2-adrenoreceptor; Intestinal epithelium; ERK; EGF receptor; PI3-kinase; Wound healing
Regulation of neuronal pituitary adenylate cyclase-activating polypeptide expression during culture of guinea-pig cardiac ganglia
Keywords: parasympathetic neurons; trophic factors; choline acetyltransferase; phosphatidylinositol 3-kinase; mitogen-activated protein kinase; explant culture; ANOVA; analysis of variance; bFGF; fibroblast growth factor basic; CARTp; cocaine- and amphetamine-regul
Caveolins bind to (Na+, K+)/H+ exchanger NHE7 by a novel binding module
Keywords: NHE; Na+/H+ exchanger; TGN; trans-Golgi network; ER; endoplasmic reticulum; CSD; Caveolin Scaffolding Domain; C-MAD; C-terminal Membrane Attachment Domain; MβCD; methyl-β-cyclodextrin; HRP; horse radish peroxidase; MES; 2-[N-morpholino] ethanesulfonic a
RhoG regulates anoikis through a phosphatidylinositol 3-kinase-dependent mechanism
Keywords: RhoG; Anoikis; PI3-kinase; Akt; Rac1; Cell survival;
Ras regulates neuronal polarity via the PI3-kinase/Akt/GSK-3β/CRMP-2 pathway
Keywords: Akt; Axon; CRMP-2; GSK-3β; MAPK; Neuronal polarity; PI3-kinase; Ras
Insulin and oleic acid increase PPARγ2 expression in cultured mouse hepatocytes
Keywords: Primary hepatocytes; PPARγ; PPARγ2; Insulin; Oleic acid; PI3-kinase; Rosiglitazone; Liver steatosis
Enhanced proangiogenic signaling in thrombospondin-1-deficient retinal endothelial cells
Keywords: Thrombospondin; Signal transduction; Endothelial cell; Angiogenesis; Retinal vasculature; Fibronectin; Cell cycle; MAP kinase; Akt/PKB; PI3-kinase
Inhibition of PI3-kinase–Akt pathway enhances dexamethasone-induced apoptosis in a human follicular lymphoma cell line
Keywords: Dexamethasone; Human; Follicular lymphoma; PI3-kinase; Akt; Mitochondria; Bim; Bad
Papillomavirus virus-like particles activate the PI3-kinase pathway via alpha-6 beta-4 integrin upon binding
Keywords: Papillomavirus; Integrin; VLP; PI3-kinase; Akt; FKHR and GSK3β
Analysis of apoptotic and survival mediators in the early post-natal and mature retina
Keywords: retina; post-natal; caspase; apoptosis; survival; PI3-kinase
Active Ras-induced effects on skeletal myoblast differentiation and apoptosis are independent of constitutive PI3-kinase activity
Keywords: Ras; PI3-kinase; Skeletal myoblasts; Apoptosis; Differentiation;
Activated c-Fms recruits Vav and Rac during CSF-1-induced cytoskeletal remodeling and spreading in osteoclasts
Keywords: Osteoclast; CSF-1; Rac; Cdc42; Rho; Vav; PI3-kinase
PI3-kinase promotes TRPV2 activity independently of channel translocation to the plasma membrane
Keywords: PI3-kinase; TRPV2; Cytotoxicity; Translocation
Coordinate expression of the PI3-kinase downstream effectors serum and glucocorticoid-induced kinase (SGK-1) and Akt-1 in human breast cancer
Keywords: Akt-1; SGK-1; PI3-kinase; Breast cancer; Insulin signalling; Immunohistochemistry
PI3-kinase activation by GM-CSF in endothelium is upstream of Jak/Stat pathway: Role of αGMR
Keywords: GM-CSF; Endothelium; PI3-kinase; Angiogenesis; αGMR;
β-Sitosterol modulates antioxidant enzyme response in RAW 264.7 macrophages
Keywords: ROS; reactive oxygen species; O2â; superoxide anion; PMA; phorbol 12-myristate 13-acetate; PMSF; phenylmethylsulfonyl fluoride; GSH; glutathione; GSSG; glutathione oxidized; GPx; glutathione peroxidase; SOD; superoxide dismutase; NBT; p-nitroblue tetraz
Mechanisms of acetylcholine- and bradykinin-induced preconditioning
Keywords: Ischemic preconditioning; Pharmacological preconditioning; Reactive oxygen species; Protein kinase; Mitochondria; PI3-kinase; ATP-sensitive potassium channels; Akt; Nitric oxide;
Expression of human TFF3 in relation to growth of HT-29 cell subpopulations: involvement of PI3-K but not STAT6
Keywords: goblet cells; TFF3; mucins; PI3-Kinase; STAT6;
The intrahepatic biliary epithelium is a target of the growth hormone/insulin-like growth factor 1 axis
Keywords: IGF1; insulin-like growth factor 1; GH; growth hormone; IRS; insulin receptor substrates; BDL; bile duct ligation; PCNA; proliferating cellular nuclear antigen; IGFBP; IGF binding protein; ERK; extracellular regulated kinases; PI3-kinase; phosphatidylinos
Evaluation of Lipin 2 as a candidate gene for autosomal dominant 1 high-grade myopia
Keywords: LPIN2; Lipin 2; SNP; single nucleotide polymorphism; MYP1; myopia 1; MYP2; myopia 2; MYP3; myopia 3; MYP4; myopia 4; MYP5; myopia 5; LOD; log of the odds ratio; NCBI; National Center for Biotechnology Information; UCSC; University of California, Santa Cru
Electroacupuncture regulates NMDA receptor NR1 subunit expression via PI3-K pathway in a rat model of cerebral ischemia-reperfusion
Keywords: Disorders of nervous system; Ischemia; Cerebral ischemia; Electroacupuncture; NMDA receptor subunit; TrkA; MAP kinase; PI3-kinase;
Diet high in lipid hydroperoxide by vitamin E deficiency induces insulin resistance and impaired insulin secretion in normal rats
Keywords: FFA; free fatty acids; IRI; immunoreactive insulin; IRS; insulin receptor substrate; LPO; lipid hydroperoxide; OGTT; oral glucose tolerance test; SSBG; steady-state blood glucose; SSPI; steady-state plasma insulin; TBARS; thiobarbituric acid reactive subs
The multifunctional family of secreted proteins containing a C-type lectin-like domain linked to a short N-terminal peptide
Keywords: ADP; adenosine diphosphate; CNTF; ciliary neurotrophic factor; CTLD; C-type lectin domains; CTLD-LSNP; C-type lectin-like domain linked to a short N-terminal peptide; GRF; growth hormone-releasing factor; HIP; hepatic intestinal pancreatic protein; HMG-I/
Norfloxacin Reduces Aortic NO Synthases and Proinflammatory Cytokine Up-Regulation in Cirrhotic Rats: Role of Akt Signaling
Keywords: eNOS; endothelial nitric oxide synthase; iNOS; inducible nitric oxide synthase; LPS; lipopolysaccharide; NO; nitric oxide; NOS; nitric oxide synthase; PI3-kinase; phosphoinositide 3-kinase; TNF-α; tumor necrosis factor-α;
Re-distribution of phospholipase C gamma 2 in macrophage precursors is mediated by the actin cytoskeleton under the control of the Src kinases
Keywords: M-CSF; Macrophage colony-stimulating factor; M-CSFR; Macrophage colony-stimulating factor receptor; PLC-γ; Phosphatidylinositide-specific phospholipase C-gamma; PI3-kinase; Phosphatidylinositol 3-kinase; M-CSF differentiation; PLC-gamma 2; Translocation;
Targeting the gatekeeper residue in phosphoinositide 3-kinases
Keywords: PI3-kinase; Inhibition; Gatekeeper
Regulatory roles and molecular signaling of TNF family members in osteoclasts
Keywords: AP-1; activator protein-1; ASK1; apoptosis signal-regulated kinase-1; CARD; caspase recruiting domain; CFU-GM; colony forming unit-granulocyte/macrophage; CRD; cysteine-rich repeat; CTR; calcitonin receptor; DD; death domain; DED; death effector domain; E
Autocrine regulation of human urothelial cell proliferation and migration during regenerative responses in vitro
Keywords: AR; amphiregulin; BTC; betacellulin; BPE; bovine pituitary extract; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EPR; epiregulin; ERK; extracellular regulated kinase; HB-EGF; heparin-binding epidermal growth factor; HER; human epi
The tumor suppressor PTEN inhibits EGF-induced TSP-1 and TIMP-1 expression in FTC-133 thyroid carcinoma cells
Keywords: Thrombospondin-1; Epidermal growth factor; PTEN; PI3-kinase; Tissue inhibitor of metalloproteinase; Follicular thyroid carcinoma cell lines;
Cardiac transcription factor Csx/Nkx2-5: Its role in cardiac development and diseases
Keywords: Homeobox; Transcriptional regulation; Cardiac development; Congenital heart disease; Cardiac hypertrophy; Cardioprotection; ANP; atrial natriuretic peptide; ASD; atrial septal defect; AV; atrioventricular; BMP; bone morphogenic protein; BNP; brain natriur