کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10739239 1046868 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
β-Sitosterol modulates antioxidant enzyme response in RAW 264.7 macrophages
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
β-Sitosterol modulates antioxidant enzyme response in RAW 264.7 macrophages
چکیده انگلیسی
Uncontrolled production of reactive oxygen species contributes to the pathogenesis of diseases such as cancer and cardiovascular disorders. Olive oil exerts remarkable preventive effects on the development of these diseases, which may be due to the action of various components of the olive oil. In fact, several findings suggest that minor components, like phytosterols such as β-sitosterol, are responsible, at least in part, for these beneficial effects. Our results show that β-sitosterol reverts the impairment of the glutathione/oxidized glutathione ratio induced by phorbol esters in RAW 264.7 macrophage cultures. These data can be correlated with the increase in manganese superoxide dismutase and glutathione peroxidase activities and the decrease in catalase activity. We also demonstrate that the effects of β-sitosterol on antioxidant enzymes depend on the estrogen/phosphatidylinositol 3-kinase pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 39, Issue 1, 1 July 2005, Pages 91-97
نویسندگان
, ,