کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9127129 | 1160201 | 2005 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulatory roles and molecular signaling of TNF family members in osteoclasts
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کلمات کلیدی
GCKROPGDEDM-CSFMADDTNFRTAK1MAP3KJun N-terminal kinaseTRAFNIKPIP3CFU-GMTHDODFNF-κBosteoprotegrinPI3-kinaseMKK3LT-αTNFTGF-βMEKKFas associated death domainNF-κB-inducing kinaselymphotoxin αTGF-β-activated kinase 1Osteoclast Differentiation FactorOPGLNuclear factor of activated T cellJnkAP-1NFATIAPIκBHSCCRDIKKFADDPKBASK1CTRERKRANKLIκB kinase - IkB kinaseMAPK - MAPKMAPK kinase kinase - MAPK کیناز کینازRheumatoid arthritis - آرتریتروماتوئیدinterleukin - اینترلوکینTransforming growth factor β - تبدیل فاکتور رشد βdeath domain - حوزه مرگdeath effector domain - دامنه موثر مرگRank - رتبهHematopoietic stem cell - سلول بنیادی هماتوپوئیتFas Ligand - فاس لیگاندFasL - فاسدtumor necrosis factor - فاکتور نکروز تومورnuclear factor kappa B - فاکتور هسته ای کاپا BRANK ligand - لیگاند RANKinhibitor of apoptosis protein - مهار کننده پروتئین آپوپتوزیسinhibitor of kappa B - مهار کننده کاپا BPleckstrin Homology - همخوانی Pleckstrincolony forming unit-granulocyte/macrophage - واحد کلنی تشکیل گرانولوسیت / ماکروفاژRIP - پاره کردنactivator protein-1 - پروتئین فعال کننده-1protein kinase B - پروتئین کیناز Bmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenReceptor interacting protein - پروتئین گیرنده گیرندهCARD - کارتextracellular signal-regulated kinase - کیناز تنظیم شده سیگنال خارج سلولیTNF receptor - گیرنده TNFcalcitonin receptor - گیرنده کلسی تونینreceptor activator of NF-κB - گیرنده گیرنده NF-κB
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Regulatory roles and molecular signaling of TNF family members in osteoclasts Regulatory roles and molecular signaling of TNF family members in osteoclasts](/preview/png/9127129.png)
چکیده انگلیسی
The tumor necrosis factor (TNF) family has been one of the most intensively studied families of proteins in the past two decades. The TNF family constitutes 19 members that mediate diverse biological functions in a variety of cellular systems. The TNF family members regulate cellular functions through binding to membrane-bound receptors belonging to the TNF receptor (TNFR) family. Members of the TNFR family lack intrinsic kinase activity and thus they initiate signaling by interacting intracellular signaling molecules such as TNFR associated factor (TRAF), TNFR associated death domain (TRADD) and Fas-associated death domain (FADD). In bone metabolism, it has been shown that numerous TNF family members including receptor activator of nuclear factor κB ligand (RANKL), TNF-α, Fas ligand (FasL) and TNF-related apoptosis-inducing ligand (TRAIL) play pivotal roles in the differentiation, function, survival and/or apoptosis of osteoclasts, the principal bone-resorbing cells. These TNF family members not only regulate physiological bone remodeling but they are also implicated in the pathogenesis of various bone diseases such as osteoporosis and bone loss in inflammatory conditions. This review will focus on our current understanding of the regulatory roles and molecular signaling of these TNF family members in osteoclasts.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 350, Issue 1, 25 April 2005, Pages 1-13
Journal: Gene - Volume 350, Issue 1, 25 April 2005, Pages 1-13
نویسندگان
Xu Feng,