Keywords: AP-1; activator protein 1; DAMP; damage associated molecular patterns; IRAK1; interleukin-1 receptor associated kinase-1; LBP; LPS binding protein; LPS; lipopolysaccharide; MAPK; mitogen-activated protein kinase; MD2; myeloid differentiation factor 2; MHC
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Keywords: Organic UV filters; Macrophage; Cytokine; TAK1; Inflammation;
Keywords: Ginger; Multiple sclerosis; Experimental autoimmune encephalomyelitis; Therapeutic potentials; AP-1; Activator protein 1; APCs; Antigen-presenting cells; ASC; apoptosis speck-like protein containing CARD; BAFF; B cell-activating factor belonging to the TN
Keywords: APCs; antigen-presenting cells; DAMPs; danger-associated molecular patterns; DCs; Donor-derived dendritic cells; ET; endotoxin tolerance; FFA; free fatty acids; Gsdmd; gasdermin D; HDAC11; Histone deacetylase 11; HFD; high fat diet; HMGB1; high mobility g
Keywords: SDF-1; stromal cell-derived factor 1; PAD; peripheral arterial disease; GPx; glutathione peroxidase; TAK1; transforming growth factor-B-activated-kinase 1; PTP1B; protein tyrosine phosphatase 1B; EDRF; endothelial-derived relaxing factor (EDRF); BH4; tetr
Keywords: GPR120â; G-protein coupled receptor 120; Barr2; beta-arrestin2; TAB1; TGF-beta activated kinase 1/MAP3K7 Binding Protein 1; LPS; lipopolysaccharide; TAK1; transforming growth factor beta-activated kinase 1; NF-κB; nuclear factor kappa-light-chain-enhan
Keywords: AP-1; activator protein 1; APC; antigen-presenting cells; ARE; AU-rich element; ASK; Apoptosis Signal regulating Kinase; ATF-2; Activating Transcription Factor 2; CRE; Cyclic AMP Responsive Element; CBP; CREB binding protein; CsA; ciclosporin A; ERK; Extr
Keywords: PTP; protein tyrosine phosphatase; PTK; protein tyrosine kinase; LMW-PTP; low molecular weight protein tyrosine phosphatase; LMW-AP; low molecular weight acid phosphatase; ACP1; gene coding for human LMW-PTP; PTP1B; tyrosine-protein phosphatase non-recept
Keywords: TNF; tumor necrosis factor; RIP; receptor interacting protein; cIAP; cellular inhibitor of apoptosis protein; TRADD; TNF receptor associated death domain; FADD; Fas associated death domain; TAK1; transforming growth factor-β-activated kinase 1; NF-κB; n
Keywords: AP-1; jun proto-oncogene; BAI3; brain-specific angiogenesis inhibitor 3; CADM2; cell adhesion molecule 2; CAGE; cap analysis of gene expression; cDNA; DNA complementary to RNA; ChIP; chromatin immunoprecipitation; FGF14; fibroblast growth factor 14; GADD4
Keywords: FLG; filaggrin; IKK; IκB kinase; K; keratin; KLK; kallikrein; NMFs; natural moisturizing factors; RIPK; receptor interacting protein kinase; SC; stratum corneum; SG; stratum granulosum; TAK1; TGFβ-activated kinase; TGase; transglutaminase; TNF; tumor ne
Keywords: ACTDs; autoimmune connective tissue diseases; SLE; systemic lupus erythematosus; RA; rheumatoid arthritis; SSc; systemic sclerosis; SS; Sjögren's syndrome; MCTD; mixed connective tissue disease; TLRs; IL-1R-like receptors; DAMPs; danger-associated molecu
Keywords: Aβ; β-amyloid protein; AD; Alzheimer's disease; AP-1; Activator protein-1; AS; Atherosclerosis; CCl4; Carbon tetrachloride; CFA; Complete Freund's Adjuvant; CIA; Type II collagen-induced arthritis; CMM; Chinese Material Medica; Con A; Concanavalin A; CO
TAK1 of black carp positively regulates IRF7-mediated antiviral signaling in innate immune activation
Keywords: TAK1; IRF7; Black carp; Interferon;
MiR-149 suppresses the inflammatory response of chondrocytes in osteoarthritis by down-regulating the activation of TAK1/NF-κB
Keywords: Osteoarthritis; Inflammation; miR-149; TAK1;
Regulation of Tak1 alternative splicing by splice-switching oligonucleotides
Keywords: Splice-switching oligonucleotides; Vivo-morpholino; Tak1; Isoform function; Lipid metabolism; 2OMePS; 2â²-O-methyl phosphorothioate; ALS; amyotrophic lateral sclerosis; AONs; Antisense oligonucleotides; AS; Alternative splicing; HFD; High-fat diet; NMD;
IL-1β induced IL-8 and uPA expression/production of dental pulp cells: Role of TAK1 and MEK/ERK signaling
Keywords: Dental pulp; Healing; Inflammation; Interleukin-1β; MEK/ERK; Signal transduction; TAK1; Urokinase plasminogen activator;
MicroRNA-200a regulates adipocyte differentiation in the domestic yak Bos grunniens
Keywords: DGAT; diacylglycerol acyltransferase; LPL; lipoprotein lipase; FABP4; fatty acid binding protein 4; SCD; stearoyl-CoA desaturase; FAS; fatty acid synthase; ACC; acetyl-coA carboxylase; ACS; acyl-CoA synthetase; C/EBPα; CCAAT/enhancer binding protein; PPA
Activation of NF-κB induced by TRIMCyp showing a discrepancy between owl monkey and northern pig-tailed macaque
Keywords: TRIM; tripartite motif; OWM; Old World monkeys; omTRIMCyp; owl monkey TRIMCyp; npmTRIMCyp; northern pig-tailed macaques; CypA; cyclophilin A; HA; hemagglutinin; CA; capsid; Ub; ubiquitin; TAK1; transforming growth factor-β-activated kinase 1; TRIMCyp; HI
Canonical and non-canonical mechanisms of Nrf2 activation
Keywords: AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; ATF4; activating transcription factor 4; Atg5; autophagy protein 5; Atg7; autophagy protein 7; Bach; BTB and CNC homology; CBP; CREB binding protein; CHD6; chromodomain-
Alisma canaliculatum ethanol extract suppresses inflammatory responses in LPS-stimulated macrophages, HCl/EtOH-induced gastritis, and DSS-triggered colitis by targeting Src/Syk and TAK1 activities
Keywords: Alisma canaliculatum A.Braun & C.D.Bouché; Inflammatory diseases; Src; Syk; TAK1;
TRIM38 regulates NF-κB activation through TAB2 degradation in osteoclast and osteoblast differentiation
Keywords: TRIM38; tripartite motif 38; BMM; bone marrow-derived macrophage-like cell; NFATc1; nuclear factor of activated T-cells c1; TRAP; tartrate-resistant acid phosphatase; RANKL; receptor activator of nuclear factor kappa B ligand; M-CSF; macrophage colony sti
Crystal structure and substrate specificity of ExoY, a unique T3SS mediated secreted nucleotidyl cyclase toxin from Pseudomonas aeruginosa
Keywords: X-ray crystallography; Nucleotidyl cyclase toxins; T3SS; Anthrax toxA family; Non-canonical secondary messengers; One-metal-ion dependent catalysis; ExoY; exogenous toxin Y; T3SS; Type III secretory systems; AA-NC; actin-activated nucleotidyl cyclase; EF;
NOD1 and NOD2: Molecular targets in prevention and treatment of infectious diseases
Keywords: AMP; antimicrobial peptide; CARD; caspase activation and recruitment domain; CMV; cytomegalovirus; DC; dendritic cell; ER; endoplasmic reticulum; GlcNAc; N-acetyl-d-glycosamine; GMDP; glucosaminyl muramyl dipeptide (N-acetyl-d-glucosaminyl-N-acetyl-d-mura
Expansion of the clinical spectrum of frontometaphyseal dysplasia 2 caused by the recurrent mutation p.Pro485Leu in MAP3K7
Keywords: MAP3K7; TAK1; Frontometaphyseal dysplasia 2; Skeletal dysplasia; Growth retardation;
Promising new therapeutic targets for regulation of inflammation and immunity: RING-type E3 ubiquitin ligases
Keywords: ALS; amyotrophiclateral sclerosis; AP-1; activator protein 1; APC; antigen-presenting cell; APC/C; anaphase promoting complex/cyclosome; CLR; C-type lectin receptor; CRL; Cullin RING ligase; ERK; extracellular signalregulated kinase; FANC; Fanconi anemia
Ubiquitin-proteasome signaling in lung injury
Keywords: AJ; adherens junctions; ALI; acute lung injury; AMPK; adnosine monophosphate activated protein kinase; ARDS; acute respiratory distress syndrome; ATP; adenosine triphosphate; CFTR; cystic fibrosis transmembrane conductance regulator; cIAP; cellular inhibi
MicroRNA-155 induces autophagy in osteoclasts by targeting transforming growth factor β-activated kinase 1-binding protein 2 upon lipopolysaccharide stimulation
Keywords: BMM; bone marrow-derived macrophages; M-CSF; macrophage-colony stimulating factor; miR; microRNA; miR-155; microRNA-155; MNC; multinucleated cells; OC; osteoclast; PBS; phosphate-buffered saline; qPCR; quantitative polymerase chain reaction; RANKL; recept
The interaction of TAK1 and TAB1 enhances LPS-induced cytokine release via modulating NF-κB activation (Larimichthys crocea)
Keywords: TAK1; TAB1; Large yellow croaker; Overexpression; NF-κB; Immune response;
BCL3 regulates RANKL-induced osteoclastogenesis by interacting with TRAF6 in bone marrow-derived macrophages
Keywords: TRAF6; tumor necrosis factor receptor-associated factor 6; BCL3; B-cell chronic lymphatic leukemia protein 3; TAK1; transforming growth factor β-activated kinase 1; RANKL; Receptor activator of nuclear factor-κB ligand; NFATC1; nuclear factor of activat
Tumor necrosis factor receptor-associated factor 6 as a nuclear factor kappa B-modulating therapeutic target in cardiovascular diseases: at the heart of it all
Keywords: A20; aka TNFα induced protein 3/TNFAIP3; AP-1; activator protein-1; CVB3; Coxsackie virus b3 strain; DAMPs; damage associated molecular patterns; IKK; inhibitor of κB kinase; IRAK1/2/4; IL-1 receptor-associated kinase 1/2/4; JNK; cJun N-terminal kinase;
Sec6 enhances cell migration and suppresses apoptosis by elevating the phosphorylation of p38 MAPK, MK2, and HSP27
Keywords: Sec6; p38 MAPK; MK2; HSP27; MAPK; Mitogen-activated protein kinases; MAP3K; MAPK kinase kinase; MAP2K; MAPK kinase; TAK1; TGFβ-activated kinase 1; ASK1; apoptosis signal-regulating kinase 1; MLK; mixed-lineage kinase; CREB; cAMP response element binding
Dusp14 protects against hepatic ischaemia-reperfusion injury via Tak1 suppression
Keywords: Dusp14; Hepatic ischaemia-reperfusion; Tak1;
Flaviviridae virus nonstructural proteins 5 and 5A mediate viral immune evasion and are promising targets in drug development
Keywords: AAF; IFN-α-activated factor; ATA; Aurintricarboxylic acid; BDV; border disease virus; BPgV; GBV-D; BVDV-1; bovine viral diarrhea virus-1; C; capsid protein; CLRs; C-type lectin receptors; Core; core protein; CSFV; classical swine fever virus; DENV; dengu
A 5-hydroxyoxindole derivative attenuates LPS-induced inflammatory responses by activating the p38-Nrf2 signaling axis
Keywords: ASK1; apoptosis signal regulating kinase 1; Cul3; cullin 3; DEF; dimethylfumarate; DEM; diethylmaleate; 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; FBS; fetal bovine serum; 5-HI; 5-hydroxyoxindole derivative; HO-1; heme oxygenase-1; iNOS; inducible NO sy
WNT receptor signalling in lung physiology and pathology
Keywords: ABC; active β-catenin/non-phosphorylated β-catenin; APC; adenomatous polyposis coli; ATI; alveolar epithelial type I cell; ATII; alveolar epithelial type II cell; AXIN; axis inhibition protein; CBR2; carbonyl reductase 2; CK1; casein kinase 1; CELSR1; c
Research paperSTRAP positively regulates TLR3-triggered signaling pathway
Keywords: STRAP; serine/threonine kinase receptor associated protein; TLR; Toll-like receptor; IFN; interferon; IRF; IFN regulatory factor; TBK1; TANK binding kinase 1; TRAF; TNF receptor associated factor; TAK1; transforming growth factor β-activated kinase 1; ST
TAK1 as the mediator in the protective effect of propofol on renal interstitial fibrosis induced by ischemia/reperfusion injury
Keywords: Propofol; Ischemia/reperfusion injury; TAK1; Renal interstitial fibrosis;
Quercetin alleviates thermal and cold hyperalgesia in a rat neuropathic pain model by inhibiting Toll-like receptor signaling
Keywords: QUE; quercetin; SNL; spinal nerve ligation; TLR; Toll-like receptors; MyD88; myeloid differentiation primary-response protein 88; TAK1; transforming growth factor-β-activated kinase; IKK; inhibitor of nuclear factor-κB-kinase; NF-κB; translocation of n
TAK-ing aim at chemoresistance: The emerging role of MAP3K7 as a target for cancer therapy
Keywords: MAP3K7; TAK1; Chemoresistance;
Glechoma hederacea extracts attenuate cholestatic liver injury in a bile duct-ligated rat model
Keywords: ALT; alanine aminotransferase; ANOVA; one-way analysis of variance; AST; aspartate aminotransferase; BDL; bile duct ligation; CTGF; connective tissue growth factor; ELISA; enzyme-linked immunosorbent assay; EMSA; electrophoretic mobility shift assay; GAPD
Innate immunity related pathogen recognition receptors and chronic hepatitis B infection
Keywords: acLDL; acylated LDL; AIM2; absent in melanoma 2; AP-1; activator protein 1; BDCA-2; blood DC antigen; BEC; biliary epithelial cells; CARD; caspase recruitment and activation domains; cDC; common dendritic cells; CL-L1; collectin liver 1; CL-K1; collectin
Interleukin 1 β-induced SMAD2/3 linker modifications are TAK1 dependent and delay TGFβ signaling in primary human mesenchymal stem cells
Keywords: Stem cells; Inflammation; TGFβ; IL1β; SMAD linker; TAK1;
Shrimp TAB1 interacts with TAK1 and p38 and activates the host innate immune response to bacterial infection
Keywords: Litopenaeus vannamei; TAB1; TAK1; p38; Bacterial infection;
Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
Keywords: α-SYN; alpha synuclein; β-TrCP; β-transducin repeat containing E3 ubiquitin protein ligase; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activated protein kinase; ARE; antioxidant response element; ASK1; apo
MicroRNA-130b transcriptionally regulated by histone H3 deacetylation renders Akt ubiquitination and apoptosis resistance to 6-OHDA
Keywords: DA; dopamine; 6-OHDA; 6-hydroxydopamine; HDAC3; histone deacetylase 3; EPO; erythropoietin; EGF; epidermal growth factor; VEGF; vascular endothelial growth factor; PI3K; phosphatidylinositol-3-kinase; TRAF2; TNF receptor associated factor-2; TAK1; TGF-β-
Identification of a selective inhibitor of transforming growth factor β-activated kinase 1 by biosensor-based screening of focused libraries
Keywords: TAK1; Chemogenomic approach; Selective Type I inhibitor; Biophysical screening;
Loss of TRADD attenuates pressure overload-induced cardiac hypertrophy through regulating TAK1/P38 MAPK signalling in mice
Keywords: TAK1; Pressure overload; TRADD; Cardiac hypertrophy;
Effect of curcumin on acute spinal cord injury in mice via inhibition of inflammation and TAK1 pathway
Keywords: Curcumin; Spinal cord injury; Inflammation; TAK1; Mouse;
Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors
Keywords: TAK1; Polypharmacology; Multitarget; Cancer; Cytokine secretion;