دانلود مقالات ISI درباره Tak1 + ترجمه فارسی

Bifidobacterium adolescentis IM38 ameliorates high-fat diet-induced colitis in mice by inhibiting NF-κB activation and lipopolysaccharide production by gut microbiota

Keywords: Bifidobacterium adolescentis; Gut microbiota; Lipopolysaccharide; Colitis; Obesity; NF-κB activation; ANOVA; one-way analysis of variance; CFU; colony-forming unit; COX-2; cyclooxygenase-2; ELISA; enzyme-linked immunosorbent assay; ERK; extracellular sig

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

Blockade of TGF-β-activated kinase 1 prevents advanced glycation end products-induced inflammatory response in macrophages

Keywords: AGEs; advanced glycation end products; DN; diabetic nephropathy; TAK1; TGF-β-activated kinase 1; BMMs; bone marrow-derived macrophages; MAPKs; mitogen-activated protein kinases; NF-κB; nuclear factor kappa B protein; MCP-1; monocyte chemo-attractant pro

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

IL-1β-induced MCP-1 expression and secretion of human dental pulp cells is related to TAK1, MEK/ERK, and PI3K/Akt signaling pathways

Keywords: Cyclooxygenase; Inflammation; Interleukin-1β; MCP-1; MEK/ERK; PI3K/Akt; Pulp; Signal transduction; TAK1

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Verproside inhibits TNF-α-induced MUC5AC expression through suppression of the TNF-α/NF-κB pathway in human airway epithelial cells

Keywords: ChIP; chromatin immunoprecipitation; COPD; chronic obstructive pulmonary disease; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; IKK; IκB kinase; NFκB; nuclear factor kappa B; RIP1; receptor interacting kinase 1; TAK1; transforming growth factor beta-

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Tetrandrine regulates hepatic stellate cell activation via TAK1 and NF-κB signaling

Keywords: α-SMA; α-smooth muscle actin; ECM; extracellular matrix; ERK; extracellular signal-regulated kinases; FADD; Fas-associated death domain protein; HSC; hepatic stellate cell; JNK; c-Jun N-terminal kinase; MAPK; mitogen-activated protein kinases; NF-κB; n

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Catalytic-independent inhibition of cIAP1-mediated RIP1 ubiquitination by EGLN3

Keywords: cIAP; cellular inhibitor of apoptosis protein; DFX; Desferrioxamine; DMOG; dimethyl oxalylglycine; EGLN; Caenorhabditis elegans gene egl-9; HA; hemagglutinin; HEK293 cells; human embryonic kidney 293 cells; IB; immunoblotting; IP; immunoprecipitation; HIF

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Porcine reproductive and respiratory syndrome virus (PRRSV) up-regulates IL-15 through PKCβ1-TAK1-NF-κB signaling pathway

Keywords: PRRSV; IL-15; PKCβ1; NF-κB; TAK1;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Therapeutic effect of methyl salicylate 2-O-β-d-lactoside on LPS-induced acute lung injury by inhibiting TAK1/NF-kappaB phosphorylation and NLRP3 expression

Keywords: Methyl salicylate 2-O-β-d-lactoside; Acute lung injury; Lipopolysaccharide; TAK1; NF-κB; NLRP3

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling

Keywords: Ubiquitin; Innate immunity; TNF; TLR3; NOD1; LUBAC; AMSH-LP; AMSH-like protein; λ-PPase; bacteriophage λ protein phosphatase; BMDM; bone marrow-derived macrophages; JNK; c-Jun N-terminal kinase; cIAP; cellular Inhibitor of Apoptosis; DUB; deubiquitylase

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Identification and characterization of transforming growth factor β-activated kinase 1 from Litopenaeus vannamei involved in anti-bacterial host defense

Keywords: TAK1; TAB2; Litopenaeus vannamei; Antimicrobial peptides (AMPs)

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Inhibitory effects of omega-3 fatty acids on early brain injury after subarachnoid hemorrhage in rats: Possible involvement of G protein-coupled receptor 120/β-arrestin2/TGF-β activated kinase-1 binding protein-1 signaling pathway

Keywords: COX-2; cyclooxygenase-2; DAPI; 4,6-diamino-2-phenyl indole; DHA; docosahexaenoic acid; EBI; early brain injury; EMSA; electrophoretic mobility shift assays; EPA; eicosapentaenoic acid; FJB; Fluoro-Jade B; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; G

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

The role of TGF-β-activated kinase 1 in db/db mice and high glucose-induced macrophage

Keywords: TAK1; MAPK; NF-κB; Diabetic nephropathy; Inflammation;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Discovery of a potent and highly selective transforming growth factor β receptor-associated kinase 1 (TAK1) inhibitor by structure based drug design (SBDD)

Keywords: TAK1; SBDD; Inhibitor; Kinase selectivity

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions

Keywords: ACAT1; acetoacetyl-CoA thiolase; ACC; acetyl-CoA carboxylase; AICAR; 5-aminoimidazole-4-carboxamide ribonucleoside; AMPK; AMP-activated protein kinase; ATAC; Ada-two-A-containing; BET; bromodomains and extra-terminal motif; BMAL1; PAS domain-containing pr

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2016 سفارش ترجمه

Epithelial Transforming Growth Factor-β Signaling Does Not Contribute to Liver Fibrosis but Protects Mice From Cholangiocarcinoma

Keywords: TGFβ; Signal Transduction; Mouse Model; Liver Cancer; α-SMA; α-smooth muscle actin; BDL; bile duct ligation; DDC; 3,5-diethoxycarbonyl-1,4-dihydro-collidin; DEN; diethylnitrosamine; HCC; hepatocellular carcinoma; HSC; hepatic stellate cell; mRNA; messe

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2016 سفارش ترجمه

Regulation of the TGF-β pathway by deubiquitinases in cancer

Keywords: AMSH; Associated molecule with SH3 domain proteases; AMSH-LP; Associated molecule with SH3 domain-like proteases; ATXN3; ataxin-3; ATXN3L; ataxin 3-like; BMPs; bone morphogenetic proteins; BRCC36; BRCA1/BRCA2-containing complex subunit 36; CHIP; carboxy t

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2016 سفارش ترجمه

Yersinia YopJ negatively regulates IRF3-mediated antibacterial response through disruption of STING-mediated cytosolic DNA signaling

Keywords: BMDMs; bone marrow-derived macrophages; c-di-GMP; cyclic diguanylate monophosphate; DMEM; Dulbecco's modified Eagle's medium; ER; endoplasmic reticulum; FBS; fetal bovine serum; GST; Glutathione S-transferase; HEK293T; human embryonic kidney; IB; immunobl

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2016 سفارش ترجمه

Toll-like receptor-3 mediates HIV-1 transactivation via NFκB and JNK pathways and histone acetylation, but prolonged activation suppresses Tat and HIV-1 replication

Keywords: TLR3; HIV; Viral transactivation; LTR; NFκB; JNK; STAT1; Histone acetylation; Epigenetics; Human monocyte-derived macrophages; TZM-bl; U38 cells; AP-1; activator protein-1; B2M; beta-2-microglobulin; BCA; bicinchoninic acid; CAT; chloramphenicol acetyltr

دانلود رایگان متن کامل مقاله ISI 56 صفحه سال انتشار : 2016 سفارش ترجمه

Dexamethasone-induced apoptosis of osteocytic and osteoblastic cells is mediated by TAK1 activation

Keywords: Dexamethasone; Osteonecrosis; TAK1; Pyk2-JNK signaling; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Isolation, semisynthesis, covalent docking and transforming growth factor beta-activated kinase 1 (TAK1)-inhibitory activities of (5Z)-7-oxozeaenol analogues

Keywords: (5Z)-7-Oxozeaenol; TAK1; Selectfluor®; Covalent docking; Resorcylic acid lactone

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Research ArticleHepatic p38α regulates gluconeogenesis by suppressing AMPK

Keywords: MAPK; Mitogen-activated protein kinases; AMPK; AMP-activated protein kinase; CREB; cAMP response element-binding protein; TAK1; transforming growth factor β-activated kinase 1; G6Pase; glucose-6-phosphatase; PEPCK; phosphoenolpyruvate carboxykinase; PGC-

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells

Keywords: TAK1; KRAS; Colorectal cancer; Thioredoxin; Treatment resistance

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Reactive oxygen species induce Cox-2 expression via TAK1 activation in synovial fibroblast cells

Keywords: COX, cyclooxygenase; HA, hyaluronic acid; NAC, N-acetyl cysteamine; OA, osteoarthritis; PGs, prostaglandins; RA, rheumatoid arthritis; ROS, reactive oxygen species; SFs, synovial fibroblast cellsReactive oxygen species; Cox-2; TAK1; Synovial tissues; OA m

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development

Keywords: TGF-β3 signaling; Palatogenesis; Tak1; Smad4; Trim33;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1)

Keywords: IFIT5; NF-κB; Phosphorylation; TAK1; IKK; Innate immunity;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

γ-Glutamyl cysteine and γ-glutamyl valine inhibit TNF-α signaling in intestinal epithelial cells and reduce inflammation in a mouse model of colitis via allosteric activation of the calcium-sensing receptor

Keywords: CaSR; calcium-sensing receptor; GPCR; G-protein-coupled receptor; IBD; inflammatory bowel disease; CD; Crohn's disease; UC; ulcerative colitis; γ-EC; γ-glutamyl cysteine; γ-EV; γ-glutamyl valine; GRK; GPCR kinase; TRAF; TNF-receptor-associated factor;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

The Nuclear Factor κB pathway: A link to the immune system in the radiation response

Keywords: Nuclear Factor κB; Immune system; Cellular radiation response; Linear energy transfer; Bystander effect; Chemokines; A20 (TNFAIP3); tumor necrosis factor inducible protein 3; ARD; ankyrin repeat domain; ATM; ataxia telangiectasia mutated protein; β-TrCP

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

Boerhavia diffusa L. ethanol extract suppresses inflammatory responses via inhibition of Src/Syk/TRAF6

Keywords: Bd-EE; Boerhavia diffusa L. ethanol extract; HPLC; high performance liquid chromatography; PGE2; prostaglandin E2; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; TLR; Toll-like receptor (TLR); NF-κB; nuclear factor-κB; AP-1; Activat

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

JAZF1 can regulate the expression of lipid metabolic genes and inhibit lipid accumulation in adipocytes

Keywords: JAZF1; TAK1; SREBP1; Adipocytes; 3T3-L1; Lipid accumulation

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKKβ

Keywords: NLK; NF-κB; TNFα; IKKβ; TAK1;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Myrsine seguinii ethanolic extract and its active component quercetin inhibit macrophage activation and peritonitis induced by LPS by targeting to Syk/Src/IRAK-1

Keywords: Ms-EE; ethanolic extract of Myrsine seguinii; PGE2; prostaglandin E2; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; (TNF)-α; tumour necrosis factor; ERK; extracellular signal-related kinase; TLR; toll-like receptors (TLR); MAPK; mit

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Phosphorylation of heat shock protein 27 antagonizes TNF-α induced HeLa cell apoptosis via regulating TAK1 ubiquitination and activation of p38 and ERK signaling

Keywords: HSP27 phosphorylation; TAK1; TNF-α; Apoptosis; p38 MAPK; ERK;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Glabridin induces glucose uptake via the AMP-activated protein kinase pathway in muscle cells

Keywords: ACC; acetyl CoA carboxylase; ACO; acyl CoA oxidase; AICAR; 5-amino-1-β-d-ribofuranosyl-imidazole-4-carboxamide; AMPK; adenosine monophosphate-activated protein kinase; AS160; Akt substrate 160 kDa; BSA; bovine serum albumin; CaMKII; Ca2+/calmodulin-depe

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway

Keywords: ACC; acetyl-CoA carboxylase; ALA; alpha-lipoic acid; ALT; alanine aminotransferase; AICAR; 5-aminoimidazole-4-carboxamide riboside; AMPK; AMP-activated protein kinase; AST; aspartate aminostransferase; ATGL; adipose triacylglycerol lipase; CaMKK; Ca2+/cal

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

The intricate interplay between RNA viruses and NF-κB

Keywords: ss; single-stranded; ds; double-stranded; HTLV; human T cell leukemia virus; SARS; severe acute respiratory syndrome; IAVs; influenza A viruses; IFN; interferon; IRF3; interferon regulatory factor 3; NF-κB; nuclear factor κB; TLRs; toll-like receptors;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

The Drosophila IMD pathway in the activation of the humoral immune response

Keywords: 20; 20-hydroxyecdysone; AMP; antimicrobial peptide; DAP; meso-diaminopimelic acid; DREDD; death-related ced-3/Nedd2-like protein; FADD; Fas-associated protein with Death Domain; IAP; inhibitor of apoptosis; IκB; inhibitor of κB; IKK; IκB kinase; imd; i

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

RanBPM interacts with TβRI, TRAF6 and curbs TGF induced nuclear accumulation of TβRI

Keywords: TGF-β; transforming growth factor β; TβRI; TGF-β type I receptor; TβRII; TGF-β type II receptor; RanBPM; Ran-binding protein in the microtubule-organizing center; TRAF6; tumor necrosis factor (TNF)-receptor-associated factor 6; MAP; mitogen-activate

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Aspirin attenuates vinorelbine-induced endothelial inflammation via modulating SIRT1/AMPK axis

Keywords: VNR; vinorelbine; SIRT1; sirtuin 1; AMPK; AMP-activated protein kinase; PKC; protein kinase C; LKB1; protein liver kinase B1; TAK1; TGF-β-activated kinase-1; TAB1; TAK-binding protein-1; ROS; reactive oxygen species; DCF-AM; 2′,7′-dichlorofluorescein

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

TGF-β1-induced phospholamban expression alters esophageal smooth muscle cell contraction in patients with eosinophilic esophagitis

Keywords: Remodeling; esophagus; eosinophils; smooth muscle; TGF-β; phospholamban; EMF; Esophageal myofibroblast; EoE; Eosinophilic esophagitis; ESM; Esophageal smooth muscle; FACS; Fluorescence-activated cell sorting; hpf; High-power field; PLN; Phospholamban; Se

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

AMPK-α1 functions downstream of oxidative stress to mediate neuronal atrophy in Huntington's disease

Keywords: 3D; three-dimensional; ACC; acety-CoA carboxylase; AD; Alzheimer's disease; AICAR; aminoimidazole carboxamide riboside; AMPK; AMP-activated protein kinase; ALS; amyotrophic lateral sclerosis; ATM; ataxia telangiectasia mutated; CaMKII; Ca2 +/calmodulin-d

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Nemo-like kinase, a multifaceted cell signaling regulator

Keywords: NLK; Nemo-like kinase; IL-6; intereukin-6; MAPK; mitogen activated protein kinase; ERK; extracellular-signal regulated kinase; Pro; proline; Ser; serine; Thr; threonine; C. elegans; Caenorhabditis elegans; POP-1; Posterior pharynx defect protein 1; LEF1;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

TAK1 ubiquitination regulates doxorubicin-induced NF-κB activation

Keywords: TAK1; Ubiquitination; Doxorubicin; USP4; ITCH;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Taraxerol inhibits LPS-induced inflammatory responses through suppression of TAK1 and Akt activation

Keywords: Taraxerol; TAK1; MAPK; Akt; NF-κB; RAW264.7 cells;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Combined CpG and poly I:C stimulation of monocytes results in unique signaling activation not observed with the individual ligands

Keywords: TLRs; Toll-like receptors; CpG; unmethylated CpG oligodeoxynucleotides; poly I:C; polyinosinic-polycytidylic acid; NO; nitric oxide; iNOS; inducible nitric oxide synthase; CREB; cAMP response element-binding protein; NFκB; nuclear factor κB; PRRs; pat

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Grass carp (Ctenopharyngodon idella) TRAF6 and TAK1: Molecular cloning and expression analysis after Ichthyophthirius multifiliis infection

Keywords: TRAF6; TAK1; Ctenopharyngodon idella; Ichthyophthirius multifiliis;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice

Keywords: AMPK; AMP-activated protein kinase; ACC; acetyl-CoA carboxylase; CNTF; ciliary neurotrophic factor; AICAR; 5-aminoimidazole-4-carboxamide ribonucleoside; KD; kinase domain; AID; autoinhibitory domain; GBD; glycogen-binding domain; CaMKKα/β; calmodulin-d

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Stimulation of TRAF6/TAK1 degradation and inhibition of JNK/AP-1 signalling by ginsenoside Rg3 attenuates hepatitis B virus replication

Keywords: Hepatitis B virus; Ginsenoside Rg3; TRAK6; TAK1; Ubiquitination;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

7b, a novel naphthalimide derivative, exhibited anti-inflammatory effects via targeted-inhibiting TAK1 following down-regulation of ERK1/2- and p38 MAPK-mediated activation of NF-κB in LPS-stimulated RAW264.7 macrophages

Keywords: 7b; Anti-inflammatory; TAK1; MAPK; NF-κB;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: Optimization of kinase selectivity and pharmacokinetics

Keywords: TAK1; Inhibitors; 7-Amino-furo[2,3-c]pyridine; Cancer; Inflammation

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1

Keywords: TAK1; Inhibitors; 7-Amino-furo[2,3-c]pyridine; Cancer; Inflammation

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه