کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10815855 | 1058520 | 2016 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
Smad3MLL1PDHTAK1LSD1E1ADnmt1Sir2httERCTIF-IANLSHMG-CoANAMPTACAT1SCNPGC-1αSnRK1KDM2Ahistone 2Bperoxisome proliferator-activated receptor γ coactivator-1αrRNADBC1H2BSuv39h1SNF1GLUT4NMLINO1BRD4CaMKKβDNA methyltransferase 15-aminoimidazole-4-carboxamide ribonucleosideCryptochromeMEF2hsp70HDACacetoacetyl-CoA thiolaseCOAmTORGAPDHHMGRSIRTRDNAHIF-1αnESAICARACCNF-κBPPAR-γLKB1CREBAMPK3-hydroxy-3-methylglutaryl coenzyme A - 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم AAMP-activated protein kinase - AMP-پروتئین کیناز فعال شده استBmal1 - BMAL1Ribosomal DNA - DNA ریبوزومیHMG-CoA reductase - HMG-CoA ردوکتازPer2 - per2Ribosomal RNA - RNA RibosomalRNA polymerase I - RNA پلیمراز Iacetyl-CoA carboxylase - استیل کروکسی سیلازAcetyl CoA - استیل کولاHistone acetylation - استیلیت هیستونEpigenetic - اپی ژنتیکsilent information regulator - تنظیم کننده اطلاعات خاموشsilent information regulator 2 - تنظیم کننده اطلاعات خاموش 2saga - حماسهClock - ساعتAging - سالخوردگیnuclear localization signal - سیگنال محلی سازی هسته ایBET - شرطmyocyte enhancer factor-2 - عامل افزایش دهنده myocyte-2hypoxia-inducible factor-1α - عامل القاء شده با هیپوکسی 1αnuclear factor-κB - فاکتور هسته ای κBFoxO - فاکسوATAC - فراخوانSmile - لبخندGlucose transporter type 4 - نوع حمل گلوکز 4nicotinamide phosphoribosyltransferase - نیکوتین آمید فسفریبوسیل ترانسفرازHuntingtin - هانتینگتنmammalian target of rapamycin - هدف پستانداران رپامایسینSuprachiasmatic nuclei - هسته های SuprachiasmaticHistone acetyltransferase - هیستون استیل ترانسفرازhistone deacetylase - هیستون داستیلازcyclic AMP response element binding protein - پروتئین اتصال دهنده عنصر پاسخ Cyclic AMPheat-shock protein 70 - پروتئین حرارت دهنده 70Pol I - پل منpyruvate dehydrogenase - پیرووات دهیدروژنازcasein kinase 1 - کازئین کیناز 1Chromatin - کروماتینHAT - کلاهcoenzyme A - کوآنزیم Aliver kinase B1 - کیناز کیناز B1Cry - گریه کردنglyceraldehyde 3-phosphate dehydrogenase - گلیسرولیدید 3-فسفات دهیدروژنازPeroxisome proliferator-activated receptor-γ - گیرنده پروتئینی فعال پروکسیوم - γ
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
AMP-activated protein kinase (AMPK) and its yeast homolog, Snf1, are critical regulators in the maintenance of energy metabolic balance not only stimulating energy production but also inhibiting energy-consuming processes. The AMPK/Snf1 signaling controls energy metabolism by specific phosphorylation of many metabolic enzymes and transcription factors, enhancing or suppressing their functions. The AMPK/Snf1 complexes can be translocated from cytoplasm into nuclei where they are involved in the regulation of transcription. Recent studies have indicated that AMPK/Snf1 activation can control histone acetylation through different mechanisms affecting not only gene transcription but also many other epigenetic functions. For instance, AMPK/Snf1 enzymes can phosphorylate the histone H3S10 (yeast) and H2BS36 (mammalian) sites which activate specific histone acetyltransferases (HAT), consequently enhancing histone acetylation. Moreover, nuclear AMPK can phosphorylate type 2A histone deacetylases (HDAC), e.g. HDAC4 and HDAC5, triggering their export from nuclei thus promoting histone acetylation reactions. AMPK activation can also increase the level of acetyl CoA, e.g. by inhibiting fatty acid and cholesterol syntheses. Acetyl CoA is a substrate for HATs, thus increasing their capacity for histone acetylation. On the other hand, AMPK can stimulate the activity of nicotinamide phosphoribosyltransferase (NAMPT) which increases the level of NAD+. NAD+ is a substrate for nuclear sirtuins, especially for SIRT1 and SIRT6, which deacetylate histones and transcription factors, e.g. those regulating ribosome synthesis and circadian clocks. Histone acetylation is an important epigenetic modification which subsequently can affect chromatin remodeling, e.g. via bromodomain proteins. We will review the signaling mechanisms of AMPK/Snf1 in the control of histone acetylation and subsequently clarify their role in the epigenetic regulation of ribosome synthesis and circadian clocks.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 28, Issue 8, August 2016, Pages 887-895
Journal: Cellular Signalling - Volume 28, Issue 8, August 2016, Pages 887-895
نویسندگان
Antero Salminen, Anu Kauppinen, Kai Kaarniranta,