Keywords: Resveratrol; Chronological aging; Sir2; Oxidative stress; Saccharomyces cerevisiae;
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Glycation inhibitors extend yeast chronological lifespan by reducing advanced glycation end products and by back regulation of proteins involved in mitochondrial respiration
Keywords: AGEs; advanced glycation end products; CR; calorie restriction; NR; non-calorie restriction; CLS; chronological lifespan; AMG; aminoguanidine; MET; metformin; HYD; hydralazine; RLS; replicative lifespan; Sch9, threonine/threonine; protein kinase; TOR; Tar
Keywords: Alba; Acetylation; Chromatin; Sir2; Nucleic acid binding; Posttranslational modification
Keywords: Chronological aging; Sir2; Acetate metabolism; Acetyl-CoA; Ethanol; Gluconeogenesis;
The role of SIRT1 in diabetic retinopathy
Keywords: SIR2; Silent Information Regulator2; HDACs; histone deacetylaser; NAD+; nicotinamide adenine dinucleotide; DM; diabetes mellitus); AGEs; advanced glycation end products; AMPK; adenosine monophosphate-activated protein kinas; TGFβ1; transforming growth fa
Role of Forkhead Box O (FOXO) transcription factor in aging and diseases
Keywords: FOXO; Forkhead box O; DBD; DNA-binding domain; NLS; Nuclear localization sequence; NES; Nuclear export sequence; IRE; Insulin-responsive element; ARDs; Age-related diseases; RTK; Receptor tyrosine kinase; PI3K; Phosphoinositide 3kinase; SGK; Serum and glu
SIRT1 and microRNAs: The role in breast, lung and prostate cancers
Keywords: SIR2; (Silent Information Regulator2); HDACs; (histone deacetylases); NAD +; (nicotinamide adenine dinucleotide); UTR; (untranslated region); pRb; (retinoblastoma protein); lnc RNA; (Long noncoding RNA); ERG; (ETS Related Gene); EMT; (epithelial to mesenc
The role of SIRT1 in diabetic cardiomyopathy
Keywords: SIR2; Silent Information Regulator2; HDACs; histone deacetylases; NAD +; nicotinamide adenine dinucleotide; DM; diabetes mellitus; CAD; coronary artery disease; HF; heart failure; DCP; diabetic cardiomyopathy; MRI; magnetic resonance imaging; MAPK; mitoge
Nicotinamide supplementation phenocopies SIR2 inactivation by modulating carbon metabolism and respiration during yeast chronological aging
Keywords: NAM; Sir2; Chronological aging; Respiration;
The NAD+-dependent deacetylase, Bifidobacterium longum Sir2 in response to oxidative stress by deacetylating SigH (ÏH) and FOXO3a in Bifidobacterium longum and HEK293T cell respectively
Keywords: Bifidobacterium longum; Lactobacillus acidophilus; Sir2; Oxidative stress; sigH; FOXO3a;
Functional divergence of SIR2 orthologs between trypanosomatid parasites
Keywords: Leishmania; SIR2; NAD+; Amplicons
The effects of Rpd3 on fly metabolism, health, and longevity
Keywords: HDACs; histone deacetylases; HATs; histone acetyltransferases; SIR2; silent information regulator 2; HDAC; rpd3; dSir2; Drosophila melanogaster; Dietary restriction; Aging; Longevity;
AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions
Keywords: ACAT1; acetoacetyl-CoA thiolase; ACC; acetyl-CoA carboxylase; AICAR; 5-aminoimidazole-4-carboxamide ribonucleoside; AMPK; AMP-activated protein kinase; ATAC; Ada-two-A-containing; BET; bromodomains and extra-terminal motif; BMAL1; PAS domain-containing pr
Resveratrol inhibits inflammatory signaling implicated in ionizing radiation-induced premature ovarian failure through antagonistic crosstalk between silencing information regulator 1 (SIRT1) and poly(ADP-ribose) polymerase 1 (PARP-1)
Keywords: AMH; anti-Müllerian hormone; COX-2; cyclooxygenase-2; IL; interleukin; iNOS; inducible nitric oxide synthase; NF-κB; nuclear factor kappa-B; PARP; poly(ADP-ribose) polymerase; POF; premature ovarian failure; PPARs; peroxisome proliferator-activated rece
Sirtuins in vascular diseases: Emerging roles and therapeutic potential
Keywords: ACE; angiotensin converting enzyme; AICAR; 5-amino-4-imidazolecarboxamide riboside; AMPK; AMP-activated protein kinase; Ang II; angiotensin II; ApoE; apolipoprotein E; AT1R; angiotensin II type 1 receptor; ATM; ataxia telangiectasia mutated; ATP; adenosin
Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases
Keywords: Aβ; amyloid β protein; AMPK; adenosine monophosphate activated protein kinase; CGNs; cerebellar granule neurons; ETC; electron transport chain; H2O2; hydrogen peroxide; HO-1; heme oxygenase-1; LXR; liver X receptor; MAPK; mitogen-activated protein kinas
SIR-nucleosome interactions: Structure-function relationships in yeast silent chromatin
Keywords: aa; amino acid; bp; base pairs; ChIP; chromatin immunoprecipitation; EM; electron microscopy; HAT; histone acetyl transferase; HM; homothallic mating-type loci; HMT; histone methyl-transferase; MALS; multi-angle light scattering; NAD; Nicotinamide Adenine
Anti-leishmanial activity of the bisnaphthalimidopropyl derivatives
Keywords: BNIP derivatives; SIR2; NAD+-dependent deacetylase inhibitors; In vivo anti-Leishmania activity;
Genetic analysis of SIRT1 gene promoter in sporadic Parkinson's disease
Keywords: ATG; autophagy-related genes; CREB; cAMP response element-binding protein; DJ-1; Parkinson's disease gene 7; DRAM; damage-regulated autophagy modulator; FOXO; forkhead box transcription factor; GBA; lysosomal glucocerebrosidase; HIC1; hypermethylated in
Research reportHydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury
Keywords: BDNF; brain-derived neurotropic factor; CaMKII; calcium/calmodulin-dependent protein kinase II; CREB; cyclic AMP-response element binding protein; FPI; fluid percussion injury; MDA; malondialdehyde; Sir2; silent information regulator 2; Hydrogen-rich sali
Cell cycle regulation of silent chromatin formation
Keywords: S. cerevisiae, Sacchromyces cerevisiae; ORC, Origin Recognition Complex; SIR, Silent Information Regulator; HMR-E, E silencer at HMR; HML-E, E silencer at HMLSilencing; Epigenetic; SIR1; SIR2; SIR3; SIR4
Characterization and differential expression analysis of complete coding sequences of Vitis vinifera L. sirtuin genes
Keywords: Sir2; Sirtuins; Hystone deacetylase; Vitis vinifera;
Regulation and protection of mitochondrial physiology by sirtuins
Keywords: Acetyl-CoA; acetyl-coenzyme A; AceCS2; acetyl-coenzyme A synthethase 2; ACC; Acetyl-CoA carboxylase; ADP; adenosine diphosphate; AIF; apoptosis-inducing factor; AMPK; 5â² adenosine monophosphate-activated protein kinase; ANT; adenine nucleotide transloca
ReviewSirtuins of parasitic protozoa: In search of function(s)
Keywords: sir2; Parasite; Plasmodium; Leishmania; Gene regulation; Antigenic variation;
dSir2 and longevity in Drosophila
Keywords: Sir2; Drosophila melanogaster; Caloric restriction; Aging;
p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence
Keywords: CKII; protein kinase CKII (also known as casein kinase II); DRB; 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole; HDAC; histone deacetylase; MBP; maltose binding protein; NOX; NADPH oxidase; PBS; phosphate-buffered saline; ROS; reactive oxygen species; SA-
The controversial links among calorie restriction, SIRT1, and resveratrol
Keywords: Ac; acetate; AMPK; AMP-activated kinase; CAECs; coronary arterial endothelial cells; CR; calorie restriction; CSE; cigarette smoke extract; eNOS; endothelial nitric oxide synthase; EX-527; 6-chloro-2,3,4,9-tetrahydro-1-H-carbazole-1-carboxamide; Fâ; flu
Changes in reactive oxygen species begin early during replicative aging of Saccharomyces cerevisiae cells
Keywords: ROS, reactive oxygen species; GFP, green fluorescent protein; WGA, wheat germ agglutinin; DHE, dihydroethidium bromide; PI, propidium iodideReactive oxygen species; Superoxide anion; Yeast; Cell aging; Oxidative stress; Mitochondrial morphology; SIR2; Fre
A high throughput screening assay for determination of chronological lifespan of yeast
Keywords: Chronological lifespan; Caloric restriction; Inoculum size; TOR1; SIR2; SCH9; RAS2
Sir2 is induced by oxidative stress in a yeast model of Huntington disease and its activation reduces protein aggregation
Keywords: Huntington disease; Yeast; Sir2; Oxidative stress; Polyglutamine; Metabolism; Aggregation
Chemical modifications of resveratrol for improved protein kinase C alpha activity
Keywords: PKC; protein kinase C; DAG; diacylglycerol; TPA; 12-O-tetradecanoylphorbol-13-acetate; PDB; protein data bank; NMR; nuclear magnetic resonance; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; HEK; human embryonic kidney; PDS; 4,4â²-dip
Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1
Keywords: SIR2; silent information regulator 2; CPS1; carbamoyl phosphate synthetase 1; Tg; transgenic; KO; knockout; SIRT5; Mitochondria; Urea cycle; Liver;
Reversible binding of zinc in Plasmodium falciparum Sir2: Structure and activity of the apoenzyme
Keywords: Sir2; Plasmodium falciparum; Zinc affinity; Deacetylase activity; Structural stability; Zinc reconstitution
Drosophila foxo acts in males to cause sexual-dimorphism in tissue-specific p53 life span effects
Keywords: Antagonistic pleiotropy; Sir2; Aging; Akt; Sexual differentiation
Sir2-dependent asymmetric segregation of damaged proteins in ubp10 null mutants is independent of genomic silencing
Keywords: Aging; Protein carbonylation; Sir2; Ubp10; Oxidative damage; Calorie Restriction
Function and metabolism of sirtuin metabolite O-acetyl-ADP-ribose
Keywords: Sirtuin; Sir2; NAD; Deacetylation; Deacetylase; O-acetyl-ADP-ribose
Regulation of yeast sirtuins by NAD+ metabolism and calorie restriction
Keywords: Sir2; NAD+; Calorie restriction; Longevity regulation; Aging
NAD: A master regulator of transcription
Keywords: NAD, Nicotinamide adenine dinucleotide; NAD(H), NAD+ and/or NADH; SIR, Silent information regulator; NAM, Nicotinamide; ADPR, ADP-ribose; OAADPR, O-acetyl-ADP-ribose; CR, Calorie restrictionNAD; Chromatin; Transcription; Histone; Sir2; Sirt1; Sirt6; Sirt7
SIRT1: Regulation of longevity via autophagy
Keywords: Aging; Caloric restriction; Lysosomes; p53; Sir2; Sirtuins
A continuous microplate assay for sirtuins and nicotinamide-producing enzymes
Keywords: Sirtuin; Sirt1; Nicotinamide; Sir2; NAD+; Deacetylase; Acetyl; CD38; Nicotinamidase; Glutamate dehydrogenase;
Localization of mouse mitochondrial SIRT proteins: Shift of SIRT3 to nucleus by co-expression with SIRT5
Keywords: SIR2; silent information regulator 2; MTS; mitochondrial targeting signal; NLS; nuclear localization signal; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; PNS; post-nuclear supernatant; PHB; prohibitin; ER; estrogen receptor; SIRT3; SIRT4; SIRT5; Intra
Quantification of endogenous sirtuin metabolite O-acetyl-ADP-ribose
Keywords: 2′-O-acetyl-ADP-ribose (OAADPr); Sirtuin; Sir2; Hst2; Ysa1
Life span extension by dietary restriction is reduced but not abolished by loss of both SIR2 and HST2 in Podospora anserina
Keywords: Dietary restriction; Sirtuins; SIR2; HST2; PNC1; Filamentous fungi; Aging
Insights into the Impact of Histone Acetylation and Methylation on Sir Protein Recruitment, Spreading, and Silencing in Saccharomyces cerevisiae
Keywords: Sir, silent information regulator; ORC, origin recognition complex; ChIP, chromatin immunoprecipitation; PCR, polymerase chain reactionsilencing; SIR2; SIR3; DOT1; SET1
The Caenorhabditis elegans nicotinamidase PNC-1 enhances survival
Keywords: PNC-1; Sir2; DAF-16; Nicotinamide; Survival; Stress; Lifespan; Aging
Valproate induces apoptosis by inducing accumulation of neutral lipids which was prevented by disruption of the SIR2 gene in Saccharomyces cerevisiae
Keywords: Budding yeast; Apoptosis; Valproate; Lipid accumulation; SIR2; VPA; valproic acid; HDAC; histone deacetylase; ROS; reactive oxygen species; TAG; triacylglycerol;
Isolation and Characterization of Conditional Alleles of the Yeast SIR2 Gene
Keywords: silencing; chromatin; transcription; Sir2
Caspase-mediated changes in Sir2α during apoptosis
Keywords: Caspase; Apoptosis; Sir2
SIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox
Keywords: Apoptosis; IGF-1; Neurons; Sir2; SIRT1
Recent aging research in Caenorhabditis elegans
Keywords: Aging; Caenorhabditis elegans; DAF-16/FoxO; SKN-1/Nrf; JNK; Germline; SIR2; TUBBY