کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
328962 1433673 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
SIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
SIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox
چکیده انگلیسی

Signaling through the insulin/IGF-1 pro-survival pathway is widely recognized to be neuroprotective as well as important for neuronal growth and physiology. In mammals, age-associated decline in circulating IGF-1 levels has been associated with neuronal aging and symptoms of neurodegeneration. Defects in IGF-1 receptor associated signaling has, however, been shown to significantly extend lifespan in models ranging from invertebrates to mouse. At least in C. elegans, restoring such defects in neurons alone reduces lifespan to wild-type levels. As we seek to delay brain aging and age-associated neuronal degeneration via nutritional and endocrinal supplements, an understanding of the mechanistic basis of this apparent paradox is important. Recent elucidation of the role of the protein deacetylase SIRT1 in cell survival and data associating IGF-1 with the regulation of SIRT1 expression may provide a direction towards resolving this issue.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 27, Issue 3, March 2006, Pages 501–505
نویسندگان
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