Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; CD40; clusters of differentiation 40; CI; confidence interval; CM; Clinical Modification; HAI; hemagglutination-inhibition; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; ICAM-1; intercellular adhesion molecule-1; ICM; International Classification of Dis
مقالات ISI 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A (ترجمه نشده)
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Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; Atorvastatin; Insulin; Diabetes mellitus type 1; Brain mitochondrial function; Brain apoptosis; Amyloid beta; T1DM; diabetes mellitus type 1; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; T2DM; diabetes mellitus type 2; C; control rats; DM; diabetic rat
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; Oxysterols; Cancer; Polymorphism; Risk; Genetics; Cholesterol; 25(OH)D; 25-hydroxyvitamin D; ABC; ATP-binding cassette; AEBS; antiestrogen-binding site; BC; breast cancer; BCR; biochemical recurrence; CETP; cholesteryl ester transfer protein; CH25H; chole
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; Statin intolerance; Myalgias; Myopathy; PCSK9 inhibitors; ACC/AHA; American College of Cardiology/American Heart Association; ASCVD; Atherosclerotic cardiovascular disease; CoQ10; Coenzyme Q 10; CK; Creatine Kinase; FDA; Federal Drug Administration; HMG-C
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; ACE; angiotensin converting enzyme; Akt; protein kinase B; DBP; diastolic blood pressure; GSK3; glycogen synthase kinase 3; HDL-C; high-density-lipoprotein cholesterol; HMGCoA; 3-hydroxy-3-methylglutaryl coenzyme A; LDL-C; low-density-lipoprotein choleste
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; TC; total cholesterol; RSD; Relative standard deviations; LDL-C; low density lipoproteins cholesterol; TG; triglyceride; HDL-C; high density lipoproteins cholesterol; CHD; coronary heart disease; Lp; lipoprotein; BMI; body mass index; ApoA; apolipoprotein
Moderate-dose simvastatin therapy potentiates the effect of vitamin D on thyroid autoimmunity in levothyroxine-treated women with Hashimoto's thyroiditis and vitamin D insufficiency
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; HDL; high-density lipoprotein; HLA-DR; human leukocyte antigen D-related; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; LDL; low-density lipoprotein; SD; standard deviation; Hypothalamic-pituitary-thyroid axis; Statins; Thyroiditis; Vitamin D;
ReviewPlant sterols, cholesterol precursors and oxysterols: Minute concentrations-Major physiological effects
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; ABC; ATP-binding cassette (transporter); HDL; high-density lipoproteins; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; LDL; low-density lipoproteins; LXR; liver X receptor; NPC1L1; Niemann-Pick C1-like 1; VLDL; very-low-density lipoproteins; Cholesterol
Fluvastatin Prevents Lung Adenocarcinoma Bone Metastasis by Triggering Autophagy
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; SREs; skeletal-related events; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; 3-MA; 3-methyadenine; Baf A1; Bafilomycin A1; MICA; MHC class I chain-related protein A; CQ; chloroquine; PFTα; pifithrin-α; ACC; acetyl-CoA carboxylase; ECM; extracellular m
Peroxisome proliferator-activated receptor γ down-regulation mediates the inhibitory effect of d-δ-tocotrienol on the differentiation of murine 3T3-F442A preadipocytes
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; Tocotrienol; Lovastatin; Adipocyte; Mevalonate; PPARγ; ANOVA; analysis of variance; C/EBPα; CCAAT/enhancer-binding protein α; FAS; fatty acid synthase; GLUT4; glucose transport protein 4; HMG CoA; 3-hydroxy-3-methylglutaryl coenzyme A; PBS; phosphate-b
Involvement of inhibition of RhoA/Rho kinase signaling in simvastatin-induced amelioration of neuropathic pain
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; ANOVA; analysis of variance; HMG-CoA; 3-Hydroxy-3-methylglutaryl coenzyme A; ir; immunoreactivity; MARCKS; myristoylated alanine-rich protein kinase C substrate; PBS; phosphate buffered saline; PKC; protein kinase C; ROCK2; Rho kinase 2; Rho kinase (ROCK)
Involvement of pregnane X receptor in the impaired glucose utilization induced by atorvastatin in hepatocytes
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; PCN; pregnenolone-16α-carbonitrile; PXR; pregnane X receptor; GLUT2; glucose transporter 2; GCK; glucokinase; PDK2; pyruvate dehydrogenase kinase isoenzyme 2; PEPCK1; phosphoenolpyruvate carboxykinase 1; G6
AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; ACAT1; acetoacetyl-CoA thiolase; ACC; acetyl-CoA carboxylase; AICAR; 5-aminoimidazole-4-carboxamide ribonucleoside; AMPK; AMP-activated protein kinase; ATAC; Ada-two-A-containing; BET; bromodomains and extra-terminal motif; BMAL1; PAS domain-containing pr
Low daily dose of 3 mg monacolin K from RYR reduces the concentration of LDL-C in a randomized, placebo-controlled intervention
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; LDL-cholesterol; Red yeast rice; Monacolin K; Homocysteine; Folic acid; BMI; body mass index; CVD; cardiovascular diseases; HDL-C; high-density lipoprotein-cholesterol; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; LDL-C; low-density lipoprotein-cho
Production of dammarane-type sapogenins in rice by expressing the dammarenediol-II synthase gene from Panax ginseng C.A. Mey
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; DS; Dammarenediol-II synthase; T-DNA; Transfer-DNA; HPLC; High performance liquid chromatography; PPD; 20 (S)-Protopanaxadiol; PPT; 20 (S)-Protopanaxatriol; DAD; Dammarenediol-II; ESI; Electrospray ionization; EIC; Extracted ion chromatogram; PSY; Phyto
Modulating effect of synthetic statins against damage induced by doxorubicin in somatic cells of Drosophila melanogaster
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; Atorvastatin; Rosuvastatin; Modulatory effect; Smart; Drosophila melanogaster; BH; balancer heterozygote descendants; CYP; cytochrome P450; CYP2C9; cytochrome P450 2C9; CYP 2C19; cytochrome P450 2C19; DXR; doxorubicin; eNOS; endothelial nitric oxide synth
Cholesterol-lowering effect of Lactobacillus plantarum NCU116 in a hyperlipidaemic rat model
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; CVDs; cardiovascular diseases; CYP7A1; cholesterol 7α-hydroxylase; HDL-C; high-density lipoprotein cholesterol; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; LDL-C; low-density lipoprotein cholesterol; SREBP-2; sterol regulatory element-binding protein
Simvastatin Increases ADAMTS13 Expression in Podocytes
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; ADAMTS13; A disintegrin-like and metalloprotease with thrombospondin type 1 repeats 13; VWF; von Willebrand factor; TTP; thrombotic thrombocytopenic purpura; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; TNF-α; tumor necrosis factor-α; IL-4; interleuk
Atorvastatin in stable angina patients lowers CCL2 and ICAM1 expression: Pleiotropic evidence from plasma mRNA analyses
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; ACE; angiotensin-converting enzyme; cDNA; complementary deoxyribonucleic acid; CCL2; gene encoding monocyte chemoattractant protein-1; Ch; total cholesterol; CRP; C-reactive protein; EDTA; ethylenediaminetetraacetic acid; EMP; endothelial microparticles;
Stem-bark of Terminalia arjuna attenuates human monocytic (THP-1) and aortic endothelial cell activation
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; AE; alcohol extract; Butylated hydroxytoluene; (BHT); H2DCFDA; 2´,7´-dichlorofluorescin diacetate; HAECs; Human aortic endothelial cells; 3-hydroxy-3-methylglutaryl coenzyme A; HMG-CoA reductase; ICAM-1; Intercellular adhesion molecule-1; IL-8; Interleu
Statins Are Associated With Reduced Risk of Esophageal Cancer, Particularly in Patients With Barrett's Esophagus: A Systematic Review and Meta-analysis
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; Esophageal Cancer Risk; Cholesterol-Lowering Drugs; HMG-CoA Reductase Inhibitors; Chemoprevention; BE; Barrett's esophagus; CI; confidence interval; EAC; esophageal adenocarcinoma; EC; esophageal cancer; ESCC; esophageal squamous cell cancer; HGD; high-gr
Lymphocyte-suppressing and systemic anti-inflammatory effects of high-dose metformin in simvastatin-treated patients with impaired fasting glucose
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; Cytokines; Inflammatory cells; Metformin; Pleiotropic effects; Statins; Systemic inflammation; CRP; C-reactive protein; FFA; free fatty acids; HDL; high-density lipoprotein; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; HOMA-IR; homeostasis model assess
Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; statins; isoprenoids; protein prenylation; synaptic plasticity; hippocampus; long-term potentiation; aCSF; artificial cerebral spinal fluid; AD; Alzheimer's disease; Akt; protein kinase B; fEPSPs; field excitatory postsynaptic potentials; FPP; farnesyl py
Basic ScienceAtorvastatin and pitavastatin enhance lipoprotein lipase production in L6 skeletal muscle cells through activation of adenosine monophosphate-activated protein kinase
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; LPL; lipoprotein lipase; AMPK; adenosine monophosphate-activated protein kinase; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; LDL; low-density lipoprotein; TG; triglyceride; HDL; high-density lipoprotein; VLDL; very low-density lipoprotein; ACC; acetyl
A raison d'être for two distinct pathways in the early steps of plant isoprenoid biosynthesis?
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; AACT; acetoacetyl-coenzyme A thiolase; Ac-CoA; acetyl-coenzyme A; AcAc-CoA; acetoacetyl-coenzyme A; ADP; adenosine diphosphate; ATP; adenosine triphosphate; CDP-ME; 4-diphosphocytidyl-2C-methyl-d-erythritol; CDP-MEP; 4-diphosphocytidyl-2C-methyl-d-erythri
Effects of simvastatin on cytokines secretion from mononuclear cells from critically ill patients with acute kidney injury
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; AKI; acute kidney injury; APACHE II; acute physiology and chronic healthy evaluation II; CRP; C-reactive protein; ELISA; enzyme linked immunosorbent assay; ICU; intensive care unit; LPS; lipopolissacharide;
Effects of red mold dioscorea on oral carcinogenesis in DMBA-induced hamster animal model
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; DE; extract of dioscorea; DMBA; 7,12-dimethyl-1,2-benz[a]anthracene; DTT; dithiothreitol; HBP; hamster buccal pouch; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; IL-1β; interleukin-1β; NBT; nitro blue tetrazolium; NO; nitric oxide; OSCC; oral squamou
Kudzu root: Traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; ACE2; angiotensin-converting enzyme 2; ADP; adenosine diphosphate; AGE; advanced glycation end-products; APV; DL-2-amino-5-phosphonovaleric acid; AT1; angiotensin II type I receptor; Aβ25-35; β-amyloid; Bcl-2; B-cell leukemia/lymphoma-2; BKCa; large-con
GTPase activating protein function of p85 facilitates uptake and recycling of the β1 integrin
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; Phosphoinositide 3-kinase; p85; Staphylococcus aureus; Statins; Breakpoint cluster region; GTPases; small-guanosine triphosphatases; PI3K; phosphoinositide 3-kinase; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; GAP; GTPase activating protein; BCR; brea
The genetics of statin-induced myopathy
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; LDL; low density lipoprotein; OATP; organic anion transporter protein; SNP; single nucleotide polymorphism; CK; creatine kinase; Genetics; Organic anion transporter; Inherited;
An Observational Study of Musculoskeletal Pain Among Patients Receiving Bisphosphonate Therapy
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; HR; hazard ratio; ICD-9-CM; International Classification of Diseases, Ninth Revision, Clinical Modification; MSKP; musculoskeletal pain; OR; odds ratio; VA; US Department of Veterans Affairs;
Impact of Ezetimibe on Atherosclerosis: Is the Jury Still Out?
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; CAD; coronary artery disease; CIMT; carotid artery intima-media thickness; CVD; cardiovascular disease; ENHANCE; Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression; FMD; flow mediated dilatation; FBF; forearm blood flow;
Cardiac fibroblasts: At the heart of myocardial remodeling
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; 15d-PGJ2; 15-deoxy-δ12,14-prostaglandin J2; α-SMA; Alpha smooth muscle actin; ACE; angiotensin converting enzyme; Ang II; angiotensin II; ANP; A-type (atrial) natriuretic peptide; ARB; angiotensin receptor blocker; AT1R/AT2R; angiotensin receptor type 1
An Analysis of the Effect of Statin Use on the Efficacy of Bacillus Calmette-Guerin Treatment for Transitional Cell Carcinoma of the Bladder
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; carcinoma; transitional cell; mycobacterium bovis; immunotherapy; BCG; bacillus Calmette-Guerin; GTP; guanosine triphosphate; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; TCC; transitional cell carcinoma; TUR; transurethral resection;
Dual mode of HMG-CoA reductase inhibition on dendritic cell invasion
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; ADMA; asymmetric dimethyl l-arginine; ATV; atorvastatin; CMFDA; 5-chloromethylfluorescein diacetate; FPP; farnesyl pyrophosphate; FTI; farnesyl-transferase inhibitor; GGP; geranylgeranyl pyrophosphate; GGTI; geranylgerany-transferase inhibitor; HMEC-1; im
Toward “Pain-Free” Statin Prescribing: Clinical Algorithm for Diagnosis and Management of Myalgia
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; AE; adverse event; AERS; Adverse Event Reporting System; CI; confidence interval; CK; creatine kinase; CoQ10; coenzyme Q10; CYP; cytochrome P; FDA; Food and Drug Administration; HDL-C; high-density lipoprotein cholesterol; HMG-CoA; 3-hydroxy-3-methylgluta
Influenza and COPD Mortality Protection as Pleiotropic, Dose-Dependent Effects of Statins
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; COPD; epidemiology; 3-hydroxy-3-methylglutaryl coenzyme A; influenza; mortality; statinsCCI, Charleson comorbidity index; CI, confidence interval; HMO, health maintenance organization; ICD-9-CM, International Classification of Disease, Ninth Revision, Cli
Asymmetric Dimethylarginine Determines the Improvement of Endothelium-Dependent Vasodilation by Simvastatin
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; ADMA; asymmetric dimethylarginine; eNOS; endothelial nitric oxide synthase; FMD; flow-mediated dilation; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; LDL; low-density lipoprotein; NO; nitric oxide; SR; sustained release;
Effects of Statins on Renal Function
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; ALLIANCE; Aggressive Lipid-Lowering Initiation Abates New Cardiac Events; CAD; coronary artery disease; CARE; Cholesterol and Recurrent Events; CI; confidence interval; CKD; chronic kidney disease; ESRD; end-stage renal disease; GFR; glomerular filtration
Modulation of host metabolism as a target of new antivirals
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; HCV; hepatitis C virus; CH; chronic hepatitis; HCC; hepatocellular carcinoma; IFN; interferon; SVR; sustained virological response; PEG-IFN; pegylated-IFN; GBV-B; GB virus B; uPA-SCID; urokinase plasminogen activator-severe combined immunodeficiency; NS;
Severe Hepatic Side Effects of Ezetimibe
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; ALAT; alanine aminotransferase; AP; alkaline phosphatase; Bili; bilirubin; CMV; cytomegalovirus; HMG coA; 3-hydroxy-3-methylglutaryl coenzyme A; Ig; immunoglobulin; LKM; liver-kidney microsomal;
Preoperative statin therapy is associated with reduced cardiac mortality after coronary artery bypass graft surgery
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; 16; 23; 30; 31; ACE; angiotensin-converting enzyme 4; ACS; acute coronary syndromes; CABG; coronary artery bypass graft; CI; confidence intervals; CPB; cardiopulmonary bypass; DOS; date of surgery; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; IREF; Isc
Identification of a functional DNA binding site for the SREBP-1c transcription factor in the first intron of the human caspase-2 gene
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; bHLH; basic helix-loop-helix; FAS; fatty acid synthase; HMG-CoA; 3-hydroxy-3-methylglutaryl Coenzyme A; LDLr; low-density lipoprotein receptor; SRE; sterol regulatory element; SREBP; sterol regulatory element binding protein; Human caspase-2; SREBP; L
Statins: Health-Promoting Agents Show Promise for Breast Cancer Prevention
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; Estrogen receptor; 3-hydroxy-3-methylglutaryl coenzyme A; Tumor development;
Post-ischemic delivery of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor rosuvastatin protects against focal cerebral ischemia in mice via inhibition of extracellular-regulated kinase-1/-2
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; statin; neuroprotection; signal transduction; ECL; enhanced chemoluminescence; eNOS; endothelial NO synthase; ERK; extracellular-regulated kinase; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; iNOS; inducible NO synthase; JNK; Jun kinase; LDF; laser Dop
The imidazoline-like drug S23515 affects lipid metabolism in hepatocyte by inhibiting the oxidosqualene:lanosterol cyclase activity
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; IBS; imidazoline binding site; MOS; 2,3-monoepoxysqualene; DOS; 2,3 ;22,23-diepoxysqualene; OSC; oxidosqualene:lanosterol cyclase; α2-AR; α2-adrenoreceptor; I1R; imidazoline 1 receptor; LXR; liver X receptor; ABC-A1/G1; ATP-binding cassette transporter
The ACAT inhibitor avasimibe increases the fractional clearance rate of postprandial triglyceride-rich lipoproteins in miniature pigs
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; ACAT; acyl coenzyme A: cholesterol acyltransferase; apo; apolipoprotein; AUC; area under the curve; ER; endoplasmic reticulum; FCR; fractional clearance rate; HDL; high density lipoprotein; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; HPLC; high perfor
Microdermabrasion: A molecular analysis following a single treatment
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; AP; activator protein; ATF; activating transcription factor; ERK; extracellular signal-regulated kinase; HMG CoA; 3-hydroxy-3-methylglutaryl coenzyme A; IL; interleukin; JNK; C-jun NH terminal kinase; MAB; monoclonal antibody; MAP; mitogen activated prote
Deficiency of PPARα disturbs the response of lipogenic flux and of lipogenic and cholesterogenic gene expression to dietary cholesterol in mouse white adipose tissue
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; NEFA; non-esterified fatty acid; TAG; triacylglycerol; FAS; fatty acid synthase; ACC; acetyl CoA carboxylase; SREBP; sterol regulatory binding protein; PPAR; peroxisome proliferator-activated receptor; LXR; liver-X receptor; LDL; low-density lipoprotein;
High cholesterol absorption efficiency and rapid biliary secretion of chylomicron remnant cholesterol enhance cholelithogenesis in gallstone-susceptible mice
Keywords: 3 هیدروکسی 3-متیل گلوتاریل کوآنزیم A; Acat2; acyl-CoA:cholesterol acyltransferase gene 2; FPLC; fast performance liquid chromatography; HDL; high density lipoprotein; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; LDL; low density lipoprotein; QTL; quantitative trait locus; VLDL; very low de