Keywords: HMG-CoA reductase; Phospholipid sterol acyltransferase; Drought tolerance; Rice; HMGR; 3-Hydroxy-3-methyl glutaryl CoA reductase; PSAT; Phospholipid: sterol acyltransferase; ABA; Abscisic acid; RWC; Relative water content; MSI; Membrane stability index; S
مقالات ISI (ترجمه نشده)
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Keywords: CPMV; cowpea mosaic virus; CYP; cytochrome P450; ELISA; Enzyme-Linked ImmunoSorbent Assay; EpHβA; 12,13β-epoxy,16β-hydroxy-β-amyrin; FPP; farnesyl diphosphate; FPS; farnesyl diphosphate synthase; GFP; green fluorescent protein; HMGR; 3-hydroxy,3-methy
Keywords: W. somnifera; Withanolides; Bioreactor; P. indica; Cell suspension cultures; CAS; Cycloaretenol synthase; DW; Dry weight; DXS; 1-deoxy-d-xylulose 5-phosphate synthase; DXR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; FPPS; Farnesyl pyrophosphate sy
Keywords: Aronia; Former smokers; Cholesterol; Inflammation; Oxidative stress; Anthocyanins; Clinical trial; BMI; body mass index; CAT; catalase; CRP; C-reactive protein; CVD; cardiovascular disease; GPX; glutathione peroxidase; HDL-C; high-density lipoprotein chol
Keywords: Farnesol; Isoprenoid biosynthesis; Methylerythritol phosphate; Mevalonate; Plants; Protein prenylation; DX; 1-deoxy-d-xylulose; FOS; fosmidomycin; FPP; farnesyl diphosphate; GGPP; geranylgeranyl diphosphate; HMGR; 3-hydroxy-3-methylglutaryl coenzyme A red
Keywords: Cancer stem-like cells; Mevalonate cascade; Ras; Rho; Stemness; Statins; Yap; ACAT; acetoacetyl-CoA transferase; acetyl-CoA; acetyl-coenzyme A; Arp2/3; actin-related protein 2/3 (actin polymerizing complex); BPs; bisphosphonates; CAMs; cell adhesion molec
Keywords: CAS; cycloartenol synthase; DDS; dammarenediol synthase; DMAPP; dimethylallyl diphosphate; DXP; 1-deoxy-d-xylulose 5-phosphate; FPP; farnesyl pyrophosphate; FPS; farnesyldiphosphate synthase; GAP; glyceraldehyde 3-phosphate; HMGR; 3-hydroxy-3-methylglutar
Keywords: A-ALD; acetylating acetaldehyde dehydrogenase; ACC; acetyl-CoA carboxylase; acetyl-AMP; acetyladenylate; ACK; acetate kinase; ACL; ATP-citrate lyase; ACS; acetyl-CoA synthetase; ADH; alcohol dehydrogenase; ALD; acetaldehyde dehydrogenase; CAT; carnitine a
Keywords: MEP; methylerythritol phosphate; MVA; mevalonate; DXS; deoxyxylulose-5-phosphate synthase; HMGR; hydroxymethylglutaryl coenzyme A reductase; DOX; 1-deoxy-d-xylulose; IPP; isopentenyl diphosphate; DMAPP; dimethylallyl diphosphate; Gossypium hirsutum L. (co
Keywords: 7-KC; 7 ketocholesterol; ACAT; acyl-CoA cholesterol acyl transferase; CHEH; cholesterol-5-6-epoxide hydrolase; CNS; central nervous system; CT; cholestane 3β-5α-6β triol; EC; epoxycholesterol; EGF; epidermal growth factor; ER; endoplasmic reticulum; ER
Keywords: AACT; acetoacetyl-CoA thiolase; ADP; adenosine diphosphate; APC; allophycocyanin; ATP; adenosine triphosphate; BChl; bacteriochlorophyll; CAR; carotenoid; CDP-ME2P; 4-(citidine 5â²-diphospho)-2-C-methyl-d-erythritol; Chl; chlorophyll; CHYβ; β-hydroxyla
Phyto-miRNAs-based regulation of metabolites biosynthesis in medicinal plants
Keywords: Phyto-miRNAs; plant miRNAs; TM; target mimicry; RNAi; RNA interference; sncRNAs; non-coding RNAs; SiRNAs; short interfering RNAs; MiRNAs; microRNAs; Pre-miRNAs; precursor miRNAs; MRE; miRNA response element; PSMs; plant secondary metabolites; BIAs; benzyl
Integrated metabolomic and transcriptomic analyses revealed the distribution of saponins in Panax notoginseng
Keywords: AACT; acetoacetyl-CoA acyltransferase; DS; dammarenediol-II synthase; DXPS; 1-deoxy-d-xylulose 5-phosphate synthase; DXPR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; FPS; farnesyl pyrophosphate synthase; FPP; farnesyl diphosphate; GDPS; gerenyl diph
3-Hydroxy-3-methyl glutaryl coenzyme A reductase is required for ovarian development in the oriental fruit fly Bactrocera dorsalis (Hendel)
Keywords: Bactrocera dorsalis; HMGR; Gene expression; RNA interference; Ovarian development;
Longitudinal expression patterns of HMGR, FPS, SS, SE and DS and their correlations with saponin contents in green-purple transitional aerial stems of Panax notoginseng
Keywords: ANOVA; analysis of variance; Ct; cycle threshold value; CYP450; cytochrome P450; DS; dammarenediol synthase gene; DS; dammarenediol synthase; FPS; farnesyl pyrophosphate synthase gene; FPS; farnesyl pyrophosphate synthase; GAPDH; glyceraldehyde phosphate
Diverse responses of tanshinone biosynthesis to biotic and abiotic elicitors in hairy root cultures of Salvia miltiorrhiza and Salvia castanea Diels f. tomentosa
Keywords: AACT; acetyl-CoA C-acetyltransferase; CPS; copalyl diphosphate synthase; CT; cryptotanshinone; CYPs; cytochromes P450; DMAPP; dimethylallyl diphosphate; DT-I; dihydrotanshinone I; DXR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; DXS; 1-deoxy-d-xylulo
RNAi mediated silencing of 3-hydroxy-3-methylglutaryl-CoA reductases (HMGR) in Centella asiatica
Keywords: HMGR; 3-Hydroxy-3-methylglutaryl-CoA reductases; CaHMGR; Centella asiatica HMGR; RNAi; RNA interference; RT-PCR; Reverse Transcriptase Polymerase Chain Reaction; hpRNA; Hairpin RNA; MVA pathway; Mevalonic acid pathway; cDNA; Complementary DNA; E. coli; Es
Diverse specialized metabolism and their responses to lactalbumin hydrolysate in hairy root cultures of Salvia miltiorrhiza Bunge and Salvia castanea Diels f. tomentosa Stib
Keywords: CA; caffeic acid; CT; cryptotanshinone; CYP76AH1; cytochrome P450 dependent monooxygenase; CYPs; cytochromes P450; DT-I; dihydrotanshinone I; DXR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; DXS; 1-deoxy-d-xylulose 5-phosphate synthase; DW; dry weigh
Developmental and extrahepatic physiological functions of SREBP pathway genes in mice
Keywords: AAV; adeno-associated virus; ACC; acetyl-CoA carboxylase; AD; Alzheimer's disease; ADD1; adipocyte determination- and differentiation-dependent factor 1; APP; amyloid precursor protein; Api6; apoptosis inhibitor 6; ApoE; apolipoprotein E; ATF6; activati
Nerolidol production in agroinfiltrated tobacco: Impact of protein stability and membrane targeting of strawberry (Fragraria ananassa) NEROLIDOL SYNTHASE1
Keywords: FDP; farnesyl diphosphate; GCMS; gas chromatography-mass spectrometry; SPME; solid phrase microextraction; IDP; isopentenyl diphosphate; DMADP; dimethylallyl diphosphate; MEP; 2-C-methyl-d-erythritol 4-phosphate; MVA; mevalonate; DMNT; 4,8-dimethyl-1,3,
Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signalling and mitochondrial metabolism
Keywords: CSCs signalling; HMGR; Bergamot; Mevalonate pathway inhibitor; Rho-GDI-signalling; Breast cancer;
Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR
Keywords: Natural products; Nuclear receptors; Liver X receptor; Farnesoid X receptor; Retinoid X receptor; Metabolic syndrome; Precision medicine; 6-ECDCA; 6α-ethyl-chenodeoxycholic acid (obeticholic acid); AA; arachidonic acid; ABC; ATP-binding cassette transpor
The molecular basis of superficial scald development related to ethylene perception and α-farnesene metabolism in 'Wujiuxiang' pear
Keywords: 1-MCP; 1-methylcyclopropene; CTols; conjugated trienols; HMGR; 3-hydroxy-3-methylglutaryl-CoA reductase; AFS; α-farnesene synthase; GPX; glutathione peroxidase; GST; glutathione S-transferase; CT; conjugated triene; ROS; reactive oxygen species; SOD; sup
Cassia auriculata flower extract attenuates hyperlipidemia in male Wistar rats by regulating the hepatic cholesterol metabolism
Keywords: Et- CAF; ethanolic extract of Cassia auriculata flower; HMGR; HMG-CoA reductase; HMGS; HMGCoA synthase; SREBP-1c; sterol regulatory element binding protein -1c; SREBP-2; sterol regulatory element binding protein- 2; CYP7A1; cholesterol 7 α-hydroxylase; A
Full length articleGlycyrrhizic acid attenuates growth of Leishmania donovani by depleting ergosterol levels
Keywords: Leishmania; Glycyrrhizic acid; HMGR; Ergosterol; HPLC;
Research articleEffect of prolonged water stress on essential oil content, compositions and gene expression patterns of mono- and sesquiterpene synthesis in two oregano (Origanum vulgare L.) subspecies
Keywords: Origanum vulgare L.; Carvacrol; (Z)-α-bisabolene; Gene expression; HMGR; Ovtps2;
Research paperCharacterization and role of the 3-methylglutaconyl coenzyme A hidratase in Trypanosoma brucei
Keywords: 3-MGCoA-H; 3-methylglutaconil-Coenzyme A hydratase; 3-HMGCoA; 3-hydroxymethylglutaryl coenzyme A; HMGR; 3-hydroximetilglutaril CoA reductase; BSF; bloodstream form; PCF; procyclic form; FCS; fetal calf serum, FCS; Tet; Tetracycline; ASCT; acetate:succinat
Potential role of lycopene in targeting proprotein convertase subtilisin/kexin type-9 to combat hypercholesterolemia
Keywords: PCSK-9; Proprotein convertase subtilisin/kexin type-9; PON-1; Paraoxonase-1; HFD; High fat Diet; HMGR; HMG-CoA reductase; EGF-A; Epidermal growth factor-A; SREBP; Sterol regulatory element binding protein; HNF1-α; Hepatocyte nuclear factor1-α; ASCVD; At
Improving the accumulation of 18α-and 18β-glycyrrhizins by over-expressing GuHMGR, GuSQS1, and GuBAS genes in Glycyrrhiza uralensis
Keywords: Glycyrrhiza uralensis; HMGR; SQS; β-AS; Over-expression;
Astaxanthin inhibits inflammation and fibrosis in the liver and adipose tissue of mouse models of diet-induced obesity and nonalcoholic steatohepatitis
Keywords: ACOX-1; acyl-coenzyme A oxidase 1; ALT; alanine aminotransferase; apoE; apolipoprotein E; Arg-1; arginase-1; ASTX; astaxanthin; Casp; caspase; CVD; cardiovascular disease; CPT-1α; carnitine palmitoyltransferase 1α; CD68; cluster of differentiation 68; C
Two Eucommia farnesyl diphosphate synthases exhibit distinct enzymatic properties leading to end product preferences
Keywords: Eucommia; Farnesyl diphosphate synthase; Metal ion dependency; Prenyltransferase; Substrate inhibition; CLD; chain length determination; DMAPP; dimethylallyl diphosphate; DOPE; discrete optimized protein energy; FPP; farnesyl diphosphate; FPS; farnesyl di
Cloning and Bioinformatic Analysis of HMGS and HMGR Genes from Panax notoginseng
Keywords: Araliaceae; bioinformatics analysis; gene cloning; HMGR; HMGS; Panax notoginseng;
Isoprenoid generating systems in plants - A handy toolbox how to assess contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthetic process
Keywords: Ac-CoA; acetyl CoA; AACT; AcAC-CoA thiolase; CLM; clomazone (2-[(2-chlorophenyl)methyl]-4,4-dimethyl-3-isoxazolidinone); DMAPP; dimethylallyl diphosphate; DMNT; (3E)-4,8-dimethyl-1,3,7-nonatriene; DOXP; deoxyxylulose phosphate; DX; 1-deoxy-d-xylulose; DXK
AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions
Keywords: ACAT1; acetoacetyl-CoA thiolase; ACC; acetyl-CoA carboxylase; AICAR; 5-aminoimidazole-4-carboxamide ribonucleoside; AMPK; AMP-activated protein kinase; ATAC; Ada-two-A-containing; BET; bromodomains and extra-terminal motif; BMAL1; PAS domain-containing pr
Upregulation of the mevalonate pathway by cholesterol depletion abolishes tolerance to N-bisphosphonate induced Vγ9Vδ2 T cell cytotoxicity in PC-3 prostate cancer cells
Keywords: ApppI; triphosphoric acid 1-adenosin-5â²-yl ester 3-(3-methylbut-3-enyl) ester; ECL; enhanced chemiluminescence; FPPS; farnesyl pyrophosphate synthase; FOH; farnesol; GGOH; geranylgraniol; HMGR; 3-hydroxy-3-methylglutaryl coenzyme A reductase; HPLC-ESI
Production of dammarane-type sapogenins in rice by expressing the dammarenediol-II synthase gene from Panax ginseng C.A. Mey
Keywords: DS; Dammarenediol-II synthase; T-DNA; Transfer-DNA; HPLC; High performance liquid chromatography; PPD; 20 (S)-Protopanaxadiol; PPT; 20 (S)-Protopanaxatriol; DAD; Dammarenediol-II; ESI; Electrospray ionization; EIC; Extracted ion chromatogram; PSY; Phyto
Methyl jasmonate elicits the solasodine production and anti-oxidant activity in hairy root cultures of Solanum trilobatum L.
Keywords: DPPH; 1,1-diphenyl-2-picrylhrdrazyl; hmgr; 3-hydroxy 3-methylglutaryl CoA reductase; MJ; methyl jasmonate; RSA; radical scavenging activity; RT-PCR; reverse transcriptase-polymerase chain reaction; TFC; total flavonoids content; TPC; total phenolic conten
An investigation of the endocrine disrupting potential of enniatin B using in vitro bioassays
Keywords: HMGR; hydroxy-methyl-glutaryl CoA reductase; StAR; steroidogenic acute regulatory; CYP11A; cytochrome P450 11A; CYP11B1; cytochrome P450 11B1; CYP11B2; aldosterone synthetase; CYP17; cytochrome P450 17; CYP21; cytochrome P450 21; 3βHSD2; 3-beta-hydroxyst
The low temperature induced rate of 3-hydroxy-3-methylglutaryl-CoA reductase in Parthenium argentatum Gray limits the theoretical rate of rubber formation
Keywords: Partheniumar gentatum Gray; Chihuahuan Desert; 3-Hydroxy-3-methylglutaryl-CoA reductase; Rubber transferase; Rubber induction; Quantitative rubber biosynthesis; HMGS; 3-hydroxy-3-methylglutaryl-CoA synthase; HMGR; 3-hydroxy-3-methylglutaryl-CoA reductase;
Potential synergistic effects of Chinese herbal prescription FTZ components detected in blood towards hepatic lipid-modulating targets
Keywords: TCM; traditional Chinese medicine; UPLC/Q-TOF-MS; ultra-performance liquid chromatography/quadruple-time-of-flight mass-spectrometry; RC; Rhizoma Coptidis; RSM; Radix Salvia Miltiorrhiza; TC; total cholesterol; TG; total triglyceride; LDL-C; low density l
Multiple genes of mevalonate and non-mevalonate pathways contribute to high aconites content in an endangered medicinal herb, Aconitum heterophyllum Wall
Keywords: HMGS; 3-hydroxy-3-methylglutaryl-CoA synthase; HMGR; 3-hydroxy-3-methylglutaryl-CoA reductase; PMK; phosphomevalonate kinase; IPPI; isopentenyl pyrophosphate isomerase; DXPS; 1-deoxy-d-xylulose 5-phosphate synthase; ISPD; 2-C-methylerythritol 4-phosphate
Exploring Leishmania donovani 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) as a potential drug target by biochemical, biophysical and inhibition studies
Keywords: HMGR; Leishmania donovani; Statins; Ergosterol; Cholesterol
Molecular modeling studies of atorvastatin analogues as HMGR inhibitors using 3D-QSAR, molecular docking and molecular dynamics simulations
Keywords: HMGR; Statins; 3D-QSAR; gem-Difluoro; Molecular dynamics simulations;
Mianserin, an antidepressant kills Leishmania donovani by depleting ergosterol levels
Keywords: Mianserin; HMGR; Ergosterol; Leishmania; HPLC;
Cloning, molecular characterization and functional analysis of 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase (HDR) gene for diterpenoid tanshinone biosynthesis in Salvia miltiorrhiza Bge. f. alba
Keywords: Salvia miltiorrhiza Bge. f. alba; SmHDR1; Expression profiling; Tanshinones; Hairy root; CTAB; cetyltrimethylammonium bromide; DMAPP; dimethylallyl diphosphate; DXR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; DXS; 1-deoxy-d-xylulose 5-phosphate synt
Contents of therapeutic metabolites in Swertia chirayita correlate with the expression profiles of multiple genes in corresponding biosynthesis pathways
Keywords: 7-DLGT; 7-deoxyloganetic acid glucosyl transferase; 8-HGO; 8-hydroxygeraniol oxidoreductase; AAC; acetyl-CoA carboxylase; AACT; acetoacetyl-CoA thiolase; ADH; arogenate dehydrogenase; ADT; prephenate dehydratase; C3H; p-coumarate 3-hydroxylase; C4H; trans
Polyphenol-rich black chokeberry (Aronia melanocarpa) extract regulates the expression of genes critical for intestinal cholesterol flux in Caco-2 cells
Keywords: ACOX-1; acyl-CoA oxidase 1; ABCA1; ATP binding cassette transporter A1; ABCG5/8; ATP binding cassette transporter G5/8; CVD; cardiovascular disease; CPT-1α; carnitine palmitoyltransferase 1α; FAS; fatty acid synthase; HMGR; 3-hydroxy-3-methylglutaryl co
Overexpression of 3-hydroxy-3-methylglutaryl coenzyme A reductase in Parthenium argentatum (guayule)
Keywords: Guayule; Natural rubber; Metabolic engineering; HMGR; 3-Hydroxy-3-methylglutaryl coenzyme A reductase
Multitargeted Low-Dose GLAD Combination Chemoprevention: A Novel and Promising Approach to Combat Colon Carcinogenesis
Keywords: DFMO; α-difluoromethylornithine; GLAD; gefitinib, licofelone, atorvastatin, and DFMO; EGFR; epidermal growth factor receptor; HMGR; 3-hydroxy-3-methylglutaryl CoA reductase; COX; cyclooxygenase;
Influence of large molecular polymeric pigments isolated from fermented Zijuan tea on the activity of key enzymes involved in lipid metabolism in rat
Keywords: LMPP; large molecular polymeric pigments; FC; free cholesterol; TC; total cholesterol; TG; triacylglycerol; HDL-C; high density lipoprotein-cholesterol; LDL-C; low density lipoprotein-cholesterol; HL; hepatic lipase; HSL; hormone-sensitive lipase; LCAT; l