دانلود مقالات ISI درباره Brd4 + ترجمه فارسی

دینامیک کروماتین در هسته فیبروز کلیه

Chromatin dynamics at the core of kidney fibrosis

Keywords: ac; acetylation; BET; bromodomain and extra terminal family proteins; BMP7; bone morphogenic protein 7; BRD4; bromodomain-containing protein 4; bp; base pairs; CKD; chronic kidney disease; CTGF; connective tissue growth factor; DDR; DNA damage response; D

دانلود رایگان متن کامل مقاله ISI 113 صفحه سال انتشار : 2018 سفارش ترجمه

تشخیص یک مهارکننده بسیار انتخابی از کینازهای آئورورا

Characterization of a highly selective inhibitor of the Aurora kinases

Keywords: PLK4; Polo-like kinase 4; FACS; fluorescence activated cell sorting; DMSO; dimethylsulfoxide; AML; acute myeloid leukemia; T-ALL; T-cell acute lymphoblastic leukemia; ABL1; Abelson Tyrosine-Protein Kinase 1; LRRK2; Leucine Rich Repeat Kinase 2; BRD4; Brom

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

تنظیم پروموتور دیررس نوع 16 پاپیلومای انسانی با طول عمر رونویسی

Regulation of the human papillomavirus type 16 late promoter by transcriptional elongation

Keywords: Papillomavirus; Gene expression; Late promoter; CDK9; CDK8; P-TEFb; Mediator; Pol II carboxy terminal domain; Brd4; Differentiation; Transcriptional elongation;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

گیرنده های اسید رتینوئیک: از مکانیسم های مولکولی به درمان سرطان

Retinoic acid receptors: From molecular mechanisms to cancer therapy

Keywords: 4-HPR; N-(4-hydroxyphenyl)retinamide; 5′-UTR; 5′-untranslated region; 9-cis-RA; 9-cis retinoic acid; 9cUAB30; (2E,4E,6Z,8E)-8-(3′,4′-dihydro-1′(2'H)-naphthalen-1′-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid; Acitretin; (2E,4E,6E,8E)-9-(4-met

دانلود رایگان متن کامل مقاله ISI 416 صفحه سال انتشار : 2015 سفارش ترجمه

اثرات راننده و مسافرتی جهش های ایزوسیترات دهیدروژناز 1 و 2 در انکوزیسیون و افزایش طول عمر

The driver and passenger effects of isocitrate dehydrogenase 1 and 2 mutations in oncogenesis and survival prolongation

Keywords: ΑKG; α-ketoglutarate; AML; acute myeloid leukemia; BCAT1; branched-chain amino acid transporter 1; BRD4; bromodomain-containing protein 4; D-2HG; D-2-hydroxyglutarate or R-2-hydroxyglutarate; D-2HGA; D-2-hydroxyglutarate aciduria; D2HGDH; D-2-hydroxyglu

دانلود رایگان متن کامل مقاله ISI 58 صفحه سال انتشار : 2014 سفارش ترجمه

سازگاری و یادگیری شبکه های مولکولی به عنوان توصیف توسعه سرطان در سطح سیستم: استفاده بالقوه در درمان ضد سرطان

Adaptation and learning of molecular networks as a description of cancer development at the systems-level: Potential use in anti-cancer therapies

Keywords: BRAF; B-Raf protein; BRD4; bromodomain-containing protein 4; CDK6; cyclin-dependent kinase 6; ERBB1; epidermal growth factor receptor; ERG; ETS-family oncogenic transcription factor; ERK; extracellular signal regulated protein kinase; FOS; FBJ murine oste

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

AZD5153, a novel BRD4 inhibitor, suppresses human thyroid carcinoma cell growth in vitro and in vivo

Keywords: Papillary thyroid carcinoma; BRD4; AZD5153; Molecularly-targeted therapy; Cell proliferation;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

microRNA-608 inhibits human hepatocellular carcinoma cell proliferation via targeting the BET family protein BRD4

Keywords: Hepatocellular carcinoma; BRD4; microRNA-608; c-Myc; Cell growth;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Discovery and lead identification of quinazoline-based BRD4 inhibitors

Keywords: BET inhibitor; BRD4; Bromodomain; Quinazoline; Cancer; Inflammation;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Dual BRD4 and AURKA Inhibition Is Synergistic against MYCN-Amplified and Nonamplified Neuroblastoma

Keywords: AURKA; aurora kinase A; BRD4; Bromodomain-containing protein 4; CI; combination index; Fa; fraction affected; p-AURKA; phosphorylated AURKA, specifically at threonine 288; LOH; loss of heterozygosity; 11q; long arm of chromosome 11;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors

Keywords: Epigenetics; Bromodomain inhibitors; BET; BRD4; Fragment; Isoquinolinone;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2018 سفارش ترجمه

Dual inhibition of BRD4 and PI3K by SF2523 suppresses human prostate cancer cell growth in vitro and in vivo

Keywords: Prostate cancer; SF2523; BRD4; AKT;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2018 سفارش ترجمه

Labelling proteins and peptides with phosphorescent d6 transition metal complexes

Keywords: Aβ; amyloid-β; BRD4; bromodomain-containing protein 4; BSA; bovine serum albumin; COX-2; cyclooxygenase-2; D/P; dye:protein ratio, used to quantify the number of metal complexes attached per protein; DNA; deoxyribonucleic acid; EC50; half maximal effect

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2018 سفارش ترجمه

PI3K pathway in prostate cancer: All resistant roads lead to PI3K

Keywords: CRPC; castration-resistant prostate cancer; ADT; androgen deprivation therapy; PI3K; phosphoinositide 3-kinase; AR; androgen receptor; PTEN; phosphatase and tensin homologue deleted on chromosome 10; INPP4B; inositol polyphosphate 4-phosphatase type II; P

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2018 سفارش ترجمه

BET bromodomain inhibitors show anti-papillomavirus activity in vitro and block CRPV wart growth in vivo

Keywords: Human papillomavirus; Epigenetics; Bromodomain extra-terminal domain protein; BRD4; BET inhibitor;

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

Cyclometalated iridium(III) luminescent complexes in therapy and phototherapy

Keywords: A2058; human metastatic melanoma cell; A2780; human ovarian carcinoma cell; A2780cisR; cisplatin-resistant A2780; A375; human melanoma cell; A549; human lung adenocarcinoma epithelial cell; A549R; cisplatin-resistant A549 cell; Aβ; beta-amyloid; acac; ac

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

A Trichostatin A (TSA)/Sp1-mediated mechanism for the regulation of SALL2 tumor suppressor in Jurkat T cells

Keywords: AP4; Activating Protein 4; BAX; Bcl-2-associated X protein; Brd4; Bromodomain-containing protein 4; Brg1; Brahma-related gene-1; C2H2; Cys2-His2 zinc finger; CBP; CREB-binding protein; CDKN2A; Cyclin-Dependent Kinase Inhibitor 2A gene; CDKN1A; Cyclin-Depe

دانلود رایگان متن کامل مقاله ISI 69 صفحه سال انتشار : 2018 سفارش ترجمه

Structure-based optimization of a series of selective BET inhibitors containing aniline or indoline groups

Keywords: BRD4; BI2536; Indoline; WPF binders; c-Myc; PD-L1; BCPs; Bromodomain-containing proteins; BET; bromodomain and extra-terminal; BRD4-BD1; first bromodomain of BRD4; CREB; cyclic-AMP response element binding protein; FA; fluorescence anisotropy; FBDD; fragm

دانلود رایگان متن کامل مقاله ISI 77 صفحه سال انتشار : 2018 سفارش ترجمه

Histone H3 lysine 4 methyltransferase KMT2D

Keywords: KMT2D; histone-lysine N-methyltransferase 2D; H3K4; histone H3 lysine 4; H3K27; histone H3 lysine 27; H3K4me1/2/3; H3K4 mono-, di- and tri-methylation; H3K27ac; H3K27 acetylation; WRAD; WDR5, RbBP5, ASH2L, and DPY30; KO; knockout; KI; knock-in; TF; transc

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and evaluation of novel dual BRD4/HDAC inhibitors

Keywords: BET bromodomain; BRD4; HDAC; Benzoyladenine; Structure-activity relationship; Polypharmacology;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of novel [1,2,4]triazolo[4,3-a]quinoxaline aminophenyl derivatives as BET inhibitors for cancer treatment

Keywords: Epigenetic readers; Bromodomains; BET; BRD4; Triazoloquinoxaline; [1,2,4]Triazolo[4,3-a]quinoxaline; Cancer;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

BRD4 has dual effects on the HMGB1 and NF-κB signalling pathways and is a potential therapeutic target for osteoarthritis

Keywords: CCK8; cell counting kit 8; BRD4; Brodomain 4; HMGB1; high mobility group box protein 1; OA; osteoarthritis; RAGE; receptor for advanced glycation end products; MMP; matrix metalloproteinases; DAMP; damage associated molecular patterns; IL-1β; Interleukin

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Targeting vasa vasorum dysfunction to prevent atherosclerosis

Keywords: Vasa vasorum; Atherosclerosis; Neoangiogenesis; Endothelial metabolism; Epigenetic regulation; microRNA; 5-aza-2′-dC; 5-aza-2′-deoxycytidine; BRD4; bromodomain-containing protein 4; BET; bromodomain and extra terminal domain; CAMs; cell adhesion molec

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and biological evaluation of 7-methylimidazo[1,5-a]pyrazin-8(7H)-one derivatives as BRD4 inhibitors

Keywords: BRD4; Bromodomain; Lysine acetylation; Antitumor;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2017 سفارش ترجمه

Involvement of Brd4 in different steps of the papillomavirus life cycle

Keywords: Brd4; Papillomavirus life cycle; E2 protein; Papillomavirus replication; Papillomavirus transcription;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

Brd4 inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-β-mediated Nox4 expression

Keywords: Brd4; Renal fibrosis; Nox4; TGF-β1;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2017 سفارش ترجمه

Development of 4,5-dihydro-benzodiazepinone derivatives as a new chemical series of BRD4 inhibitors

Keywords: Bromodomain inhibitors; BRD4; Dihydrobenzodiazepinone; Apoptosis; Epigenetics;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Inhibition of BRD4 suppresses tumor growth and enhances iodine uptake in thyroid cancer

Keywords: BRD4; JQ1; Thyroid cancer; NIS; C-MYC;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Epigenetic dysregulation of interleukin 8 (CXCL8) hypersecretion in cystic fibrosis airway epithelial cells

Keywords: CF; Epigenetics; CXCL8; BRD4;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Failure to interact with Brd4 alters the ability of HPV16 E2 to regulate host genome expression and cellular movement

Keywords: Human papillomavirus; E2; Brd4; Cancer; Exon array; Affymetrix

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

BRD4 regulates fructose-inducible lipid accumulation-related genes in the mouse liver

Keywords: BRD4; Histone acetylation; Fructose; Lipid metabolism; LiverAcly, ATP citrate lyase; Atp2b2, ATPase, Ca++ transporting, plasma membrane 2; Brd4, bromodomain containing 4; Cyp8b1, cytochrome P450 family 8 subfamily b polypeptide 1; Dak, dihydroxyacetone ki

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Epigenetic blockade of neoplastic transformation by bromodomain and extra-terminal (BET) domain protein inhibitor JQ-1

Keywords: Bromodomain; Brd4; JQ-1; Neoplastic transformation; NF-κB;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions

Keywords: ACAT1; acetoacetyl-CoA thiolase; ACC; acetyl-CoA carboxylase; AICAR; 5-aminoimidazole-4-carboxamide ribonucleoside; AMPK; AMP-activated protein kinase; ATAC; Ada-two-A-containing; BET; bromodomains and extra-terminal motif; BMAL1; PAS domain-containing pr

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2016 سفارش ترجمه

Therapeutic targeting of BET protein BRD4 delays murine lupus

Keywords: Systemic lupus erythematosus; BET proteins; BRD4; JQ1;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery and structure-activity relationship studies of N6-benzoyladenine derivatives as novel BRD4 inhibitors

Keywords: BRD4; Bromodomain; Benzoyladenine; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

BRAD4 plays a critical role in germinal center response by regulating Bcl-6 and NF-κB activation

Keywords: BRD4; Germinal center B cells; Antibody responses; Bcl6

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

I-BET151 selectively regulates IL-6 production

Keywords: BRD4; bromodomain protein 4; IL-1β; interleukin 1β; IL-6; interleukin-6; IL-10; interleukin 10; EAE; experimental autoimmune encephalomyelitis; ELISA; enzyme-linked immunosorbent assay; LPS; lipopolysaccharide; NF-κB; nuclear factor kappa B; TNFα; tum

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Methylmercury-induced changes in gene transcription associated with neuroendocrine disruption in largemouth bass (Micropterus salmoides)

Keywords: 11-KT; 11-ketotestosterone; ABCB7; ATP-binding cassette sub-family B (MDR/TAP), member 7; AMACR; alpha-methylacyl-CoA racemase; AR; androgen receptor; BEST; Biomonitoring of Environmental Status and Trends; BRD4; bromodomain containing 4; CASP3; caspase 3

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis

Keywords: BRD4; bromodomain-containing protein 4; CDK9; cyclin dependent kinase 9; CHX; cyclohexamide; EV; empty vector; FP; fusion protein; Lys/K; lysine; mcherry; monomeric cherry fluorescent protein; MEF; mouse embryonic fibroblast; MS; mass spectrometry; P-TEFb

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

The intricate interplay between RNA viruses and NF-κB

Keywords: ss; single-stranded; ds; double-stranded; HTLV; human T cell leukemia virus; SARS; severe acute respiratory syndrome; IAVs; influenza A viruses; IFN; interferon; IRF3; interferon regulatory factor 3; NF-κB; nuclear factor κB; TLRs; toll-like receptors;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Transcriptional control of HIV latency: Cellular signaling pathways, epigenetics, happenstance and the hope for a cure

Keywords: HIV latency; Epigenetics; Tat; P-TEFb; Inducible proviruses; Latency reversal; NF-κB; 7SK snRNP; BRD4;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Transcriptional Control by NF-κB: Elongation in Focus

Keywords: NF-κB; transcription elongation; P-TEFb; Brd4; DSIF

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family

Keywords: BRD4; Bromodomains; Benzodiazepines; Alprazolam; Benzotriazepines;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Identification of the P-TEFb complex-interacting domain of Brd4 as an inhibitor of HIV-1 replication by functional cDNA library screening in MT-4 cells

Keywords: HIV-1 replication; Host factor; cDNA library; Brd4; P-TEFb complex; Tat-dependent LTR transcription

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Intracellular delivery of acetyl-histone peptides inhibits native bromodomain–chromatin interactions and impairs mitotic progression

Keywords: FRAP, fluorescence recovery after photobleaching; GFP, green fluorescent protein; PTD, peptide transduction domainPeptide transduction; Acetyl-histone tail; Bromodomain; Brd4; FRAP

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Amino acid substitutions that specifically impair the transcriptional activity of papillomavirus E2 affect binding to the long isoform of Brd4

Keywords: Papillomavirus; E2; Brd4; Bromodomain-containing protein 4; Transcription; Protein–protein interaction; Viral–host interaction

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه