کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5589600 | 1569809 | 2017 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Histone H3 lysine 4 methyltransferase KMT2D
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کلمات کلیدی
ESCshistone H3 lysine 4histone H3 lysine 27H3K4 methylationMLL4TrithoraxH3K27 acetylationH3K27acBRD4TRRKMT2DH3K4H3K27TrxCBPPPARγc/ebpβ - c / ebpβCCAAT/enhancer-binding protein β - CCAAT / پروتئین اتصال دهنده تقویت کننده βEnhancer - افزاینده، افزایش دهندهGene expression - بیان ژنknock-in - دست کشیدنEmbryonic stem cells - سلولهای بنیادی جنینیTranscription factor - عامل رونویسیEpigenetic regulation - مقررات اپی ژنتیکknockout - ناکاوتCREB-binding protein - پروتئین اتصال CREBBromodomain-containing protein 4 - پروتئین حاوی برومودومین 4Peroxisome proliferator-activated receptor-γ - گیرنده پروتئینی فعال پروکسیوم - γ
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Histone H3 lysine 4 methyltransferase KMT2D Histone H3 lysine 4 methyltransferase KMT2D](/preview/png/5589600.png)
چکیده انگلیسی
Histone-lysine N-methyltransferase 2D (KMT2D), also known as MLL4 and MLL2 in humans and Mll4 in mice, belongs to a family of mammalian histone H3 lysine 4 (H3K4) methyltransferases. It is a large protein over 5500 amino acids in size and is partially functionally redundant with KMT2C. KMT2D is widely expressed in adult tissues and is essential for early embryonic development. The C-terminal SET domain is responsible for its H3K4 methyltransferase activity and is necessary for maintaining KMT2D protein stability in cells. KMT2D associates with WRAD (WDR5, RbBP5, ASH2L, and DPY30), NCOA6, PTIP, PA1, and H3K27 demethylase UTX in one protein complex. It acts as a scaffold protein within the complex and is responsible for maintaining the stability of UTX. KMT2D is a major mammalian H3K4 mono-methyltransferase and co-localizes with lineage determining transcription factors on transcriptional enhancers. It is required for the binding of histone H3K27 acetyltransferases CBP and p300 on enhancers, enhancer activation and cell-type specific gene expression during differentiation. KMT2D plays critical roles in regulating development, differentiation, metabolism, and tumor suppression. It is frequently mutated in developmental diseases, such as Kabuki syndrome and congenital heart disease, and various forms of cancer. Further understanding of the mechanism through which KMT2D regulates gene expression will reveal why KMT2D mutations are so harmful and may help generate novel therapeutic approaches.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 627, 5 September 2017, Pages 337-342
Journal: Gene - Volume 627, 5 September 2017, Pages 337-342
نویسندگان
Eugene Froimchuk, Younghoon Jang, Kai Ge,