Keywords: ChIP; chromatin immunoprecipitation; COL1A1; collagen type I alpha 1; ECM; extracellular matrix; EHMT1; euchromatic histone-lysine N-methyltransferase 1; EHZ2; enhancer of zeste homolog 2 (histone methyltransferases); HP1; heterochromatin protein 1; H3K27
مقالات ISI (ترجمه نشده)
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Keywords: Jmjd3; Jumonji domain-containing protein 3; H3K27me3; histone 3 lysine 27 trimethylation; HPDLs; human periodontal ligament cells; PBS; phosphate-buffered saline; Q-PCR; quantitative real-time polymerase chain reaction; GAPDH; glyceraldehyde-3-phosphate d
Keywords: 5-HT; serotonin (5-hydroxytryptamine); A83-01; TGF-β kinase/activin receptor-like kinase inhibitor; ACTB; actin beta/beta-actin; ASCL1; achaete-scute homolog 1 (MASH1); ASOs; anti-sense oligonucleotides; Bcl-xL; b-cell lymphoma-extra large; BDNF; brain d
Keywords: TME; tumour microenvironment; PD-1; programmed cell death 1; PD-L1; programmed death ligand 1; PD-L2; programmed death ligand 2; PTMs; post-translational histone modifications; DNMTi; DNA methyltransferase inhibitor; HDACi; histone deacetylase inhibitor;
Keywords: 6-OHDA; 6-hydroxydopamine; Aβ; amyloid-β; AD; Alzheimer disease; ALS; amyotrophic lateral sclerosis; APOE4; apolipoprotein E4; APP; amyloid precursor protein; ASCL1; achaete-scute family basic helix-loop-helix transcription factor 1; ATP; adenosine trip
Keywords: Hydrogen; DNA microarray; Gene set enrichment analysis; Histone H3K27; Mitochondrial unfolded protein response; CDAA; Choline-deficient l-amino acid-defined; Fgf21; Fibroblast growth factor 21; GEO; Gene Expression Omnibus; GSEA; Gene set enrichment analy
Keywords: BCL-2; B-cell lymphoma 2; CA-125; cancer antigen-125; CAFs; cancer-associated fibroblasts; CCL17; chemokine (C-C motif) ligand 17; CCL2; chemokine (C-C motif) ligand 2; CXCL12; chemokine (C-X-C motif) ligand 12; DFS; disease-free survival; DNMT; DNA methy
Keywords: ACLY; ATP-citrate lyase; ATM; ataxia telangiectasia mutated; BCL-2; B-cell leukemia-2; Chk2; checkpoint homolog kinase 2; CiC; citrate carrier; DIC; dicarboxylate carrier; DNMT; DNA methyltransferase; FH; fumarate hydratase; H3K27; histone 3 lysine 27; HA
Keywords: NAFLD; Non-alcoholic fatty liver disease; dG-TAM; (E)-α-(deoxyguanosin-N2-yl)-tamoxifen; dG-DesMeTAM; (E)-α-(deoxyguanosin-N2-yl)-N-desmethyltamoxifen; ALT; alanine transaminase; AST; aspartate transaminase; LDH; lactate dehydrogenase; α-SMA; α-smooth
Myeloid Kdm6b deficiency results in advanced atherosclerosis
Keywords: Atherosclerosis; Epigenetic; H3K27; Histone modification; Jmjd3; Kdm6b; Macrophage;
Polymorphisms in non-coding RNAs and risk of colorectal cancer: A systematic review and meta-analysis
Keywords: SNP; single nucleotide polymorphism; HOTAIR; HOX transcript antisense RNA; PRC2; polycomb repressive complex 2; H3K27; 27th amino acid in Histone H3; LncRNAs; long non-coding RNAs; PFS; progression-free survival; TTP; thrombotic thrombocytopenic purpura;
CCRK is a novel signalling hub exploitable in cancer immunotherapy
Keywords: 9G8; serine and arginine rich splicing factor 7; AKT; AKT serine/threonine kinase; AR; androgen receptor; ARE; androgen response element; ARG1; arginase 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and rad3-related protein; BMDC; mous
Epithelial mesenchymal transition Transcription Factor (TF): The structure, function and microRNA feedback loop
Keywords: SNAIL; Snail family transcriptional repressor; ZEB; Zinc finger E-box binding homeobox; BMP1; Bone Morphogenetic protein1; TWIST; twist family bHLH transcription factor 1; GSC; goosecoid hemeobox; TGF-β; transforming growth factor beta; NPC; nasopharynge
Histone H3 lysine 4 methyltransferase KMT2D
Keywords: KMT2D; histone-lysine N-methyltransferase 2D; H3K4; histone H3 lysine 4; H3K27; histone H3 lysine 27; H3K4me1/2/3; H3K4 mono-, di- and tri-methylation; H3K27ac; H3K27 acetylation; WRAD; WDR5, RbBP5, ASH2L, and DPY30; KO; knockout; KI; knock-in; TF; transc
The regulation of Jmjd3 upon the expression of NF-κB downstream inflammatory genes in LPS activated vascular endothelial cells
Keywords: H3K27; Jmjd3; NF-κB; Inflammation; Vascular endothelial cell;
EZH2 regulates spinal neuroinflammation in rats with neuropathic pain
Keywords: EDTA; ethylenediaminetetraacetic acid; EZH2; enhancer of zeste homolog-2; H3K27; histone H3 on K27; H3K27TM; tri-methylated H3K27; MeCP2; methyl-CpG-binding protein 2; PRC2; polycomb complex 2; pSNL; partial sciatic nerve ligation; nociception; cytokine;
Irreversible down-regulation of miR-375 in the livers of Fischer 344 rats after chronic furan exposure
Keywords: Furan; Liver cancer; Epigenetic; miRNAs; miR-375; ANT; adjacent tissue; CTGF; connective tissue growth factor; H3K9; histone 3 lysine 9; H3K27; histone 3 lysine 27; miRNAs; microRNAs; NT; normal tissue; TRT; treatment-related cholangiofibrotic tissue; YAP
Histone demethylase JMJD3 at the intersection of cellular senescence and cancer
Keywords: Cancer; Senescence; Inflammation; Aging; Jumonji; JMJD3; SASP; H3K27;
Nuclear Factor, Erythroid 2-Like 2 Regulates Expression of Type 3 Inositol 1,4,5-Trisphosphate Receptor and Calcium Signaling in Cholangiocytes
Keywords: Gene Regulation; Signal Transduction; Primary Biliary Cirrhosis; ANIT; α-napthylisothiocyanate; ATP; adenosine triphosphate; GCLC; glutamate cysteine ligase catalytic subunit; HO-1; heme oxygenase; H3K9; histone H3 lysine 9; H3K27; histone H3 lysine 27;
JMJD3 as an epigenetic regulator in development and disease
Keywords: Jumonji; Jmjd3; Utx; Histone demethylation; H3K27;
Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR
Keywords: acetyl-CoA; acetyl coenzyme A; ALARM NMR; a La assay to detect reactive molecules by nuclear magnetic resonance; Asf1; anti-silencing function 1; AZ; AstraZeneca; BME; β-mercaptoethanol; BSA; bovine serum albumin; CoA; coenzyme A; CPM; N-[4-(7-diethylami
Akt1 as a putative regulator of Hox genes
Keywords: Hox; homeobox gene; Akt; v-akt murine thymoma viral oncogene homolog; PKB; protein kinase B; PI3K; phosphatidylinositol 3-kinase; RT-PCR; reverse transcription-polymerase chain reaction; MEF; mouse embryonic fibroblast; GEO; gene expression omnibus; COBRA
Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer
Keywords: cDNA; complementary DNA; EGFR; epidermal growth factor receptor; EMT; epithelial-mesenchymal transition; DMEM; Dulbecco's modified Eagle's medium; EV cells; empty vector transfected cells; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; H3K27; histon
Synthetic trimethyllysine receptors that bind histone 3, trimethyllysine 27 (H3K27me3) and disrupt its interaction with the epigenetic reader protein CBX7
Keywords: CBX7; chromobox homolog 7; H3K27; histone H3 lysine 27; H3K27me3; histone H3 lysine 27 trimethylated; Post-translational modifications; Methylation; Epigenetics; Protein-protein interactions; Supramolecular chemistry; Calixarenes;
Global histone modification of H3K27 correlates with the outcomes in patients with metachronous liver metastasis of colorectal cancer
Keywords: Histone modification; Prognostic factor; Liver metastasis; H3K27; H3K36; EZH2
A687V EZH2 is a gain-of-function mutation found in lymphoma patients
Keywords: DLBCL; diffuse large B-cell lymphoma; CPM; counts per minute; GCB; germinal Center B-cell-like; H3K27; histone H3 lysine 27; NHL; non-Hogdkin lymphoma; PKMT; protein lysine methyltransferase; PRC2; Polycomb Repressive Complex 2; SAM; S-adenosylmethionine;
Enhancer of zeste homolog 2: A potential target for tumor therapy
Keywords: Enhancer of zeste homolog 2; H3K27; Methylation; Phosphorylation; Cancer therapy;
Research ArticleThe polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells
Keywords: PcG; polycomb group; PRC; polycomb repressive complex; H3K27; histone H3 at lysine 27; HCC; hepatocellular carcinoma; ED; embryonic day; EHS; Engelbreth-Holm-Swarm; OSM; oncostatin M; TNF; tumour necrosis factor; shRNA; short-hairpin RNA; ERP; enhance
Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity
Keywords: SET domain; HMTase; WHISTLE; H3K4; H3K27
Immunoglobulin locus silencing and allelic exclusion
Keywords: BCR; B-cell receptor; BRG1; brahma-related gene 1; CHIP; chromatin immunoprecipitation; D; diversity; Dnmt1; DNA (cytosine 5) methyltransferase 1; EGFP; enhanced green fluorescent protein; GL; germline; GFP; green fluorescent protein; H3K4; histone H3, ly