Keywords: 1H NMR; proton nuclear magnetic resonance; aa; acyl; ae; diacyl; ATP; adenosine triphosphate; AUC; area under the curve; CAG; trinucleotide cytosine-adenine-guanine; DI/LC-MS/MS; direct injection liquid chromatography mass spectrometry; FDR; false discove
مقالات ISI (ترجمه نشده)
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Keywords: Huntington disease; Huntingtin; Calpains; Calpastatin; Proteolytic cleavage; Aggregation; CAPN; calpain; CAST; calpastatin protein; Cast; mouse calpastatin gene; HD; Huntington disease; HDKI; HdhQ111 knock-in mice; Htt; huntingtin protein; polyQ; polyglut
Keywords: CV; Coefficient of variation; HTT; Heat tolerance test; HOTT; Heat occupational tolerance test; ICC; Intra-class correlation coefficient; LOA; Limits of agreement; TEM; Typical error of the measurement; Heat tolerance; Occupational health; Validity; Relia
Keywords: Aβ; beta-amyloid; APOE; apolipoprotein E; APP; amyloid precursor protein; AD; Alzheimer's disease; CRISPR; clustered regularly interspaced short palindromic repeats; DAT; dopamine transporter; ER; estrogen receptor; FAD; familial Alzheimer's disease;
Keywords: APP; amyloid precursor protein; CASP6; caspase-6; Co-IP; co-immunoprecipitation; CRM; cis-regulatory module; DDBJ; DNA Data Bank of Japan; EMBL; European Molecular Biology Laboratory; HD; Huntington disease; HTT; huntingtin; IPI; International Protein Ind
Keywords: AC; adenylate cyclase; Actn4; α-Actinin-4; ARF6; ADP-ribosylation factor 6; ATD; amino terminal domain; CAIN; calcineurin inhibitor protein; CaM; calmodulin; CaMKII; Ca2+/calmodulin-dependent protein kinase II; Cbln1; cerebellin 1 precursor; CC; coiled-c
Keywords: PolyQ; Polyglutamine; Htt; Huntingtin; Httex1; Htt Exon 1; HD; Huntington's disease; PulSA; Pulse Shape Analysis; i; Cells With Inclusions; ni; Cells With Diffuse Httex1; RFU; Relative Fluorescence Units; IPA; Ingenuity Pathway Analysis; FDR; False Discov
Keywords: HD; Huntington disease; Htt; Huntingtin; MSN; medium spiny neuron; S1R; sigma-1 receptor; ER; endoplasmic reticulum; YAC128; yeast artificial chromosome 128Q expansion mice; 3-PPP; R(+)-3-(3-Hydroxyphenyl)-N-propylpiperidine hydrochloride; SOC; store-oper
Keywords: BACHD; bacterial artificial chromosome mouse model of HD; HD; Huntington's disease; HTT; Huntingtin protein; Htt; huntingtin gene; ipRGCs; intrinsically photoreceptive retinal ganglion cells; KI; knock in; SCN; suprachiasmatic nucleus; UCLA; University of
Keywords: AD; Alzheimer's disease; PD; Parkinson's disease; ssNMR; solid-state NMR; α-syn; α-synuclein; β2m; β2-microglobulin; apoA-I; apolipoprotein A-I; polyQ; polyglutamine; IDP; intrinsically disordered protein; htt; huntingtin; MD; molecular dynamics; MHC
Keywords: ALS; amyotrophic lateral sclerosis; AR; androgen receptor; BDNF; brain-derived neurotrophic factor; CGRP; calcitonin gene-related peptide; ChAT; choline acetyltransferase; DAB; diaminobenzidine; DLN; dorsal nucleus; ENK; enkephalin; GFAP; glial fibrillary
Keywords: 6-OHDA; 6-hydroxydopamine; Aβ; amyloid-β; AD; Alzheimer disease; ALS; amyotrophic lateral sclerosis; APOE4; apolipoprotein E4; APP; amyloid precursor protein; ASCL1; achaete-scute family basic helix-loop-helix transcription factor 1; ATP; adenosine trip
Keywords: HTT; Huntingtin; MLF; myeloid leukemia factor; HD; Huntington's disease; Poly Q; polyglutamine; GFP; green fluorescent protein; FRAP; fluorescence recovery after photo bleaching; RFI; relative fluorescence intensity; CREB; cAMP response element-binding
Keywords: AD; Alzheimer disease; ADME; absorption, distribution, metabolism and excretion; AO; adverse outcome; AOP; adverse outcome pathway; AOP-KB; adverse outcome pathway knowledge base; BDNF; brain derived neurotrophic factor; B/H; Bradford-Hill; CI; complex I
Keywords: ABIN; A20 binding and inhibitor of NF-κB; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; Atg; autophagy-related gene; C9ORF72; chromosome 9 open reading frame 72; CC; coiled-coil; cIAP; cellular inhibitor of apoptosis protein; CYLD; cylin
Keywords: HD; Huntington's disease; CAG; cytosine-adenine-guanine; HTT; Huntingtin; TMS; Total Motor Score; UHDRS; Unified Huntington's Disease Rating Scale; TFC; Total Functional Capacity; MMSE; Mini Mental State Examination; SDMT; Symbol Digit Modality Test; TMT;
Keywords: PTE; Potentially toxic elements; LOD; limit of detection; LOQ; limit of quantification; SD; standard deviation; MLV-index; Munoo-Liisa-Vitaility index; CEC; cation exchange capacity; HTT; highest treatment temperature; Potentially toxic elements; Contamin
Keywords: HD; Huntington's disease; PolyQ; polyglutamine; FRET; fluorescence resonance energy transfer; Htt; huntingtin protein; CD; circular dichroism; FTIR; Fourier transform infrared spectroscopy; XRD; X-ray diffraction; NMR; nuclear magnetic resonance; AFM; ato
Keywords: bronchiolitis obliterans; rapamycin; regulatory B lymphocytes; mouse heterotopic tracheal transplant; FoxP3β regulatory T cells; BO; bronchiolitis obliterans; Bregs; regulatory B lymphocytes; DMSO; dimethyl sulfoxide; Foxp3; forkhead box protein 3; HTT;
Keywords: ANOVA; analysis of variance; DA; dopamine; DD; constant darkness; HD; Huntington's disease; HET; heterozygous; HOM; homozygous; HTT; human Huntingtin gene; LD; 12:12 light-dark; MAP; methamphetamine; MASCO; methamphetamine-sensitive circadian oscillator;
Keywords: Ambra1; activating molecule in Beclin1-regulated autophagy 1; Atg; autophagy-related protein; BDNF; brain-derived neurotrophic factor; BNIP3; BCL2/adenovirus E1B 19Â kDa interacting protein 3; CREB; cAMP response element-binding; DIC; dynein intermediate
Keywords: AAV4; adeno-associated virus serotype 4; BDNF; brain-derived neurotrophic factor; bFGF; fibroblast growth factor 2; BME; β-mercaptoethanol; BMP; bone morphogenetic protein; Cas9; CRISPR associated protein 9; Cla; claustrum; CN; caudate nucleus; CRISPR; c
Keywords: 24OHC; 24S-Hydroxycholesterol; 27OHC; 27-Hydroxycholesterol; ABC; ATP-binding cassette transporter; ACAT; Acyl-Coa:cholesterol acyltransferase; AD; Alzheimer disease; ApoE; Apolipoprotein E; BACHD; Bacterial artificial chromosome HD; BDNF; Brain-derived n
Keywords: Dendritic spine; Synaptic plasticity; Neurodegenerative diseases; Psychiatric disorders; Glutamate receptor; Calcium signaling; ADHD; attention deficit hypersensitive disorders; FXS; Fragile X-syndrome; CNS; central nervous system; GABA; gamma amino butyr
Keywords: ANOVA; analysis of variance; CF; cryo-fractured; CM; compression molding; DSC; differential scanning calorimetry; HAMS; high-amylose maize starch; HTT; hydrothermal treatment; NF; non-fractured; NMS; normal maize starch; RH; relative humidity; SEC; size-e
Keywords: HTT; hypothetical teaching trajectory; CS-CI; coding scheme-correspondence index; EDR; educational design research; DL; data literacy; ASS; algorithmic statistical skills; GC; graphing calculator; CN; classroom network; SLG; statistical learning goal; C
Keywords: AICAR; 5â²aminoimidazole-4-carboxyamide-ribonucleoside; AD; Alzheimer's disease; ATF-2; activating transcription factor-2; AMPK; AMP-activated protein kinase; Bnip3; BCL2/adenovirus E1B 19Â kDa interacting protein 3; BnipL/Nix; BCL2/adenovirus E1B 19Â
Keywords: AD; Alzheimer's disease; PD; Parkinson's disease; HD; Huntington's disease; CJD; Creutzfeld-Jacob disease; mAb; monoclonal antibody; scFv; single-chain Fv; VH; variable domain of the heavy chain; VL; variable domain of the light chain; VHH; variable dom
Keywords: 12; 15; BO; bronchiolitis obliterans; DAPI; 4,6-diamidine-2-phenylindole dihydrochloride; G-CSF; granulocyte colony-stimulating factor; GM-CSF; granulocyte macrophage colony-stimulating factor; H&E; hematoxylin and eosin; HPF; high-power field; HTT; heter
Keywords: Akt-GSK3β; Akt-Glycogen Synthase Kinase 3β; ALS; Amyotrophic Lateral Sclerosis; CCCP; Carbonyl cyanide m-chlorophenyl hydrazine; CMT; Charcot-Marie-Tooth; DA; Dopamine; DISC1; Disrupted In Schizophrenia 1; FEZ1; Fasciculation and Elongation Protein-
Keywords: ESC; embryonic stem cell; NSC; neural stem cell; NPC; neural progenitor cell; IF; intermediate filament; CNS; central nervous system; PNS; peripheral nervous system; RA; retinoic acid; IFA; immunofluorescence assay; HTT; huntingtin; Human embryonic stem c
Keywords: AChE; acetylcholinesterase; AD; Alzheimer's disease; AIF; apoptosis induce factor; Aβ; amyloid-beta; BBB; blood brain barrier; CA; caffeic acid; CD; circular dichroism; CGA; chlorogenic acid; CNS; central nervous system; CHOP; C/EBP Homologous Protein; E
Beta catenin is regulated by its subcellular distribution and mutant huntingtin status in Huntington's disease cell STHdhQ111/HdhQ111
Keywords: Beta catenin; Huntington's disease; MicroRNA-214; Mutant huntingtin; STHdhQ111/HdhQ111; BDNF; Brain Derived neurotrophic factor; HD; Huntington's Disease; Htt; Huntingtin (mouse); HYPK; Huntingtin Yeast Partner K; miR-214; MicroRNA-214; snRNA; Small Nucle
Pharmacological disruption of the MID1/α4 interaction reduces mutant Huntingtin levels in primary neuronal cultures
Keywords: HTT; Huntingtin; HD; Huntington's Disease; MID1; Midline 1; PP2A; Protein Phosphatase 2A; mHTT; Mutant Huntingtin; wtHTT; Wild type Huntingtin; S6K; 40S ribosomal S6 kinase; mTOR; Mammalian target of rapamycin; CGN; Cerebellar granule neurons; MAP2; Mic
Resveratrol protects neuronal-like cells expressing mutant Huntingtin from dopamine toxicity by rescuing ATG4-mediated autophagosome formation
Keywords: Huntington; Parkinson; Dopaminergic neurons; Autophagy; Anti-oxidant; Neurodegeneration; CD; Cathepsin D; DA; dopamine; E2; 17-β-Estradiol; HD; Huntington Disease; Htt; Huntingtin; LIR; LC3-interacting region; PE; PhosphatydilEthanolamin; RV; Resveratrol
Polyglutamine expansion diseases: More than simple repeats
Keywords: Neurodegenerative disease; Polyglutamine protein; Aggregation modulation; Post-translational modification; Molecular partner; Ataxin-3; APR; aggregation-prone region; αB-c; AlphaB-crystallin; AR; androgen receptor; Atx1; ataxin-1; Atx3; ataxin-3; Atn1; a
Aberrant subcellular localization of SQSTM1/p62 contributes to increased vulnerability to proteotoxic stress recovery in Huntington's disease
Keywords: ATF4; activating transcription factor 4; BSA; bovine serum albumin; CHX; cycloheximide; CQ; hydroxychloroquine; HD; Huntington's disease; HDAC6; histone deacetylase 6; Htt; huntingtin; mHtt; mutant huntingtin; Lamp1; lysosomal associated membrane protein
AOPs in hazard characterization for human health
Keywords: Mode of action; Adverse outcome pathways; Key event; Key event relationship; Weight of evidence; Quantitation; AO; adverse outcome; AOP; adverse outcome pathway; AOP-KB; adverse outcome pathway knowledge base; B/H; Bradford-Hill; EAGMST; OECD Extended Adv
A passive decay-heat removal system for an ABWR based on air cooling
Keywords: ABWR; advanced boiling water reactor; AC; air cooler; ACS; air cooling system; CFD; computational fluid dynamics; DC; direct current; DHRS; decay heat removal system; FBR; fast breeder reactor; HTT; heat transfer tube; IC; isolation condenser; LWR; light
IL-17 contributes to the pathogenesis of obliterative bronchiolitis via regulation of M1 macrophages polarization in murine heterotopic trachea transplantation models
Keywords: OB; obliterative bronchiolitis; H&E; hematoxylin-eosin; HTT; heterotopic trachea transplantation; KO; knock-out; LPS; lipopolysaccharide; WT; wild-type; BMDMs; bone marrow-derived macrophages; IL-17; Macrophages; Obliterative bronchiolitis; Trachea transp
Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
Keywords: α-SYN; alpha synuclein; β-TrCP; β-transducin repeat containing E3 ubiquitin protein ligase; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activated protein kinase; ARE; antioxidant response element; ASK1; apo
Thermal adaptation in North American cicadas (Hemiptera: Cicadidae)
Keywords: MFT; minimum flight temperature; MVT; maximum voluntary tolerance temperature; HTT; heat torpor temperature; Tb; body temperature; Temperature; Thermal responses; Cicadinae; Tibicininae;
Base-driven sunlight oxidation of silver nanoprisms for label-free visual colorimetric detection of hexahydro-1,3,5-trinitro-1,3,5-triazine explosive
Keywords: HTT; Detection; Silver nanoprisms; Colorimetry; Sunlight oxidation;
Epigallocatechin-3-gallate increases autophagy signaling in resting and unloaded plantaris muscles but selectively suppresses autophagy protein abundance in reloaded muscles of aged rats
Keywords: ATG; autophagy-related gene; Bak1; BCL2-antagonist/killer 1; Bcl-2; B-cell lymphoma 2; Bcl-XL; Bcl2-like 1; Beclin1; BCL2 interaction myosin/moesin like coiled-coil protein 1; Cdkn2A; cyclin-dependent kinase inhibitor 2A; Dapk1; death associated protein k
The metalloproteinase ADAM10: A useful therapeutic target?
Keywords: APL; Acute Promyelocytic Leukemia; ADAM; A Disintegrin And Metalloproteinase; AP2; Adaptor Protein-2; AD; Alzheimer's Disease; Aβ; Amyloid beta; APP; Amyloid Precursor Protein; ACE; Angiotensin Converting Enzyme; APRIL; A Proliferation-Inducing Ligand; B
Synaptopathic mechanisms of neurodegeneration and dementia: Insights from Huntington's disease
Keywords: 5-HT; 5-hydroxytryptamine; 7,8-DHF; 7,8-dihydroxyflavone; ACh; acetylcholine; AD; adenosine; ADL; activities of daily living; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPK; 5â²AMP-activated protein kinase; BDNF; brain-derived neurotro
Systemic study of a natural feedback loop in Huntington's disease at the onset of neurodegeneration
Keywords: Grb2; Growth factor receptor bound protein 2; Htt; Huntingtin; mHtt; mutant Huntingtin; FoxD3; Forkhead box D3; Sos-1; son of sevenless homolog 1; Gab1; Grb2 associated binding protein 1; MAPK; mitogen activated protein kinase; ERK; Extra cellular signal
DNA methylation in Huntington's disease: Implications for transgenerational effects
Keywords: HD; Huntington's disease; Htt; huntingtin; DNMT; DNA methyltransferase; HDAC; histone deacetylase; DNA methylation; Epigenetic; Transgenerational; Neurodegenerative;
Strategies for producing biochars with minimum PAH contamination
Keywords: HTT; highest treatment temperature; I.D.; inner diameter; Biochar; Pyrolysis; PAH; Pyrolysis temperature; Carrier gas; Feedstock;
Deliberate processing of carrot purées entails tailored serum pectin structures
Keywords: HG; homogalacturonan; RG; rhamnogalacturonan; GalA; galacturonic acid; HTT; high temperature treatment; LTT; low temperature treatment; HPH; high pressure homogenization; PME; pectin methyl-esterase; UA; uronic acid; MWCO; molecular weight cut off; DM; de