کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8920265 | 1643350 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
AOPs in hazard characterization for human health
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کلمات کلیدی
AOPOECDPBPKKERhttWOEMOAMIEQSAR - بزرگسال Mode of action - حالت عملQuantitative Structure Activity Relationship - رابطه فعالیت ساختاری کمیIntegrated approaches to testing and assessment - روشهای یکپارچه برای تست و ارزیابیmolecular initiating event - رویداد آغازین مولکولیKey event - رویداد کلیدیOrganisation for Economic Co-operation and Development - سازمان همکاری اقتصادی و توسعهphysiologically based pharmacokinetic models - مدل های فارماکوکینتیک مبتنی بر فیزیولوژیکadverse outcome pathway - مسیر ناخوشایندAdverse outcome - نتیجه منفیWeight of evidence - وزن شواهدAdverse Outcome Pathways - پیامدهای ناخواستهQuantitation - کمیتIATA - یاتا
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The AOP provides a convenient organizational construct as one element of broader strategies to advance more efficient and predictive integrated testing and assessment approaches. It is anticipated to increase focus on earlier key events (often measured in vitro or in non-test methods) at lower levels of biological organization by relating them to traditionally measured endpoints. Development of AOPs in an OECD program with formalized descriptions being assimilated in a publically accessible electronic knowledge base is anticipated to contribute to this advancement. These descriptions which include structured consideration of supporting qualitative weight of evidence and associated quantitation are anticipated to increase transparency in the extent of supporting data as a basis to consider potential regulatory application. A range of applications is envisaged, such as mode of action analysis and integrated assessment and testing strategies. Experience currently in application in hazard assessment for human health relates principally to priority setting for testing, due in part, to gaps in biological knowledge, lack of quantitation for dose response modelling and the need for additional development and acceptance of quantitative in vitro to in vivo extrapolation models.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Toxicology - Volume 3, April 2017, Pages 80-86
Journal: Current Opinion in Toxicology - Volume 3, April 2017, Pages 80-86
نویسندگان
M.E. (Bette) Meek,