Keywords: مسیر ناخوشایند; AOP(s); adverse outcome pathway(s); IATAs; integrated approaches to testing and assessment; KE(s); key event(s); MIE(s); molecular initiating event(s); OECD; Organization for Economic Cooperation and Development; adverse outcome pathway; in vitro toxicolo
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Keywords: مسیر ناخوشایند; Triclosan; Chicken embryo; Proteome; Adverse outcome pathway; Liver;
Keywords: مسیر ناخوشایند; Carbon nanomaterials; Systems toxicology; Mechanism of action; Toxicogenomics; Multi-omics; Adverse outcome pathway;
Keywords: مسیر ناخوشایند; Gender difference; Environmental toxicology; Mammalian; Gene expression; Risk assessment; Adverse outcome pathway; Computational biology;
Keywords: مسیر ناخوشایند; AOP; adverse outcome pathway; CERAPP; Collaborative Estrogen Receptor Activity Prediction Project; EDC; endocrine disrupting chemical; ER; estrogen receptor; HT; high-throughput; IUPAC; International Union of Pure and Applied Chemistry; InChI; Internation
Keywords: مسیر ناخوشایند; Acute inhalation toxicity; In vitro; In silico; Ex vivo; Quantitative structure-activity relationships (QSAR); Adverse outcome pathway; Aggregate exposure pathway; Dosimetry; Integrated approach to testing and assessment (IATA); Risk assessment; ADME; abs
Keywords: مسیر ناخوشایند; AO; adverse outcome; AOP; adverse outcome pathway; BMD; benchmark dose modelling; BQE; biological quality element; CA; concentration addition; CAG; cumulative assessment group; CMEP; chemical monitoring and emerging pollutants; CRA; cumulative risk assess
Keywords: مسیر ناخوشایند; Adverse outcome pathway; Chemical assessment; Human health; Environment;
Keywords: مسیر ناخوشایند; Aggregate exposure pathway; Risk assessment; Adverse outcome pathway;
Keywords: مسیر ناخوشایند; ADME; absorption, distribution, metabolism and excretion; AFND; allele frequency net database; ALT; alanine aminotransferase; AOP; adverse outcome pathway; AOP-KB; AOP knowledge base; AST; aspartate aminotransferase; BSEP; bile salt export protein; CAR; c
Keywords: مسیر ناخوشایند; ACD; Allergic Contact Dermatitis; ACN; Acetonitrile; AOP; Adverse Outcome Pathway; DCYA; Dansyl Cysteamine; GC-MS; Gas Chromatography-Mass Spectrometry; GMP; Good Manufacture Practice; IFRA; International Fragrance Association; HTS; High Throughput Sc
Keywords: مسیر ناخوشایند; Triclosan; Chicken embryo; Transcriptome; Adverse outcome pathway; Tarsus length;
Keywords: مسیر ناخوشایند; Adverse outcome pathway; Constitutive activated receptor; Transcript profiling; Liver cancer; Peroxisome proliferator-activated receptor alpha; Aryl hydrocarbon receptor; Oxidative stress; Genotoxicity; p53; Estrogen receptor; ToxPi; Key events; Molecular
Keywords: مسیر ناخوشایند; AOP; adverse outcome pathway; bactin; beta actin; dio; deiodinase; dpf; days post-fertilization; dph; days post-hatch; EDC; endocrine disrupting chemical; hpf; hours post-fertilization; HPT; hypothalamic-pituitary-thyroid; LSW; Lake Superior water; nis; s
Keywords: مسیر ناخوشایند; AE_Tani; atom environment and Hellinger distance approach; AHR; aryl hydrocarbon receptor; AOP; Adverse Outcome Pathway; AO; adverse outcome; AP_Tani; atom pair and Tanimoto similarity approach; ER; estrogen receptor; GR; glucocorticoid receptor; MAD; med
Keywords: مسیر ناخوشایند; Teratology; Developmental toxicity; Safety assessment; In vitro; In silico; Non-mammalian; Adverse outcome pathway; Virtual embryo;
Keywords: مسیر ناخوشایند; Non-animal methods; Data integration; Defined approaches; Information sources; Data interpretation procedure; Adverse outcome pathway; Key event;
Keywords: مسیر ناخوشایند; AOP; Nanoparticle; Key Event; Liver toxicity; Inflammation; AO; adverse outcome; AOP; Adverse Outcome Pathway; CNTs; carbon nanotubes; H2O2; hydrogen peroxide; IATA; Integrated Approaches to Testing and Assessment; ILSI-RSI; International Life Sciences Ri
Keywords: مسیر ناخوشایند; AC50; half-maximal activity concentration; AOP; Adverse Outcome Pathway; AggE; Aggregate Entropy; EZ; embryonic zebrafish; HTS; high-throughput screening; Hpf; hours post fertilization; LD50; 50% lethal dose; MoA; mechanisms of action; POD; point of depar
Keywords: مسیر ناخوشایند; Retinoic acid; Embryogenesis; Teratogen; Morphogen; Biomarker; Embryotoxicity; Homeostasis; Synthesis; Metabolism; AER; apical ectodermal ridge; AOP; adverse outcome pathway; Bmp; bone morphogenic protein; Col; collagen; CRABP; cellular retinoic acid bind
Keywords: مسیر ناخوشایند; A; alanine; AOP; adverse outcome pathway; C; cysteine; Cys; cysteine; DNCB; 2,4-Dinotrochlorobenzene; DPRA; direct peptide reactivity assay; EGDMA; Ethylene glycol dimethacrylate; F; phenylalanine; FN; false negative; FP; false positive; GHS; Global harmo
Keywords: مسیر ناخوشایند; CRA; cumulative risk assessment; DAG; directed acyclic graphs; CAFO; concentrated animal feeding operation; SES; socioeconomic status; MOA; mode of action; AOP; adverse outcome pathway; WOE; weight of evidence; NRC; National Research Council; USEPA; U.S.
Keywords: مسیر ناخوشایند; Epigenetics; Epigenomic modifications; Risk assessment; Environmental; Mechanisms; Adverse outcome pathway;
Keywords: مسیر ناخوشایند; Adverse outcome pathway; Honey bee; Nicotinic acetylcholine receptor activation; Colony loss; Neonicotinoids; Network;
Keywords: مسیر ناخوشایند; AOP; adverse outcome pathway; dpf; days post fertilization; dpi; days post injection; fc; fold change; GEO; gene expression omnibus; GFP; green fluorescent protein; MPEG; macrophage expressed gene; MPX; myeloperoxidase; OECD; organization for economic co-
Keywords: مسیر ناخوشایند; Flame retardants; Bird; In vivo; In vitro; Adverse outcome pathway; Toxic effects;
Keywords: مسیر ناخوشایند; Endocrine disrupting properties; Weight of evidence; Mode of action; Adverse outcome pathway;
Keywords: مسیر ناخوشایند; AD; Alzheimer disease; ADME; absorption, distribution, metabolism and excretion; AO; adverse outcome; AOP; adverse outcome pathway; AOP-KB; adverse outcome pathway knowledge base; BDNF; brain derived neurotrophic factor; B/H; Bradford-Hill; CI; complex I
Keywords: مسیر ناخوشایند; 3T3 NRU PT; 3T3 neutral red uptake phototoxicity testing; AOP; Adverse Outcome Pathway; DMSO; dimethyl sulfoxide; ICH; International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use; IFRA; Internation
Keywords: مسیر ناخوشایند; Androgen receptor; Antagonist; Flutamide; Fish; Reproduction; Adverse outcome pathway;
Keywords: مسیر ناخوشایند; Chlordecone; Chinese rare minnow (Gobiocypris rarus); Endocrine disruption; Adverse outcome pathway (AOP); AOP; Adverse Outcome Pathway; MIE; Molecular Initiating Event; KE; Key Event; AO; Adverse Outcome; T; Testosterone; E2; Estradiol; ER; Estrogen Rece
Keywords: مسیر ناخوشایند; Respiratory sensitization; Framework; Workshop report; Sensitization; In vivo; In vitro; Hazard identification; Tiered approach; Skin; Inhalation; AOP; adverse outcome pathway; APC; Antigen Presenting Cell; BAL; bronchoalveolar lavage; CLP; Classified,
Keywords: مسیر ناخوشایند; AOP; adverse outcome pathway; BMD; benchmark dose; BMDS; Benchmark Dose Software; BMDL; 95% lower confidence limit on the benchmark dose; BMR; benchmark response; CHD; congenital heart defects; CI; confidence interval; DCA; dichloroacetic acid; IRIS; Inte
Keywords: مسیر ناخوشایند; Adverse outcome pathway; Weight of evidence; Quantitative AOP; Molecular initiating event; Mode of action; Key event relationships; Bradford Hill criteria;
Keywords: مسیر ناخوشایند; Development; Adverse outcome pathway; Fathead minnow; Endocrine disruption;
Keywords: مسیر ناخوشایند; Air pollution; Criteria pollutants; Multipollutant; Adverse outcome pathway;
Keywords: مسیر ناخوشایند; Marine mussel; Fluoxetine; Propranolol; Bioaccumulation; Biomarkers; Lysosomal responses; Drug-drug interaction; Adverse outcome pathway;
Keywords: مسیر ناخوشایند; 5α-R; 5α-reductase type 2; ADME; absorption, distribution, metabolism and excretion; AG; andrographolide; AGD; anogenital distance; AOP; adverse outcome pathway; AR; androgen receptor; BPAD; biological pathway altering dose; CHH; congenital hypogonadotr
Keywords: مسیر ناخوشایند; Adverse outcome pathway; Biomarker; Omics; Environmental risk assessment; Aquatic organisms; Interspecific difference
Keywords: مسیر ناخوشایند; Adverse outcome pathway; Aryl hydrocarbon receptor; Liver tumor promotion; Mode of action;
Keywords: مسیر ناخوشایند; δ-ALA; delta aminolevulinic acid; ALAD; aminolevulinic acid dehydratase; AOP; adverse outcome pathway; BW; body weight; CASAC; Clean Air Scientific Advisory Committee; DNA; deoxyribonucleic acid; EPA; Environmental Protection Agency; FSH; follicle stimul
Keywords: مسیر ناخوشایند; Adverse outcome pathway; Weight of evidence; Mode of action; Bradford-Hill considerations;
Keywords: مسیر ناخوشایند; Sensitisation of the respiratory tract; Respiratory allergy; Occupational asthma; Adverse outcome pathway
Keywords: مسیر ناخوشایند; Skin sensitization; Integrated testing strategy; Keratinocytes; Allergic contact dermatitis; Animal-free testing; LLNA; QSAR; DPRA; Adverse outcome pathway;
Keywords: مسیر ناخوشایند; Category approach; Repeated-dose toxicity; Testicular toxicity; Methoxyacetic acid; Adverse outcome pathway;
Keywords: مسیر ناخوشایند; Marine mussel; Fluoxetine; Mode of action; cAMP signaling; Biomarkers; Adverse outcome pathway;
Keywords: مسیر ناخوشایند; AOP; Adverse Outcome Pathway; AER; apical ectodermal ridge; DAPI; 4â²6-diamidino-2-phenolindole; dpf; days post fertilization; DMSO; dimethyl sulfoxide; GFP; enhanced green fluorescent protein; EGFR; Epidermal Growth Factor Receptor; hpf; hours post fert
Keywords: مسیر ناخوشایند; Category approach; Repeated-dose toxicity; Allyl ester; Hepatotoxicity; Adverse outcome pathway;
Keywords: مسیر ناخوشایند; ACD; allergic contact dermatitis; AOP; adverse outcome pathway; ECHA; European Chemicals Agency; GHS; globally harmonized system of classification and labeling of chemicals; LLNA; local lymph node assay; LMW; low molecular weight; OECD; Organisation for E
Mechanism-informed read-across assessment of skin sensitizers based on SkinSensDB
Keywords: مسیر ناخوشایند; Adverse outcome pathway; Skin sensitizer; Read-across; SkinSensDB;