کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8920184 1643344 2018 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The adverse outcome pathway: A multifaceted framework supporting 21st century toxicology
ترجمه فارسی عنوان
مسیر ناخواسته: یک چارچوب چند منظوره از سم شناسی قرن بیست و یکم
کلمات کلیدی
مسیر معکوس، ارزیابی شیمیایی، سلامتی انسان، محیط،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
The adverse outcome pathway (AOP) framework serves as a knowledge assembly, interpretation, and communication tool designed to support the translation of pathway-specific mechanistic data into responses relevant to assessing and managing risks of chemicals to human health and the environment. As such, AOPs facilitate the use of data streams often not employed by risk assessors, including information from in silico models, in vitro assays and short-term in vivo tests with molecular/biochemical endpoints. This translational capability can increase the capacity and efficiency of safety assessments both for single chemicals and chemical mixtures. Our mini-review describes the conceptual basis of the AOP framework and aspects of its current status relative to use by toxicologists and risk assessors, including four illustrative applications of the framework to diverse assessment scenarios.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Toxicology - Volume 9, June 2018, Pages 1-7
نویسندگان
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