کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5562506 | 1562699 | 2018 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chemical stability and in chemico reactivity of 24 fragrance ingredients of concern for skin sensitization risk assessment
ترجمه فارسی عنوان
پایداری شیمیایی و در واکنش شیمیایی 24 عطر از مواد مورد نیاز برای ارزیابی خطر حساسیت پوست
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کلمات کلیدی
HTSMIEACDGMPPOVACNAOPGC–MS - GC-MSiFRa - IFRAPeroxide value - ارزش پراکسیدAcetonitrile - استونیتریلSkin sensitization - حساسیت پوستAllergic contact dermatitis - درماتیت تماس آلرژیکmolecular initiating event - رویداد آغازین مولکولیReactivity index - شاخص واکنش پذیریgas chromatography–mass spectrometry - طیف سنجی جرم کروماتوگرافی گازhigh throughput screening - غربالگری بالاadverse outcome pathway - مسیر ناخوشایندStability studies - مطالعات پایداریFragrance ingredients - مواد تشکیل دهنده عطر
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Twenty-four pure fragrance ingredients have been identified as potential concern for skin sensitization. Several of these compounds are chemically unstable and convert into reactive species upon exposure to air or light. In the present work, a systematic investigation of the correlation between chemical stability and reactivity has been undertaken. The compounds were subjected to forced photodegradation for three months and the chemical changes were studied with GC-MS. At the end of the stability study, two-thirds of the samples were found to be unstable. The generation of chemically reactive species was investigated using the in chemico HTS-DCYA assay. Eleven and fourteen compounds were chemically reactive before and after three months, respectively. A significant increase in reactivity upon degradation was found for isoeugenol, linalool, limonene, lyral, citronellol and geraniol; in the same conditions, the reactivity of hydroxycitronellal decreased. The non-reactive compounds α-isomethyl ionone, benzyl alcohol, amyl cinnamal and farnesol became reactive after photo-oxidative degradation. Overall, forced degradation resulted in four non-reactive fragrance compounds to display in chemico thiol reactivity, while ten out of 24 compounds remained inactive. Chemical degradation does not necessarily occur with generation of reactive species. Non-chemical activation may be involved for the 10 stable unreactive compounds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 46, February 2018, Pages 237-245
Journal: Toxicology in Vitro - Volume 46, February 2018, Pages 237-245
نویسندگان
Cristina Avonto, Mei Wang, Amar G. Chittiboyina, Stanislav Vukmanovic, Ikhlas A. Khan,