دانلود مقالات ISI درباره مسیر ناخوشایند + ترجمه فارسی

Toward an adverse outcome pathway for impaired growth: Mitochondrial dysfunction impairs growth in early life stages of the fathead minnow (Pimephales promelas)

Keywords: مسیر ناخوشایند; 2,4-dinitrophenol and octylamine; Mitochondrial dysfunction; Growth; Fish early life stages; ATP production; Adverse outcome pathway;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction

Keywords: مسیر ناخوشایند; VPA; valproic acid; PHH; primary human hepatocytes; HDAC; histone deacetylase; AOP; adverse outcome pathway; MeDIP; Methylated DNA Immunoprecipitation; PSW-ANOVA; Probe Sliding Window-ANOVA; DMR; differential methylated regions; DMG; differentially methyl

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Linking mode of action of the model respiratory and photosynthesis uncoupler 3,5-dichlorophenol to adverse outcomes in Lemna minor

Keywords: مسیر ناخوشایند; Lemna minor; 3,5-dichlorophenol; Reactive oxygen species; Growth; PSII; Lipid peroxidation; Oxidative phosphorylation; Mode of action; Adverse outcome pathway;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Assessing the impact of benzo[a]pyrene with the in vitro fish gut model: An integrated approach for eco-genotoxicological studies

Keywords: مسیر ناخوشایند; NF; naphthoflavone; 3Rs; Replace, Reduce, Refine; ADME; Adsorption, Distribution, Metabolism and Excretion; AHR; Aryl hydrocarbon receptor; AOP; Adverse Outcome Pathway; APH; Acid phosphatase; B[a]P; Benzo[a]pyrene; DMSO; Dimethyl sulfoxide; ECVAM; Europe

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Minimum datasets to establish a CAR-mediated mode of action for rodent liver tumors

Keywords: مسیر ناخوشایند; CAR; Constitutive androstane receptor; Nitrapyrin; Metofluthrin; Rodent; Liver; Tumor; Mode of action; Minimal dataset; AOP; Adverse Outcome Pathway; AE; associative events; BrdU; 5-bromo-2′-deoxyuridine; BROD; benzyloxyresorufin-O-debenzylation; BQ; be

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2018 سفارش ترجمه

Regulatory identification of BPA as an endocrine disruptor: Context and methodology

Keywords: مسیر ناخوشایند; Bisphenol A; Endocrine disruption; ED; SVHC; Substance of very high concern; REACh; ANSES; Agence Nationale de Sécurité Sanitaire de l'alimentation, de l'environnement et du travail (French Agency for Food, Environmental and Occupational Health & Sa

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2018 سفارش ترجمه

Intra- and inter-laboratory reproducibility and predictivity of the HaCaSens assay: A skin sensitization test using human keratinocytes, HaCaT

Keywords: مسیر ناخوشایند; Skin sensitization; Adverse outcome pathway; Keratinocytes; Validation; Alternative method; HaCaSens;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

A strategy for systemic toxicity assessment based on non-animal approaches: The Cosmetics Europe Long Range Science Strategy programme

Keywords: مسیر ناخوشایند; ADME; absorption, distribution, metabolism, elimination; AOP; adverse outcome pathway; EFSA; European Food and Safety Agency; EURL ECVAM; European Union Reference Laboratory for Alternatives to Animal Testing; FDA; US Food and Drug Administration; IATA; I

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2018 سفارش ترجمه

An AOP-based alternative testing strategy to predict the impact of thyroid hormone disruption on swim bladder inflation in zebrafish

Keywords: مسیر ناخوشایند; Thyroid hormone disruption; Deiodinase inhibition assay; Zebrafish embryo; Swim bladder inflation; Adverse outcome pathway;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

Evidence-based adverse outcome pathway approach for the identification of BPA as en endocrine disruptor in relation to its effect on the estrous cycle

Keywords: مسیر ناخوشایند; Bisphenol A; Endocrine disruption; Female reproduction; Estrogen; ↑; increase; ↓; decrease; 2G; 2-generation study; 3G; 3-generation study; ANSES; Agence Nationale de Sécurité Sanitaire de l'alimentation, de l'environnement et du travail, (French Ag

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

In vitro to in vivo extrapolation for high throughput prioritization and decision making

Keywords: مسیر ناخوشایند; ADME; chemical absorption, distribution, metabolism, and excretion; AOP; adverse outcome pathway; fu; fraction of chemical unbound; HTS; high throughput screening; IVIVE; in vitro to in vivo extrapolation; PBPK; physiologically based pharmacokinetic; QSAR

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

Human-based systems: Mechanistic NASH modelling just around the corner?

Keywords: مسیر ناخوشایند; Elafibranor (PubChem CID: 9864881); Obeticholic acid (PubChem CID: 447715); Pioglitazone (PubChem CID: 4829); Rosiglitazone (PubChem CID: 77999); Fenofibrate (PubChem CID: 3339); Serine (PubChem CID: 5951); ACC1; acetyl-coenzyme A carboxylase 1; AdipoR; a

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

AOP-DB: A database resource for the exploration of Adverse Outcome Pathways through integrated association networks

Keywords: مسیر ناخوشایند; Adverse Outcome Pathways (AOPs); Risk assessment; Data mining; Database; Data integration; Association networks; ACHE; acetylcholinesterase; ACh; acetylcholine; AO; Adverse Outcome; AOP; Adverse Outcome Pathway; AOP-DB; Adverse Outcome Pathway Data Base;

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2018 سفارش ترجمه

Finding synergies for 3Rs - Toxicokinetics and read-across: Report from an EPAA partners' Forum

Keywords: مسیر ناخوشایند; Physiologically-based kinetic (PBK) modelling; Hazard and risk assessment; Weight-of-evidence (WoE); Threshold of toxicological concern (TTC); In vitro to in vivo extrapolation (IVIVE); Integrated approach for testing and assessment (IATA); Absorption; Di

دانلود رایگان متن کامل مقاله ISI 68 صفحه سال انتشار : 2018 سفارش ترجمه

Evolution of clinical and environmental health applications of exhaled breath research: Review of methods and instrumentation for gas-phase, condensate, and aerosols

Keywords: مسیر ناخوشایند; Breath research; Exhaled breath condensate (EBC); Exhaled breath aerosol (EBA); Volatile organic compounds (VOCs); Analytical techniques; Biomarkers; 1D; one-dimensional; ADME; absorption, distribution, metabolism, and excretion; AOP; adverse outcome path

دانلود رایگان متن کامل مقاله ISI 70 صفحه سال انتشار : 2018 سفارش ترجمه

Development of the Adverse Outcome Pathway (AOP): Chronic binding of antagonist to N-methyl-d-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities of children

Keywords: مسیر ناخوشایند; Adverse Outcome Pathway; Regulatory Toxicology; Developmental Neurotoxicity;

دانلود رایگان متن کامل مقاله ISI 76 صفحه سال انتشار : 2018 سفارش ترجمه

AOPs in hazard characterization for human health

Keywords: مسیر ناخوشایند; Mode of action; Adverse outcome pathways; Key event; Key event relationship; Weight of evidence; Quantitation; AO; adverse outcome; AOP; adverse outcome pathway; AOP-KB; adverse outcome pathway knowledge base; B/H; Bradford-Hill; EAGMST; OECD Extended Adv

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Assessment of skin sensitization under REACH: A case report on vehicle choice in the LLNA and its crucial role preventing false positive results

Keywords: مسیر ناخوشایند; Adverse Outcome Pathway; AOO; Local Lymph Node Assay; Skin sensitization; Test substance stability in the vehicle; False positive results; BrdU-ELISA;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Prior knowledge-based approach for associating contaminants with biological effects: A case study in the St. Croix River basin, MN, WI, USA

Keywords: مسیر ناخوشایند; Contaminants; Chemical mixtures; Chemical-gene interactions; Comparative toxicogenomics database; Adverse outcome pathway;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

QSAR development and profiling of 72,524 REACH substances for PXR activation and CYP3A4 induction

Keywords: مسیر ناخوشایند; AD; applicability domain; AOP; adverse outcome pathway; CYP; cytochrome P450; CYP3A4; human cytochrome P450 isoform 3A4; DTU; Technical University of Denmark; Food; National Food Institute; hPXR; full-length human Pregnane X Receptor; hPXR-LBD; human Preg

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

QSAR models for thyroperoxidase inhibition and screening of U.S. and EU chemical inventories

Keywords: مسیر ناخوشایند; QSAR; Thyroperoxidase (TPO) inhibition; Adverse Outcome Pathway (AOP); Screening; BHA; REACH; AD; applicability domain; AOP; adverse outcome pathway; AUR; Amplex®UltraRed; BHA; butylated hydroxyanisole; DNT; developmental neurotoxicity; DTU Food; Technic

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

The challenge of the application of 'omics technologies in chemicals risk assessment: Background and outlook

Keywords: مسیر ناخوشایند; Omics; Transcriptomics; Weight-of-evidence; Registration, Evaluation, Authorisation, and Restriction (REACH); Plant protection products; Regulatory toxicology; Hazard assessment; Test method validation; Test method standardisation; AOP; Adverse outcome pa

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

The application of molecular modelling in the safety assessment of chemicals: A case study on ligand-dependent PPARγ dysregulation

Keywords: مسیر ناخوشایند; ADMET; absorption, distribution, metabolism, excretion and toxicity; AOP; adverse outcome pathway; BHK21 ATCC CCL10; baby hamster kidney cell line from the American Type Culture Collection; CAS; chemical abstracts service; CoMSIA; comparative molecular si

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

An in vitro skin sensitization assay termed EpiSensA for broad sets of chemicals including lipophilic chemicals and pre/pro-haptens

Keywords: مسیر ناخوشایند; ACD; allergic contact dermatitis; AOO; acetone:olive oil = 4:1; AOP; Adverse Outcome Pathway; ARE; antioxidant response element; ATF3; activating transcription factor 3; BKC; benzalkonium chloride; DCs; dendritic cells; DMSO; dimethyl sulfoxide; DNAJB4;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Nrf2 pathway activation upon rotenone treatment in human iPSC-derived neural stem cells undergoing differentiation towards neurons and astrocytes

Keywords: مسیر ناخوشایند; Neural stem cells; Rotenone; Nrf2 pathway; Astrocyte; Dopaminergic neurons; Neurite length; Neurotoxicity; AOP; Adverse Outcome Pathway; ARE; Antioxidant-Responsive-Element; DA; Dopaminergic; DIV; days in vitro; GABA; Gamma-Aminobutyric Acid; GABRA1; Gam

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Chemical photoallergy: photobiochemical mechanisms, classification, and risk assessments

Keywords: مسیر ناخوشایند; 3T3 NRU PT; 3T3 neutral red uptake phototoxicity testing; AOP; adverse outcome pathway; DEREK; deductive estimation of risk from existing knowledge; HOMO-LUMO gap; energy gap between the highest occupied molecular orbital and the lowest unoccupied molecul

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2017 سفارش ترجمه

Comparison and validation of an in vitro skin sensitization strategy using a data set of 33 chemical references

Keywords: مسیر ناخوشایند; Ac; Acylating agents; ACD; Allergic Contact Dermatitis; AOP; Adverse Outcome Pathway; ARE; Antioxidant Response Element; DC; dendritic cell; DMSO; dimethyl sulfoxide; DNCB; dinitrochlorobenzene; DPRA; Direct Peptide Reactivity Assay; ECVAM; European Centr

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop

Keywords: مسیر ناخوشایند; Regulatory toxicology; Transcriptomics; Metabolomics; Good laboratory practice (GLP); Weight-of-evidence (WoE); Adverse outcome pathway (AOP); Mode-of-action (MoA); Gene expression; Differentially expressed genes; ANOVA; Analysis of variance; AOP; Adverse

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

An AOP analysis of selective serotonin reuptake inhibitors (SSRIs) for fish

Keywords: مسیر ناخوشایند; Adverse Outcome Pathway; Antidepressant; Read-Across Hypothesis; Behavior; Physiology; 5-HT; Transport; Fluoxetine; Sertraline; Aquatic; Vertebrates; Fish; SERT;

دانلود رایگان متن کامل مقاله ISI 52 صفحه سال انتشار : 2017 سفارش ترجمه

Predicting skin sensitisation using a decision tree integrated testing strategy with an in silico model and in chemico/in vitro assays

Keywords: مسیر ناخوشایند; Skin sensitisation; Derek Nexus; DPRA; KeratinoSens; LuSens; h-CLAT; U-SENS; Integrated testing strategy; In silico assessment; ACD; allergic contact dermatitis; AOP; adverse outcome pathway; CLP; classification labelling and packaging; DC; dendritic cell

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Can currently available non-animal methods detect pre and pro-haptens relevant for skin sensitization?

Keywords: مسیر ناخوشایند; Adverse Outcome Pathway; Skin sensitization; Pre-hapten; Pro-hapten; DPRA; h-CLAT; KeratinoSens™; Reaction mechanistic domain;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Impaired anterior swim bladder inflation following exposure to the thyroid peroxidase inhibitor 2-mercaptobenzothiazole part II: Zebrafish

Keywords: مسیر ناخوشایند; Thyroid disruption; 2-Mercaptobenzothiazole; Zebrafish embryo; Swim bladder inflation; Fish early-life stage; Adverse outcome pathway

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Relevance of the rat lung tumor response to particle overload for human risk assessment-Update and interpretation of new data since ILSI 2000

Keywords: مسیر ناخوشایند; Particle overload; Species differences; Adverse outcome pathway; Poorly soluble particles; Nonhuman primates; Rats;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2016 سفارش ترجمه

Case studies putting the decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping) into practice

Keywords: مسیر ناخوشایند; Carbonaceous nanomaterials; Metal oxide and metal sulphate nanomaterials; Amorphous silica nanomaterials; Organic pigments; Grouping; Read-across; Intrinsic material and system-dependent properties; Biopersistence and biodistribution; Cellular effects; Ap

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2016 سفارش ترجمه

Molecular initiating events of the intersex phenotype: Low-dose exposure to 17α-ethinylestradiol rapidly regulates molecular networks associated with gonad differentiation in the adult fathead minnow testis

Keywords: مسیر ناخوشایند; Subnetwork enrichment analysis; Sperm maturation; Adverse outcome pathway; Doublesex and mab-3 related transcription factor 1; Forkhead box L2;

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2016 سفارش ترجمه

The potential of AOP networks for reproductive and developmental toxicity assay development

Keywords: مسیر ناخوشایند; Adverse outcome pathway; AOP network; Assay development; Reproduction; Embryonic and larval development;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Aligning the 3Rs with new paradigms in the safety assessment of chemicals

Keywords: مسیر ناخوشایند; 3Rs; replacement, refinement and reduction of animals in research; AOP; adverse outcome pathway; EURL-ECVAM; European Union Reference Laboratory for Alternatives to Animal Testing; ICCVAM; Interagency Coordinating Committee on the Validation of Alternativ

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

A systems toxicology approach on the mechanism of uptake and toxicity of MWCNT in Caenorhabditis elegans

Keywords: مسیر ناخوشایند; Multiwall carbon nanotubes; Caenorhabditis elegans; Phagocytosis; Adverse outcome pathway; Systems toxicology;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Functional genomic screening approaches in mechanistic toxicology and potential future applications of CRISPR-Cas9

Keywords: مسیر ناخوشایند; 3-BrPA; 3 bromopyruvate; AOP; adverse outcome pathway; ARF4; ADP-ribosylation factor 4; BFA; brefeldin A; BT; 1,2,4-benzenetriol; CML; chronic myeloid leukemia; COSMID; CRISPR off-target sites with mismatches, insertions, and deletions; CRISPR-Cas9; clust

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

A decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping)

Keywords: مسیر ناخوشایند; AOP; adverse outcome pathway; APPIE; Association of Powder Process Industry; ASTM; American Society for Testing and Materials; ATP; adenosine triphosphate; BAM; German Federal Institute for Materials Research and Testing; BAuA; German Federal Institute fo

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2015 سفارش ترجمه

Applying the skin sensitisation adverse outcome pathway (AOP) to quantitative risk assessment

Keywords: مسیر ناخوشایند; Skin sensitisation; Adverse outcome pathway; Risk assessment; Mathematical modelling;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Bisphenol A-Why an adverse outcome pathway framework needs to be applied

Keywords: مسیر ناخوشایند; Bisphenol A; Human health risk assessment; Membrane-bound estrogen receptor; Adverse outcome pathway;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Benzo[a]pyrene modulates the biotransformation, DNA damage and cortisol level of red sea bream challenged with lipopolysaccharide

Keywords: مسیر ناخوشایند; Benzo[a]pyrene; DNA damage; EROD activity; Cytochrome P4501A1; Adverse outcome pathway;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Effects of BDE-209 contaminated sediments on zebrafish development and potential implications to human health

Keywords: مسیر ناخوشایند; AChE; acetylcholinesterase; AhR; aryl hydrocarbon receptor; AOP; adverse outcome pathway; BDE-209; decabromodiphenyl ether; CPF; chlorpyrifos; Dpf; days post-fertilization; DEGs; differentially expressed genes; GC-NICI-MS; gas chromatography coupled to

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors

Keywords: مسیر ناخوشایند; AOP; adverse outcome pathway; hCAR; human constitutive androstane receptor; mCAR; mouse constitutive androstane receptor; rCAR; rat constitutive androstane receptor; cDNA; complementary DNA; CITCO; 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldeh

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه