کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8551911 | 1562112 | 2017 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The challenge of the application of 'omics technologies in chemicals risk assessment: Background and outlook
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کلمات کلیدی
DNELGHSDMELOmicsECETOCECHAGLPMIEMOAIPCsCeficC&LEuropean Chemical Industry CouncilMADOECDEURL ECVAMNRCAOPTRFCLPCEBSqRT-PCRPHEWOEPODLRIITSEuropean Union Reference Laboratory for Alternatives to Animal Testing - آزمایشگاه مرجع اتحادیه اروپا برای جایگزینی برای تست حیواناتEuropean Chemicals Agency - آژانس مواد شیمیایی اروپاHazard assessment - ارزیابی خطرIntegrated testing strategy - استراتژی تست یکپارچهInternational Programme on Chemical Safety - برنامه بین المللی ایمنی مواد شیمیاییPublic Health England - بهداشت عمومی انگلستانGood Laboratory Practice - تمرین خوب آزمایشگاهیMode-of-action - حالت عملtest guideline - دستورالعمل آزمونREACH - رسیدنmolecular initiating event - رویداد آغازین مولکولیWorld Health Organisation - سازمان بهداشت جهانیDerived No Effect Level - سطح متوالی بدون اثرRegulatory toxicology - سم شناسی مقرراتیDEG - شماNational Research Council - شورای تحقیقات ملیclassification and labelling - طبقه بندی و برچسب گذاریMIAME - مامانTranscriptomics - متن ترانهPlant protection products - محصولات گیاهان داروییadverse outcome pathway - مسیر ناخوشایندWeight-of-evidence - وزن شواهدDifferentially expressed gene - ژن بیان شده متفاوت استWHO - کهIATA - یاتا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
This survey by the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) highlights that 'omics technologies are generally not yet applied to meet standard information requirements during regulatory hazard assessment. While they are used within weight-of-evidence approaches to investigate substances' modes-of-action, consistent approaches for the generation, processing and interpretation of 'omics data are not applied. To date, no 'omics technology has been standardised or validated. Best practices for performing 'omics studies for regulatory purposes (e.g., microarrays for transcriptome profiling) remain to be established. Therefore, three frameworks for (i) establishing a Good-Laboratory Practice-like context for collecting, storing and curating 'omics data; (ii) 'omics data processing; and (iii) quantitative WoE approaches to interpret 'omics data have been developed, that are presented in this journal supplement. Application of the frameworks will enable between-study comparison of results, which will facilitate the regulatory applicability of 'omics data. The frameworks do not constitute prescriptive protocols precluding any other data analysis method, but provide a baseline for analysis that can be applied to all data allowing ready cross-comparison. Data analysis that does not follow the frameworks can be justified and the resulting data can be compared with the Framework-based common analysis output.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 91, Supplement 1, December 2017, Pages S14-S26
Journal: Regulatory Toxicology and Pharmacology - Volume 91, Supplement 1, December 2017, Pages S14-S26
نویسندگان
Ursula G. Sauer, Lize Deferme, Laura Gribaldo, Jörg Hackermüller, Tewes Tralau, Ben van Ravenzwaay, Carole Yauk, Alan Poole, Weida Tong, Timothy W. Gant,