Keywords: Neonicotinoids; Aldehyde Oxidase; DNA damage; Oxidative stress; Telomerase; IMI; imidacloprid; IMIâ¯+â¯NH; desnitro-imidacloprid; CBMN; cytokinesis block micronucleus assay; BNMN; binucleated cells with micronucleus; CBPI; cytokinesis block proliferatio
مقالات ISI (ترجمه نشده)
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Keywords: CVD; cardiovascular disease; FA; fatty acid; ECHA; trifunctional enzyme subunit alpha; ECHB; trifunctional enzyme subunit beta; THIM; 3-ketoacyl-CoA thiolase; ER; estrogen receptor; PPARA; peroxisome proliferator-activated receptor alpha; PRGC1; peroxisom
Keywords: ANSES; Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (French Agency for Food, Environmental and Occupational Health & Safety); CRO; contract research organization; CV; coefficient of variation; DART; deve
Keywords: Microbial based cleaning products; MBCPs; Microbial cleaner; Probiotic cleaner; Risk assessment; Safety assessment; Risk management; Ecolabelling; BEUC; Bureau Européen des Unions de Consommateurs CCPSA; Canada Consumer Product Safety Act; CEPA; Canadian
Keywords: Steaming; Seafood; Toxic elements; PFCs; PAHs; Musk fragrances and UV-Filters; 4-MBC; 3-(4-Methylbenzylidene)camphor; AHTN; 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene; ANOVA; analysis of variance; AsV; arsenic V; BaP; benzo(a)pyrene; BM
Keywords: Health risk assessment; Air freshener consumer products; Inhalation and dermal hazard; Fragrance ingredients; Tiered 1 and 2 risk assessment; IAQ; indoor air quality; KME; Korean Ministry of Environment; KNLIC; Korean National Law Information Center; SCCN
Keywords: Risk assessment; NOAEL; Benchmark dose; ECHA; ATSDR; 28-day to 90-day extrapolation; Study duration; Point of departure;
Keywords: ADME; Absorption, Distribution, Metabolism, Excretion; AOPs; adverse outcome pathways; AUC; Area under the Curve; AEs; assessment elements; AOs; assessment options; BMDL; benchmark dose lower bound; CAAT; Center for Alternatives to Animal Testing; Cefic-L
Keywords: mtDNA; mitochondrial DNA; ELI; Extremity Longevity Index; CR; Centenarian Rate; OECD; Organization for Economic Co-operation and Development; F/M100; female/male ratio among centenarians; ECHA; European Challenge for Healthy Ageing; GEHA; Genetics of Heal
Keywords: Classification; Hazard characterization; Risk assessment; Carcinogenicity; IARC; GHS; ACGIH; American Conference of Government Industrial Hygienists; CoC; United Kingdom Committee on Carcinogenicity; ECHA; European Chemicals Agency; EFSA; European Food Sa
Keywords: 6ACM; 6-acetylmorphine; ADI; acceptable daily intake; ALP; alprazolam; AM; amphetamine; ATC; Anatomical Therapeutic Classification; ATS; amphetamine-type stimulant; BE; benzoylecgonine; BQ; benchmark quotient; BW; body weight; CAF; caffeine; CBD; cannabid
Keywords: DNA damage; Vitotox®; In silico; ECHA database; Food contact materials; Polycarbonate replacement products; BaP; benzo[a]pyrene; BPA; bisphenol A; CLP; Classification, Labelling and Packaging; ECHA; European CHemicals Agency; 4-NQO; 4-Nitroquinoline 1-ox
Keywords: ACSA; Agricultural Chemical Safety Assessment of the ILSI HESI; ARA; Actual Regulatory Acceptance by regulatory authorities; CARACAL; Competent Authorities for REACH and GLP; CLP; classification and labelling process; CMR; Carcinogenic, Mutagenic and Repr
Keywords: AD; Applicability Domain; BOD; Biological Oxygen Demand; ECHA; European Chemicals Agency; FN; False Negative; FP; False Positive; MCC; Matthews Correlation Coefficient; (N)RB; (Non)Readily Biodegradable; OECD TG; Organisation for Economic Co-operation and
Keywords: DNEL; derived no effect level; ECHA; European Chemicals Agency; LD; lethal dose; LOAEL; lowest observed adverse effect level; MoS; margin of safety; NOAEL; no observed adverse effect level; REACH; registration, evaluation, authorization and restriction of
Keywords: C&L; Classification and Labelling; CLP; Classification and Labelling and Packaging Regulations; CMR; carcinogenicity, mutagenicity and reproductive toxicity; D/RT; developmental/reproductive toxicity; EC; European Community; ECETOC; European Centre for Ec
Keywords: CEN; European Committee for Standardization; CLP; classification, labeling and packaging of substances and mixtures regulation; RBA; relative bioavailability; ECHA; European Chemicals Agency; RBALP; relative bioaccessibility leaching procedure; REACH; Reg
Keywords: AF; assessment factor; bw; body weight; DNEL; Derived No Effect Level; ECETOC; European Centre for Ecotoxicology and Toxicology of Chemicals; ECHA; European Chemicals Agency; EFSA; European Food Safety Authority; EH; epoxide hydrolase; EPS; expanded polys
Keywords: 2D-GC; 2-dimensional gas chromatography, or GCÂ ÃÂ GC; CLP; classification, labelling and packaging of substances and mixtures (Regulation (EC) No. 1272/2008); C-range; carbon range; CSR; Chemical Safety Report; CONCAWE; Conservation of Clean Air and Wat
Keywords: BAuA; Bundesanstalt für Arbeitsschutz und Arbeitsmedizin (German NIOSH); BSI; British Standards Institution; CARACAL; Competent Authorities for REACH and CLP (EU); CEIN; Center for the Environmental Implications of Nanotechnology (University of Californi
Keywords: CAS; Chemical abstract service; CBI; Confidential business information; CLP; Classification, labelling, packaging; CMR; Carcinogenic, mutagenic, reproductive toxin; ECHA; European chemicals agency; EPA; US Environmental Protection Agency; FIFRA; US Federa
Keywords: ACD; allergic contact dermatitis; AOP; adverse outcome pathway; ECHA; European Chemicals Agency; GHS; globally harmonized system of classification and labeling of chemicals; LLNA; local lymph node assay; LMW; low molecular weight; OECD; Organisation for E
In vitro percutaneous absorption and metabolism of Bisphenol A (BPA) through fresh human skin
Keywords: BPA; Bisphenol A; BPA-gluc; BPA-glucuronide; BPA-sulf; BPA-sulfate; ECHA; European Chemicals Agency; CoRAP; substance evaluation process by ECHA; EFSA; European Food Safety Authority; EPA; U.S. Environmental Protection Agency; OECD TG; Organisation for Ec
Minimum datasets to establish a CAR-mediated mode of action for rodent liver tumors
Keywords: CAR; Constitutive androstane receptor; Nitrapyrin; Metofluthrin; Rodent; Liver; Tumor; Mode of action; Minimal dataset; AOP; Adverse Outcome Pathway; AE; associative events; BrdU; 5-bromo-2â²-deoxyuridine; BROD; benzyloxyresorufin-O-debenzylation; BQ; be
Regulatory identification of BPA as an endocrine disruptor: Context and methodology
Keywords: Bisphenol A; Endocrine disruption; ED; SVHC; Substance of very high concern; REACh; ANSES; Agence Nationale de Sécurité Sanitaire de l'alimentation, de l'environnement et du travail (French Agency for Food, Environmental and Occupational Health & Sa
Evidence-based adverse outcome pathway approach for the identification of BPA as en endocrine disruptor in relation to its effect on the estrous cycle
Keywords: Bisphenol A; Endocrine disruption; Female reproduction; Estrogen; â; increase; â; decrease; 2G; 2-generation study; 3G; 3-generation study; ANSES; Agence Nationale de Sécurité Sanitaire de l'alimentation, de l'environnement et du travail, (French Ag
Finding synergies for 3Rs - Toxicokinetics and read-across: Report from an EPAA partners' Forum
Keywords: Physiologically-based kinetic (PBK) modelling; Hazard and risk assessment; Weight-of-evidence (WoE); Threshold of toxicological concern (TTC); In vitro to in vivo extrapolation (IVIVE); Integrated approach for testing and assessment (IATA); Absorption; Di
(Q)SAR tools for priority setting: A case study with printed paper and board food contact material substances
Keywords: (Q)SAR; Mutagenicity; Prioritization; Food contact materials; Alternative methods; AD(I); applicability domain (index); ECHA; European Chemicals Agency; EFSA; European Food Safety Authority; FACET; Flavours, Additives and food Contact materials Exposure T
The challenge of the application of 'omics technologies in chemicals risk assessment: Background and outlook
Keywords: Omics; Transcriptomics; Weight-of-evidence; Registration, Evaluation, Authorisation, and Restriction (REACH); Plant protection products; Regulatory toxicology; Hazard assessment; Test method validation; Test method standardisation; AOP; Adverse outcome pa
Margin of safety for two UV filters estimated by in vitro permeation studies mimicking consumer habits: Effects of skin shaving and sunscreen reapplication
Keywords: Benzophenone-3; Ethylhexyl triazone; Shaving skin; Human exposure assessment; Systemic exposure dose; Margin of safety; AD; applied dose (sunscreen); ASA; amount of the substance applied; BP3; Benzophenone-3; CID; compound identifier; DE; dermis; EC; Euro
Are some “safer alternatives” hazardous as PBTs? The case study of new flame retardants
Keywords: AD; applicability domain; BCF; bioconcentration factor; BDBP-TAZTO; 1.3-bis(2,3-dibromopropyl)-5-allyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione; BFR; brominated flame retardants; bor AD; borderline applicability domain; BPA-BDPP; bisphenol A tetraphenyl diph
A new integrated in silico strategy for the assessment and prioritization of persistence of chemicals under REACH
Keywords: REACH; Registration, Evaluation, Authorisation and restriction of CHemicals; P; persistent; nP; non-persistent; vP; very persistent; nP/P; non-persistent/persistent; P/vP; persistent/very persistent; HL; half-lives; DT50; disappearance time 50; PBT; persi
Integrated in silico strategy for PBT assessment and prioritization under REACH
Keywords: REACH; Registration, Evaluation, Authorisation and Restriction of Chemicals; (Q)SAR; (quantitative) structure-activity relationship; ECHA; European Chemicals Agency; UBA; Umweltbundesamt; MCDM; multi-criteria decision making; WoE; weight of evidence; AD;
The JRC Nanomaterials Repository: A unique facility providing representative test materials for nanoEHS research
Keywords: Representative nanomaterials; Nanomaterials; Repository; OECD WPMN testing programme; Harmonisation of test guidelines; ECHA; European Chemicals Agency; (E)NM; (Engineered) NanoMaterial; JRC; European Commission's Joint Research Centre; nanoEHS; Nanotechn
Heavy metals (Pb, Cd, As and MeHg) as risk factors for cognitive dysfunction: A general review of metal mixture mechanism in brain
Keywords: ABCC; ATP-binding cassette; AchE; acetylcholine esterase; As; arsenic; BBB; blood brain barrier; BDNF; brain derived neuronal factor; CaM; calmodulin; CAM-K; calmodulin K; CAMKII; calmodulin-dependent protein kinase-II; CAM-II; calmodulin-II; Cd; cadmium;
Identification of potential PBT behavior of personal care products by structural approaches
Keywords: PCP; personal care products; WWTPs; wastewater treatment plants; PBT; persistent, bioaccumulative and toxic; QSAR; quantitative structure-activity relationship; OPBT; occurrent, persistent, bioaccumulative and toxic; PPCPs; pharmaceuticals and personal
Polyester monomers lack ability to bind and activate both androgenic and estrogenic receptors as determined by In Vitro and In Silico methods
Keywords: A; agonist; ANN; Artificial Neural Network; AR; androgen receptor; CART; Classification and Regression Tree; CASRN; Chemical Abstracts Service Registry Number; CHDA; 1,4-cyclohexanedicarboxylic acid; CHDM; 1,4-cyclohexanedimethanol; DEG; diethylene glycol
The 'BlueScreen HC' assay as a decision making test in the genotoxicity assessment of flavour and fragrance materials
Keywords: AIT; allyl isothiocyanate; CN; citronellyl nitrile; BSHC; BlueScreen HC; CA; chromosome aberration; CPDB; carcinogenic potency database; ECHA; European Chemicals Agency; ECVAM; European centre for the validation of alternative methods; EFSA; European food
A first European scale multimedia fate modelling of BDE-209 from 1970 to 2020
Keywords: ADV; aerosol deposition velocity; DecaBDE; decabromodiphenyl ether; E&E; electronic and electrical; EBFRIP; European brominated flame retardant industry panel; ECHA; European Chemicals Agency; EVn-BETR; European Variant Berkeley Trent; LRAT; long range at
Two novel prediction models improve predictions of skin corrosive sub-categories by test methods of OECD Test Guideline No. 431
Keywords: AUROC; area under ROC curve; Cat; sub-category of corrosive chemical in the UN GHS; ECHA; European Chemical Agency; OECD; Organisation for Economic Co-operation and Development; PM; prediction model; PMvar1; Prediction Model variation #1; PMvar2; Predicti
A decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping)
Keywords: AOP; adverse outcome pathway; APPIE; Association of Powder Process Industry; ASTM; American Society for Testing and Materials; ATP; adenosine triphosphate; BAM; German Federal Institute for Materials Research and Testing; BAuA; German Federal Institute fo
Short communicationThe National Library of Medicine's (NLM) Hazardous Substances Data Bank (HSDB): Background, recent enhancements and future plans
Keywords: ATSDR; Agency for Toxic Substances and Disease Registry; CPSC; Consumer Product Safety Commission; DEA; Drug Enforcement Agency; DHS; Department of Homeland Security; EPA; Environmental Protection Agency; ECHA; European Chemicals Agency; FDA; Food and Dru
Combining the European chemicals regulation and an (eco)toxicological screening for a safer membrane development
Keywords: REACH regulation; European chemical policy; (Eco)toxicological assessment; Polymeric membrane; CLP; Classification, Labelling and Packaging; CMR; carcinogenic, mutagenic and toxic for reproduction; DMA; N,N-Dimethylacetamide; DMSO; dimethyl sulfoxide; ECH
Optimizing the aquatic toxicity assessment under REACH through an integrated testing strategy (ITS)
Keywords: ACR; acute-to-chronic ratios; AF; assessment factor; BCF; bioconcentration factor; BOD5; 5-days biochemical oxygen demand; C&L; classification and labeling; CLP; classification, labeling and packaging; COD; chemical oxygen demand; CSA; chemical safety ass
The usefulness of the validated SkinEthic⢠RHE test method to identify skin corrosive UN GHS subcategories
Keywords: BLR; between-laboratory reproducibility; ECHA; European Chemicals Agency; ESAC; ECVAM Scientific Advisory Committee; EU; European Union; EUCLP; European Union System of Classification of Chemicals implemented in the EU Classification, Labelling and Packag
Sub-categorisation of skin corrosive chemicals by the EpiSkin⢠reconstructed human epidermis skin corrosion test method according to UN GHS: Revision of OECD Test Guideline 431
Keywords: BLR; Between-laboratory reproducibility; ECHA; European Chemicals Agency; ESAC; ECVAM Scientific Advisory Committee; EU; European Union; EU CLP; European Union System of Classification of Chemicals implemented in the EU Classification, Labelling and Packa
Selection of appropriate tumour data sets for Benchmark Dose Modelling (BMD) and derivation of a Margin of Exposure (MoE) for substances that are genotoxic and carcinogenic: Considerations of biological relevance of tumour type, data quality and uncertain
Keywords: AIC; Akaike Information Criterion; BMD; Benchmark Dose; BMDL; Lower Benchmark Dose; BMDU; Upper Benchmark Dose; BMR; Benchmark Response; COC; Committee On Carcinogenicity; ECHA; European Chemicals Agency; EFSA; European Food Safety Authority; EPA; Environ
CommentaryAssessment of reproductive toxicity under REACH
Keywords: ECHA; European Chemicals Agency; GT; German Society of Toxicology; OECD; Organisation of Economic Cooperation and Development; REACH-EU; Regulation on the Registration, Evaluation, Authorisation and Restriction of Chemicals; TG; test guideline; Test str
Decision trees for evaluating skin and respiratory sensitizing potential of chemicals in accordance with European regulations
Keywords: CLP; European Council requirements for Classification, Labeling and Packaging of substances and mixtures; EC; the concentration of chemical required to induce a 3-fold stimulation index in the local lymph node assay; ECHA; European Chemicals Agency; EPA;
Workshop ReportRegulatory assessment of in vitro skin corrosion and irritation data within the European framework: Workshop recommendations
Keywords: A.I.S.E; International Association for Soaps, Detergents and Maintenance products; BfR; German Federal Institute For Risk Assessment; Cat; category; ECHA; European Chemicals Agency; ECVAM; European Centre for the Validation of Alternative Methods; ESAC; E