کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849490 | 1561755 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Investigation of the genotoxicity of substances migrating from polycarbonate replacement baby bottles to identify chemicals of high concern
ترجمه فارسی عنوان
بررسی سمیت مواد ژنتیکی مواد مهاجرت از بطری های جایگزین پلی کربنات جایگزین برای شناسایی مواد شیمیایی مورد توجه
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کلمات کلیدی
BPACLPBAP4-NQOECHA databaseStructural alertECHA4-Nitroquinoline 1-oxide - 4-نیتریکینولین 1-اکسیدS/N - S / NDNA damage - آسیبDNAEuropean Chemicals Agency - آژانس مواد شیمیایی اروپاBenzo[a]pyrene - بنزو [a] پییرنBisphenol A - بیسفنول ای، بیسفنول ARegistration, Evaluation, Authorisation and Restriction of Chemicals - ثبت، ارزیابی، مجوز و محدودیت مواد شیمیاییIn silico - درون رایانهای، این سیلیکوREACH - رسیدنClassification, Labelling and Packaging - طبقه بندی، برچسب گذاری و بسته بندیFood contact materials - مواد تماس با مواد غذاییsignal to noise ratio - نسبت سیگنال به نویزPolycarbonate - پلی کربنات
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
چکیده انگلیسی
Due to the worldwide concern that bisphenol A might act as an endocrine disruptor, alternative materials for polycarbonate (PC) have been introduced on the European market. However, PC-replacement products might also release substances of which the toxicological profile - including their genotoxic effects - has not yet been characterized. Because a thorough characterization of the genotoxic profile of all these substances is impossible in the short term, a strategy was developed in order to prioritize those substances for which additional data are urgently needed. The strategy consisted of a decision tree using hazard information related to genotoxicity. The relevant information was obtained from the database of the European Chemicals Agency (ECHA), in silico prediction tools (ToxTree and Derek NexusTM) and the in vitro Vitotox® test for detecting DNA damage. By applying the decision tree, substances could be classified into different groups, each characterized by a different probability to induce genotoxic effects. Although none of the investigated substances could be unequivocally identified as genotoxic, the presence of genotoxic effects could neither be excluded for any of them. Consequently, all substances require more data to investigate the genotoxic potential. However, the type and the urge for these data differs among the substances.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 89, March 2016, Pages 126-137
Journal: Food and Chemical Toxicology - Volume 89, March 2016, Pages 126-137
نویسندگان
Birgit Mertens, Coraline Simon, Melissa Van Bossuyt, Matthias Onghena, Tara Vandermarken, Kersten Van Langenhove, Heidi Demaegdt, Els Van Hoeck, Joris Van Loco, Karin Vandermeiren, Adrian Covaci, Marie-Louise Scippo, Marc Elskens, Luc Verschaeve,