کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8554074 | 1562698 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro percutaneous absorption and metabolism of Bisphenol A (BPA) through fresh human skin
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کلمات کلیدی
BPAEPAPBSOECD TGUGTEFSAUDPGASULTECHA3′-phosphoadenosine-5′-phosphosulfate - 3'-فسفودوژنسی-5'-فسفسولفاتPAPs - PAP هاU.S. Environmental Protection Agency - آژانس حفاظت از محیط زیست ایالات متحدهEuropean Chemicals Agency - آژانس مواد شیمیایی اروپاEuropean Food Safety Authority - اداره ایمنی اروپاuridine 5′-diphosphoglucuronic acid - اسید یدید 5'-دی فسفوگلوکورونیکbisphenol A (BPA) - بیسفنول A (BPA)Bisphenol A - بیسفنول ای، بیسفنول ASulfatase - سولفاتازbuffered saline solution - محلول نمک بافر
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
Bisphenol A (BPA) is a high production volume compound. It is mainly used as a monomer to make polymers for various applications including food-contact materials. The primary route of exposure to BPA in the general population is through oral intake (EFSA 2015) however, other potential sources of exposure have also been identified, such as dermal contact. In the present study, the percutaneous absorption through human skin has been investigated in an in vitro study according to OECD TG 428 (Skin Absorption: In Vitro Method). In order to investigate potential dermal BPA metabolism during absorption, radiolabelled BPA was applied to fresh, metabolically competent, human skin samples (ring labelled 14C BPA concentrations tested were 2.4, 12, 60 and 300 mg/L). Measured as total radioactivity the mean absorbed dose (receptor compartment) ranged from 1.7-3.6% of the applied doses and the dermal delivery (epidermis + dermis + receptor compartment), sometimes also named bioavailable dose was 16-20% of the applied doses, with the majority of the radioactivity associated with epidermis compared to dermis and receptor fluid. No metabolism was observed in any of the epidermis samples; however some metabolism was observed in dermis and receptor fluid samples with formation of BPA-glucuronide and BPA-sulfate, and some polar metabolites.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 47, March 2018, Pages 147-155
Journal: Toxicology in Vitro - Volume 47, March 2018, Pages 147-155
نویسندگان
Frank Toner, Graham Allan, Stephen S. Dimond, John M. Jr, Dieter Beyer,