Keywords: Aβ; amyloid-β-peptide; ACh; acetylcholine; Apo; apolipoprotein; APP; amyloid precursor protein; CYP; cytochrome P-450; DYRK1; dual specificity tyrosine-phosphorylation-regulated kinase 1A; GABA; γ-aminobutyric acid; GSK; glycogen synthase- kinase; HSV-
مقالات ISI (ترجمه نشده)
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Keywords: AL; alantolactone; AL-GSH; glutathione conjugate of alantolactone; AL-Cys; cysteine conjugate of alantolactone; AUC; area under the concentration-time curve; Cys; cysteine; CYP450; cytochrome P450; DAD; diode array detector; GSH; glutathione; GST; glutath
Keywords: Vildagliptin; Drug-induced liver injury; Hypersensitivity; Covalent binding; Nucleophilic trapping agents; ALG; alogliptin; ANG; anagliptin; CRP; C-reactive protein; CYP; cytochrome P450; DILI; drug-induced liver injury; DLST; drug-induced lymphocyte stim
Keywords: 11βHSD; 11β-Hydroxysteroid dehydrogenase; ABC; ATP-binding cassette; AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; BCRP; breast cancer resistance protein; CAR; constitutive androstane receptor; CYP; cytochrome P45
Keywords: Carcinogenesis; Chemoprevention; Chemotherapy; Oxidative stress; Nrf2; Phytochemicals; AKT; protein kinase B; AMPK; AMP-activated protein kinase; ARE; antioxidant response element; ATF-2; activating transcriptional factor; BBN; N-butyl-N-(4-hydroxybutyl)n
Keywords: Bee pollen; Phytometabolites; Nutrition; Therapeutic benefits; Food safety; GC-MS; gas chromatography-mass spectrometry; LC-ESI/MS; liquid chromatography-electrospray ionization mass spectrometry; TLC; thin layer chromatography; HPLC-DAD-ESI/MS; high-pe
Keywords: Innovative technology; Mobile English-Learning game; Self-learning; UGT; UGEM;
Keywords: ABC; ATP binding cassette; ACE; angiotensin converting enzyme; AT1; angiotensin 2 receptor type 1; CES; carboxylesterase; CYP; cytochrome P450; GI; gastrointestinal; P-gp; permeability glycoprotein; UGT; uridine 5â²-diphospho-glucuronosyltransferase; Gut
Keywords: α-SMA; α-smooth muscle actin; AIF; apoptosis inducing factor; AP-1; activator protein 1; ARE; antioxidant response element; Bax; Bcl-2 associated X protein; Bcl-2; B-cell lymphoma 2; Bcl-xl; B cell lymphoma extra large; CDKCs; cyclin:CDK complexes; c-My
Keywords: Naringenin; Glucuronidation; UDP-Glucuronosyltransferase (UGT); Liver microsome; Intestine microsome; UGT; UDP-glucuronosyltransferase;
Keywords: AOS; alginate oligosaccharides; CHI1; chalcone isomerase 1; CHI2; chalcone isomerase 2; CS; callus suspension cultures; CYP93A1; 3,9-dihydroxypterocarpan 6a-monooxygenase; 2,4-D; 2,4-dichlorophenoxyacetic acid; ECS; elicited callus suspension cultures; EC
Keywords: BCRP; breast cancer resistant protein; BSEP; bile salt efflux pump; GA; gestational age; GLUT1; glucose transporter 1; MCT1; monocarboxylate transporter 1; MDR; multidrug-resistance protein; MRP; multidrug-resistance like protein; NTCP; Na+-taurocholate c
Keywords: AUC; area under the concentration-time curve; AST; aspartate transaminase; ALT; alanine transaminase; BCRP; breast cancer resistance protein; BEI; biliary excretion index; CL/F; oral clearance; Clbiliary; in vitro biliary clearance; ER; Efflux Ratio; LCâ
Keywords: Vaccinium; Transcriptome; Flavonoid biosynthesis; Anthocyanin biosynthesis; Fruit development; 4CL; 4-coumarate-CoA ligase; ANS; anthocyanidin synthase; BB; blue-stage Bluecrop fruit; BBP; pulp of blue, ripe-stage Bluecrop cultivar fruit; BBS; skin of blu
Keywords: ADAM; advanced dissolution, absorption, and metabolism; AED; antiepileptic drug; AUC; area-under-the-curve; B/P; blood to plasma ratio; BID; twice daily; BMI; body mass index; CBZ; carbamazepine; CLint; intrinsic clearance; CLR; renal clearance; CL; clear
Keywords: 2-AG; 2-arachidonoyl glycerol; 11-nor-THC-COOH; 11-nor-tetrahydrocannabinol-9-caboxylic acid; 11-OH-THC; 11-hydroxy-tetrahydrocannabinol; 8-OH-THC; 8-hydroxy-tetrahydrocannabinol; CB; cannabinoid; CB1R; Type I cannabinoid receptor; CB2R; Type II cannabino
Keywords: Androgens; Intracrinology; Steroid biosynthesis; Hormone-dependent cancer; Testosterone; 11-oxygenated androgens; 11KA4; 11-keto-androstenedione; 11KDHT; 11-keto-5α-dihydrotestosterone; 11KT; 11-keto-testosterone; 11OHA4; 11β-hydroxy-androstenedione; 11
Keywords: Clint; intrinsic clearance; Clint app.; apparent intrinsic clearance; DAD; diod array detector; DMSO; dimethyl sulfoxide; ER; endoplasmic reticulum; fu; unbound fraction of a drug in the microsomal incubation mixture; HPLC; high performance liquid chromat
Pharmacokinetics, tissue distribution and excretion of luteolin and its major metabolites in rats: Metabolites predominate in blood, tissues and are mainly excreted via bile
Keywords: Luteolin; Metabolite; Pharmacokinetics; Bioavailability; Distribution; Excretion; ADME; absorption, distribution, metabolism and excretion; AUC; area under the curve; BCRP; breast cancer resistance protein; CE; collision energy; Cmax; peak concentration;
Keywords: Acyl glucuronide; Drug development; Drug toxicity; In vitro screening; In vivo model; Immune activation; Protein adduct; Reactive metabolite; UDP-glucuronosyltransferase; ADR; adverse drug reaction; AG; acyl glucuronide; AGE; advanced glycation end prod
Keywords: AD; Alzheimer's disease; Aβ; amyloid beta; ABC; ATP-binding cassette; P-gp, ABCB1; ABC transporters P-glycoprotein; BBB; blood-brain barrier; BCSFB; blood-CSF barrier; ISF; brain interstitial fluid; CSF; cerebrospinal fluid; CP; choroid plexus; IFN; inte
Keywords: ABCC; ATP-binding cassette sub-family C; ABCG2; ATP-binding cassette sub-family G member 2 (BCRP); DHFA; Dihydroferulic acid; DMCA; 3,4-dimethoxycinnamic acid; FA; Ferulic acid; FA-glu; Ferulic acid-4-O-glucuronide; FA-sul; Ferulic acid-4-O-sulfate; HT; H
Keywords: ADMET; absorption, distribution, metabolism, excretion, toxicity; AHR; aryl hydrocarbon receptor; AUC; area under the curve; BVU; (E)-5-(2-bromovinyl) uracil; CAR; constitutive androstane receptor; cMOAT; Canalicular multispecific organic anion transporte
Keywords: Morphine; Morphine-6-glucuronide; UGT; P-gp;
Keywords: Cold acclimation; Oat (Avena sativa); Rye (Secale cereale); Freezing tolerance; Plasma membrane; Detergent resistant membrane (microdomain, lipid raft); Sterol; Sphingolipid; Phospholipid; CA; cold acclimation; NA; non-acclimation; PM; plasma membrane; DR
Keywords: 3-PBA; 3-phenoxybenzoic acid; 3-PBAlc; 3-phenoxy-benzylalcohol; 8-OhdG; 8-hydroxy-2â²-deoxyguanosine; AchE; acetylcholinesterase; ADH; alcohol dehydrogenase; ALDH; aldehyde dehydrogenase; ANT; anthracene; ARE; antioxidant response element; AUC; area unde
Keywords: PAPS; 3â²-Phosphoadenosine 5â²-phosphosulfate; DTNB; 5,5â²-Dithiobis(2-nitrobenzoic acid); APAP; Acetaminophen; ALT; Alanine aminotrasferase; BSA; Bovine serum albumin; CCl4; Carbon tetrachloride; Ccr2; C-C chemokine receptor 2; CFB; Clofibrate; CD;
Keywords: Ams-Np; amylosucrase from Neisseria polysaccharea; AS; amylosucrase; Glc; glucose; COSY; correlation spectroscopy; GS; glucansucrase; GtfR-So; glucansucrase from Streptococcus oralis; HPLC; high-performance liquid chromatography; HRMS; high resolution mas
Keywords: Tyrosine kinase inhibitors; Drug transporter; Drug interaction; Therapeutic drug monitoring; Skin disorders; ADR; Adverse drug reaction; AUC; Area under the curve; BBB; Blood-brain barrier; BCRP/ABCG2; Breast cancer resistance protein; CNS; Central nerv
Keywords: MoA; mode of action; HPT; hypothalamic pituitary thyroid; UGT; uridine diphosphate glucuronosyltransferase; NOAEL; no observed adverse effect level; CAR; Constitutive Androstane Receptor; PCBs; polychlorinated biphenyls; USEPA; United States Environmental
Keywords: CAS; cycloartenol synthase; DDS; dammarenediol synthase; DMAPP; dimethylallyl diphosphate; DXP; 1-deoxy-d-xylulose 5-phosphate; FPP; farnesyl pyrophosphate; FPS; farnesyldiphosphate synthase; GAP; glyceraldehyde 3-phosphate; HMGR; 3-hydroxy-3-methylglutar
Keywords: CYP; cytochrome P450; 3-D; three-dimensional; APAP; acetaminophen; NAPQI; N-acetyl-p-benzoquinone imine; GSH; glutathione; ROS; reactive oxygen species; UGT; UDP-glucuronosyltransferase; SULT; sulfotransferase; ABT; 1-aminobenzotriazole; mBCl; monochlorob
Keywords: AhR; aryl hydrocarbon receptor; ARE; antioxidant response element; BT; black tea; CYP; cytochrome P450; DME; drug-metabolizing enzymes; DR4; direct repeat with 4Â bp spacer; DRE; dioxin response elements; GT; green tea beverage; EC; epicatechin; EGC; epig
Keywords: Aβ; amyloid-β-peptide; AD; Alzheimer's disease; BR; bilirubin; BV; biliverdin; BVR; biliverdin reductase; CAT; catalase; CCNA2; gene encoding for cyclin-A2; CCNB1; gene encoding for G2/mitotic-specific cyclin-B1; CEP2; centrosomal protein 2; Cmax; pea
Keywords: ADP; adenosine 5â²-diphosphate; AA; arachidonic acid; CLA; conjugated linoleic acid; COX-1; cyclooxygenase-1; CVD; cardiovascular disease; DHA; docosahexaenoic acid; EFSA; European Food Safety Authority; EPA; eicosapentaenoic acid; GP; glycoprotein; ICAM
Keywords: 5FU; 5-fluorouracile; ABC; ATP-binding cassette; AUC; area under the curve; BCRP; breast cancer resistance protein; Cmax; maximum (peak) plasma concentration; CYP; cytochrome p450 enzymes; DDI; drug-drug interactions; EIAEDS; enzyme-inducing antiepilept
Keywords: ABC; ATP binding cassette; ADR; adverse drug reactions; ALA; alpha-linolenic acid; ALT; alanine aminotransferase; CVD; cardiovascular disease; AUC; area under the concentration-time curve; Cmax; maximal plasma concentration; CYP; cytochrome P; EGCG; epi
Keywords: HTx; hepatocyte transplant; OLT; orthotopic liver transplantation; CYP; cytochrome P450; DLT; domino liver transplantation; OD; organ donor; MD; metabolic and diseased livers; MMA; methylmalonic acidemia; PHO; primary hyperoxaluria; MSUD; Maple Syrup Urin
Keywords: Akt; protein kinase B; AP-1; activator protein 1; ARNT; aryl hydrocarbon receptor nuclear translocate; ATP5F1; ATP synthase H+ transporting mitochondrial Fo complex-subunit B1; CAV1; caveolin-1; CDKs; cyclin dependent protein kinases; CHM; Chinese herbal
Keywords: CNT; Confederación Nacional del Trabajo, National Confederation of Labor; FNTT; Federación Nacional de Trabajadores de la Tierra, National Federation of Rural Workers; UGT; Unión General de Trabajadores, Workers' General Union; Land reform; Conflict;
Food-drug interactions involving multiple mechanisms: A case study with effect of Capsaicin on the pharmacokinetics of Irinotecan and its main metabolites in rat
Keywords: APC; 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxy-camptothecin; AUC; Area under the plasma concentration-time curve; CAP; Capsaicin; CES; Carboxylesterase; CPT; Camptothecin; CPT-11; Irinotecan; CYP; cytochrome P450; DMEs; Drug-meta
Tissue-specific and intracellular localization of indican synthase from Polygonum tinctorium
Keywords: Indigo; Indican; Indican synthase; Secondary metabolism; UDP-Glucosyltransferase; Intracellular localization; Polygonum tinctorium; indican; indoxyl-β-D-glucoside; indigo; 2-(1,3-dihydro-3-oxo-2H-indazol-2-yliden)-1,2-dihydro-3H-indol-3-on; UGT; UDP-gluc
Shikonin upregulates the expression of drug-metabolizing enzymes and drug transporters in primary rat hepatocytes
Keywords: AhR; aryl hydrocarbon receptor; AP1; activating protein 1; ARE; antioxidant-response element; CAR; constitutive androstane receptor; CYP; cytochrome P450; DREs; dioxin-responsive elements; EMSA; electromobility gel shift assay; FBS; fetal bovine serum; GS
miR-141-3p commonly regulates human UGT1A isoforms via different mechanisms
Keywords: MicroRNA; Post-transcriptional regulation; UGT; Interindividual difference; Liver; Intestine;
LC-MS/MS method for the simultaneous quantification of intestinal CYP and UGT activity
Keywords: 1-OH-MDZ; 1-hydroxymidazolam; 4-OH-DCL; 4-hydroxydiclofenac; 5-OH-OME; 5-hydroxyomeprazole; CYP; cytochrome P450 enzymes; DXP; dextrorphan; ESI; electrospray ionization; EZE-Glc; ezetimibe glucuronide; LC-MS/MS; liquid chromatography tandem mass spectro
Identification of UDP glucosyltransferases from the aluminum-resistant tree Eucalyptus camaldulensis forming β-glucogallin, the precursor of hydrolyzable tannins
Keywords: Eucalyptus camaldulensis; Myrtaceae; Aluminum tolerance; Biosynthetic pathway; Gallotannin; Galloylglucose; Glucosyltransferase; UGT; β-Glucogallin;
Significance of A-to-I RNA editing of transcripts modulating pharmacokinetics and pharmacodynamics
Keywords: ABC; ATP-binding cassette transporter; ADAR; adenosine deaminase acting on RNA; ADH; alcohol dehydrogenase; AhR; aryl hydrocarbon receptor; AKR; aldo-keto reductase; ALS; amyotrophic lateral sclerosis; AZIN1; antizyme inhibitor 1; AMPA; α-amino-3-hydroxy
In vitro percutaneous absorption and metabolism of Bisphenol A (BPA) through fresh human skin
Keywords: BPA; Bisphenol A; BPA-gluc; BPA-glucuronide; BPA-sulf; BPA-sulfate; ECHA; European Chemicals Agency; CoRAP; substance evaluation process by ECHA; EFSA; European Food Safety Authority; EPA; U.S. Environmental Protection Agency; OECD TG; Organisation for Ec
A rapid and simple HPLC-MS/MS method for the simultaneous quantification of valproic acid and its five metabolites in human plasma and application to study pharmacokinetic interaction in Chinese epilepsy patients
Keywords: VPA; valproic acid; UGT; uridine diphosphate glucuronosyltransferases; HPLC; MS/MS high performance liquid chromatography tandem mass spectrometry; HPLC; high-performance liquid chromatography; GC-MS; gas chromatograph tandem mass spectrometry; SRM; sel
UGT polymorphisms and lamotrigine clearance during pregnancy
Keywords: Pregnancy; Lamotrigine; UGT; Polymorphism; Sex of foetus;