کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8536945 | 1560923 | 2018 | 67 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cannabis use during pregnancy: Pharmacokinetics and effects on child development
ترجمه فارسی عنوان
مصرف کانابیس در دوران بارداری: فارماکوکینتیک و اثرات آن بر رشد کودک
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کلمات کلیدی
CBDCB2R2-AGGPCReCB2-arachidonoyl glycerolUGTPNDCyPTHCCmaxMOACB1RG-protein-coupled receptor - G-پروتئین گیرندهUDP-glucuronosyltransferase - UDP-گلوکورونوسیل ترانسفرازΔ9-Tetrahydrocannabinol - Δ9-تتراهیدروکانیابینولendocannabinoid - آندوکانابینوئیدPregnancy - بارداریMode of action - حالت عملmaximum concentration - حداکثر غلظتintraperitoneal - داخل صفاقیIntravenous - داخل وریدیExposure - در معرض قرار گرفتنCNS - دستگاه عصبی مرکزیOral - دهانیChild development - رشد کودکgestational day - روز بارداریpostnatal day - روز پس از زایمانsubcutaneous - زیر جلدیCytochrome P450 - سیتوکروم پی۴۵۰central nervous system - سیستم عصبی مرکزیCannabis - شاهدانهPharmacokinetics - فارماکوکینتیکCannabidiol - کانابیدیولCannabinoid - کانابینوئید
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
چکیده انگلیسی
The broad-based legalization of cannabis use has created a strong need to understand its impact on human health and behavior. The risks that may be associated with cannabis use, particularly for sensitive subgroups such as pregnant women, are difficult to define because of a paucity of dose-response data and the recent increase in cannabis potency. Although there is a large body of evidence detailing the mode of action of Î9-tetrahydrocannabinol (THC) in adults, little work has focused on understanding how cannabis use during pregnancy may impact the development of the fetal nervous system and whether additional plant-derived cannabinoids might participate. This manuscript presents an overview of the historical and contemporary literature focused on the mode of action of THC in the developing brain, comparative pharmacokinetics in both pregnant and nonpregnant model systems and neurodevelopmental outcomes in exposed offspring. Despite growing public health significance, pharmacokinetic studies of THC have focused on nonpregnant adult subjects and there are few published reports on disposition parameters during pregnancy. Data from preclinical species show that THC readily crosses the placenta although fetal exposures appear lower than maternal exposures. The neurodevelopmental data in humans and animals suggest that prenatal exposure to THC may lead to subtle, persistent changes in targeted aspects of higher-level cognition and psychological well-being. There is an urgent need for well-controlled studies in humans and preclinical models on THC as a developmental neurotoxicant. Until more information is available, pregnant women should not assume that using cannabis during pregnancy is safe.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 182, February 2018, Pages 133-151
Journal: Pharmacology & Therapeutics - Volume 182, February 2018, Pages 133-151
نویسندگان
Kimberly S. Grant, Rebekah Petroff, Nina Isoherranen, Nephi Stella, Thomas M. Burbacher,