Keywords: Aripiprazole; Risperidone; Olanzapine; Cannabinoid receptors; Adolescent rat; 5-HT; serotonin; ADHD; attention deficit hyperactivity disorder; ANOVA; analysis of variance; APDs; antipsychotic drugs; BSA; bovine serum albumin; cAMP; cyclic adenosine monoph
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Keywords: Endocannabinoid signaling; CB1R; Oligomerisation; G-proteins; Non-G proteins; Astrocytes; Brain;
Keywords: Ach; acetylcholine; 2-AG; 2-arachidonoylglycerol; Ang II; angiotensin II; AT1R; type 1 angiotensin receptor; BK; bradykinin; CB1R; type 1 cannabinoid receptor; DAG; diacylglycerol; DAGL; diacylglycerol lipase; EC; endocannabinoid; ERK; extracellular signa
Keywords: 2-AG; 2-arachidonoyl glycerol; 11-nor-THC-COOH; 11-nor-tetrahydrocannabinol-9-caboxylic acid; 11-OH-THC; 11-hydroxy-tetrahydrocannabinol; 8-OH-THC; 8-hydroxy-tetrahydrocannabinol; CB; cannabinoid; CB1R; Type I cannabinoid receptor; CB2R; Type II cannabino
Keywords: Cat; Ovary; Oviduct; CB1R; FAAH; Endocannabinoid system;
Keywords: ABHD6; α-β-hydrolase domain 6; ACEA; arachidonyl-2â²-chloroethylamide; AEA; anandamide; CBD; cannabidiol; CBDV; cannabidivarin; CB1R; cannabinoid type 1 receptor; CB2R; cannabinoid type 2 receptor; DAGL; diacylglycerol lipase; Î9-THC; Î9-tetrahydroca
Keywords: 2-AG; 2-Arachidonoylglycerol; ACN; Acetonitrile; AEA; Anandamide; cAMP; cyclic adenosine 5â²-monophosphate; CB1R; Cannabinoid Receptor 1; CB2R; Cannabinoid Receptor 2; CI; Cell Index; CNR1; Cannabinoid Receptor 1 gene; CNR2; Cannabinoid Receptor 2 gene;
Keywords: CB1R; cannabinoid receptor 1; BW; body weight; DIO; diet-induced obesity; ED50; the dose where the predicted effect reaches 50%; Emax; the dose where the predicted effect reaches 100%; LED; least statistically effective dose; USV; ultrasonic vocalization;
Keywords: Alcohol; Endocannabinoids; Sex differences; Anxiety; Amygdala; Prefrontal cortex; 2-AG; 2-arachidonoylglycerol; AEA; anandamide; ANOVA; analyses of variance; BAL; blood alcohol level; BLA; basolateral amygdala; CB1R; cannabinoid-type 1 receptor; CIA; chro
Keywords: AD; Alzheimer's disease; cAMP; cyclic adenosine monophosphate; CB1R; Cannabinoid receptor 1; CNS; central nervous system; co-IP; co-immunoprecipitation; Cy3; cyanine 3; D2R; dopamine receptor 2; ERK1/2; extracellular signal-regulated kinase 1/2; FITC; f
Keywords: Enteroendocrine Cells; Obesity; Gastrointestinal Peptides; Apo A-IV; apolipoprotein A-IV; BA; bile acids; CB1R; cannabinoid receptor 1 receptor CB1R; CCK; cholecystokinin; CCK-1R; CCK-1 receptor; CNS; central nervous system; DAG; des-acyl ghrelin; DIO; di
Keywords: PolyIC; polyriboinosinic:polyribocytidylic acid; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; mPFC; medial prefrontal cortex; oPFC; orbital prefrontal cortex; NAcc; nucleus accumbens; PND; post-natal day; ED; embryonic day; MIA; m
Keywords: Cannabinoids; Cannabis; CB1R; Dependence; Downregulation; Recovery; Tolerance; Upregulation; Withdrawal
Keywords: Antipsychotics; Cannabinoid; CB1R; OMAR; Schizophrenia; Smoking;
Keywords: Water intake; CB1R; ACEA; Vasopressin; Oxytocin; Corticosterone;
Keywords: Cannabinoid; Cannabis; CB1R; Cognitive; Inhibitory; Prefrontal cortex;
Keywords: Cannabinoids; Cannabis; CB1R; Cognition; Dopamine; Experimental; GABA; Glutamate; Laboratory; Psychosis; RCT; Schizophrenia; THC;
Keywords: 2-AG; 2-arachidonoylglycerol; 5-HT; 5-hydroxytryptamine or serotonin; AEA; N-arachidonoylethanolamine or anandamide; cAMP; cyclic adenosine monophosphate; CB1R; cannabinoid receptor-1; DAPI; 4,6-diamidino-2-phenylindole; DR; dorsal root; FL; fictive locom
Keywords: AMPA; α-amino-3-hydroxy-5-methylisoxazole-4-propionate; CB1R; type 1 cannabinoid receptor; Cbln-1; precerebellin; CF-LTD; climbing fiber long term depression; CF-PC; climbing fiber-Purkinje cell; E; embryonic day; LTD; long term depression; LTP; long ter
Keywords: Adolescent cannabis abuse; CB1R; mGluR2/3; LTD; Cannabinoids;
Keywords: AM251; N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1 H-pyrazole-3-carboxamide; BP; blood pressure; CB1R; cannabinoid receptor 1; ERK1/2; extracellular signal-regulated kinase1/2; p-ERK1/2; phosphorylated ERK1/2; HR; heart rate; MAP
Keywords: CB1R; cannabinoid type 1 receptor; TRPV1; transient receptor potential vanilloid receptor 1; SS; seizure severity; SD; seizure duration; ADD; afterdischarge duration; ADT; afterdischarge threshold; Cum ADD; cumulative afterdischarge duration; DCX; doublec
Keywords: CB1R; Cannabis; Cannabinoid; Marijuana; PET; Rimonabant; Radioligand; Prefrontal cortex; Schizophrenia;
Keywords: 2-AG; 2-arachidonoylglycerol; AEA; N-arachidonylethanolamine anandamide; CB1R; cannabinoid type one receptor; CBG; corticosteroid-binding globulin; CRH; corticotrophin-releasing hormone; eCB; endocannabinoid; ECS; endocannabinoid signaling; epm; elevated
Keywords: Diabetes; Cancer; Insulin; Anti-diabetics; Cannabinoid; Obesity; 2-AG; 2-arachidonoyl glycerol; ACC; acetyl-CoA carboxylase; AMPK; adenosine monophosphate-activated protein kinase; CB1R; cannabinoid 1 receptor; CB2R; cannabinoid 2 receptor; CPT-1; carniti
Keywords: LPS; lipopolysaccharide; TLR; toll-like receptor; CB1R; cannabinoid receptor 1; HSC; hepatic stellate cell; NF-κB; nuclear factor-κB; TNF; tumor necrosis factor; IL; interleukin; MCP-1; monocyte chemoattractant protein-1; 2-AG; 2-arachidonoylglycerol; S
Keywords: AEA; anandamide; CB1R; cannabinoid type-1 receptor; DRG; dorsal root ganglion; FAAH; fatty acid amide hydrolase; FABP; fatty acid binding protein; i.pl; intraplantar; MβC; methyl-β-cyclodextrin; PPARα; peroxisome proliferator-activated receptor alpha;
Keywords: AC; adenylyl cyclase; BAT; brown adipose tissue; BMP; bone morphogenetic protein; BST; bed nucleus of the stria terminalis; CB1R; cannabinoid receptor type 1; CNS; central nervous system; CREB; cAMP-response element binding protein; DRN; dorsal raphe nucl
Keywords: 2-AG; 2-arachidonoylglycerol; AC; adenylyl cyclase; CB1r; cannabinoid type 1 receptors; CREB; cAMP response element binding protein; CRF; corticotropin releasing factor; EC; endocannabinoid; HPA; hypothalamic-pituitary-adrenal; LC; locus coeruleus; MM
Keywords: Claustrum; Cannabinoid; CB1R; Dog; FAAH; Immunohistochemistry
Exposure to cannabinoid agonist WIN 55,212-2 during early adolescence increases alcohol preference and anxiety in CD1 mice
Keywords: WIN 55,212-2 (WIN); Cannabinoid receptor 1 (CB1R); Cannabinoid receptor 2 (CB2R); Adolescence; Alcohol preference; Anxiety; WIN; WIN 55,212-2; CB1R; Cannabinoid receptor 1; CB2R; Cannabinoid receptor 2; eCB; endocannabinoid; TH; Tyrosine hydroxylase; TrpO
The tamoxifen derivative ridaifen-B is a high affinity selective CB2 receptor inverse agonist exhibiting anti-inflammatory and anti-osteoclastogenic effects
Keywords: Cannabinoid receptors; G-protein coupled receptors; Inverse agonist; Antagonist; Drug action; AC; adenylyl cyclase; CB1R; cannabinoid receptor type 1; CB2R; cannabinoid receptor type 2; CHO; Chinese hamster ovary; CP-55,940; 5-(1,1-dimethylheptyl)-2-[5-hy
Repeated Cannabidiol treatment reduces cocaine intake and modulates neural proliferation and CB1R expression in the mouse hippocampus
Keywords: Cocaine; Cannabidiol; Self-administration; Addiction; Neurogenesis; 5-HT1AR; 5-hydroxytryptamine 1 A receptor; ANOVA; Analysis of variance; BrdU; 5-bromo-2â²-deoxyuridine; CB1R; Type 1 cannabinoid receptor; CB2R; Type 2 cannabinoid receptor; CBD; Cannabi
MAPK activation patterns of AT1R and CB1R in SHR versus Wistar astrocytes: Evidence of CB1R hypofunction and crosstalk between AT1R and CB1R
Keywords: ADHD; Attention Deficit Hyperactivity Disorder; MAPK; Mitogen-activated protein kinases; ALAAC; Association for Assessment and Accreditation of Laboratory Animal Care International; Ang; Angiotensin; AT1R; Ang type 1 receptor; AT2R; Ang type 2 receptor; B
Archival ReportCB1 Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal
Keywords: CB1R; Cognition; Knockout mice; Nicotine; Plasticity; Withdrawal;
Acute and long-term effects of Î9-tetrahydrocannabinol on object recognition and anxiety-like activity are age- and strain-dependent in mice
Keywords: THC; Cannabinoids; Adolescence; Memory; Anxiety; CB1R;
Functional selectivity at G-protein coupled receptors: Advancing cannabinoid receptors as drug targets
Keywords: THC; Î9-tetrahydrocannabinol; 5-HT2B; serotonin 2B receptor; AC; adenylyl cyclase; AEA; anandamide; Akt; protein kinase B; cAMP; cyclic adenosine monophosphate; CBR; cannabinoid receptor; CB1R; cannabinoid receptor 1; CB2R; cannabinoid receptor 2; CNS; c
Endocannabinoids in brain plasticity: Cortical maturation, HPA axis function and behavior
Keywords: 2-AG; 2-arachidonoylglycerol; ACTH; adrenal corticotropic hormone; AEA; N-arachidonoylethaonlamine/anandemide; BLA; basolateral amygdala; CB; cannabinoid; CB1R; cannabinoid receptors Type 1; CP; CP 55,940; CRH; corticotrophin releasing hormone; GABA; gamm
Distinct roles of neuronal and microglial CB2 cannabinoid receptors in the mouse hippocampus
Keywords: AAV; adeno-associate virus; AP; anterior posterior; CaMKII; calcium/calmodulin-dependent protein kinase II; Cas9; CRISPR-associated protein 9; CB1R; type-1 cannabinoid receptor; CB2R; type-2 cannabinoid receptor; CNS; central nervous system; CRISPR; clust
Blockade of Cannabinoid CB1 receptor attenuates the acquisition of morphine-induced conditioned place preference along with a downregulation of ERK, CREB phosphorylation, and BDNF expression in the nucleus accumbens and hippocampus
Keywords: CB1R; Cannabinoid CB1 receptor; ERK; extracellular signal-regulated kinase; CREB; cAMP response element-binding protein; BDNF; brain-derived neurotrophic factor; NAc; nucleus accumbens; CPP; conditioned place preference; MAPKs; mitogen-activated protein k
Parabens inhibit fatty acid amide hydrolase: A potential role in paraben-enhanced 3T3-L1 adipocyte differentiation
Keywords: AADAC; arylacetamide deacetylase; AEA; arachidonoyl ethanolamide; BnP; benzylparaben; BuP; butylparaben; CB1R; cannabinoid receptor 1; CB2R; cannabinoid receptor 2; CMNA; cyano(6-methoxynaphthalen-2-yl)methyl acetate; EC; endocannabinoid; FAAH; fatty acid
Formation of OX-1R/CB1R heteromeric complexes in embryonic mouse hypothalamic cells: Effect on intracellular calcium, 2-arachidonoyl-glycerol biosynthesis and ERK phosphorylation
Keywords: 2-AG; 2-arachidonoylglycerol; ACEA; arachidonyl-2-chloroethylamide; AgRP; agouti-related peptide; CB1R; cannabinoid receptor; CHO; chinese hamster ovary cells; DAG; diacylglycerol; DAGL; diacylglycerol lipase; ERK; extracellular-signal-regulated kinases;
Cannabinoid receptor agonists modulate calcium channels in rat retinal müller cells
Keywords: 2-AG; 2-arachidonoyl glycerol; AEA; anandamide; [Ca2+]i; intracellular calcium concentration; CB1R; cannabinoid CB1 receptor; CB2R; cannabinoid CB2 receptor; DMSO; dimethyl sulfoxide; eCB; endocannabinoid; GS; glutamine synthetase; PBS; phosphate-buffered
Synthetic cannabinoid JWH-018 and its halogenated derivatives JWH-018-Cl and JWH-018-Br impair Novel Object Recognition in mice: Behavioral, electrophysiological and neurochemical evidence
Keywords: JWH-018; Novel object recognition; Hippocampus; LTP; GABA/glutamate release; AM251; 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide; CB1R; Cannabinoid receptor 1; JWH-018; 1-pentyl-3-(1-naphthoyl)indole; JWH-0
ReviewAstrocytes: Orchestrating synaptic plasticity?
Keywords: A1R; adenosine A1 receptor; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; CB1R; cannabinoid receptor type 1; GPCR; G protein-coupled receptor; LTD; long-term depression; LTP; long-term potentiation; NMDAR; N-methyl-d-aspartate rec
SGIP1 alters internalization and modulates signaling of activated cannabinoid receptor 1 in a biased manner
Keywords: Seven transmembrane receptors; G-protein coupled receptors; Cannabinoid receptor 1; Protein-protein interactions; Bias signaling; Receptor endocytosis; SGIP1; src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1; CC
Blocking GluN2B subunits reverses the enhanced seizure susceptibility after prolonged febrile seizures with a wide therapeutic time-window
Keywords: FSs; febrile seizures; IL-1β; interleukin-1β; IL-1Ra; interleukin-1 receptor antagonist; TLE; temporal lobe epilepsy; MES; maximal electrical shock; KA; kainic acid; CB1R; cannabinoid type 1 receptor; Febrile seizures; GluN2B; IL-1β; Seizure susceptibi
Research reportCannabinoids & Stress: Impact of HU-210 on behavioral tests of anxiety in acutely stressed mice
Keywords: CB; cannabinoid; HU-210; 1,1-dimethylheptyl-11-hydroxytetrahydrocannabinol; OFT; open field test; EPM; elevated-plus maze; FS; forced swimming test; CB1R; cannabinoid type-1 receptor; Cannabinoids; HU-210; Anxiety; Acute stress;
Endocannabinoids drive the acquisition of an alternative phenotype in microglia
Keywords: ABDH6; α,β-hydrolase-6; ABDH12; α,β-hydrolase-12; AEA; anandamide; 2-AG; 2-arachidonoylglycerol; Arg-1; Arginase-1; CB1R; cannabinoid receptor 1; CB2R; cannabinoid receptor 2; DAGLs; diacylglycerol lipases; eCBs; endocannabinoids; eCBSS; endocannabino
CB1 cannabinoid receptor antagonist attenuates left ventricular hypertrophy and Akt-mediated cardiac fibrosis in experimental uremia
Keywords: α-SMA; α-smooth muscle actin; ANP; atrial natriuretic peptide; β-MHC; myosin heavy chain beta; BNP; brain natriuretic peptide; BW; body weight; CB1R; cannabinoid receptor type 1; CKD; chronic kidney disease; CMR; cardiac magnetic resonance; CVD; cardio