کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7280867 | 1473918 | 2015 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Endocannabinoids drive the acquisition of an alternative phenotype in microglia
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کلمات کلیدی
ARG-1eCBsNAPE-PLDFAAH2-arachidonoylglycerolAEACB2RCB1RSOCS3PLCCB2 receptorsIGF-1magl2-AGArginase-1 - آرژنین 1anandamide - آناندامیدFatty acid amide hydrolase - اسید آمینه هیدرولاز اسید چربendocannabinoids - اندوکانبایوئید هاsuppressor of cytokine signaling 3 - سرکوب سیگنالینگ سیتوکین 3Insulin growth factor-1 - عامل رشد انسولین- 1phospholipase C - فسفولیپاز CM2 polarization - قطبش M2monoacylglycerol lipase - لیپاز monoacylglycerol لیپازMicroglia - میکروگلیاهاCannabinoid receptor 1 - گیرنده کانابینوئید 1cannabinoid receptor 2 - گیرنده کانابینوئید 2
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The ability of microglia to acquire diverse states of activation, or phenotypes, reflects different features that are determinant for their contribution to homeostasis in the adult CNS, and their activity in neuroinflammation, repair or immunomodulation. Despite the widely reported immunomodulatory effects of cannabinoids in both the peripheral immune system and the CNS, less is known about how the endocannabinoid signaling system (eCBSS) influence the microglial phenotype. The general aim of the present study was to investigate the role of endocannabinoids in microglia polarization by using microglia cell cultures. We show that alternative microglia (M2a) and acquired deactivated microglia (M2c) exhibit changes in the eCB machinery that favor the selective synthesis of 2-AG and AEA, respectively. Once released, these eCBs might be able to act through CB1 and/or CB2 receptors in order to influence the acquisition of an M2 phenotype. We present three lines of evidence that the eCBSS is critical for the acquisition of the M2 phenotype: (i) M2 polarization occurs on exposure to the two main endocannabinoids 2-AG and AEA in microglia cultures; (ii) cannabinoid receptor antagonists block M2 polarization; and (iii) M2 polarization is dampened in microglia from CB2 receptor knockout mice. Taken together, these results indicate the interest of eCBSS for the regulation of microglial activation in normal and pathological conditions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain, Behavior, and Immunity - Volume 49, October 2015, Pages 233-245
Journal: Brain, Behavior, and Immunity - Volume 49, October 2015, Pages 233-245
نویسندگان
M. Mecha, A. Feliú, F.J. Carrillo-Salinas, A. Rueda-Zubiaurre, S. Ortega-Gutiérrez, R. GarcÃa de Sola, C. Guaza,