Keywords: حداکثر غلظت; AE; adverse event; AUC; area under the curve; CI; confidence interval; Cmax; maximum concentration; HCC; hepatocellular carcinoma; HR; hazard ratio; OS; overall survival; PK; pharmacokinetic; PVA; polyvinyl alcohol; TTP; time to progression; W/O; water-in
مقالات ISI حداکثر غلظت (ترجمه نشده)
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Keywords: حداکثر غلظت; ABC; ATP-binding casette; aCSF; artificial cerebrospinal fluid; AP; anterior-posterior; aPPF; artificial peripheral perfusion fluid; AUC; area under the curve; BBB; blood-brain barrier; Cmax; maximum concentration; DMSO; dimethyl sulfoxide; DV; dorso-vetr
Keywords: حداکثر غلظت; Transmission; Pharmacogenomics; Incipient tuberculosis; HIV; Diabetes; Biomarkers; DAIDS; Division of AIDS; NIAID; National Institute of Allergy and Infectious Diseases; NIH; National Institutes of Health; TB; tuberculosis; RePORT; Regional Prospective Ob
Keywords: حداکثر غلظت; 2-AG; 2-arachidonoyl glycerol; 11-nor-THC-COOH; 11-nor-tetrahydrocannabinol-9-caboxylic acid; 11-OH-THC; 11-hydroxy-tetrahydrocannabinol; 8-OH-THC; 8-hydroxy-tetrahydrocannabinol; CB; cannabinoid; CB1R; Type I cannabinoid receptor; CB2R; Type II cannabino
Keywords: حداکثر غلظت; RLP; regional limb perfusion; MCP; metacarpo-phalangeal; MTP; metatarso-phalangeal; Cmax; maximum concentration; AUC; area under the curve; MRSA; methicillin resistant Staphylococcus aureus; PK; pharmacokinetics; MDR; multidrug resistant; PAE; post antibi
Keywords: حداکثر غلظت; Maximum tolerated dose; Chronic toxicity; Carcinogenicity; Toxicokinetics; Gender difference; ADME; absorption, distribution, metabolism, and excretion; AUCs; areas under the curve; Cmax; maximum concentration; KMD; kinetically-derived maximum dose; MTD;
Keywords: حداکثر غلظت; biliary excretion; drug interactions; efflux pumps; MRP; permeability; ATV; atorvastatin; MET; metformin; 2-OH ATV; 2-hydroxyatorvastatin; CYP; cytochrome P450; MDCK; Madin-Darby canine kidney; MDR; multidrug resistance gene; BCRP; breast cancer resistanc
Keywords: حداکثر غلظت; SACP; simulated annealing of chemical potential; CFA; constrained fragment analysis; FE Pred; predicted relative free energy; ÎÎGs; relative solvation change; D5W; 5% dextrose (glucose) in water; Vdss; steady-state volume of distribution; Cl; clearance;
Keywords: حداکثر غلظت; salt; solubility; pH; dissolution; poorly water soluble; solution phase; solid phase; equilibrium; salt dissociation; phase-transformation; API; active pharmaceutical ingredient; AUC; area under curve; Cmax; maximum concentration; FaSSIF; fasted state sim
Keywords: حداکثر غلظت; AUC24; area under the concentration time curve in 24Â h; CL; clearance; Cmax; maximum concentration; Cmin; minimum concentration; FN; febrile neutropenia; Ke; elimination rate-constant; MIC; minimal inhibitory concentration; SD; standard deviation; t1/2;
Keywords: حداکثر غلظت; AE; Apple extract; AE+BE; Apple and blackcurrant extracts; iAUC; Incremental area under the curve; Cmax; Maximum concentration; CON; Control treatment; DVP-SI; Digital volume pulse stiffness index; DVP-RI; Digital volume pulse reflection index; GIP; Gluco
Keywords: حداکثر غلظت; Natural products; Dietary supplements; Herbal medicines; Drug interactions; Cytochrome P450; Transporters; Metabolic enzymes; CYP450; cytochrome P450; Cmax; maximum concentration; DDI; drug-drug interactions; MDP; methylenedioxyphenyl; NP; natural produ
Keywords: حداکثر غلظت; LS; lauryl sulfate; SLS; sodium lauryl sulfate; SEM; scanning electron microscopy; SD; standard deviation; Cmax; maximum concentration; tmax; time to reach Cmax; AUC; area under the curve; Sustained-release; Suspension; Lauryl sulfate; Salt; Complex; Spra
Keywords: حداکثر غلظت; ANOVA; analysis of variance; AUC0â¿¿24; area under the curve of blood concentration vs. time from tâ¿¿=â¿¿0 to tâ¿¿=â¿¿24 after oral administration; BA; oral bioavailability; Cmax; maximum concentration; CWM; cold wet-milling; CoQ10; coenzyme Q10; DSC; di
Keywords: حداکثر غلظت; AOB; Area over baseline; Cmax; Maximum concentration; CON; Control treatment; DVP-SI; Digital volume pulse stiffness index; DVP-RI; Digital volume pulse reflection index; GIP; Glucose-dependent insulinotropic polypeptide; GLP-1; Glucagon-like peptide-1; H
Keywords: حداکثر غلظت; DCX; docetaxel; PK; phamacokinetic; PD; pharmacodynamic; HPLC; high-performance liquid chromatography; UV; ultraviolet; MS/MS; tandem mass spectrometry; UPLC; ultra-performance liquid chromatography; MTBE; methyl t-butyl ether; LC; liquid chromatography;
Keywords: حداکثر غلظت; AUC; area under the curve; BMI; body mass index; BODIPY; 4,4-difluoro-5-(4-phenyl-1,3-butadienyl)-4-bora-3a,4a-diaza-/s/-indacene-3-undecanoic acid; BP; blood pressure; CHD; coronary heart disease; CJC; cranberry juice cocktail; Cmax; maximum concentratio
Keywords: حداکثر غلظت; ALT; alanine aminotransferase; AST; aspartate aminotransferase; AUC; area under the curve; BMI; body mass index; BP; blood pressure; BUN; blood urea nitrogen; CI; confidence intervals; Cmax; maximum concentration; CNS; central nervous system; EIA; enzyme
Keywords: حداکثر غلظت; NO; nitric oxide; p.o.; per os; Tmax; maximum time; AUC0-inf; area under curve (time 0Â >Â infinite); CMC; carboxymethyl cellulose; NMR; nuclear magnetic resonance; Cmax; maximum concentration; AUC0-t; area under curve (time 0Â >Â last time); Nicorand
Keywords: حداکثر غلظت; AUC; area under the curve; BMI; body mass index; CVD; cardiovascular disease; HDL-C; high-density lipoprotein cholesterol; HOMA-IR; homeostasis model assessment of insulin resistance; IAUC; incremental AUC; maxC; maximum concentration; MetS; metabolic syn
Bioavailability and Cardiovascular Effects of Adrenaline Administered by Anapen Autoinjector in Healthy Volunteers
Keywords: حداکثر غلظت; Anapen; Autoinjectors; Adrenaline pharmacokinetics; Anaphylaxis; Cardiovascular responses; AUC; Area under the curve; BMI; Body mass index; Cmax; Maximum concentration; Emax; Maximum effect; HR; Heart rate; PK; Pharmacokinetic; SBP; Systolic blood pressur
Cellulose-based amorphous solid dispersions enhance rifapentine delivery characteristics in vitro
Keywords: حداکثر غلظت; Rifapentine (PubChem CID: 6323497); Rifampicin (PubChem CID: 5458213); 3-Formylrifamycin (PubChem CID: 6438444); Hydroxypropylmethylcellulose acetate succinate (PubChem CID: 121950); ASD; amorphous solid dispersion; AUC; area under the curve; CASub; cellu
Pharmacokinetic differences of mifepristone between sexes in animals
Keywords: حداکثر غلظت; UPLC-MS/MS; ultra-performance liquid chromatography-tandem mass spectrometry; IS; internal standard; NADPH; nicotinamide adenine dinucleotide phosphate; QC; quality control; Cmax; maximum concentration; Tmax; time to peak; t1/2; half-life period; MRT; a
Amorphous Solid Dispersion of Meloxicam Enhanced Oral Absorption in Rats With Impaired Gastric Motility
Keywords: حداکثر غلظت; amorphous; drug-excipient interaction; gastrointestinal transit; oral absorption; poorly water-soluble drugs; solid dispersion; AUC; area under the curve of blood concentration versus time curve; ASD-MEL/EUD; amorphous solid dispersion of meloxicam with p
Enhanced biopharmaceutical effects of tranilast on experimental colitis model with use of self-micellizing solid dispersion technology
Keywords: حداکثر غلظت; ANOVA; analysis of variance; AUC; area under the curve of plasma concentration vs. time; BA; oral bioavailability; BCS; biopharmaceutics classification system; BMA; butyl methacrylate; Cmax; maximum concentration; DLS; dynamic light scattering; GI; gastro
Use of physiologically based kinetic modelling-facilitated reverse dosimetry to convert in vitro cytotoxicity data to predicted in vivo liver toxicity of lasiocarpine and riddelliine in rat
Keywords: حداکثر غلظت; Physiologically based kinetic (PBK) model; Lasiocarpine; Riddelliine; Liver toxicity; In vitro-in vivo extrapolation; Reverse dosimetry; BMDL5-BMDU5; lower/upper limit of the 90% confidence interval of the benchmark dose that gives a 5% response; BMDL10;
BCRP/ABCG2 and high-alert medications: Biochemical, pharmacokinetic, pharmacogenetic, and clinical implications
Keywords: حداکثر غلظت; ABC; ATP-binding cassette; AUC; area under the time-concentration curve; BCRP; breast cancer resistance protein; Cmax; maximum concentration; CYP; cytochrome P450; DOAC; direct oral anti-coagulant; GI; gastrointestinal; MRP1; multidrug resistance protei
New nano-matrix oral formulation of nanoprecipitated cyclosporine A prepared with multi-inlet vortex mixer
Keywords: حداکثر غلظت; AUC; area under the curve of blood concentration versus time curve; BA; bioavailability; BCS; biopharmaceutics classification system; Cmax; maximum concentration; CsA; cyclosporine A; CV; coefficient of variation; DLS; dynamic light scattering; FNP; flash
Estradiol prodrugs (EP) for efficient oral estrogen treatment and abolished effects on estrogen modulated liver functions
Keywords: حداکثر غلظت; AUC; area under the curve; BW; body weight; C0; extrapolated concentration time zero (i. v.); Cmax; maximum concentration; CA-II; carbonic anhydrase II; CBG; cortisol binding globulin; COC; combined oral contraceptive; EDTA; ethylene diamine tetra acetic
Recombinant Human C1-Esterase Inhibitor to Treat Acute Hereditary Angioedema Attacks in Adolescents
Keywords: حداکثر غلظت; C1-esterase; Hereditary angioedema; Adolescent; Safety; Efficacy; Ruconest; Pharmacokinetics; AE; Adverse event; C1-INH; C1-esterase inhibitor; Cmax; Maximum concentration; HAE; Hereditary angioedema; IV; Intravenous; OLE; Open-label extension; RCT; Rando
Amorphous solid dispersion of cyclosporine A prepared with fine droplet drying process: Physicochemical and pharmacokinetic characterization
Keywords: حداکثر غلظت; ASD; amorphous solid dispersion; ASD/CsA; amorphous solid dispersion of cyclosporine A; AUC; area under the curve of blood concentration versus time curve; BA; bioavailability; Cmax; maximum concentration; CsA; cyclosporine A; CV; coefficient of variation
Pharmacokinetic based study on “lagged stimulation” of Curcumae Longae Rhizoma - Piper nigrum couplet in their main active components' metabolism using UPLC-MS-MS
Keywords: حداکثر غلظت; Curcumae Longae Rhizoma; Piper nigrum; UHPLC-MS-MS; Lagged stimulation; Pharmacokinetics; TCM; Traditional Chinese Medicine; Cur; curcumin; Pip; piperine; UPLC-MS-MS; ultra-performance liquid chromatography-mass spectrometry; ESI; electrospray ionizatio
Self-micellizing solid dispersion of cyclosporine A for pulmonary delivery: Physicochemical, pharmacokinetic and safety assessments
Keywords: حداکثر غلظت; AUC; area under the curve of blood concentration versus time curve; BALF; bronchoalveolar lavage fluid; BUN; blood urea nitrogen; Cmax; maximum concentration; CsA; cyclosporine A; CsA-RP; amorphous cyclosporine A-based respirable powder; FPD; fine particl
Bioavailability enhancement of itraconazole-based solid dispersions produced by hot melt extrusion in the framework of the Three Rs rule
Keywords: حداکثر غلظت; ACN; acetonitrile; API; active pharmaceutical ingredient; ASD; amorphous solid dispersions; AUC; area under the curve; BCS; biopharmaceutics classification system; CD; cyclodextrin; Cmax; maximum concentration; DSC; differential scanning calorimetry; FA;
Quantification of IDP-73152, a novel antibiotic, in plasma from mice, rats and humans using an ultra-high performance liquid chromatography/tandem mass spectrometry method for use in pharmacokinetic studies
Keywords: حداکثر غلظت; AUC0â24; area under the curve from time zero to 24Â h; AUC0ââ; area under the curve from time zero to infinity; AUMC0ââ; the area under the first moment curve from time zero to infinity; CL; clearance; Cmax; maximum concentration; IS; internal s
Protective effects of tranilast on experimental colitis in rats
Keywords: حداکثر غلظت; AUC; area under the concentration versus time curve; BCS; biopharmaceutics classification system; CD; Crohn's disease; Cmax; maximum concentration; DAB; 3,3â²-diaminobenzidine; HDTMAB; hexadecyltrimethylammonium bromide; HE; hematoxylin-eosin; IBD; inf
Quantification of EC-18, a synthetic monoacetyldiglyceride (1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol), in rat and mouse plasma by liquid-chromatography/tandem mass spectrometry
Keywords: حداکثر غلظت; ACN; acetonitrile; AUC0ââ; area under the curve from time zero to infinity; AUMC0ââ; the area under the first moment curve from time zero to infinity; CL; clearance; Cmax; maximum concentration; FA; formic acid; IPA; isopropyl alcohol; IS; interna
Sitagliptin inhibit human lymphocytes proliferation and Th1/Th17 differentiation in vitro
Keywords: حداکثر غلظت; ADA; adenosine deaminase; CBA; cytometric bead array; Cmax; maximum concentration; DC; dendritic cells; DM1; type 1 diabetes mellitus; DPP-4; dipeptidyl peptidase-4; EGR2; early growth response 2; FBS; fetal bovine serum; GIP; glucose-dependent insulinotr
Regulation of hepatic abcb4 and cyp3a65 gene expression and multidrug/multixenobiotic resistance (MDR/MXR) functional activity in the model teleost, Danio rerio (zebrafish)
Keywords: حداکثر غلظت; ABC; ATP-binding cassette; CYP; cytochrome P450; KTC; ketoconazole; MDR/MXR; multidrug/multixenobiotic resistance; P-gp; P-glycoprotein; PCN; pregnenolone 16α-carbonitrile; PXR; pregnane X-receptor; ARmax; maximum accumulation rate; Cmax; maximum concent
The margin of internal exposure (MOIE) concept for dermal risk assessment based on oral toxicity data - A case study with caffeine
Keywords: حداکثر غلظت; AUC; area under the curve; BMDL; benchmark dose lower confidence interval; Cmax; maximum concentration; HLV; human limit value; MOE; margin of exposure (synonymous to MOS); MOIE; margin of internal exposure; MOS; margin of safety; NOAEL; no observed adver
IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds
Keywords: حداکثر غلظت; API; active pharmaceutical ingredient; AUC; area under the curve; BCS; biopharmaceutics classification system; BP; blood-to-plasma ratio; Cmax; maximum concentration; CL; clearance; Do; dose number according to BCS; DDI; drug-drug interaction; EFPIA; Euro
IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes
Keywords: حداکثر غلظت; AFE; Average Fold Error; AAFE; Absolute Average Fold Error; API; Active pharmaceutical ingredient; AUC; Area under the curve; BCS; Biopharmaceutics classification system; BE; Bioequivalence; BP; Blood-to-plasma ratio; CCC; Concordance Correlation Coeffici
IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results
Keywords: حداکثر غلظت; API; Active pharmaceutical ingredient; AUC; Area under the curve; BCS; Biopharmaceutics classification system; BE; Bioequivalence; BP; Blood-to-plasma ratio; CL; Clearance; CL/F; Apparent clearance; Cmax; Maximum concentration; Do; Dose number; fa; Fracti
Coloaded Nanoparticles of Paclitaxel and Piperlongumine for Enhancing Synergistic Antitumor Activities and Reducing Toxicity
Keywords: حداکثر غلظت; paclitaxel; piperlongumine; nanoparticles; synergistic effect; 5-FU; 5-fluorouracil; C6; Coumarin-6; Cmax; maximum concentration; CD31; cluster of differentiation 31; CI; combination index; CLSM; confocal laser scanning microscopy; DL; drug loading; DMEM;
Involvement of organic cation transporter 3 (Oct3/Slc22a3) in the bioavailability and pharmacokinetics of antidiabetic metformin in mice
Keywords: حداکثر غلظت; Metformin; OCT3; Transporter; Intestinal absorption; Bioavailability; Mouse; AUC; area under the plasma concentration-time curve; CL; clearance; Cmax; maximum concentration; OCT/Oct; organic cation transporter; SLC; solute carrier; tmax; time to maximum
Development of SYN-004, an oral beta-lactamase treatment to protect the gut microbiome from antibiotic-mediated damage and prevent Clostridium difficile infection
Keywords: حداکثر غلظت; Antibiotic risk factors; Beta-lactamase; Clostridium difficile; Healthcare-associated infections; Microbiome; AAD; antibiotic-associated diarrhea; CDI; Clostridium difficile infection; Conc; concentration; Cmax; maximum concentration; CRO; ceftriaxone; FM
Polysialic acid-modifying liposomes for efficient delivery of epirubicin, in-vitro characterization and in-vivo evaluation
Keywords: حداکثر غلظت; AUC(0-t); area under the drug concentration-time curve values; Cmax; maximum concentration; CLz; total clearance; DiR; 1,1â²-dioctadecyl-3,3,3â²,3â²-tetramethyl indotricarbocyanine iodide; DiR-CL; DiR-labeled common liposomes; DiR-SL; DiR-labeled PSA-B
Neuropharmacological efficacy of the traditional Japanese Kampo medicine yokukansan and its active ingredients
Keywords: حداکثر غلظت; Aβ; amyloid β; AD; Alzheimer's disease; ADL; activities of daily living; BBB; blood-brain barrier; BPSD; behavioral and psychological symptoms of dementia; BrdU; bromodeoxyuridine; Cmax; maximum concentration; CHOP; C/EBP homologous protein; CYP; cyto
1-Alpha, 25-dihydroxyvitamin D3 alters the pharmacokinetics of mycophenolic acid in renal transplant recipients by regulating two extrahepatic UDP-glucuronosyltransferases 1A8 and 1A10
Keywords: حداکثر غلظت; AcMPAG; acyl mycophenolic acid glucuronide; ChIP; chromatin immunoprecipitation; Cmax; maximum concentration; DR; direct repeat; MMF; mycophenolate mofetil; MPA; mycophenolic acid; MPAG; mycophenolic acid glucuronide; PK; pharmacokinetics; PD; pharmacodyn
LC-MS/MS for Therapeutic Drug Monitoring of anti-infective drugs
Keywords: حداکثر غلظت; Liquid chromatography-tandem mass spectrometry (LC-MS/MS); Therapeutic Drug Monitoring (TDM); Pharmacokinetics/pharmacodynamics (PK/PD); Anti-infectives; Matrix effects; Antimicrobial stewardship (AMS); Free drug concentration; Laboratory proficiency test