کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8336525 | 1540630 | 2016 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Drinks containing anthocyanin-rich blackcurrant extract decrease postprandial blood glucose, insulin and incretin concentrations
ترجمه فارسی عنوان
نوشیدنی حاوی عصاره سیاه سبوس دار غنی از آنتوسایانین باعث کاهش غلظت گلوکز خون، انسولین و انکریت می شود
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کلمات کلیدی
GLP-1time of maximum concentrationNEFAGIPtmaxCmaxAOBRandomized controlled trial - آزمایش تصادفی کنترل شدهAnthocyanins - آنتوسیانین non-esterified fatty acids - اسیدهای چرب غیر استرادیدهIncretins - افزایش می یابدinsulin - انسولینcon - باtriacylglycerol - تری آسیل گلیسرول TAG یا triacylglycerols - تری گلیسرید یا تری آسیل گلیسرولBerries - توت هاmaximum concentration - حداکثر غلظتcontrol treatment - درمان کنترلPolyphenols - پلیفنلهاglucagon-like peptide-1 - پپتید 1-گلوکاگون-مانندPostprandial glycemia - گلیسمی پس از فروپاشیglucose-dependent insulinotropic polypeptide - گلیکول وابسته به پلی پپتید انسولینوتروپیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Blackcurrants are rich in polyphenolic glycosides called anthocyanins, which may inhibit postprandial glycemia. The aim was to determine the dose-dependent effects of blackcurrant extract on postprandial glycemia. Men and postmenopausal women (14 M, 9 W, mean age 46 years, S.D.=14) were enrolled into a randomized, double-blind, crossover trial. Low sugar fruit drinks containing blackcurrant extract providing 150-mg (L-BE), 300-mg (M-BE) and 600-mg (H-BE) total anthocyanins or no blackcurrant extract (CON) were administered immediately before a high-carbohydrate meal. Plasma glucose, insulin and incretins (GIP and GLP-1) were measured 0-120 min, and plasma 8-isoprostane F2α, together with arterial stiffness by digital volume pulse (DVP) was measured at 0 and 120 min. Early plasma glucose response was significantly reduced following H-BE (n=22), relative to CON, with a mean difference (95% CI) in area over baseline (AOB) 0-30 min of â0.34 mmol/l.h (â0.56, â0.11, P<.005); there were no differences between the intermediate doses and placebo. Plasma insulin concentrations (AOB 0-30 min) were similarly reduced. Plasma GIP concentrations (AOB 0-120 min) were significantly reduced following H-BE, with a mean difference of â46.6 ng/l.h (â66.7, â26.5, P<.0001) compared to CON. Plasma GLP-1 concentrations were reduced following H-BE at 90 min. There were no effects on 8-isoprostane F2α or vascular function. Consumption of blackcurrant extract in amounts roughly equivalent to 100-g blackcurrants reduced postprandial glycemia, insulinemia and incretin secretion, which suggests that inclusion of blackcurrant polyphenols in foods may provide cardio-metabolic health benefits. This trial was registered at clinicaltrials.gov as NCT01706653.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 38, December 2016, Pages 154-161
Journal: The Journal of Nutritional Biochemistry - Volume 38, December 2016, Pages 154-161
نویسندگان
Monica L. Castro-Acosta, Leanne Smith, Rosalind J. Miller, Danielle I. McCarthy, Jonathan A. Farrimond, Wendy L. Hall,