دانلود مقالات ISI درباره حداکثر غلظت + ترجمه فارسی

Andrographis paniculata: Dissolution investigation and pharmacokinetic studies of four major active diterpenoids after multiple oral dose administration in healthy Thai volunteers

Keywords: حداکثر غلظت; 1; andrographolide; 2; 14-deoxy-11, 12-didehydroandrographolide; 3; neoandrographolide; 4; 14-deoxyandrographolide; AUC; area under plasma concentration-time curve; Cmax; maximum concentration; Cl; clearance; EDTA; ethylenediaminetetraacetic acid; F; bioa

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

Stable loading and delivery of disulfiram with mPEG-PLGA/PCL mixed nanoparticles for tumor therapy

Keywords: حداکثر غلظت; DSF; disulfiram; mPEG-PLGA; methoxy poly(ethylene glycol)-b-poly(lactide-co-glycolide); PCL; poly(ε-caprolactone); NPs; nanoparticles; DMF; N,N′-dimethylformamide; CH3CN; acetonitrile; DLS; dynamic light scattering; TEM; transmission electron microscop

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2016 سفارش ترجمه

Quercetin-loaded freeze-dried nanomicelles: Improving absorption and anti-glioma efficiency in vitro and in vivo

Keywords: حداکثر غلظت; ATCC; American Tissue Culture Collection; BBB; blood-brain barrier; CMC; critical micelle concentration; DL; drug loading; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; DPH; 1,6-diphenyl-1,3,5-hexatriene; EE; encapsulation efficiency

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2016 سفارش ترجمه

Combined therapy using bevacizumab and turmeric ethanolic extract (with absorbable curcumin) exhibited beneficial efficacy in colon cancer mice

Keywords: حداکثر غلظت; Bevacizumab; Colorectal cancer; Curcumin; Turmeric; Turmerone; 5-FU; 5-fluorouracil; ALT; alanine aminotransferase; AST; aspartate aminotransferase; AUC; area under concentrationâ¿¿time curve; Cmax; maximum concentration; CK; creatine kinase; FBS; fetal b

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2016 سفارش ترجمه

Predicting points of departure for risk assessment based on in vitro cytotoxicity data and physiologically based kinetic (PBK) modeling: The case of kidney toxicity induced by aristolochic acid I

Keywords: حداکثر غلظت; Physiologically based kinetic (PBK) model; Aristolochic acid I (AAI); Kidney toxicity; In vitro-in vivo extrapolation; Risk assessment; Physiologically based pharmacokinetic (PBPK) model; AA; aristolochic acid; AAI; aristolochic acid I; AAII; aristoloch

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2016 سفارش ترجمه

Dietary pretreatment with green tea polyphenol, (−)-epigallocatechin-3-gallate reduces the bioavailability and hepatotoxicity of subsequent oral bolus doses of (−)-epigallocatechin-3-gallate

Keywords: حداکثر غلظت; ALT; alanine aminotransferase; AUC0→6h; exposure over 6 h; Cmax; maximum concentration; EGCG; (−)-epigallocatechin-3-gallate; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GPX; glutathione peroxidase; GSR; glutatione reductase; GST; glutathione-S

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Evaluation of the Plasmatic and Parenchymal Elution Kinetics of Two Different Irinotecan-Loaded Drug-Eluting Embolics in a Pig Model

Keywords: حداکثر غلظت; AUC; area under the curve; Cmax; maximum concentration;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Idarubicin-Loaded ONCOZENE Drug-Eluting Embolic Agents for Chemoembolization of Hepatocellular Carcinoma: In Vitro Loading and Release and In Vivo Pharmacokinetics

Keywords: حداکثر غلظت; AE; adverse event; AUC0-24 h; area under the concentration-time curve from 0-24 hours; Cmax; maximum concentration; DEE; drug-eluting embolic; HCC; hepatocellular carcinoma; LLOQ; lower limit of quantification; MDR; multidrug resistance; PK; pharmacok

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Evaluation of the dopamine β-hydroxylase (DβH) inhibitor nepicastat in participants who meet criteria for cocaine use disorder

Keywords: حداکثر غلظت; Cocaine; Dopamine-β-hydroxylase; Nepicastat; SYN117; AE; Adverse Event; ANOVA; Analysis of Variance; AUC; Area Under the Curve; BP; Blood Pressure; Cmax; Maximum Concentration; DA; Dopamine; DβH; Dopamine-β-hydroxylase; DSM; Diagnostic and Statistical

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Cardiovascular pharmacologyCardiovascular safety pharmacology profile of etamicastat, a novel peripheral selective dopamine-ß-hydroxylase inhibitor

Keywords: حداکثر غلظت; DBH; dopamine-ß-hydroxylase; LC-MS/MS; liquid chromatography - mass spectrometry; AUC; area under plasma concentration-time curve; tmax; time to maximum concentration; t1/2; terminal half-life; Cmax; maximum concentration; LLOQ; lower limit of quanti

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Preclinical pharmacokinetic evaluation and metabolites identification of methyl salicylate-2-O-β-d-lactoside in rats using LC-MS/MS and Q-TOF-MS methods

Keywords: حداکثر غلظت; AS; salicylic acid; AUC; area under the blood concentration-time curve; Cmax; maximum concentration; ESI; electrospray ionization; IS; internal standard; LC-MS/MS; liquid chromatography-mass spectrometry/mass spectrometry; MSL; methyl salicylate-2-O-β-

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

A randomised, placebo-controlled, Phase II, dose-ranging trial of once-daily treatment with olodaterol, a novel long-acting β2-agonist, for 4 weeks in patients with chronic obstructive pulmonary disease

Keywords: حداکثر غلظت; Olodaterol; COPD; Long-acting β2-agonist; Once-daily; AE; adverse event; AUC0-6; area under the curve from 0 to 6 h; COPD; chronic obstructive pulmonary disease; Cmax; maximum concentration; FEV1; forced expiratory volume in 1 s; FVC; forced vital ca

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Effects of EGCG content in green tea extract on pharmacokinetics, oxidative status and expression of inflammatory and apoptotic genes in the rat ocular tissues

Keywords: حداکثر غلظت; AUC; area under curve; Cmax; maximum concentration; EC; (−)-epicatechin; EGC; (−)-epigallocatechin; EGCG; (−)-epigallocatechin gallate; GC; (−)-gallocatechin; GCG; (−)-gallocatechin gallate; GPx3; glutathione peroxidase-3; GSH; reduced glutathio

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Comparison of physiologic and pharmacologic parameters in Asian and mauritius cynomolgus macaques

Keywords: حداکثر غلظت; Cynomolgus macaque; Background parameters; Physiologic comparison; Pharmacologic comparison; Asian macaque; Mauritius macaque; AUC; area under the curve; Cmax; maximum concentration; ELISA; Enzyme-Linked Immunosorbent Assay; KLH; keyhole limpet hemocyanin

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2015 سفارش ترجمه

Intranasal microemulsion for targeted nose to brain delivery in neurocysticercosis: Role of docosahexaenoic acid

Keywords: حداکثر غلظت; ABZ; albendazole; ABZ-SO; Albendazole sulfoxide; ACN; acetonitrile; ALP; alkaline phosphatase; ANOVA; analysis of variance; AUC; area-under-the-curve; BBB; blood brain barrier; Cmax; maximum concentration; CUR; Curcumin; CYPs; cytochrome P450; DHA; docosa

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2015 سفارش ترجمه

The relationship between in vivo antiviral activity and pharmacokinetic parameters of peramivir in influenza virus infection model in mice

Keywords: حداکثر غلظت; PK; pharmacokinetic; IV; intravenous; PD; pharmacodynamic; AUC; area under the concentration-time curve; Cmax; maximum concentration; IC50; 50% inhibitory concentration; IC95; 95% inhibitory concentration; T>IC95; time that drug concentration exceeds IC

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Pharmacokinetics of oral vitamin D3 and calcifediol

Keywords: حداکثر غلظت; AUC; area under the concentration vs time curve; Cmax; maximum concentration; Clast; concentration quantified before the next study drug intake; GMR; geometric mean ratio; HPLC; high performance liquid chromatography; tmax; time to reach Cmax; RCT; random

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Target-mediated clearance and bio-distribution of a monoclonal antibody against the Kunitz-type protease inhibitor 2 domain of Tissue Factor Pathway Inhibitor

Keywords: حداکثر غلظت; AUC; area under the curve; Cl; clearance; DAB; 3,3′-diaminobenzidine; dIF; double immunofluorescence; EGFR; epidermal growth factor receptor; GAG; glycosaminoglycans; GPI; glycosylphosphatidylinositol; FVIII; Factor VIII; FIX; Factor IX; FXa; Factor Xa;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Pharmacokinetics and Antitumor Efficacy of Chemoembolization Using 40 µm Irinotecan-Loaded Microspheres in a Rabbit Liver Tumor Model

Keywords: حداکثر غلظت; ALP; alkaline phosphatase; AST; aspartate aminotransferase; AUC; area under the curve; Cmax; maximum concentration; CRLM; colorectal liver metastases; DE; drug-eluting; TANDEM-IRI; irinotecan-loaded drug-eluting microspheres (Embozene TANDEM Microspheres)

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Original ResearchFull Report: Clinical-LiverTelaprevir Twice Daily Is Noninferior to Telaprevir Every 8 Hours for Patients With Chronic Hepatitis C

Keywords: حداکثر غلظت; OPTIMIZE; Clinical Trial; Protease Inhibitor; DAA; AE; adverse event; AUC24,ss; area under the plasma concentration-time curve from time of administration up to 24 hours; CI; confidence interval; Cmax; maximum concentration; Cmax,ss; maximum steady-state

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Frontiers in Liver TransplantationDrug-drug interactions with oral anti-HCV agents and idiosyncratic hepatotoxicity in the liver transplant setting

Keywords: حداکثر غلظت; ALT; Alanine aminotransferase; AST; Aspartate aminotransferase; AUC; Area under the curve; BOC; Boceprevir; BSEP; Bile salt export pump; Cmax; Maximum concentration; CNI; Calcineurin inhibitors; CYP; Cytochrome P450; DAA; Direct acting antivirals; DDI; Dr

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Concentration of coffee extract using nanofiltration membranes

Keywords: حداکثر غلظت; Nanofiltration; Coffee extract; Maximum concentration; Solid loss; Permeability

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Improved dissolution and pharmacokinetic behavior of dipyridamole formulation with microenvironmental pH-modifier under hypochlorhydria

Keywords: حداکثر غلظت; ANOVA; analysis of variance; AUC; area under the curve of blood concentration vs. time; BA; bioavailability; Cmax; maximum concentration; CV; coefficient of variation; DP; dipyridamole; DPG; granule formulation of dipyridamole; FA; fumaric acid; HCl; hydr

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Novel formulations of dipyridamole with microenvironmental pH-modifiers for improved dissolution and bioavailability under hypochlorhydria

Keywords: حداکثر غلظت; ANOVA; analysis of variance; API; active pharmaceutical ingredient; AA; adipic acid; D; l-aspartic acid; AUC; area under the curve of plasma concentration vs. time; BCS; biopharmaceutics classification system; CA; citric acid monohydrate; Cmax; maximum co

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Elucidation of (−)-epicatechin metabolites after ingestion of chocolate by healthy humans

Keywords: حداکثر غلظت; IS; internal standard; Cmax; maximum concentration; Tmax; maximum time; T1/2; elimination half-life; AUC; area under the curve; EC-3'-Gluc; [(-)-epicatechin-3'-β-D-glucuronide]; EC-4'-Gluc; [(-)-epicatechin-4'-β-D-glucuronide]; EC-7-Gluc; [(-)-epicatech

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Phase II, dose ranging study of the safety and immunogenicity of single dose West Nile vaccine in healthy adults ≥50 years of age

Keywords: حداکثر غلظت; AE; adverse event; AR; adverse reaction; AUC; area under the curve; E; envelope; GMT; geometric mean titer; Cmax; maximum concentration; PRNT; plaque reduction neutralization test; prM; pre-membrane; SAE; serious adverse event; SOC; system organ class; US

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

MAP0004, Orally Inhaled Dihydroergotamine for Acute Treatment of Migraine: Efficacy of Early and Late Treatments

Keywords: حداکثر غلظت; AE; adverse event; Cmax; maximum concentration; DHE; dihydroergotamine mesylate; FEV1; forced expiratory volume in 1 second; ICHD-II; International Classification of Headache Disorders, 2nd edition; mITT; modified intent-to-treat;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Comparison of a genomic and a multiplex cell imaging approach for the detection of phospholipidosis

Keywords: حداکثر غلظت; AUC; area under the concentration-time curve from 0 to 24 h; ANIT; α-naphthyl-isothiocyanate; BNF; β-naphthoflavone; CAD; cationic amphiphilic drug; Cmax; maximum concentration; DMSO; dimethylsulfoxide; EM; electron microscopy; FDA; Food and Drug Admin

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Evaluation of VCH-759 monotherapy in hepatitis C infection

Keywords: حداکثر غلظت; HCV; hepatitis C virus; RNA; ribonucleic acid; IC50; 50% inhibitory concentration; t.i.d.; three times daily; b.i.d.; twice daily; IC90; 90% inhibitory concentration; DNA; deoxyribonucleic acid; TI; therapeutic index; CC50; 50% cytotoxic concentration; PK

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Effect of Fruit Juices on the Oral Bioavailability of Fexofenadine in Rats

Keywords: حداکثر غلظت; food interactions; oral absorption; transporters; organic anion-transporting polypeptide; p-glycoprotein; bioavailability; API:; atmospheric pressure ionization; AUC0n:; area under the concentration vs. time curve from 0 to time of the last measurable con

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه

Vitamin E bioavailability in humans

Keywords: حداکثر غلظت; apoE4; Bioavailability; Biokinetics; Deuterated; Natural; Tocopherol; Smokers; Synthetic; all rac; synthetic (all racemic) α-tocopherol; apoE; apolipoprotein E; AUC; area under the curve; CEHC; carboxyethyl-hydroxychroman; CM; chylomicrons; Cmax; maximum

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه

A phase I study of recombinant human C1 inhibitor in asymptomatic patients with hereditary angioedema

Keywords: حداکثر غلظت; Hereditary angioedema; C1 inhibitor; C4; complement; pharmacodynamics; pharmacokinetics; human; C1INH; C1 esterase inhibitor; C4b/c; C4b, C4bi, or C4c; Cmax; Maximum concentration; Cmin; Minimum concentration; ECG; Electrocardiography; HAE; Hereditary ang

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Effect of Alvimopan and Codeine on Gastrointestinal Transit: A Randomized Controlled Study

Keywords: حداکثر غلظت; BMI; body mass index; Cmax; maximum concentration; CYP; cytochrome; GC; geometric center; 99mTc; 99m-labeled technetium; 111In; 111-labeled indium; Tmax; time at maximum concentration; t1/2; half-time (in reference to transit);

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Pharmacokinetics of monobutylphthalate, the active metabolite of di-n-butylphthalate, in pregnant rats

Keywords: حداکثر غلظت; AUC; area under the concentration-time curve; CIIT; CIIT Centers for Health Research; Cls; systemic clearance; Cmax; maximum concentration; DBP; di-n-butyl phthalate; DEHP; di(2-ethylhexyl) phthalate; GD; gestation day; HPLC; high-performance liquid chr

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

The retinoid X receptor agonist bexarotene (Targretin) synergistically enhances the growth inhibitory activity of cytotoxic drugs in non-small cell lung cancer cells

Keywords: حداکثر غلظت; AP-1; activator protein-1; ATCC; American Type Culture Collection; CDK4; cyclin-dependent kinase 4; CI; combination index; Cmax; maximum concentration; CTCL; cutaneous T cell lymphoma; DMSO; dimethyl sulfoxide; FAM; 6-carboxy-fluorescein; ICn; concentrati

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه