Quercetin-loaded freeze-dried nanomicelles: Improving absorption and anti-glioma efficiency in vitro and in vivo

A novel drug delivery system for the treatment of glioma was developed. Quercetin-loaded freeze-dried nanomicelles (QUE-FD-NMs) significantly increased cellular uptake of quercetin into Caco-2 cells with low cytotoxicity, effective penetration of the blood-brain barrier, and powerful cytotoxicity on C6 glioma cells. Furthermore, QUE-FD-NMs exhibited significant anti-tumor effects in vivo, providing significant survival benefit. Therefore, freeze-dried nanomicelles loaded with quercetin are a promising drug delivery system for targeting brain tumors, particularly glioma.102