Keywords: ضریب نفوذپذیری ظاهری; Hydrophobic ion pairing; Complex stability; Intestinal permeability; In vitro; AL; alendronate sodium; PEI; polyethyleneimine; NLC; nanostructured lipid carrier; FASSIF-V2; fasted state simulated intestinal fluid; HBSS; Hanks' balanced salt solution; HE
مقالات ISI ضریب نفوذپذیری ظاهری (ترجمه نشده)
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Keywords: ضریب نفوذپذیری ظاهری; artificial membrane insert system (AMI-system); regenerated cellulose; Caco-2 cells; intestinal absorption; apparent permeability coefficient; FaSSIF/FaHIF;
Keywords: ضریب نفوذپذیری ظاهری; BA; bioavailability; C7; sodium enanthate; C9; sodium pelargonate; C10; sodium caprate; C11:1; sodium undecylenate; C12; sodium laurate; C12E8; polyoxyethylene-8 lauryl ether; CCh; carbachol; ER; enhancement ratio; ÎISC; change in short circuit current;
Keywords: ضریب نفوذپذیری ظاهری; biliary excretion; drug interactions; efflux pumps; MRP; permeability; ATV; atorvastatin; MET; metformin; 2-OH ATV; 2-hydroxyatorvastatin; CYP; cytochrome P450; MDCK; Madin-Darby canine kidney; MDR; multidrug resistance gene; BCRP; breast cancer resistanc
Keywords: ضریب نفوذپذیری ظاهری; nitric oxide; absorption enhancer; transcellular route; mucus layer; passive diffusion; permeability; duodenum; log P; DTT; dithiothreitol; FD-4; fluorescein isothiocyanatedextran 4000; KHB; Krebs-Henseleit bicarbonate; NO; nitric oxide; NOC7; 1-hydroxy-2
Keywords: ضریب نفوذپذیری ظاهری; ANOVA; analysis of variance; BSA; bovine serum albumin; DMSO; dimethyl sulfoxide; JSS; steady state flux; Log P; logarithm of partition coefficient; MW; molecular weight; Papp; apparent permeability coefficient; PBS; phosphate buffered saline (adjusted to
Keywords: ضریب نفوذپذیری ظاهری; BBB; blood-brain barrier; RBE4; rat brain microvascular endothelial cells; HLG; hypoxia/low glucose; FITC-dextran; fluorescein isothiocyanate-dextran; HIF-1α; hypoxia inducible factor-1alpha; VEGF; vascular endothelial growth factor; TJ; tight junction
Keywords: ضریب نفوذپذیری ظاهری; amorphous; poorly water soluble drugs; formulation; solid dispersion; flubendazole; spray drying; ordered mesoporous silica; oral absorption; filarial disease; ACN; acetonitrile; API; active pharmaceutical ingredient; AUC; area under the curve; Cmax; maxi
Keywords: ضریب نفوذپذیری ظاهری; HT29-MTX intestinal cell model; Apparent permeability coefficient; Cholesterol; β-Sitosterol; Pine-derived phytosterols; Sterol transport; PinVita™ FSP DuPont
Keywords: ضریب نفوذپذیری ظاهری; Alprenolol (PubChem CID: 2119); Atenolol (PubChem CID: 2249); Cyclosporin A (PubChem CID: 5,284,373); Doxorubicin (PubChem CID: 31,703); Gentamicin (PubChem CID: 3467); Metoprolol (PubChem CID: 4171); Pindolol (PubChem CID: 4828); Rifampicin (PubChem CID:
Keywords: ضریب نفوذپذیری ظاهری; AF660; Alexa Fluor 660; BBB; blood brain barrier; CNS; central nervous system; DLS; dynamic light scattering; ECM; endothelial cell medium; Enf; enfuvirtide; Epf; epifluorescence; FI; fluorescence intensity; FD40; FITC-Dextran 40; FITC; fluoresceinamine;
Keywords: ضریب نفوذپذیری ظاهری; 3Rs; reduce, refine, replace; A; apical; ABC; ATP-binding cassette; B; basal; BCF; bioconcentration factor; BTA; bi-directional transport assay; CETA; concentration equilibrated transport assay; Ci; Curie; Dpm; disintegrations per minute; Kow; octanol-w
Keywords: ضریب نفوذپذیری ظاهری; HCA; high content analysis; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide; MCFA; medium chain fatty acids from C8-C12; C10; sodium salt of capric acid; uC11; sodium salt of 10-undecylenic acid; PE; permeation enhancer; Papp; apparent
Keywords: ضریب نفوذپذیری ظاهری; NPs; nanoparticles; CME; clathrin-mediated endocytosis; BBB; blood-brain barrier; FBS; fetal bovine serum; TEER; transepithelial electrical resistance; Papp; apparent permeability coefficient; ALP; alkaline phosphatase; LacCer; lactosylceramide; PBS; ph
Keywords: ضریب نفوذپذیری ظاهری; PAMPAs; parallel artificial membrane permeability assays; IPM; isopropyl myristate; Papp/kp; apparent permeability coefficient; Ko/w; octanol-water partition coefficient; Skin; Parallel artificial membrane permeability assays (PAMPAs); Isopropyl myrista
The influence of compatibility of Si-Ni decoction with metabolism in intestinal bacteria on transports of toxic diterpenoid alkaloids from processed aconite root across Caco-2 monolayers
Keywords: ضریب نفوذپذیری ظاهری; AD; Decoction of processed aconite root; ALD; Decoction of processed aconite root and honey-processed liquorice; AP; Apical; BCRP; Breast cancer resistance protein; BL; Basolateral; DDAs; Diester-diterpenoid alkaloids; EIC; Extracted ion chromatogram; ER;
A dabigatran etexilate phospholipid complex nanoemulsion system for further oral bioavailability by reducing drug-leakage in the gastrointestinal tract
Keywords: ضریب نفوذپذیری ظاهری; Dabigatran etexillate; Nanoemulsions; Phospholipid complex; pH-dependent solubility; Bioavailability; DE; dabigatran etexilate; DE-PC; dabigatran etexilate-phospholipid complex; SGIF; simulated gastrointestinal fluids; GI; gastrointestinal; SGF; simulated
Labrasol® and Salts of Medium-Chain Fatty Acids Can Be Combined in Low Concentrations to Increase the Permeability of a Macromolecule Marker Across Isolated Rat Intestinal Mucosae
Keywords: ضریب نفوذپذیری ظاهری; permeation enhancer; macromolecular drug delivery; epithelial delivery/permeability; peptide delivery; oral drug delivery; BA; bioavailability; BCS; Biopharmaceutics Classification System; C10; sodium caprate; C11:1; sodium undecylenate; C12; sodium laura
Improving oral bioavailability of resveratrol by a UDP-glucuronosyltransferase inhibitory excipient-based self-microemulsion
Keywords: ضریب نفوذپذیری ظاهری; ACN; acetonitrile; AP; apical; BL; basolateral; CYP450; cytochrome P450 proteins; FBS; fetal bovine serum; IC50; half-inhibitory concentration; MEM; minimum essential medium; MTT; 3-(40,50-dimethylthiazol-20-yl)-2,5-diphenyltetrazolium bromide; NEAA; none
In vitro screening of dual flavonoid combinations for reversing P-glycoprotein-mediated multidrug resistance: Focus on antiepileptic drugs
Keywords: ضریب نفوذپذیری ظاهری; Epilepsy; Dual flavonoid combinations; Flavonoids; In vitro studies; P-glycoprotein; Pharmacoresistance; AEDs; Antiepileptic drugs; CBZ; Carbamazepine; CBZ-E; Carbamazepine-10,11-epoxide; CNS; Central nervous system; DMSO; dimethyl sulfoxide; DMEM; Dulbec
A systematic review of pharmacokinetic studies on herbal drug Fuzi: Implications for Fuzi as personalized medicine
Keywords: ضریب نفوذپذیری ظاهری; Aconitum carmichaeli Debx.; Aconitum alkaloids; Pharmacokinetics; Herb-drug interactions; Toxicology; Personalized medicine; DMEs; drug-metabolizing enzymes; ETs; efflux transporters; BB; bioavailability barrier; DDAs; diester-diterpene alkaloids; MDAs; m
Transport of soybean protein-derived antihypertensive peptide LSW across Caco-2 monolayers
Keywords: ضریب نفوذپذیری ظاهری; Antihypertensive peptide; Caco-2 cell; LSW; PepT1; Transport; ACN; acetonitrile; ACE; angiotensin-converting enzyme; AP; apical side; BL; basolateral side; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; LSW; Leu-Ser-Trp; IRW; Ile-A
Research paperMucin dispersions as a model for the oromucosal mucus layer in in vitro and ex vivo buccal permeability studies of small molecules
Keywords: ضریب نفوذپذیری ظاهری; BSA; bovine serum albumin; HBSS; Hanks' balanced salt solution; HFDS; human freeze-dried saliva; Log P; logarithm of partition coefficient; Log D; logarithm of distribution coefficient; MW; molecular weight; Papp; apparent permeability coefficient; PBS;
Hybrid polymeric matrices for oral modified release of Desvenlafaxine succinate tablets
Keywords: ضریب نفوذپذیری ظاهری; Desvenlafaxine succinate; Controlled release matrix; Apparent permeability coefficient; Everted sac; Papp; apparent permeability coefficient; DSV; Desvenlafaxine succinate; DSC; differential scanning calorimetry; FDA; Food and Drug Administration; HPMC; h
Cellular internalization, transcellular transport, and cellular effects of silver nanoparticles in polarized Caco-2 cells following apical or basolateral exposure
Keywords: ضریب نفوذپذیری ظاهری; Caco-2; Nanomaterials; Transport; DMEM; Dulbecco's modified Eagle's medium; FCS; fetal calf serum; Ab; antibiotic-antimycotic mix stock solution; BSA; bovine serum albumin; ICP-MS; inductively coupled plasma mass spectrometry; FITC; fluorescein-isothioc
Evaluating the Transport Kinetics of a Model Compound Released From Cellulosic Coacervate Compositions Into Artificial Sebum
Keywords: ضریب نفوذپذیری ظاهری; bioavailability; coacervation; controlled release; permeability; polymeric drugs; site-specific delivery; skin; cat-HEC; cationic-hydroxyethyl cellulose; cat-HECDS; cationic-hydroxyethyl cellulose dodecyl sulfate; CPB; citrate-phosphate buffer; Daq; aqueo
Andrographolide-loaded nanoparticles for brain delivery: Formulation, characterisation and in vitro permeability using hCMEC/D3 cell line
Keywords: ضریب نفوذپذیری ظاهری; AG; andrographolide; ATM; adsorptive-mediated transcytosis; BBB; blood-brain barrier; BSA; bovine serum albumin; CNS; central nervous system; DLS; Dynamic Light Scattering; DMSO; dimethyl sulfoxide; ECA; ethylcyanoacrylate; EE; encapsulation efficiency; E
Trimethyl chitosan based conjugates for oral and intravenous delivery of paclitaxel
Keywords: ضریب نفوذپذیری ظاهری; 2â²SPTX; 2â²-O-succinyl-paclitaxel; AUC; area under the concentrationtime curve; BSA; bovine serum albumin; CMC; critical micelle concentration; DMEM; Dulbecco's Modified Eagle Medium; DMSO; dimethyl sulfoxide; DSC; differential scanning calorimetry;
Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites
Keywords: ضریب نفوذپذیری ظاهری; ABC transporters; transporters; skin; P-glycoprotein; tissue partition; ABCB1; ATP binding cassette subfamily B member 1; ABCG2; ATP binding cassette subfamily G member 2; BCRP; breast cancer resistance protein; CRC; colorectal cancer; CYP3A4; cytochrome
Assessment of ABCG2-mediated transport of pesticides across the rabbit placenta barrier using a novel MDCKII in vitro model
Keywords: ضریب نفوذپذیری ظاهری; ABCG2; ATP-binding cassette sub-family G member 2; CPF; chlorpyrifos; DAPI; 4â²-6-diamidino-2-phenylindole; FTC; fumitremorgin C; MDCKII; Madin-Darby canine kidney type II cells; MRL; maximum residue limits; Papp; apparent permeability coefficient; TEER;
Validation of UHPLC-MS/MS methods for the determination of kaempferol and its metabolite 4-hydroxyphenyl acetic acid, and application to in vitro blood-brain barrier and intestinal drug permeability studies
Keywords: ضریب نفوذپذیری ظاهری; 4-HPAA; 4-hydroxyphenyl acetic acid; ACN; acetonitrile; BSA; bovine serum albumin; Cal; calibrator; CCl; cell layer capacitance; CNS; central nervous system; CV%; coefficient of variation; CPT-cAMP; 8-(4-chlorophenylthio)-adenosine-3â²,5â²-cyclic monoph
Quercetin-loaded freeze-dried nanomicelles: Improving absorption and anti-glioma efficiency in vitro and in vivo
Keywords: ضریب نفوذپذیری ظاهری; ATCC; American Tissue Culture Collection; BBB; blood-brain barrier; CMC; critical micelle concentration; DL; drug loading; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; DPH; 1,6-diphenyl-1,3,5-hexatriene; EE; encapsulation efficiency
Investigation of the absorption of resveratrol oligomers in the Caco-2 cellular model of intestinal absorption
Keywords: ضریب نفوذپذیری ظاهری; DMEM; Dulbecco's Modified Eagle Medium; FBS; fetal bovine serum; GUS; glucuronidase; LC-UV; liquid chromatography with ultraviolet absorbance detection; LY; lucifer yellow; n.d.; not detected; Papp; apparent permeability coefficient; SD; standard devi
New biomimetic barrier Permeapad™ for efficient investigation of passive permeability of drugs
Keywords: ضریب نفوذپذیری ظاهری; Permeapad™; Permeability testing; Biomimetic barrier; Apparent permeability coefficient; Franz cell diffusion system
Development of an online-SPE-LC-MS method for the investigation of the intestinal absorption of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PHIP) and its bacterial metabolite PHIP-M1 in a Caco-2 Transwell system
Keywords: ضریب نفوذپذیری ظاهری; PHIP; 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine; PHIP-M1; 7-hydroxy-5-methyl-3-phenyl-6,7,8,9-tetrahydropyrido[3â²,2â²:4,5]imidazo[1,2-a]pyrimidin-5-ium chloride; Papp; apparent permeability coefficient; HCA; heterocyclic aromatic amine; CE; colli
Condensed catechins and their potential health-benefits
Keywords: ضریب نفوذپذیری ظاهری; ACE; angiotensin I-converting enzyme; AMPK; AMP-activated protein kinase; AUC; area under the curve; BGL; blood glucose level; CaMKK; Ca2+/camodulin-dependent protein kinase kinase; COX; cyclooxygenases; EC; (â)-epicatechin; EDRF; endothelium derived-re
Evaluation of the appropriate time range for estimating the apparent permeability coefficient (Papp) in a transcellular transport study
Keywords: ضریب نفوذپذیری ظاهری; Caco-2 cells; Transcellular transport; Apparent permeability coefficient; Model analysis; Intracellular distribution; Membrane permeability
Oral delivery of shRNA based on amino acid modified chitosan for improved antitumor efficacy
Keywords: ضریب نفوذپذیری ظاهری; Chitosan; Amino acid modification; Survivin shRNA; Oral delivery; Antitumor efficacy; ANOVA; analysis of variance; CH; chitosan-histidine; CHC30; chitosan-histidine-cysteine with molecular weight of 30Â kDa; CHC30 NC; CHC30/ shSur-pDNA nanocomplexes
Assessment of verbascoside absorption in human colonic tissues using the Ussing chamber model
Keywords: ضریب نفوذپذیری ظاهری; BHT; butylated hydroxytoluene; Isc; Short circuit current; MF; microfiltrated; OMWW; Olive Mill Waste Water; Papp; apparent permeability coefficient; Papp,tissue; the apparent permeability coefficient tissue; Papp,total; apparent permeability coefficient
Lecithin in mixed micelles attenuates the cytotoxicity of bile salts in Caco-2 cells
Keywords: ضریب نفوذپذیری ظاهری; SDC; sodium deoxycholate; BS; bile salts; PC; phosphatidylcholine; TEER; transepithelial electrical resistance; Papp; apparent permeability coefficient; FD-4; FITC-dextran 4400; Mixed micelles; Bile salt; Lecithin; Caco-2 cells; Cytotoxicity;
Reduced system exposures of total rhein and baicalin after combinatory oral administration of rhein, baicalin and berberine to beagle dogs and rats
Keywords: ضریب نفوذپذیری ظاهری; Rh; rhein; BG; baicalin; B; baicalein; Be; berberine; SHXXT; San-Huang-Xie-Xin-Tang; HLJDT; Huang-Lian-Jie-Du-Tang; PSP; phenolsulfonphthalein; HPLC; High performance liquid chromatography; Papp; apparent permeability coefficient; Rhein; Baicalin; Berberi
In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins
Keywords: ضریب نفوذپذیری ظاهری; AαBA; 3-acetyl-α-boswellic acid; AβBA; 3-acetyl-β-boswellic acid; AKBA; 3-acetyl-11-keto-β-boswellic acid; BA; boswellic acid; αBA; α-boswellic acid; βBA; β-boswellic acid; BSE; Boswellia serrata gum resin extract; HLM; human liver microsomes; KB
Synthesis and evaluation of nitric oxide-releasing DDB derivatives as potential Pgp-mediated MDR reversal agents in MCF-7/Adr cells
Keywords: ضریب نفوذپذیری ظاهری; DDB; dimethyl-4,4â²-dimethoxy-5,6,5â²,6â²-dimethylenedioxybiphenyl-2,2â²-dicarboxylate; NO; nitric oxide; MDR; multidrug resistance; VER; Verapamil; Dox; doxorubicin; EDCI; 1-(3-dimethyl aminopropyl)-3-ethylcarbodiimide hydrochloride; DMAP; 4-dimethyl
The mycotoxin patulin increases colonic epithelial permeability in vitro
Keywords: ضریب نفوذپذیری ظاهری; TEER; transepithelial electrical resistance; PD; potential difference; KH; Krebs-Henseleit buffer; CCh; carbachol; Papp; apparent permeability coefficient; CN; cell number; NA; nuclear area; NI; nuclear intensity; MMP; mitochondrial membrane potential;
Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport
Keywords: ضریب نفوذپذیری ظاهری; CSKSSDYQC peptide; Goblet cell-targeting; Mucus; Caco-2/HT29-MTX co-cultured cells; N-trimethyl chitosan chloride nanoparticles; CSK; CSKSSDYQC; TJs; tight junctions; NPs; nanoparticles; TMC; N-trimethyl chitosan chloride; INS; insulin; FITC; fluorescein
Simultaneous LC-MS/MS Determination of Danshensu and Paeoniflorin for Permeability Studies in Caco-2 Intestinal Absorption Model
Keywords: ضریب نفوذپذیری ظاهری; Denshensu; Paeoniflorin; Caco-2 cell; Apparent permeability coefficient; LC-MS/MS;
Quantitative determination of oxidized carbon nanotube probes in yeast by capillary electrophoresis with laser-induced fluorescence detection
Keywords: ضریب نفوذپذیری ظاهری; Capillary electrophoresis; Laser-induced fluorescence detection; Carbon nanotube probes; Yeast; Apparent permeability coefficient
Functional and pharmacological mechanisms of nucleoside transport across the basolateral membrane of rabbit tracheal epithelial cells
Keywords: ضریب نفوذپذیری ظاهری; RTEC; rabbit tracheal epithelial cells; NBMPR; nitro-benzyl-mercapto-purine-ribose; ei; equilibrative NBMPR-insensitive; es; equilibrative NBMPR-sensitive; PKA; protein kinase A; PKC; protein kinase C; A23187; a calcium ionophore; H89; a PKA inhibitor; HB