کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7595533 | 1492124 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Investigation of the absorption of resveratrol oligomers in the Caco-2 cellular model of intestinal absorption
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کلمات کلیدی
DMEMLC–UVTRISn.d.TEERGUSSPEFBSDulbecco’s modified Eagle medium - Modified Eagle اصلاح شده Dulbeccoε-Viniferin - ε-وینفرینAutomated sample preparation - آماده سازی نمونه های خودکارSolid phase extraction - استخراج فاز جامدstandard deviation - انحراف معیارTris(hydroxymethyl)aminomethane - تریس (هیدروکسی متیل) آمینومتانnot detected - تشخیص داده نشدIntestinal absorption - جذب رودهResveratrol - رسوراترولfetal bovine serum - سرم جنین گاوapparent permeability coefficient - ضریب نفوذپذیری ظاهریlucifer yellow - لوسیفر زردTrans-epithelial electrical resistance - مقاومت الکتریکی Trans-epithelialPapp - پاپGlucuronidase - گلوکورونیداز
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Investigation of the absorption of resveratrol oligomers in the Caco-2 cellular model of intestinal absorption Investigation of the absorption of resveratrol oligomers in the Caco-2 cellular model of intestinal absorption](/preview/png/7595533.png)
چکیده انگلیسی
Resveratrol oligomers are biologically active polyphenols found in wine. No information about the bioavailability of these polyphenols is available. In order to discover if the resveratrol oligomers can pass the intestinal barrier, transport of the dimer ε-viniferin and the tetramer hopeaphenol was studied in the Caco-2 transwell system. A flux through the cell monolayer could neither be observed for ε-viniferin nor for hopeaphenol (apparent permeability coefficient (Papp) < 1 Ã 10â6 cm sâ1). In contrast, resveratrol showed a Papp of 11.9 Ã 10â6 cm sâ1. Nevertheless, about 16-30% of the oligomers were found in the lysed cellular fraction. This leads to the conclusion that the intestinal absorption rate of the two resveratrol oligomers, ε-viniferin and hopeaphenol, is low and negligible when compared to resveratrol. Therefore, it is unlikely that the oligomers could elicit a systemic biological effect after dietary intake. However, the compounds may act locally on the intestinal epithelium.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 167, 15 January 2015, Pages 245-250
Journal: Food Chemistry - Volume 167, 15 January 2015, Pages 245-250
نویسندگان
Ina Willenberg, Maria Michael, Jasmin Wonik, Laura C. Bartel, Michael T. Empl, Nils Helge Schebb,