Keywords: پاپ; solubility; dissolution; permeability; oral absorption; species difference; dog; BCS; Fa; fraction of oral dose absorbed; Fah; Fa in humans; Fad; Fa in dogs; kel; elimination rate constant; Do; dose number; MAD; maximum absorbable dose; BW; body weight; F
مقالات ISI پاپ (ترجمه نشده)
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Keywords: پاپ; Hydrophobic ion pairing; Complex stability; Intestinal permeability; In vitro; AL; alendronate sodium; PEI; polyethyleneimine; NLC; nanostructured lipid carrier; FASSIF-V2; fasted state simulated intestinal fluid; HBSS; Hanks' balanced salt solution; HE
Keywords: پاپ; A to BA; pical to Basolateral; ANOVA; Analysis of variance; AUC; Area under the curve; B to A; Basolateral to Apical; BA; Bioavailability; CL; Clearance; CMC; Carboxymethyl cellulose; DMSO; Dimethyl sulfoxide; ER; Extraction ratio; FDA; Food and Drug Admi
Keywords: پاپ; Bmax; maximum binding capacity; CNV; choroidal neovascularization; DCT; dopachrome tautomerase; DHI; 5,6-dihydroxyindole; DHICA; 5,6-dihydroxyindole-2-carboxylic acid; DOPA; dihydroxyphenylalanine; HPLC; high performance liquid chromatography; IQ; 5,6-ind
Keywords: پاپ; Aptamers; Blood brain barrier; Cancer stem cells; Gene editing; Gene therapy; Therapeutic RNA delivery; DOTAP; N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl-sulfate; DSPE-PEG; poly (ethylene glycol)-grafted 1,2-distearoyl-sn-glycero- 3-phos
Keywords: پاپ; Mucus; Cell-based models; Mucosal model; Epithelium model; Permeation; Absorption; 2D; two-dimension; 3D; three-dimension; ALI; air-liquid culture; BCS; biopharmaceutics classification system; CV; cervicovaginal; CVM; cervicovaginal mucus; DDS; drug deliv
Keywords: پاپ; Papp; Apparent permeability; CNS; Central nervous system; CV; Coefficients of variation; GR; Glucocortocoidreceptor; HR; High responding; HPI-axis; Hypothalamic-pituitary-interrenal axis; LR; Low responding; MR; Mineralcorticoid receptors; Oprd; Opioid re
Keywords: پاپ; BA; bioavailability; C7; sodium enanthate; C9; sodium pelargonate; C10; sodium caprate; C11:1; sodium undecylenate; C12; sodium laurate; C12E8; polyoxyethylene-8 lauryl ether; CCh; carbachol; ER; enhancement ratio; ÎISC; change in short circuit current;
Keywords: پاپ; Asthma; epithelium; epithelial barrier function; tight junction; antigen sensitization; airway hyperresponsiveness; GAPDH; Glyceraldehyde 3-phosphate dehydrogenase; OVA; Ovalbumin; Papp; Apparent permeability; PAS; Periodic acid-Schiff; UCSF; University
Keywords: پاپ; Baicalin; Baicalein; Flavonoids; Chemoprevention; Inflammatory diseases; 6-OHDA; 6-hydroxydopamine; 12-LOX; 12-lipoxygenase; AIDS; acquired immunodeficiency disorder syndrome; AhR; aryl hydrocarbon receptor; AIH; autoimmune hepatitis; AICAR; 5-aminoimidaz
Keywords: پاپ; biliary excretion; drug interactions; efflux pumps; MRP; permeability; ATV; atorvastatin; MET; metformin; 2-OH ATV; 2-hydroxyatorvastatin; CYP; cytochrome P450; MDCK; Madin-Darby canine kidney; MDR; multidrug resistance gene; BCRP; breast cancer resistanc
Keywords: پاپ; Ab; antibody; ALP; alkaline phosphatase; ATR; atrazine; ATR-HRP; atrazine conjugated with horseradish peroxidase; CE; counter electrode; CNT; carbon nanotubes; CV; cyclic voltammetry; ELISA; enzyme-linked immunosorbent assay; HDPE; high-density polyethyle
Keywords: پاپ; Antibiotic drug resistance; Caenorhabditis elegans; Methicillin-resistant Staphylococcus aureus; MRSA; Intracellular infection; Pharmacokinetics; AMR; Antimicrobial resistance; Caco-2; heterogeneous human epithelial colorectal adenocarcinoma cells; CFUs;
Keywords: پاپ; API; active pharmaceutical ingredient; BE; bioequivalence; CLSM; confocal laser scanning microscopy; DDS; drug delivery system; ELISA; enzyme-linked immunosorbent assay; EMA; European Medicines Agency; FDA; U.S. Food & Drug Administration; FITC; fluoresce
Keywords: پاپ; nitric oxide; absorption enhancer; transcellular route; mucus layer; passive diffusion; permeability; duodenum; log P; DTT; dithiothreitol; FD-4; fluorescein isothiocyanatedextran 4000; KHB; Krebs-Henseleit bicarbonate; NO; nitric oxide; NOC7; 1-hydroxy-2
Keywords: پاپ; ANOVA; analysis of variance; BSA; bovine serum albumin; DMSO; dimethyl sulfoxide; JSS; steady state flux; Log P; logarithm of partition coefficient; MW; molecular weight; Papp; apparent permeability coefficient; PBS; phosphate buffered saline (adjusted to
Keywords: پاپ; BBB; blood-brain barrier; RBE4; rat brain microvascular endothelial cells; HLG; hypoxia/low glucose; FITC-dextran; fluorescein isothiocyanate-dextran; HIF-1α; hypoxia inducible factor-1alpha; VEGF; vascular endothelial growth factor; TJ; tight junction
Keywords: پاپ; amorphous; poorly water soluble drugs; formulation; solid dispersion; flubendazole; spray drying; ordered mesoporous silica; oral absorption; filarial disease; ACN; acetonitrile; API; active pharmaceutical ingredient; AUC; area under the curve; Cmax; maxi
Keywords: پاپ; BCA; bicinchoninic acid; CFSE; carboxyfluorescein diacetate succinimidyl ester; DAPI; (4â²,6-diamidino-2-phenylindole, dihydrochloride); DMEM; Dulbecco's Modified Eagle's Medium; DPBS; Dulbecco's phosphate-buffered saline; EDC; N-(3-dimethylaminopropyl)-
Keywords: پاپ; Alprenolol (PubChem CID: 2119); Atenolol (PubChem CID: 2249); Cyclosporin A (PubChem CID: 5,284,373); Doxorubicin (PubChem CID: 31,703); Gentamicin (PubChem CID: 3467); Metoprolol (PubChem CID: 4171); Pindolol (PubChem CID: 4828); Rifampicin (PubChem CID:
Keywords: پاپ; 3Rs; reduce, refine, replace; A; apical; ABC; ATP-binding cassette; B; basal; BCF; bioconcentration factor; BTA; bi-directional transport assay; CETA; concentration equilibrated transport assay; Ci; Curie; Dpm; disintegrations per minute; Kow; octanol-w
Keywords: پاپ; AF660; Alexa Fluor 660; BBB; blood brain barrier; CNS; central nervous system; DLS; dynamic light scattering; ECM; endothelial cell medium; Enf; enfuvirtide; Epf; epifluorescence; FI; fluorescence intensity; FD40; FITC-Dextran 40; FITC; fluoresceinamine;
Keywords: پاپ; NPs; nanoparticles; CME; clathrin-mediated endocytosis; BBB; blood-brain barrier; FBS; fetal bovine serum; TEER; transepithelial electrical resistance; Papp; apparent permeability coefficient; ALP; alkaline phosphatase; LacCer; lactosylceramide; PBS; ph
Keywords: پاپ; HCA; high content analysis; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide; MCFA; medium chain fatty acids from C8-C12; C10; sodium salt of capric acid; uC11; sodium salt of 10-undecylenic acid; PE; permeation enhancer; Papp; apparent
Keywords: پاپ; P-gp; P-glycoproteins; BEs; bioactive excipients; AP; apical; BL; basolateral; Papp; apparent permeability; CYP3A4; cytochrome P450 3A; HCC; hepatocellular carcinoma; BBB; blood-brain barrier; ER; Estrogen receptor; Cell line; Nanomedicine; Permeability
Keywords: پاپ; ANF; antinutritional factor; AUC; area under the curve; dpm; disintegrations per minute; DI; distal intestine; GLUT2; high-capacity, low affinity, bidirectional, facilitative transport protein for hexoses; Kt; transporter affinity constant; KTI; soybean K
The influence of compatibility of Si-Ni decoction with metabolism in intestinal bacteria on transports of toxic diterpenoid alkaloids from processed aconite root across Caco-2 monolayers
Keywords: پاپ; AD; Decoction of processed aconite root; ALD; Decoction of processed aconite root and honey-processed liquorice; AP; Apical; BCRP; Breast cancer resistance protein; BL; Basolateral; DDAs; Diester-diterpenoid alkaloids; EIC; Extracted ion chromatogram; ER;
Blood-brain barrier permeability and neuroprotective effects of three main alkaloids from the fruits of Euodia rutaecarpa with MDCK-pHaMDR cell monolayer and PC12 cell line
Keywords: پاپ; EF; Euodiae Fructus; EDM; evodiamine; RCP; rutaecarpine; DEDM; dehydroevodiamine; Papp; apparent permeability coefficients; P-gp; P-glycoprotein; MPP+; 1-methyl-4-phenylpyridinium ion; H2O2; hydrogen peroxide; TCM; traditional Chinese medicine; BBB; blood
In vitro assessment of the interactions of dopamine β-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein
Keywords: پاپ; BBB; blood-brain barrier; BCRP; Breast Cancer Resistance Protein; BSA; bovine serum albumin; DAD; diode-array detection; DBH; dopamine β-hydroxylase; DDIs; drug-drug interactions; DMSO; dimethyl sulfoxide; EMA; European Medicines Agency; HBSS; Hanks bala
A dabigatran etexilate phospholipid complex nanoemulsion system for further oral bioavailability by reducing drug-leakage in the gastrointestinal tract
Keywords: پاپ; Dabigatran etexillate; Nanoemulsions; Phospholipid complex; pH-dependent solubility; Bioavailability; DE; dabigatran etexilate; DE-PC; dabigatran etexilate-phospholipid complex; SGIF; simulated gastrointestinal fluids; GI; gastrointestinal; SGF; simulated
Effect of glycated insulin on the blood-brain barrier permeability: An in vitro study
Keywords: پاپ; Type 2 diabetes; Glycated insulin; AGE products; Permeability; Blood-brain barrier; BBB; blood-brain barrier; CNS; central nervous system; AGE; advanced glycated end product; HUVEC; human umbilical vein endothelial cells; T2DM; type 2 diabetes mellitus;
Improving oral bioavailability of resveratrol by a UDP-glucuronosyltransferase inhibitory excipient-based self-microemulsion
Keywords: پاپ; ACN; acetonitrile; AP; apical; BL; basolateral; CYP450; cytochrome P450 proteins; FBS; fetal bovine serum; IC50; half-inhibitory concentration; MEM; minimum essential medium; MTT; 3-(40,50-dimethylthiazol-20-yl)-2,5-diphenyltetrazolium bromide; NEAA; none
Labrasol® and Salts of Medium-Chain Fatty Acids Can Be Combined in Low Concentrations to Increase the Permeability of a Macromolecule Marker Across Isolated Rat Intestinal Mucosae
Keywords: پاپ; permeation enhancer; macromolecular drug delivery; epithelial delivery/permeability; peptide delivery; oral drug delivery; BA; bioavailability; BCS; Biopharmaceutics Classification System; C10; sodium caprate; C11:1; sodium undecylenate; C12; sodium laura
Mimicking brain tissue binding in an in vitro model of the blood-brain barrier illustrates differences between in vitro and in vivo methods for assessing the rate of brain penetration
Keywords: پاپ; Blood-brain barrier; Endothelial cells; Brain exposure; Drug discovery; BBB permeability; Brain tissue binding; In vitro model; In-situ brain perfusion; BBB; blood-brain barrier; bBCEC; bovine brain capillary endothelial cells; EC; endothelial cells; CNS;
High hepatic exposure of furanocoumarins in Radix Angelica dahuricae is associated with transporter mediated active uptake
Keywords: پاپ; ABT; 1-aminobenzotriazole; AUC0-â; area under the curve; BER; bergapten; Cmax; maximum plasma concentration; CsA; cyclosporine A; CYP; cytochrome P450; DMEM/F-12; Dulbecco's modified Eagle medium nutrient mixture F-12; DMSO; dimethyl sulfoxide; Æu; unb
In vitro screening of dual flavonoid combinations for reversing P-glycoprotein-mediated multidrug resistance: Focus on antiepileptic drugs
Keywords: پاپ; Epilepsy; Dual flavonoid combinations; Flavonoids; In vitro studies; P-glycoprotein; Pharmacoresistance; AEDs; Antiepileptic drugs; CBZ; Carbamazepine; CBZ-E; Carbamazepine-10,11-epoxide; CNS; Central nervous system; DMSO; dimethyl sulfoxide; DMEM; Dulbec
Evaluation of drug permeation under fed state conditions using mucus-covered Caco-2 cell epithelium
Keywords: پاپ; BM; biosimilar mucus; C10; sodium caprate; C12; sodium laurate; NaTC; sodium taurocholate; PC; phosphatidylcholine; MO; monoolein; OA; oleic acid; TEER; transepithelial electrical resistance; HBSS; Hank's Balanced Salt Solution; PAA; polyacrylic acid; FeS
Improved oral bioavailability of notoginsenoside R1 with sodium glycocholate-mediated liposomes: Preparation by supercritical fluid technology and evaluation in vitro and in vivo
Keywords: پاپ; CCD; central composite design; NGR1@Liposomes; NGR1-loaded liposomes; DLS; dynamic light scattering; EE; encapsulation efficiency; FACS; fluorescent-activated cell sorting; HPLC; high-performance liquid chromatography; ISCRPE; improved supercritical rever
Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA)
Keywords: پاپ; Antibiotic resistance; MRSA; VRSA; Multi-drug resistance; C. elegans; Caco-2; heterogeneous human epithelial colorectal adenocarcinoma cells; CFUs; colony forming units; HaCaT; human keratinocytes; Papp; apparent permeability; VISA; vancomycin-intermedia
A systematic review of pharmacokinetic studies on herbal drug Fuzi: Implications for Fuzi as personalized medicine
Keywords: پاپ; Aconitum carmichaeli Debx.; Aconitum alkaloids; Pharmacokinetics; Herb-drug interactions; Toxicology; Personalized medicine; DMEs; drug-metabolizing enzymes; ETs; efflux transporters; BB; bioavailability barrier; DDAs; diester-diterpene alkaloids; MDAs; m
Anti-inflammatory properties of an extract of M. ilicifolia in the human intestinal epithelial Caco-2 cell line
Keywords: پاپ; IL-8; Interleukin-8; IEC; Intestinal epithelial cell; LTA; Lipoteichoic acid; PAPP; Phenol red apparent permeability; TEER; Trans-epithelial electrical resistance; TLR-2; Toll-like receptor-2; Inflammation; Caco-2 cells; M. ilicifolia; Toxicity; Anti-infl
Involvement of intestinal efflux and metabolic instability in the pharmacokinetics of platycodin D in rats
Keywords: پاپ; Platycodin D (PD); Absorption time; Intestinal first-pass effect; Limited intestinal permeability; Gastrointestinal metabolism; PD; platycodin D; DMSO; dimethyl sulfoxide; PEG; polyethylene glycol; Papp; apparent permeability coefficients; HBSS; Hank's ba
Transport of soybean protein-derived antihypertensive peptide LSW across Caco-2 monolayers
Keywords: پاپ; Antihypertensive peptide; Caco-2 cell; LSW; PepT1; Transport; ACN; acetonitrile; ACE; angiotensin-converting enzyme; AP; apical side; BL; basolateral side; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; LSW; Leu-Ser-Trp; IRW; Ile-A
Research paperMucin dispersions as a model for the oromucosal mucus layer in in vitro and ex vivo buccal permeability studies of small molecules
Keywords: پاپ; BSA; bovine serum albumin; HBSS; Hanks' balanced salt solution; HFDS; human freeze-dried saliva; Log P; logarithm of partition coefficient; Log D; logarithm of distribution coefficient; MW; molecular weight; Papp; apparent permeability coefficient; PBS;
Research paperIn vitro uptake and transport studies of PEG-PLGA polymeric micelles in respiratory epithelial cells
Keywords: پاپ; ANOVA; analysis of variance; CA; curcumin acetate; CPZ; chlorpromazine; HBSS; Hank's balanced salt solution; LY; Lucifer Yellow; MEM; minimum essential medium; mPEG; methoxypoly (ethylene glycol); MβCD; methyl-β-cyclodextrin; NR; Nile Red; Papp; appar
P-Glycoprotein in skin contributes to transdermal absorption of topical corticosteroids
Keywords: پاپ; P-gp; P-glycoprotein; BCRP; breast cancer resistance protein; SC; stratum corneum; ABC; ATP-binding cassette; MDR1; multidrug resistance 1; MDCK II; Madin-Darby canine kidney II; BL; basal; AP; apical; ER; efflux ratio; Papp; apparent permeability coeffic
Hybrid polymeric matrices for oral modified release of Desvenlafaxine succinate tablets
Keywords: پاپ; Desvenlafaxine succinate; Controlled release matrix; Apparent permeability coefficient; Everted sac; Papp; apparent permeability coefficient; DSV; Desvenlafaxine succinate; DSC; differential scanning calorimetry; FDA; Food and Drug Administration; HPMC; h
Improved synthesis and comparative analysis of the tool properties of new and existing D-ring modified (S)-blebbistatin analogs
Keywords: پاپ; Blebbistatin; Myosin II; Photostability; Solubility; Cell membrane permeability; 2-mTHF; 2-methyltetrahydrofuran; A-B; apical-to-basolateral; B-A; basolateral-to-apical; CV; column volume; DMAP; 4-(dimethylamino)pyridine; DMEM; Dulbecco's modified Eagle m
Cellular internalization, transcellular transport, and cellular effects of silver nanoparticles in polarized Caco-2 cells following apical or basolateral exposure
Keywords: پاپ; Caco-2; Nanomaterials; Transport; DMEM; Dulbecco's modified Eagle's medium; FCS; fetal calf serum; Ab; antibiotic-antimycotic mix stock solution; BSA; bovine serum albumin; ICP-MS; inductively coupled plasma mass spectrometry; FITC; fluorescein-isothioc
Evaluating the Transport Kinetics of a Model Compound Released From Cellulosic Coacervate Compositions Into Artificial Sebum
Keywords: پاپ; bioavailability; coacervation; controlled release; permeability; polymeric drugs; site-specific delivery; skin; cat-HEC; cationic-hydroxyethyl cellulose; cat-HECDS; cationic-hydroxyethyl cellulose dodecyl sulfate; CPB; citrate-phosphate buffer; Daq; aqueo