A dabigatran etexilate phospholipid complex nanoemulsion system for further oral bioavailability by reducing drug-leakage in the gastrointestinal tract

In this study, we successfully developed a dabigatran etexilate-phospholipid complex (DE-PC) nanoemulsion system. With the advantage of both phospholipid complexes and nanoemulsions, DE-PC nanoemulsions significantly reduced drug leakage and precipitation in the gastrointestinal tract and improved the bioavailability of dabigatran etexilate. The drug-phospholipid complex nanoemulsion system provides a promising approach for the oral administration of pH-dependent soluble drugs.180