کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8288572 1536258 2018 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of glycated insulin on the blood-brain barrier permeability: An in vitro study
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Effect of glycated insulin on the blood-brain barrier permeability: An in vitro study
چکیده انگلیسی
According to our results, glycated insulin presented altered conformation and more exposed hydrophobic patches than insulin. Formation of oligomeric species and advanced glycated end products (AGEs) were determined. Lower cell viability, higher apoptosis, and more ROS were detected upon treatment of cells with glycated insulin. Finally, glycated insulin led to increased Lucifer yellow and FITC-dextran transportation across the BBB model which could result from ROS producing and apoptosis-inducing activities of AGE-insulin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Biochemistry and Biophysics - Volume 647, 1 June 2018, Pages 54-66
نویسندگان
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