دانلود مقالات ISI درباره پاپ + ترجمه فارسی

Ipratropium is 'luminally recycled' by an inter-play between apical uptake and efflux transporters in Calu-3 bronchial epithelial cell layers

Keywords: پاپ; a-b; apical to basolateral; ALI; air-liquid interface; b-a; basolateral to apical; FITC; fluorescein isothiocyanate; HBSS; Hank's Balanced Salt Solution; IPRL; isolated perfused rat lungs; MATE; multidrug and toxin extrusion transporters; MRP; Multidrug

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2017 سفارش ترجمه

Andrographolide-loaded nanoparticles for brain delivery: Formulation, characterisation and in vitro permeability using hCMEC/D3 cell line

Keywords: پاپ; AG; andrographolide; ATM; adsorptive-mediated transcytosis; BBB; blood-brain barrier; BSA; bovine serum albumin; CNS; central nervous system; DLS; Dynamic Light Scattering; DMSO; dimethyl sulfoxide; ECA; ethylcyanoacrylate; EE; encapsulation efficiency; E

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

Trimethyl chitosan based conjugates for oral and intravenous delivery of paclitaxel

Keywords: پاپ; 2′SPTX; 2′-O-succinyl-paclitaxel; AUC; area under the concentrationtime curve; BSA; bovine serum albumin; CMC; critical micelle concentration; DMEM; Dulbecco's Modified Eagle Medium; DMSO; dimethyl sulfoxide; DSC; differential scanning calorimetry;

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2017 سفارش ترجمه

Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites

Keywords: پاپ; ABC transporters; transporters; skin; P-glycoprotein; tissue partition; ABCB1; ATP binding cassette subfamily B member 1; ABCG2; ATP binding cassette subfamily G member 2; BCRP; breast cancer resistance protein; CRC; colorectal cancer; CYP3A4; cytochrome

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2017 سفارش ترجمه

Determinants of Intestinal Availability for P-glycoprotein Substrate Drugs Estimated by Extensive Simulation With Mathematical Absorption Models

Keywords: پاپ; drug-drug interaction; P-glycoprotein; physiologically based pharmacokinetic model; modeling and simulation; intestinal absorption; substrate drug; CLh; hepatic clearance; CLr; renal clearance; CYP3A; cytochrome P450 3A; DDI; drug-drug interaction; EQ

دانلود رایگان متن کامل مقاله ISI 57 صفحه سال انتشار : 2017 سفارش ترجمه

Assessment of ABCG2-mediated transport of pesticides across the rabbit placenta barrier using a novel MDCKII in vitro model

Keywords: پاپ; ABCG2; ATP-binding cassette sub-family G member 2; CPF; chlorpyrifos; DAPI; 4′-6-diamidino-2-phenylindole; FTC; fumitremorgin C; MDCKII; Madin-Darby canine kidney type II cells; MRL; maximum residue limits; Papp; apparent permeability coefficient; TEER;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

P-gp, MRP2 and OAT1/OAT3 mediate the drug-drug interaction between resveratrol and methotrexate

Keywords: پاپ; Res; resveratrol; MTX; methotrexate; P-gp; P-glycoprotein; MRP2; multidrug resistance-associated protein 2; MDR1; multidrug resistance 1; OATs; organic anion transporters; DDIs; drug-drug interactions; Papp; apparent permeability coefficients; ER; Efflux

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Validation of UHPLC-MS/MS methods for the determination of kaempferol and its metabolite 4-hydroxyphenyl acetic acid, and application to in vitro blood-brain barrier and intestinal drug permeability studies

Keywords: پاپ; 4-HPAA; 4-hydroxyphenyl acetic acid; ACN; acetonitrile; BSA; bovine serum albumin; Cal; calibrator; CCl; cell layer capacitance; CNS; central nervous system; CV%; coefficient of variation; CPT-cAMP; 8-(4-chlorophenylthio)-adenosine-3′,5′-cyclic monoph

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

The bacterial cell envelope as delimiter of anti-infective bioavailability - An in vitro permeation model of the Gram-negative bacterial inner membrane

Keywords: پاپ; CL; cardiolipin; ER; electrical resistance; IM; inner membrane; KRB; Krebs-Ringer buffer; LC; liquid condensed; LE; liquid expanded; MIC; minimal inhibitory concentration; OM; outer membrane; PC; phosphatidylcholine; PL; phospholipid; Papp; apparent perme

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Prospective, Randomized, Concurrently-Controlled Study of a Stent Graft versus Balloon Angioplasty for Treatment of Arteriovenous Access Graft Stenosis: 2-Year Results of the RENOVA Study

Keywords: پاپ; ACPP; access circuit primary patency; AE; adverse event; AVF; arteriovenous fistula; AVG; arteriovenous graft; CI; confidence interval; ePTFE; expanded polytetrafluoroethylene; ESRD; end-stage renal disease; IPF; index of patency function; ITT; intention-

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Quercetin-loaded freeze-dried nanomicelles: Improving absorption and anti-glioma efficiency in vitro and in vivo

Keywords: پاپ; ATCC; American Tissue Culture Collection; BBB; blood-brain barrier; CMC; critical micelle concentration; DL; drug loading; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; DPH; 1,6-diphenyl-1,3,5-hexatriene; EE; encapsulation efficiency

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2016 سفارش ترجمه

Simulated gastrointestinal digestion and in vitro colonic fermentation of spent coffee (Coffea arabica L.): Bioaccessibility and intestinal permeability

Keywords: پاپ; SC; spent coffee; DPPH; 2,2-diphenyl-1-picrylhydrazyl; ABTS; 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid); TEAC; Trolox Equivalent Antioxidant Capacity; TE; Trolox equivalents; NDSCF; non-digested SC fraction; Papp; apparent permeability coeff

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Investigation of the absorption of resveratrol oligomers in the Caco-2 cellular model of intestinal absorption

Keywords: پاپ; DMEM; Dulbecco's Modified Eagle Medium; FBS; fetal bovine serum; GUS; glucuronidase; LC-UV; liquid chromatography with ultraviolet absorbance detection; LY; lucifer yellow; n.d.; not detected; Papp; apparent permeability coefficient; SD; standard devi

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Development of an online-SPE-LC-MS method for the investigation of the intestinal absorption of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PHIP) and its bacterial metabolite PHIP-M1 in a Caco-2 Transwell system

Keywords: پاپ; PHIP; 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine; PHIP-M1; 7-hydroxy-5-methyl-3-phenyl-6,7,8,9-tetrahydropyrido[3′,2′:4,5]imidazo[1,2-a]pyrimidin-5-ium chloride; Papp; apparent permeability coefficient; HCA; heterocyclic aromatic amine; CE; colli

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Condensed catechins and their potential health-benefits

Keywords: پاپ; ACE; angiotensin I-converting enzyme; AMPK; AMP-activated protein kinase; AUC; area under the curve; BGL; blood glucose level; CaMKK; Ca2+/camodulin-dependent protein kinase kinase; COX; cyclooxygenases; EC; (−)-epicatechin; EDRF; endothelium derived-re

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Research paperEffects of herbal drugs in Mahuang decoction and their main components on intestinal transport characteristics of Ephedra alkaloids evaluated by a Caco-2 cell monolayer model

Keywords: پاپ; TCM; traditional Chinese medicine; MHP; multi-herb prescription; LEP; l-ephedrine; DPEP; d-pseudoephedrine; LMEP; l-methylephedrine; P-gp; P-glycoprotein; ER; efflux ratio; AP; apical; BL; basolateral; Papp; apparent permeability; PAB; permeability from A

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Oral delivery of shRNA based on amino acid modified chitosan for improved antitumor efficacy

Keywords: پاپ; Chitosan; Amino acid modification; Survivin shRNA; Oral delivery; Antitumor efficacy; ANOVA; analysis of variance; CH; chitosan-histidine; CHC30; chitosan-histidine-cysteine with molecular weight of 30 kDa; CHC30 NC; CHC30/ shSur-pDNA nanocomplexes

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Comparison of MDCK-MDR1 and Caco-2 cell based permeability assays for anti-malarial drug screening and drug investigations

Keywords: پاپ; MDCK; Madin-Darby canine kidney; MDR1; multi-drug resistance gene 1; Caco-2; colorectal adenocarcinoma; P-gp; P-glycoprotein; Papp; permeability coefficient; PAPMA; parallel artificial membrane permeability assay; LC-MS; liquid chromatography-mass spe

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

N-alkylation of highly quaternized chitosan derivatives affects the paracellular permeation enhancement in bronchial epithelia in vitro

Keywords: پاپ; A; surface area (cm2); ALI; air-liquid interface; CSLM; confocal scanning laser microscopy; DA; degree of acetylation; DQ; degree of quaternization; DS; degree of substitution; ER; permeation enhancement ratio; FBS; fetal bovine serum; FCS; fetal calf s

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Lecithin in mixed micelles attenuates the cytotoxicity of bile salts in Caco-2 cells

Keywords: پاپ; SDC; sodium deoxycholate; BS; bile salts; PC; phosphatidylcholine; TEER; transepithelial electrical resistance; Papp; apparent permeability coefficient; FD-4; FITC-dextran 4400; Mixed micelles; Bile salt; Lecithin; Caco-2 cells; Cytotoxicity;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Assessment of verbascoside absorption in human colonic tissues using the Ussing chamber model

Keywords: پاپ; BHT; butylated hydroxytoluene; Isc; Short circuit current; MF; microfiltrated; OMWW; Olive Mill Waste Water; Papp; apparent permeability coefficient; Papp,tissue; the apparent permeability coefficient tissue; Papp,total; apparent permeability coefficient

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Milk enhances intestinal absorption of green tea catechins in in vitro digestion/Caco-2 cells model

Keywords: پاپ; DMEM; Dulbecco's Modified Eagle's medium; EC; epicatechin; ECG; epicatechin gallate; EGC; epigallocatechin; EGCG; epigallocatechin gallate; FBS; fetal bovine serum; GCG; gallocatechin gallate; GTE; green tea extract; HBSS; Hank's balanced salt solution; H

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Reduced system exposures of total rhein and baicalin after combinatory oral administration of rhein, baicalin and berberine to beagle dogs and rats

Keywords: پاپ; Rh; rhein; BG; baicalin; B; baicalein; Be; berberine; SHXXT; San-Huang-Xie-Xin-Tang; HLJDT; Huang-Lian-Jie-Du-Tang; PSP; phenolsulfonphthalein; HPLC; High performance liquid chromatography; Papp; apparent permeability coefficient; Rhein; Baicalin; Berberi

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins

Keywords: پاپ; AαBA; 3-acetyl-α-boswellic acid; AβBA; 3-acetyl-β-boswellic acid; AKBA; 3-acetyl-11-keto-β-boswellic acid; BA; boswellic acid; αBA; α-boswellic acid; βBA; β-boswellic acid; BSE; Boswellia serrata gum resin extract; HLM; human liver microsomes; KB

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and evaluation of nitric oxide-releasing DDB derivatives as potential Pgp-mediated MDR reversal agents in MCF-7/Adr cells

Keywords: پاپ; DDB; dimethyl-4,4′-dimethoxy-5,6,5′,6′-dimethylenedioxybiphenyl-2,2′-dicarboxylate; NO; nitric oxide; MDR; multidrug resistance; VER; Verapamil; Dox; doxorubicin; EDCI; 1-(3-dimethyl aminopropyl)-3-ethylcarbodiimide hydrochloride; DMAP; 4-dimethyl

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

The mycotoxin patulin increases colonic epithelial permeability in vitro

Keywords: پاپ; TEER; transepithelial electrical resistance; PD; potential difference; KH; Krebs-Henseleit buffer; CCh; carbachol; Papp; apparent permeability coefficient; CN; cell number; NA; nuclear area; NI; nuclear intensity; MMP; mitochondrial membrane potential;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Evaluation of air-interfaced Calu-3 cell layers for investigation of inhaled drug interactions with organic cation transporters in vitro

Keywords: پاپ; OCT; organic cation transporters; PKPD; pharmacokinetic/pharmacodynamic; NHBE; normal human bronchial epithelial; RT-PCR; reverse transcriptase polymerase chain reaction; TEER; transepithelial electrical resistance; ASP+; 4-(4-(diethylamino)styryl)-N-meth

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport

Keywords: پاپ; CSKSSDYQC peptide; Goblet cell-targeting; Mucus; Caco-2/HT29-MTX co-cultured cells; N-trimethyl chitosan chloride nanoparticles; CSK; CSKSSDYQC; TJs; tight junctions; NPs; nanoparticles; TMC; N-trimethyl chitosan chloride; INS; insulin; FITC; fluorescein

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Lipophilicity study of some non-steroidal anti-inflammatory agents and cephalosporin antibiotics: A review

Keywords: پاپ; 13C NMR; carbon nuclear magnetic resonance; 1H NMR; proton nuclear magnetic resonance; ADME; absorption distribution metabolism elimination; AID; adjuvant induced disease; AUC; plasma-time curve; BBB; blood-brain barrier; BMC; biopartitioning micellar

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2011 سفارش ترجمه

Design, synthesis and biological evaluation of mannosyl triazoles as FimH antagonists

Keywords: پاپ; ABTS; 2,2′-azino-di-(3-ethylbenzthiazoline-6-sulfonic acid); AUC; area under the curve; BSA; bovine serum albumin; CRD; carbohydrate recognition domain; D; distribution coefficient; DCM; dichloromethane; DMSO; dimethyl sulfoxide; GIT; gastrointestinal t

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2011 سفارش ترجمه

P-glycoprotein and cytochrome P450 3A4 involvement in risperidone transport using an in vitro Caco-2/TC7 model and an in vivo model

Keywords: پاپ; ab; apical to basolateral; AQ; absorptive quotient; AUCT; area under the curve; ba; basolateral to apical; ClR; renal clearance; Cmax; maximum plasma concentration; CYP; cytochrome P450; ER; efflux ratio; F; fraction not metabolised; FA; fraction absorbed

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Sensitive electrochemical enzyme immunoassay microdevice based on architecture of dual ring electrodes with a sensing cavity chamber

Keywords: پاپ; Dual-ring electrode; Differential pulse voltammetry (DPV); Competitive inhibition ELISA; Electrochemical immunoassay; PAPP

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Functional and pharmacological mechanisms of nucleoside transport across the basolateral membrane of rabbit tracheal epithelial cells

Keywords: پاپ; RTEC; rabbit tracheal epithelial cells; NBMPR; nitro-benzyl-mercapto-purine-ribose; ei; equilibrative NBMPR-insensitive; es; equilibrative NBMPR-sensitive; PKA; protein kinase A; PKC; protein kinase C; A23187; a calcium ionophore; H89; a PKA inhibitor; HB

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Transport of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid and its acyl glucuronide by human intestinal Caco-2 cells

Keywords: پاپ; ACSRC; Auckland Cancer Society Research Centre; AP; apical; BL; basolateral; CYP; cytochrome P450; DMSO; dimethyl sulphoxide; DMXAA; 5,6-dimethylxanthenone-4-acetic acid; DMXAA-G; DMXAA acyl glucuronide; HBSS; Hanks' balanced salt solution; HEPES; N-[2-

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه